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      • Incidence and Mortality of Female Breast Cancer in Jiangsu, China

        Wu, Li-Zhu,Han, Ren-Qiang,Zhou, Jin-Yi,Yang, Jie,Dong, Mei-Hua,Qian, Yun,Wu, Ming Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.6

        Objectives: The aim of this study was to describe and analyze the incidence and mortality of female breast cancer in Jiangsu Province of China. Methods: Incidence and mortality data for female breast cancer and corresponding population statistics from eligible cancer registries in Jiangsu from 2006 to 2010 were collected and analyzed. Crude rates, age-specific rates and age-standardized rates of incidence and mortality were calculated, and annual present changes (APCs) were estimated to describe the time trends. Results: From 2006 to 2010, 11,013 new cases and 3,068 deaths of female breast cancer were identified in selected cancer registry areas of Jiangsu. The annual average crude incidence and age-standardized incidence by world population (ASW) were 25.2/ and 17.9/100,000 respectively. The annual average crude and ASW for mortality rates were 7.03/ and 4.81/100,000. The incidence was higher in urban areas than that in rural areas, and this was consistent in all age groups. No significant difference was observed in mortality between urban and rural areas. Two peaks were observed when looking at age-specific rates, one at 50-59 years and another at over 85 years. During the 5 years, incidence and mortality increased with APCs of 4.47% and 6.89%, respectively. Compared to the national level, Jiangsu is an area with relatively low risk of female breast cancer. Conclusion: Breast cancer has become a main public health problem among Chinese females. More prevention and control activities should be conducted to reduce the burden of this disease, even in relatively low risk areas like Jiangsu.

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        Dynamic characteristics of the cavitation clouds of submerged Helmholtz self-sustained oscillation jets from high-speed photography

        Qiang Wu,Wei Wei,Bo Deng,Pan Jiang,Deng Li,Mengda Zhang,Zhenlong Fang 대한기계학회 2019 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.33 No.2

        Experiments were conducted to investigate the cavitation behavior of Helmholtz self-sustained oscillation jets. In this paper, highspeed photographic technology was used to capture the flow details of cavitation with various nozzle structures and operating pressures from 1.0 MPa to 3.0 MPa. Furthermore, an in-house code based on a matrix approach that processes gray values with various statistical methods was used to quantitatively evaluate the cavitation jet of waters generated by Helmholtz nozzles. The mean values of the normalized gray levels of the images were used as a metric to measure the lengths of the cavitation clouds. When the original data were smoothed by a 15th lowess filter to exclude the noise of the images, the periods of cavitation cloud shedding were obtained accordingly, and the average period had a magnitude of 10 -4 . All of the smoothed results of the original data captured a two-peak shape that comprises a large peak and a mild hump. Image processing results showed that the Helmholtz nozzle produced greater cavitation intensity than a traditional conical nozzle. The shear-layer instability waves disappeared within 10d 1 downstream from the injector exit. The cavitation clouds propagated a distance of approximately 1–10d 1 at various pressure ratios, and the clouds were continuous within this distance. The geometry of the nozzle strongly affected the length and shedding period of the cavitation cloud. As described in the discussion section of this paper, when the cavity length was doubled, the length of the cavitation cloud decreased approximately 26.5 %; however, the period of the cavitation cloud shedding increased approximately 10 %. The longest cavitation cloud appeared when the ratio of the cavity diameter and the upper nozzle diameter was eight. Excessively small or large diameters were not conducive to the development of cavitation, whereas the effect of the pressure ratio on the cavitation cloud length was positive. When other conditions remained unchanged, the lump shedding period decreased as the pressure ratio was increased to 25. When the pressure ratio exceeded 25, the cavitation cloud shedding period remained constant.

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        A Novel Facile and Green Synthesis Protocol to Prepare High Strength Regenerated Silk Fibroin/SiO2 Composite Fiber

        Qiang Liu,Zhaohui Meng,Ronghui Wu,Liyun Ma,Wu Qiu,Honghao Zhang,Shuihong Zhu,Lingqing Kong,Zijjie Xu,Aniruddha Patil,Xiangyang Liu 한국섬유공학회 2019 Fibers and polymers Vol.20 No.10

        In this work, regenerated silk fibroin (RSF) and silicon dioxide (SiO2) composite fiber was successfully extrudedby wet spinning method. The effect of SiO2 addition on structure of the composite fiber at microscopic level is studied, whichsubsequently correlated to the mechanical performance. The best concentration ratio for composite fiber is identified byscreening SiO2 concentration from 0.025 w/w% to 0.5 w/w%. The experimental results revealed that the SiO2 at a lowconcentration of 0.1 w/w% was well distributed. The breaking stress, breaking strain and Young’s modulus at 0.1 w/w% SiO2addition of the RSF fibers increased considerably compared to the neat RSF fibers from 243±3 to 458±21 MPa, 51±4 % to54±7 % and 6.34±0.55 to 11.69±1.12 GPa, respectively. To the best of our knowledge, this is the first report for RSF/SiO2composite fiber. We believed the insight provided in this report which looks into the structural evolution should be beneficialto the future design and building of other advanced functional fibers.

      • Investigation of a Novel IGCT Module for DC Circuit Breaker

        Qiang Yi,Yifei Wu,Yi Wu,Fei Yang,Zhihui Zhang,Chong Gao 전력전자학회 2019 ICPE(ISPE)논문집 Vol.2019 No.5

        Power semiconductors for DC circuit breaker (DCCB) have attracted great attentions due to their fast and arc-less operation under full-range current-breaking. Since the robustness of Integrated Gate-Commutated Thyristor (IGCT) is the highest among all full-control power semiconductors, it becomes the perfect power semiconductor candidate for DC circuit breaker. In this paper, the principle and operation of hybrid circuit breaker are introduced. Technical analysis of full-control power semiconductor is conducted and IGCT is the best choice for HCB. Then, A novel power semiconductor circuit based on two IGCTs, diode-bridge, snubber-circuit and MOV is proposed and designed both topologically and structurally. The selection of full-control power semiconductor is discussed and fast recover diode must be used to ensure reliability. Furthermore, the internal current distribution is analyzed. Finally, a test of a single-stage IGCT module prototype demonstrates successful current-breaking at over 10kA and below 4kV, which is promising in the area of fault protection in future MVDC distribution system.

      • Clinical Application of Endoscopic Inguinal Lymph Node Resection after Lipolysis and Liposuction for Vulvar Cancer

        Wu, Qiang,Zhao, Yi-Bing,Sun, Zhi-Hua,Ni, Jing,Wu, Yu-Zhong,Shao, Heng-Hua,Qu, Jun-Wei,Huang, Xin-En Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12

        Aim: To examine lymph nodes obtained after lipolysis and liposuction of subcutaneous fat of the inguinal region of female vulvar cancer patients to explore the feasibility of clinical application. Methods: The field of operation was on the basis of the range of the conventional resection of inguinal lymph nodes. We injected lipolysis liquid fanwise, started liposuction after 15-20 minutes; then the subcutaneous fatty tissue was sucked out clearly by suction tube. We selected the first puncture holes located on 2-3 cm part below anterior superior spine, the others respectively being located 3cm and 6cm below the first for puncturing into the skin, imbedding a trocar to intorduce $CO_2$ gas and the specular body, and excise the lymph nodes by ultrasonic scalpel. The surgical field chamber was set with negative pressure drainage and was pressured with a soft saline bag after surgery. Results: A lacuna emerged from subcutaneous of the inguinal region after lipolysis and liposuction, with a wide fascia easily exposed at the bottom where lymph nodes could be readily excised. The number of lymph nodes of ten patients excised within the inguinal region on each side was 4-18. The excised average number of lymph nodes was 11 when we had mature technology. Conclusion: Most of adipose tissue was removed after lipolysis and liposuction of subcutaneous tissue of inguinal region, so that the included lymph nodes were exposed and easy to excise by endoscope. This surgery avoided the large incision of regular surgery of inguinal region, the results indicating that this approach is feasible and safe for used as an alternative technology.

      • Magnetic Resonance Image Manifestations of the Atypical Meningioma

        Wu, Qing-Wu,Yan, Rui-Fang,Li, Qiang,Hu, Ying,Zhou, Feng-Mei,Ren, Ji-Peng,Yang, Rui-Min,Zhang, Yan Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11

        Through retrospective analysis of 13 cases of magnetic resonance image (MRI) manifestations of atypical meningiomas confirmed by operation and pathology in the First Affiliated Hospital of Xinxiang Medical University, the objective of this study was to evaluate the diagnostic value of MRI in order to improve the accuracy rate of preoperative diagnosis. In this retrospective analysis of MRI findings for atypical meningiomas in First Affiliated Hospital of Xinxiang Medical University from January to July in 2012, the location, morphology and tumor signals and other tumor imaging characteristics were covered. In 13 cases of atypical meningioma patients of this group, most tumors were located at typical sites (10/13), mainly the falx cerebri, parasagittal, convexity, saddle area. Only two cases were at atypical locations, 1 in the cerebellar hemisphere and 1 in a lateral ventricle. Most of the tumors showed T1 and T2 isointensity signals, and necrosis, calcification, and peritumoral edema were always featured. DWI showed isointensity in 11 cases (11/13), and hyperintensity in 2. Some 9 cases had dural tail signs, 12 had accurate positioning (12/13), and 2 were postoperative recurrences. MRI has high value in the diagnosis of atypical meningiomas, with important roles in early clinical diagnosis, treatment and prognosis evaluation.

      • 5-Aminoisoquinolinone Reduces the Expression of Vascular Endothelial Growth Factor-C via the Nuclear Factor-kappa B Signaling Pathway in CT26 Cells

        Wu, Wei-Qiang,Fauzee, Nilufer Jasmine Selimah,Wang, Ya-Lan Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.3

        Objective: VEGF-C has recently been identified as a key molecule which is involved in tumor lymphangiogenesis. The aim of this research was to investigate the role of PARP-1 inhibition in the regulation of VEGF-C expression in CT26 cells. Methods: CT26 cells were treated with or without the PARP-1 inhibitor 5-aminoisoquinolinone (5-AIQ). The expression of PARP-1, NF-kB, and VEGF-C proteins in CT26 cells was measured by Western blot analysis and the VEGF-C mRNA level was determined by reverse transcription polymerase chain reaction (RT-PCR). CT26-secreted VEGF-C was detected by enzyme-linked immunosorbent assay (ELISA). Results: The results of Western blot analysis showed that the expression levels of PARP-1, NF-kB, and VEGF-C were reduced in 5-AIQ treated CT26 cells and the levels of VEGF-C mRNA in 5-AIQ treated CT26 were significantly lower than t in 5-AIQ-untreated cells (P<0.05). The concentrations of CT26-secreted VEGF-C were also dramatically decreased (P<0.05). Conclusion: Here, we provide evidence for the first time that PARP-1 inhibition dramatically reduces VEGF-C expression via the nuclear factor NF-kB signaling pathway. We therefore propose that PARP-1 inhibition has an anti-lymphangiogenic effect and may contribute to the prevention of metastatic dissemination via the lymphatic system.

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