certainty and Dependence Analysis of Performance Limit State for Structural Multidimensional Fragility Evaluation

Qi’ang Wang,Ziyan Wu,Lu Liu 대한토목학회 2017 KSCE Journal of Civil Engineering Vol.21 No.4

Considering uncertainty and dependence of performance limit states (PLSs), the study addresses a methodology to evaluate multidimensional fragility. The purpose is to identify the PLS uncertainty quantitatively. The dependence between each PLS parameters is also investigated. The limit state band is firstly proposed to describe the bi-dimensional case. Through interval estimation, the band area with a certain confidence level is determined. A reinforcement concrete bridge is used as example to illustrate the proposed approach for developing fragility curves. PLS threshold samples are obtained to formulate limit state function using incremental dynamic analysis. The study investigates the sensitivity of the method for fragility assessment when different confidence levels are considered. In addition, influence of correlation coefficient between PLSs is evaluated. Results show that a fragility interval is obtained with the introduction of limit state band. The interval length decreases as with the reduction of the confidence level. The probability of failure becomes smaller when the dependence between PLSs is ignored, which will result in overestimation of the structural seismic performance

Sustainable Development Thought ; the Development Philosophy for Human Being in 21st Century

Qi, Lu 서울대학교 지리교육과 2000 地理敎育論集 Vol.43 No.1

Stimuli-Responsive Graphene Oxide-Polymer Nanocomposites

Qi Lu,장효선,Wen Jiao Han,이진현,최형진 한국고분자학회 2019 Macromolecular Research Vol.27 No.11

Graphene oxide (GO) attracts tremendous attention for application in high-performance stimuli-responsive “smart” materials because of its unique and excellent electrical, mechanical, thermal, and optical properties, high biocompatibility, and potential application in a variety of fields, including nanocomposite-based devices. Even at an extremely small loading, the chemical, physical, and mechanical properties of GO-polymer nanocomposites can be significantly changed due to its one-atom thickness and large surface area. Therefore, GO-based filler-containing polymer nanocomposites are sensitive to various external stimuli, such as electric and magnetic fields, pH, thermal or optical excitations, and stress. This article reviews the compositions, preparations, and characteristics of a variety of external stimuli-responsive nanocomposites containing GO and other graphene-based fillers. Particularly, the electrorheological and magnetorheological behaviors of smart fluids are described with well-known models and relationships. Finally, various applications of GO-polymer nanocomposites are briefly presented.

Reviews on Customer Knowledge Management Researches

Qi-cheng Lu,Wei Feng 한국산업정보학회 2007 한국산업정보학회 학술대회논문집 Vol.2007 No.3

A Colorimetric and Fluorescent pH Probe for Extremely Acidic Conditions and its Application in pH Test Paper

Qi-Hua You,Jinhai Shen,Ganping Shen,Liyun Peng,Yuanqin Lu,Qi Fu,Yuqing Xu,Lei Zhang 대한화학회 2018 Bulletin of the Korean Chemical Society Vol.39 No.3

Here, we report a highly water-soluble colorimetric and fluorescent pH probe that works in the pH range 0.2–3.0. The probe showed a rapid response, high stability, and excellent reversibility to acidity. Moreover, the fluorescence of probe was not influenced by the existence of high concentration of cations. The pKa of probe was calculated to be 2.25 ± 0.06. Furthermore, the pH test papers coated with the probe exhibited a distinct color change in acidic conditions.

Genetic variations in the bitter taste receptor gene TAS2R38 are related to cigarette smoking behavior in Han Chinese smokers

Qi Fei-Yan,Zhu Zhou-Hai,Li Meng,Guan Ying,Peng Qi-Yuan,Lu She-Ming,Liu Zhi-Hua,Wang Ming-Feng,Miao Ming-Ming,Chen Zhang-Yu,Li Xue-Mei,Bai Jie,Yao Jian-Hua 한국유전학회 2022 Genes & Genomics Vol.44 No.11

Background: Smoking behavior is influenced by multiple genes, including the bitter taste gene TAS2R38. It has been reported that the correlation between TAS2R38 and smoking behavior has ethnicity-based differences. However, the TAS2R38 status in Chinese smokers is still unclear. Objective: This study aims to investigate the possible relationship between genetic variations in TAS2R38 (A49P, V262A and I296V) and smoking behaviors in the Han Chinese population. Methods: The haplotype analyses were performed and smoking behavior questionnaire was completed by 1271 individuals. Genetic association analyses for smoking behavior were analyzed using chi-square test. Further, for investigating the molecular mechanism of TAS2R38 variants effect on smoking behavior, we conducted TAS2R38-PAV and TAS2R38-AVI expression plasmids and tested the cellular calcium assay by cigarette smoke compounds stimulus in HEK293. Results: Significant associations of genetic variants within TAS2R38 were identified with smoking behavior. We found a higher PAV/PAV frequency than AVI/AVI in moderate and high nicotine dependence (FTND ≥ 4; X2 = 4.611, 1 df, p = 0.032) and strong cigarette smoke flavor intensity preference (X2 = 4.5383, 1 df, p = 0.033) in participants. Furthermore, in the in vitro cellular calcium assay, total particle matter (TPM), N-formylnornicotine and cotinine, existing in cigarette smoke, activated TAS2R38-PAV but not TAS2R38-AVI-transfected cells. Conclusion: Our data highlights that genetic variations in TAS2R38 are related to smoking behavior, especially nicotine dependence and cigarette smoke flavor intensity preference. Our findings may encourage further consideration of the taste process to identify individuals susceptible to nicotine dependence, particularly Han Chinese smokers.

A Study on China’s New Media Industry Policy

Qi Lu 동북아경상학회 2021 동북아경상연구 Vol.2 No.2

Purpose – This study examined policies such as entry and investment in the new media field, focusing on major policies in the media industry. This study examined the new media industry policy, which was classified by referring to correlated books of Chinese media industry policy, and although there are various regulations in each field, this paper examined only entry and investment in each field. Design/Methodology/Approach – In this paper, literature research and descriptive methods using Chinese Internet articles were used to solve the research problems presented above, including related books, papers, and documents published in China. Findings – The development of the Chinese media industry is estimated to have the greatest impact on political development in the future.For this reason, China’s media industry has continued to carry out system reforms internally in a large environment of “reform and opening,” took the initiative in corporateization transformation, and is expected to expand investment space externally and gradually expand the level of openness. Research Implications – Due to the nature of this study, which was conducted based on literature research, limited research methods were selected because the research was conducted by finding regulations using books, research papers, and the Internet, and the opinions of policy-related personnel and experts could not be directly confirmed or investigated.This is beyond the scope of this researcher’s research ability in a situation where access to information in China is not free.In the future, we hope that more active research will be conducted according to China’s political development and information opening situation.

Proposal of a Pretreatment Nomogram for Predicting Local Recurrence after Intensity-Modulated Radiation Therapy in T4 Nasopharyngeal Carcinoma: A Retrospective Review of 415 Chinese Patients

Lu-Lu Zhang,Yi-Yang Li,Jiang Hu,Guan-Qun Zhou,Lei Chen,Wen-Fei Li,Ai-Hua Lin,Jun Ma,Zhen-Yu Qi,Ying Sun 대한암학회 2018 Cancer Research and Treatment Vol.50 No.4

Purpose Local relapse-free survival (LRFS) differs widely among patients with T4 category nasopharyngeal carcinoma (NPC). We aimed to build a nomogram incorporating clinicopathological information to predict LRFS in T4 NPC after definitive intensity-modulated radiation therapy (IMRT). Materials and Methods Retrospective study of 415 Chinese patients with non-metastatic T4 NPC treated with definitive IMRT with or without chemotherapy at our cancer center between October 2009 and September 2013. The nomogram for LRFS at 3 and 5 years was generated based on multivariate Cox proportional hazards regression, and validated using bootstrap resampling, assessing discriminative performance using the concordance index (C-index) and determining calibration ability via calibration curves. Results Five-year LRFS was 88.8%. We identified and incorporated four independent prognostic factors for LRFS: ethmoid sinus invasion, primary gross tumor volume, age, and pretreatment body mass index. The C-index of the nomogram for local recurrence was 0.732 (95% confidence interval, 0.726 to 0.738), indicating excellent predictive accuracy. The calibration curve revealed excellent agreement between nomogram-predicted and observed LRFS probabilities. Risk subgroups based on total point score cutoff values enabled effective discrimination of LRFS. Conclusion This pretreatment nomogram enables clinicians to accurately predict LRFS in T4 NPC after definitive IMRT, and could help to facilitate personalized patient counselling and treatment strategies.

Unified Description of Event-by-event Fluctuations in Some Global Observables in Nucleus-nucleus Collisions at High Energies

Qi-Wen Lu,Ling-Ling Liu,Fu-Hu Liu,N. N. Abd Allah 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.4

Event-by-event fluctuations in the multiplicity, the total transverse energy, the mean transverse energy, and the mean transverse momentum in nucleus-nucleus collisions at high energies are uniformly described by using a multi-component Erlang distribution obtained in the framework of a multisource thermal model. The calculated results are compared and found to be in agreement with the experimental data of the WA98, NA49, and PHENIX Collaborations.

Risk Assessment of Secondary Primary Malignancies in Nasopharyngeal Carcinoma: A Big-Data Intelligence Platform-Based Analysis of 6,377 Long-term Survivors from an Endemic Area Treated with Intensity-Modulated Radiation Therapy during 2003-2013

Lu-Lu Zhang,Guo-Hong Li,Yi-Yang Li,Zhen-Yu Qi,Ai-Hua Lin,Ying Sun 대한암학회 2019 Cancer Research and Treatment Vol.51 No.3

Purpose The incidence, risk factors and survival impact of secondary primary malignancies (SPMs) among survivors of nasopharyngeal carcinoma (NPC) treated with definitive intensity-modulated radiation therapy (IMRT) with or without chemotherapy are poorly characterized. Materials and Methods Consecutive patients (n=6,377) from the big-data intelligence platform at Sun Yat-sen University Cancer Center, China (in a high-incidence area) with newly diagnosed non-metastatic pathologically proven non-keratinizing undifferentiated NPC treated with IMRT±chemotherapy between January 2003 and June 2013 were retrospectively analyzed. Cumulative incidence of SPMs was calculated using the Kaplan-Meier method. Cox proportional hazards model was used to identify potential risk factors for SPMs and assess whether SPMs affect overall survival. Results Of the 6,377 patients, 189 (3.0%) suffered SPMs (median follow-up, 62 months). One-, 2-, 3-, 4-, and 5-cumulative risks of SPMs were 0.4%, 0.9%, 1.6%, 2.2%, and 2.6%, respectively. Latency from start of IMRT to SPMs diagnosis was 37 months (range, 6 to 102 months). In patients with SPMs, 14.3% suffered SPMs within 1 year post-IMRT: 1-3 years, 38.1%; 3-5 years, 33.9%; and > 5 years, 13.7%. Lung cancer was the most common SPM (50/6,377, 0.78%). Multivariate analysis demonstrated sex (male, 64% increase), age (! 50 years, 68% increase), and smoking history (41% increase) were significant risk factors for SPMs, and SPMs were associated with poorer overall survival. Conclusion This large cohort study confirms SPMs a dreadful complication for long-term survivors of NPC treated with IMRT. SPMs negatively impact overall survival in NPC. Close follow-up is recommended for older male survivors with a smoking history.