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- 저자 : Qi‑Lei Dai (검색결과 9 건)
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Qi‑Lei Dai,Kun Li,Kai‑Ren Meng,Zhou Fang,Wen Chen,Tian‑Bao Yang,Chi Feng,Jin‑Ming Wu,R. D. K. Misra 대한금속·재료학회 2023 METALS AND MATERIALS International Vol.29 No.4
Advanced automotive industries generate large demand for the next generation of high strength and high toughness springsteels. Vanadium-containing 55SiCrV spring steels subjected to rapid-induction heating treatment can fulfil such requirements. However, the effect of vanadium microalloying under online rapid-induction heat treatments is rarely reported. Acomparative study of the microstructure and tensile properties of 55SiCr and 55SiCrV spring steel wires subjected to a novelonline rapid induction heat treatment has been demonstrated herein. It is found that the tensile strength of the 55SiCr springwire decreases with the decrease in the wire speed in online rapid-induction heating, and the plasticity increases. Whereas,the tensile strength of the 55SiCrV steel wire increases with the decrease in the wire speed with the retained high plasticity,which is attributed to the strengthening effect of the dislocations. Through the optimized rapid-induction heating/coolingthermal cycles and intermediate-temperature tempering treatment, the tensile strength of the 55SiCrV steel wire approaches2106 MPa with total elongation of 9.7%. Compared with the 55SiCr spring steel, the addition of V in 55SiCrV spring steelchanges the strengthening and toughening mechanisms via the grain refinement and enhancement in the hardenability andtempering resistance. The finely dispersed V-containing secondary phases are rarely found in the matrix, which indicates thatthe precipitation effect stemming from the addition of V is not the dominant strengthening factor in the online rapid-inductionheat process. The proposed novel online rapid-induction heat treatment provides a promising pathway for the mechanicalproperty improvement of the spring steel.
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Research on Large‑scale Photovoltaic Planning Based on Risk Assessment in Distribution Network
Lei Wang,Minyu Yuan,Fan Zhang,Xuli Wang,Jing Ma,Lei Dai,Xianjun Qi,Rui Bi 대한전기학회 2020 Journal of Electrical Engineering & Technology Vol.15 No.3
Risks caused by large amounts of distributed photovoltaic (PV) feeding into distribution networks, have an impact on PV planning, which has become a critical consideration for distribution networks’ operation. In this paper, a large-scale PV planning method is proposed which based on risk assessment in distribution networks. Cluster division is used to group large-scale distributed PVs. A risk assessment is performed on the distribution network, considering the correlation between PVs and loads. The efects of load fuctuations, PV quantity, capacity and location on the operational risk of the distribution network are analyzed and discussed. A large-scale PV planning model is established with the goal of maximizing the comprehensive benefts, considering the penalty cost of node voltage over-limit and branch power fow over-limit risk. Finally, the genetic algorithm is used to solve the planning model. The simulation results demonstrate the efectiveness of the proposed method.
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Xu, Ling,Dai, Wei-Qi,Xu, Xuan-Fu,Wang, Fan,He, Lei,Guo, Chuan-Yong Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.7
Backgrounds: To investigate the inhibiting effects of multi-target anti-microRNA antisense oligonucleotide (MTg-AMOs) on proliferation and migration of human gastric cancer cells. Methods: Single anti-microRNA antisense oligonucleotides (AMOs) and MTg-AMOs for miR-221, 21, and 106a were designed and transfected into SGC7901, a gastric cancer cell line, to target the activity of these miRNAs. Their expression was analyzed using stem-loop RT-PCR and effects of MTg-AMOs on human gastric cancer cells were determined using the following two assay methods: CCK8 for cell proliferation and transwells for migration. Results: In the CCK-8 cell proliferation assay, $0.6{\mu}mol/L$ was selected as the preferred concentration of MTg-AMOs and incubation time was 72 hours. Under these experimental conditions, MTg-AMOs demonstrated better suppression of the expression of miR-221, miR-106a, miR-21 in gastric cancer cells than that of single AMOs (P = 0.014, 0.024; 0.038, respectively). Migration activity was also clearly decreased as compared to those in randomized and blank control groups ($28{\pm}4$ Vs $54{\pm}3$, P <0.01; $28{\pm}4$ Vs $59{\pm}4$, P < 0.01). Conclusions: MTg-AMOs can specifically inhibit the expression of multiple miRNAs, and effectively antagonize proliferation and migration of gastric cancer cells promoted by oncomirs.
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The miR-146a rs2910164 G > C Polymorphism and Susceptibility to Digestive Cancer in Chinese
Wu, Dong,Wang, Fan,Dai, Wei-Qi,He, Lei,Lu, Jie,Xu, Ling,Guo, Chuan-Yong Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.1
Background: Several studies have reported the role of the miR-146a rs2910164 G > C polymorphism as a susceptibility factor for several digestive cancers. However, the results have been controversial. Therefore, we conducted the present meta-analysis to obtain the most reliable estimate of the association. Methods: PubMed, Embase and Web of Science databases were searched. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were extracted and pooled to assess the strength of the association between miR-146a rs2910164 G > C polymorphism and digestive cancer risk. A total of four eligible studies including 3,447 cases and 5,041 controls based on the search criteria were included. Results: We observed that miR-146a rs2910164 G > C polymorphism was not significantly correlated with digestive cancer risks when all studies were pooled into the meta-analysis. While we found that miR-146a rs2910164 polymorphism was not associated with gastric cancer, it was significantly linked with hepatocellular cancer risk (the homozygote codominant model: OR = 1.40, 95% CI = 1.04-1.87). In the stratified analysis by ethnicity, significant associations were observed in Chinese population for the allele contrast model (OR = 1.25; 95% CI = 1.12-1.38), for the homozygote codominant model (OR = 1.62; 95% CI = 1.28-2.04), and for the recessive model (OR = 1.38; 95% CI = 1.16-1.64). However, studies with Asian groups presented no significant association for all genetic models. Conclusions: This meta-analysis suggests that the miR-146a rs2910164 G > C polymorphism is a low-penetrant risk factor for digestive cancers in Chinese.
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Laser-processing of transparent solid materials for advanced photonic device applications
Feng Zhu,Rui Yang,Lei Wang,Yong-Sen Yu,Qi-Dai Chen,Hong-Bo Sun 한국생산제조학회 2012 한국생산제조시스템학회 학술발표대회 논문집 Vol.2012 No.10
We demonstrate the laser processing for fabrication of advanced photonic devices including fiber gratings and high transmittance biomimetic windows. The fiber gratings, including fiber Bragg gratings (FBGs) and long period fiber gratings (LPFGs), are fabricated in non-sensitized standard telecom single-mode fiber by femtosecond (fs) laser, making them hightemperature (1000 ℃) stable. The FBG written by fs laser combined with phase mask method is used for monitoring the thermal effect in fs laser interaction with silica glass. The peak temperature of the thermal impulse is estimated about 4800 ℃, which decays to around 500 ℃ in the pulse interval for irradiation of 1.1 mJ at repetition rate of 1 kHz. When the pulse energy and repetition rate increase in the fabrication process of FBGs, the fs-laser-induced grating regions extend from the fiber core to the cladding?air boundary due to the laser self-focusing. With the help of selective chemical etching of the laser modified grating regions, a microhole array structured FBG is formed, which is demonstrated in the application of simultaneous sensing for refractive index (RI) and temperature. For the fs laser direct writing of LPFGs, the period is 100 μm, making the total length of the LPFG only 5 mm. The LPFGs can couple the guided mode to high-order cladding modes of second-order diffraction, resulting in a high RI sensitivity of 5265 nm/RI unit in the RI range of 1.433 ∼ 1.443 and a low-temperature sensitivity of ?15.52 pm/℃ from 20 ℃ to 500 ℃. In addition, the high transmittance biomimetic windows are produced by direct laser interference ablation. The interfered laser beams are introduced into the surface of a bare optical substrate, where structured surfaces consisting of a micropillar array are produced by the multiple exposure of the two-beam interference ablation. As an example of the application, zinc sulfide substrates are processed with this technology.
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Wang, Hao,Duan, Xiang-Long,Qi, Xiao-Li,Meng, Lei,Xu, Yi-Song,Wu, Tong,Dai, Peng-Gao Korean Society for Molecular and Cellular Biology 2017 Molecules and cells Vol.40 No.1
Aberrant hypermethylation of Wnt antagonists has been observed in gastric cancer. A number of studies have focused on the hypermethylation of a single Wnt antagonist and its role in regulating the activation of signaling. However, how the Wnt antagonists interacted to regulate the signaling pathway has not been reported. In the present study, we systematically investigated the methylation of some Wnt antagonist genes (SFRP2, SFRP4, SFRP5, DKK1, DKK2, and APC) and their regulatory role in carcinogenesis. We found that aberrant promoter methylation of SFRP2, SFRP4, DKK1, and DKK2 was significantly increased in gastric cancer. Moreover, concurrent hypermethylation of SFRP2 and DKK2 was observed in gastric cancer and this was significantly associated with increased expression of ${\beta}-catenin$, indicating that the joint inactivation of these two genes promoted the activation of the Wnt signaling pathway. Further analysis using a multivariate Cox proportional hazards model showed that DKK2 methylation was an independent prognostic factor for poor overall survival, and the predictive value was markedly enhanced when the combined methylation status of SFRP2 and DKK2 was considered. In addition, the methylation level of SFRP4 and DKK2 was correlated with the patient's age and tumor differentiation, respectively. In conclusion, epigenetic silencing of Wnt antagonists was associated with gastric carcinogenesis, and concurrent hypermethylation of SFRP2 and DKK2 could be a potential marker for a prognosis of poor overall survival.
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Hao Wang,Xiang-Long Duan,Xiao-Li Qi,Lei Meng,Yi-Song Xu,Tong Wu,Peng-Gao Dai 한국분자세포생물학회 2017 Molecules and cells Vol.40 No.1
Aberrant hypermethylation of Wnt antagonists has been observed in gastric cancer. A number of studies have focused on the hypermethylation of a single Wnt antagonist and its role in regulating the activation of signaling. However, how the Wnt antagonists interacted to regulate the signaling pathway has not been reported. In the present study, we systematically investigated the methylation of some Wnt antagonist genes (SFRP2, SFRP4, SFRP5, DKK1, DKK2, and APC) and their regulatory role in carcinogenesis. We found that aberrant promoter methylation of SFRP2, SFRP4, DKK1, and DKK2 was significantly increased in gastric cancer. Moreover, concurrent hypermethylation of SFRP2 and DKK2 was observed in gastric cancer and this was significantly associated with increased expression of -catenin, indicating that the joint inactivation of these two genes promoted the activation of the Wnt signaling pathway. Further analysis using a multivariate Cox proportional hazards model showed that DKK2 methylation was an independent prognostic factor for poor overall survival, and the predictive value was markedly enhanced when the combined methylation status of SFRP2 and DKK2 was con-sidered. In addition, the methylation level of SFRP4 and DKK2 was correlated with the patient’s age and tumor differentiation, respectively. In conclusion, epigenetic silencing of Wnt antagonists was associated with gastric carcinogenesis, and concurrent hypermethylation of SFRP2 and DKK2 could be a potential marker for a prognosis of poor overall survival.
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Exogenous Natural Glycoprotein Multiple Mechanisms of Anti-tumor Activity
Yuan, Hong-Liang,Liu, Xiao-Lei,Dai, Qi-Chang,Song, Hui Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.4
Natural glycoproteins can induce apoptosis of tumor cells and exert anti-tumor activity by immunomodulatory functions, cytotoxic and anti-inflammation effects, and inhibition of endothelial growth factor. Given their prospects as novel agents, sources of natural antitumor glycoproteins have attracted attention and new research directions in glycoprotein biology are gradually shifting to the direction of cancer treatment and prevention of neoplastic disease. In this review, we summarize the latest findings with regard to the tumor suppressor signature of glycoproteins and underlying regulatory mechanisms.
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