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Pan-Pan Shu,Lu-Xi Li,Qin-Min He,Jun Pan,Xiao-Lei Li,Min Zhu,Ye Yang,Yuan Qu 고려인삼학회 2021 Journal of Ginseng Research Vol.45 No.2
Background: Panax stipuleanatus represents a folk medicine for treatment of inflammation. However, lack of experimental data does not confirm its function. This article aims to investigate the analgesic and anti-inflammatory activities of triterpenoid saponins isolated from P. stipuleanatus. Methods: The chemical characterization of P. stipuleanatus allowed the identification and quantitation of two major compounds. Analgesic effects of triterpenoid saponins were evaluated in two models of thermal- and chemical-stimulated acute pain. Anti-inflammatory effects of triterpenoid saponins were also evaluated using four models of acetic acid-induced vascular permeability, xylene-induced ear edema, carrageenan-induced paw edema, and cotton pellet-induced granuloma in mice. Results: Two triterpenoid saponins of stipuleanosides R₁ (SP-R₁) and R₂ (SP-R₂) were isolated and identified from P. stipuleanatus. The results showed that SP-R₁ and SP-R₂ significantly increased the latency time to thermal pain in the hot plate test and reduced the writhing response in the acetic acid-induced writhing test. SP-R₁ and SP-R₂ caused a significant decrease in vascular permeability, ear edema, paw edema, and granuloma formation in inflammatory models. Further studies showed that the levels of inflammatory mediators, nitric oxide, malondialdehyde, tumor necrosis factor-α, and interleukin 6 in paw tissues were downregulated by SP-R₁ and SP-R₂. In addition, the rational harvest of three- to five-year-old P. stipuleanatus was preferable to obtain a higher level of triterpenoid saponins. SP-R₂ showed the highest content in P. stipuleanatus, which had potential as a chemical marker for quality control of P. stipuleanatus. Conclusion: This study provides important basic information about utilization of P. stipuleanatus resources for production of active triterpenoid saponins.
Iterative Learning Control for a Class of Mixed Hyperbolic-parabolic Distributed Parameter Systems
Qin Fu,Wei-Guo Gu,Pan-Pan Gu,Jian-Rong Wu 제어·로봇·시스템학회 2016 International Journal of Control, Automation, and Vol.14 No.6
This paper deals with the problem of iterative learning control algorithm for a class of mixed distributedparameter systems. Here, the considered distributed parameter systems are composed of mixed hyperbolicparabolicpartial differential equations. The domain of the system is divided into two parts in which the system ishyperbolic and parabolic, respectively, with transmission conditions at the interface. According to the characteristicsof the systems, iterative learning control laws are proposed for such mixed hyperbolic-parabolic distributedparameter systems based on P-type learning scheme. Using the contraction mapping method, it is shown that thescheme can guarantee the output tracking errors on L2 space converge along the iteration axis. A simulation exampleillustrates the effectiveness of the proposed method.
Qin Pan,Qilong Wang,Fengling Luo,Min Li,Xianru Xia Dongdong Shi,Xiao-Lian Zhang 한국당과학회 2012 한국당과학회 학술대회 Vol.2012 No.1
Tuberculosis (TB) has been a major world-wide cause of death for centuries. One-third of the world’s population is infected with Mycobacterium tuberculosis (M.tb), the etiologic agent of TB. The development of potent new anti-TB drugs is urgently needed. The major M.tb surface lipoglycans, mannose-capped Lipoarabinomannan (ManLAM) had immunosuppressive effects during M.tb infection. In this study, aptamer ZXL1 which specifically bound to ManLAM from the virulent strain M.tb H37Rv was screened out by Systematic Evolution of Ligands by EXponential enrichment (SELEX). The binding affinity of ZXL1 to ManLAM was measured as 8.907X10-8 M of quilibrium dissociation constant (Kd) value by surface plasmon resonance (SPR) analysis. We found that aptamer ZXL1 prevented the ManLAM-induced immunosuppressive effects on DCs and inhibited M. tb entry into macrophages. More importantly, we found that single injection of aptamer ZXL1 significantly prolonged the survival rate of infected mice, and prevent the infected rhesus monkeys from weight loss. The Bacterial numbers were significantly lower in the lungs and spleens in ZXL1-treated groups. These results suggest that aptamer ZXL1 can be used as antimycobacterial agent or as TB vaccine adjuvent.
Qin Fu,Pan-Pan Gu,Jian-Rong Wu 제어·로봇·시스템학회 2017 International Journal of Control, Automation, and Vol.15 No.5
This paper deals with the problem of iterative learning control for large-scale interconnected linear systemsin the presence of fixed initial shifts. According to the characteristics of the systems, iterative learning controllaws are proposed for such large-scale interconnected linear systems based on the PD-type learning schemes. Theproposed controller of each subsystem only relies on local output variables without any information exchanges withother subsystems. Using the contraction mapping method, we show that the schemes can guarantee the output ofthe system converges uniformly to the corresponding output limiting trajectory over the whole time interval alongthe iteration axis. Simulation examples illustrate the effectiveness of the proposed method.
Gao, Pan,Tao, Ning,Ma, Qin,Fan, Wen-Xi,Ni, Chen,Wang, Hui,Qin, Zhi-Hai Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.9
Aim: The purpose of this study was to investigate anti-tumor effects and safety of DH332, a new ${\beta}$-carboline alkaloids derivatives in vitro and in vivo. Materials and Methods: The effects of DH332 on human (RAMOS RA.1) and mouse (J558) B lymphoma cell lines were detected using a CCK-8 kit (Cell Counting Kit-8), and apoptosis was detected by flow cytometry with PI/annexinV staining. Western blotting was used to detected caspase-3 and caspase-8. Neurotoxic and anti-tumor effects were evaluated in animal experiments. Results: DH332 exerts a lower neurotoxicity compared with harmine. It also possesses strong antitumor effects against two B cell lymphoma cell lines with low $IC_{50s}$. Moreover, DH332 could inhibit the proliferation and induce the apoptosis of RAMOS RA.1 and J558 cell lines in a dose-dependent manner. Our results suggest that DH332 triggers apoptosis by mainly activating the caspase signaling pathway. In vivo studies of tumor-bearing BALB/c mice showed that DH332 significantly inhibited growth of J558 xenograft tumors. Conclusions: DH332 exerts effective antitumor activity in vitro and in vivo, and has the potential to be a promising drug candidate for lymphoma therapy.
Qin Chen,Wen-Wen Yang,Pan Shen,Qing-Ri Cao,Beom-Jin Lee,Jing-Hao Cui 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.6
The present study aimed to evaluate the gastrointestinalmucosa irritation of three platycodin formulations. Platycodin-loaded core pellets were prepared viaextrusion–spheronization method and coated withEudragit L100-55 (L100) or Eudragit S100 (S100) forpH-dependent release. The release of platycodin D fromcoated pellets exhibited pH dependent release profiles. Thepharmacokinetic study in rats showed that Tmax of thecoated pellets were prolonged as compared to that of uncoatedpellets. The S100-coated pellets possess a lowerCmax and decreased AUC0–24h as compared to the L100-coated and uncoated pellets. Hematoxylin-eosin stainingand nuclear factor Kappa B (NF-jB) measurement werecarried out to observe the gastrointestinal mucosa irritations. The results revealed that the irritations of platycodinon the upper gastrointestinal mucosa are dose-dependent. However, no obvious irritation effect on the gastrointestinaltissues of rats was detected after oral administration ofthe coated pellets. In addition, the amount of NF-jB in thestomach of rats treated with the uncoated pellets was aboutfivefold higher as compared to that of the coated pellets. Insummary, the L100-coated platycodin pellets exhibitedhigher oral bioavailability and less gastrointestinal mucosairritations as compared to the other two formulations.
Qin, Hai-Xia,Cui, Hong-Kai,Pan, Ying,Yang, Jun,Ren, Yan-Fang,Hua, Cai-Hong,Hua, Fang-Fang,Qiao, Yu-Huan Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.7
Objective: To investigate the effects of histone deacetylase 6 (HDAC6) siRNA on cell proliferation and cell apoptosis of the HeLa cervical carcinoma cell line and the molecular mechanisms involved. Methods: Division was into three groups: A, the untreated group; B, the control siRNA group; and C, the HDAC6 siRNA group. Lipofectamine 2000 was used for siRNA transfection, and Western blot analysis was used to determine the protein levels. Cell proliferation and apoptosis were characterized using a CCK-8 assay and flow cytometry, respectively. Results: HDAC6 protein expression in the HDAC6 siRNA-transfection group was significantly lower (P < 0.05) than in the untreated and control siRNA groups. The CCK-8 kit results demonstrated that the proliferation of HeLa cells was clearly inhibited in the HDAC6 siRNA transfection group (P < 0.05). In addition, flow cytometry revealed that the early apoptotic rate ($26.0%{\pm}0.87%$) was significantly elevated (P < 0.05) as compared with the untreated group ($10.6%{\pm}1.19%$) and control siRNA group ($8.61%{\pm}0.98%$). Furthermore, Western blot analysis indicated that bcl-2 protein expression in the HDAC6 siRNA-transfection group was down-regulated, whereas the expression of p21 and bax was up-regulated. Conclusion: HDAC6 plays an essential role in the occurrence and development of cervical carcinoma, and the down-regulation of HDAC6 expression may be useful molecular therapeutic method.
Qin, Shuanglin,Wang, Pan,Huang, Shuangping,Liu, Shuai,Wang, Gaopeng,Wang, Liping,Sun, Meng,Wang, Xiaoji Korean Chemical Society 2015 대한화학회지 Vol.59 No.6
The reductive amination of cyclohexanone with ammonia over Cu-Cr-a/γ-Al<sub>2</sub>O<sub>3</sub> was investigated. It was found that a proper solvent with high solubility of ammonia and 4Å molecular sieves for the elimination of generated water contributed to the formation of cyclohexylamine in the premixing process. In addition, the addition of ammonia in the fixedbed reactor could obviously improve the conversion of cyclohexanone to cyclohexylamine. Finally, reaction conditions including reaction temperature, hydrogen pressure and charging rate of the premix were optimized. Under the optimized conditions, cyclohexylamine was obtained in 83.06% yield.
Position error compensation of the multi-purpose overload robot in nuclear power plants
Qin, Guodong,Ji, Aihong,Cheng, Yong,Zhao, Wenlong,Pan, Hongtao,Shi, Shanshuang,Song, Yuntao Korean Nuclear Society 2021 Nuclear Engineering and Technology Vol.53 No.8
The Multi-Purpose Overload Robot (CMOR) is a key subsystem of China Fusion Engineering Test Reactor (CFETR) remote handling system. Due to the long cantilever and large loads of the CMOR, it has a large rigid-flexible coupling deformation that results in a poor position accuracy of the end-effector. In this study, based on the Levenberg-Marquardt algorithm, the spatial grid, and the linearized variable load principle, a variable parameter compensation model was designed to identify the parameters of the CMOR's kinematics models under different loads and at different poses so as to improve the trajectory tracking accuracy. Finally, through Adams-MATLAB/Simulink, the trajectory tracking accuracy of the CMOR's rigid-flexible coupling model was analyzed, and the end position error exceeded 0.1 m. After the variable parameter compensation model, the average position error of the end-effector became less than 0.02 m, which provides a reference for CMOR error compensation.