한국인 폐확산능 정상예측식의 임상적 유용성과 정확성

나승원 ( Seung Won Ra ),박태선 ( Tai Sun Park ),홍윤기 ( Yoon Ki Hong ),홍상범 ( Sang Bum Hong ),심태선 ( Tae Sun Shim ),임채만 ( Chae Man Lim ),이상도 ( Sang Do Lee ),고윤석 ( Youn Suck Koh ),김우성 ( Woo Sung Kim ),김동순 ( Dong 대한결핵 및 호흡기학회 2008 Tuberculosis and Respiratory Diseases Vol.64 No.2

연구배경: 폐확산능을 해석하는 데 필요한 정상예측식으로는 한국인을 대상으로 하여 박 등이 개발한 식(박 식)이 있으나 아직 외국 정상예측식을 많이 사용하고 있다. 이에 국내에서 많이 사용하는 외국 정상예측식인 Burrows 식과 박 식의 임상적 유용성과 정확성을 비교하고자 하였다. 방법: 1. 임상적 유용성 연구; 2006년 7월부터 12월까지 6개월간 폐확산능검사를 시행한 환자 중 두 식을 각각 정상예측식으로 적용하였을 때 폐확산능 해석이 다른 276명(대상군 A)을 대상으로 하였다. 대상군 A에게 두 식을 각각 적용하였을 때 폐확산능 해석과 임상적 판단과의 일치도를 비교하여 임상적 유용성을 평가하였다. 2. 간질성폐질환 진단의 정확성 비교; 2001년부터 2006년까지 폐조직검사를 시행하여 확진된 간질성폐질환군과 서울아산병원에서 모집한 정상군을 대상으로 하여 정상예측식으로 두 식을 각각 적용하였을 때 폐확산능 해석의 정확도를 비교하였고, 두 식이 차이가 나는지 맥니머의 카이스퀘어 검정을 하였다. 결과: 1. 임상적 판단과의 일치도 비교; 276명을 임상정보를 토대로 폐확산능을 예측하여 분류한 결과 정상 54명, 감소 220명, 불분명이 2명이었다. 예측식으로 박 식과 Burrows 식을 적용하였을 때 임상적 판단과 일치하는 환자는 각각 78%와 22%이었다(p<0.001). 2. 간질성폐질환 진단의 정확성 비교; 박 식은 민감도 90.1%, 특이도 100%이었고 Burrows 식은 민감도 64.2%, 특이도 100%로 민감도가 통계학적으로 유의하게 박 식이 높았다(p<0.001). 결론: 우리나라 정상예측식인 박 식이 외국 정상예측식인 Burrows 식을 정상예측식으로 적용하는 것보다 임상적 유용성이나 간질성폐질환 진단의 민감도에서 더 우월하였다. 향후 폐확산능검사의 정상예측식으로 박 식을 사용해야 할 것으로 사료된다. Background: Park et al. developed the Korean reference equation for the measurement of diffusing capacity in 1985. However, the equation has not been widely used in Korea and foreign reference equations have been popularly used. We intended to compare the clinical usefulness and the accuracy of the the Korean reference equation (Park`s equation) with that of the foreign equation (Burrows` equation) that is commonly used in Korea. Methods: 1. Evaluation of clinical usefulness; Among 1,584 patients who underwent diffusing capacity (DLCO) at the Asan Medical Center from July to December 2006, group A subjects included 276 patients who had different interpretations of DLCO in trials employing Burrows` equation and Park`s equation. Clinical assessment was decided by consensus of two respiratory physicians. In order to evaluate the clinical usefulness of Burrows` equation and Park`s equation, agreement of clinical assessment and DLCO interpretation were measured. 2. Evaluation of accuracy; Group B subjects were 81 patients with interstitial lung disease (ILD) and 39 normal subjects. The 81 ILD patients were diagnosed following a surgical lung biopsy. The accuracy of diagnosing ILD as well as sensitivity and specificity were evaluated according to the use of the reference equations (Burrows` equation and Park`s equation) for DLCO. Results: Agreement between clinical assessment and interpretation of DLCO was 22% for the use of Burrows` equation and 78% for the use of Park`s equation. The sensitivity and specificity of the Burrows` equation for diagnosing ILD were 64.2% and 100%. The sensitivity and specificity of the Park`s equation for diagnosing ILD were 90.1% and 100%. The sensitivity of the Park`s equation for diagnosing ILD was significantly higher than that of Burrows` equation (p<0.001). Conclusion: The Korean reference equation (Park`s equation) was more clinically useful and had higher sensitivity for diagnosing ILD than the foreign reference equation (Burrows` equation). (Tuberc Respir Dis 2008;64:80-86)

우심방을 침범한 거대 비호지킨씨 림프종 1예

강상범,진승원,이은경,박용현,최용호,김용주,박준철,김재형,홍순조,최규보,권종범,원용순,박건,이은희 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.4

한의진단명과 진단요건의 표준화 연구 III : 3차년도 연구결과 보고

최선미,양기상,최승훈,박경모,박종현,심범상,김성우,노석선,이인선,정진홍,이진용,김달래,임형호,김윤범,박성식,송태원,김종우,이승기,최윤정,신순식 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the third year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows : - analyzing and differentiating of epidemic febrile disease - analyzing and differentiating in accordance with the Sasang constitution medicine based on four-type recognition - differentiation of disease according to pathological changes of Chong and Ren channels - standards for diagnosis of women's disease - standards for diagnosis of children's disease - standards for diagnosis of motor and sensor disturbance (-muscle. born, joint, etc.) - standards for diagnosis of neuropsychiatric disease - standards for diagnosis of five sense organ disease - standards for diagnosis of external disease The indivisual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name, notion of diagnosis pattern, index of differentiation of symptoms and signs, the main point of diagnosis, analysis of diagnosis pattern, discrimination of diagnosis pattern, prognosis, a way of curing a disease, prescription, herbs in common use, disease appearing the diagnosis pattern, documents. The standards for diagnosis of each disease was arranged by the diagnostic requirements in the following order : another name, notion of disease, the main point of diagnosis, analyzing and differentiating of disease, analysis of disease, discrimination of disease, prognosis, a way of curing and prescription of disease, disease in western medicine appearing the disease in oriental medicine, documents.

纖維補强이 콘크리트의 力學的 特性과 鐵筋콘크리트의 龜裂性狀에 미치는 影響에 關한 硏究

朴承範,姜信業 충남대학교 1977 工業技術開發硏究所論文集 Vol.4 No.2

This study was attempted to investigate the mechanical properties of concrete and crack control effects of reinforced concrete with steel and glass fiber. The experimental program includes tests on the properties of fresh concrete containing fibers, compressive strength, tensile strength, flexural strength, Young's modulus, Shrinkage and deformation of steel or glass fiber reinforced concrete. Also this study was carried out to investigate the effect of steel or glass fiber to retard the development in reinforced concrete subject to uniaxial tension and thus facilitate the use of steels of higher strength. The major conclusions that can be drawn from the studies are as follows: 1. The effect of the fibers in various mixes on fresh concrete confirmed that fibers do have a significant effect on the properties of fresh concrete, bringing much more stable and exhibiting a signiflcant reduction in surface bleeding, and that the cohesion is greatly improved and the internal resistance increases with fiber concentration. But the addition of an excess contents and length of fibers brings about the reduction of workablity. 2. With the addition of steel fibers (1.5% Vol.) to concrete, the compressive strength as compared with plain concrete showed a very slight increase, but excess addition, over 1.5% Vol. of steel and glass fiber reduced its strength. 3. Splitting tensile strength of fiber reinforced concrete showed a significant increase tendency, as compared with plain concrete. In case of containing steel fiber (2.5% 30mm), it showed that the maximum increase rate of 1.48 times as much rate, and in case of containing glass fiber (2.5%, 30mm), the increase rate of strength was 1.25 times as much rate. 4. Flexural strength of fiber reinforced concrete showed a significant increase tendency, as compared with plain concrete. Containing steel fiber (2.5%, 30mm) showed the maximum increase rate of 1.64 times as much rate and containing glass fiber (2.5%, 30mm) showed the increase rate of strength of 1.32 times as much rate, and in general, the 30mm length brougth the best results. 5. The strength ratio (σb/σc and σt/σc) increased, when steel fiber's average spacing was up to 3.05mm, but decreased when beyond 3.05mm, and it was confirmed that tensile or flexural strengths of steel fiber reinforceed concrete are apparently governed by fiber's average spacing. 6. The compressive strain of fiber reinforced concrete showed a significant increasing tendency as the fiber was added, but Young's modulus, with the addition of steel and glass fibers, showed a slight decrease tendency. And according to the increase of flexural strength, a considerable increase was seen in toughness. 7. With the addition of fiber's the shrinkage of concrete was significantly decreased, in both case of adding steel fibers or glass fibers 12.5%, 30mm, and showed a significant decrease ratio, in average 30.4% and 36.7%, as compared with plain concrete. 8. With the increase of fiber volume fraction and length, the gained stress in reinforcing bar in concrete specimens increased in all crack widths, but at different rates, with the decrease of fiber diameter, the stress showed a considerable increasing tendency. And the duoform steel fibers showed the greatest improvement, as compared with the other types tested. 9. The influence of fiber dimensions in order of significanse on the machanical properties of concrete and the crack control of reinforced concrete was explained as follows: content, length, aspect ratio and diameter.

회전근 개 병변에서 골 단일광자방출전산화 단층촬영과 단순 방사선 사진의 비교

박진영,박선건,김승철,임종범 단국대학교 2000 論文集 Vol.35 No.-

purpose : The increased uptake on the bone scan represents the zone of increased bon metabolism. Single photon emission computerized tomography(SPECT) is more precise in detecting lesions of increased uptake than planar bone scan. The purpose of this study is to examine applicability of bone SPECT to shoulder lesions and to analyze the efficacy of SPECT compared with simple X-ray in rotator cuff lesion. Materials and Methods : Subjects were 21 patients with of rotator cuff lesion confirmed by surgical(arthroscopic or open) procedure. Increased uptake(bone SPECT) and sclerosis of greater tuberosity and anterior acromion on X-ray were considered positive. Results : For acromion, sensitivity of the bone SPECT was 90.9% and specificity was 50.0%. For greater tuberosity, sensitivity was 92.3% and specificity 37.5%. For acromioclavicular joint, sensitivity was 80.0% and specificity 81.3%. Conclusion : This study demonstrates that the uptake of radioisotope in shoulder is increased in patients with painful partial or total rotator cuff tear. And extrinsic mechanical pressure seems to be the cause of rotator cuff lesion of the shoulder.

Glass 纖維補强에 依한 Mortar의 脆性開善에 關한 硏究

朴承範 충남대학교 공업기술개발연구소 1976 工業技術開發硏究所論文集 Vol.3 No.2

In this paper, the properties of mortar with randomly distributed Glass Fibers were investigated to understand the effect of Glass Fibers, and the impact, tensile and bending strength, and deflection of composites fabricated mortar by alkali-resistant Fiber. As the results of tests, the inclusion of alkali-resistant Fiber in the mortar significantly increased the durable properties, strength, and deflection. In can be foreseen that given a durable Glass, the composites will have pronounced advantages over existing sheet materials in respect of impact strength, bending strength and resistance to the crack.

동일한 시료에 대한 국내 기관간의 STR 분석결과 비교 : STR 유전자좌 분석법의 표준화 설정을 위하여

박종태,신경진,양윤석,우광만,이숭덕,이승환,이정빈,정연보,조승희,한길로,한면수,홍승범 大韓法醫學會 2001 대한법의학회지 Vol.25 No.1

This paper described a collaborative exercise intended to see what kinds of short tandem repeat (STR) loci are used in different DNA typing laboratories in Korea and to compare their results for the demonstration whether uniformity of DNA profiling results from different laboratory could be achieved in Korea Laboratories were asked to test five tissue DNAs using methods routinely used in each laboratory and to report the results to the coordinating laboratory. The exercise demonstrated that each laboratory was using different STR loci for the typing with different STR numbers,2 VNTRS,36 STRs and amelogenin in total, and the direct comparison of the results from all the laboratory for the 18 loci could not be done as only one laboratory submitted typing results. Among 21 loci for which several laboratories submitted typing results, results for 14 loci were the same and results for the other 7 loci were different depending on the participating laboratory. D1S80, F13A01, D16S539, D21S11, D18S51, D3S1744 were the loci with different typing results. Even in the cases where commercial kits were used, the results were not the same depending on the machines used, that is the capillary electrophoresis or the gel based electrophoresis. The reason for the different results, points about the standardization of the methods arid the profiling data were described.

粘土鑛物의 混入이 Mortar의 性狀에 미치는 影響에 關한 實驗的 硏究

朴承範,權吳憲 충남대학교 공업기술개발연구소 1976 工業技術開發硏究所論文集 Vol.3 No.2

This paper discribes an experimental study on the properties of Cement-Bentonite mortar for grouting. Recently, low strength cement mortar mixed with clay minerals has been widely employed in foundation treatment, cutoff wall and curtain, strengthening soft soil layer, etc. The experiments were intended to clarify the properties of the cement mortar with the bentonites which were available in the local market. Of the study, fluidity, tendency of segregation and compressive strength of mortar were analyzed with two kinds of clay minerals, namely, A and B-Type Bentonite.

유리纖維 補强 콘크리트 流動 特性에 관한 硏究

朴承範,任昌悳,尹義植 忠南大學校 産業技術硏究所 1989 산업기술연구논문집 Vol.4 No.1

Concrete is an excellent structural material, but it has many problems due to brittle behavior, weak resistance in tension, flexibility and toughness. In order to improve these problems, usually fiber reinforced concrete is used. But in the case of GFRC insufficient workability is caused by using glass fiber and there is lack of studying on it. This report of the following concrete of GFRC was experimented by the different W/C, S/A, glass fiber contents and maximum size of Aggregates. The results of this study is as follows; 1) Optimum S/A ratio is 0.6 at the glass fiber contents of from 0.25% to 0.75% in GFRC, but it cannot be obtained optimum S/A ratio at over 0.75. 2) Even though increasing the W/C ratio, we can get more slump, but slump is much more influenced by fiber contents in GFRC rather than increasing the W/C ratio. 3) Workability of GFRC is much more influenced by fiber contents than fiber length. 4) Workability of GFRC is a little improved by the bigger maximum size of aggregates.

전문 마라톤화용 기능성 개발을 위한 운동역학적 연구(Ⅰ)

박승범,서국웅,김용재 한국운동역학회 2001 한국운동역학회지 Vol.11 No.3

Various approaches can be used to study a special field such as biomechanical aspects of marathon shoes. A runner who wants to buy a pair of running shoes is confronted with a wide range of models, ranging from inexpensive to expensive, from soft to hard, and from red to yellow. These marathon shoes may have special features like wedges or exchangeable damping elements which visually underline the special quality of the shoes. Advertisements for running shoes in marathoner's magazines explain their products by using words such as "support", "rearfoot control", "cushioning", "shock distributor" and "heel stabilizer". One aspect of marathon shoes biomechanical design is the protection and /or the reduction of injuries. In other words, it is aspect of forces acting on the human body, and also the effects these forces produce in this system. The problems can be studied using theoretical techniques using mathematical models and some of these are discussed int below. A marathon shoe must fit not only overall length and ball width, but with respect to several other aspects such as the instep, arch, top lines, and heel and toe curve. A marathon shoes must fit your biomechanical needs very, very well. Match the support in the shoe as closely as possible to your pronation factor, or how much motion your feet experience when on the ground. Marathon shoes must fit your feet even better than the proverbial glove. They swell from the ramped-up circulation that accompanies continuous activity, and may actually spread out a bit as the 26 bones and dozens of tendons, ligaments and muscles in each foot adapt to several hours of pounding. Marathon shoes should be racing flats only if you think you can win. What makes no sense is to think that is significant when compared with how hard your shoes have to work during the last few miles to support your rapidly fading body. Lightweight shoes mean lightweight support. A large variety of elements which have various names, such as inserts, arch supports, arch cookies, orthotics, and orthoses, can be put into a shoes. The inserts for the sports shoe market consist of many different types of plastics and E.V.A(Ethylene Vinyl Acetate). Another type of insert is the built-in insert which is incorporated into or onto the sole of the shoe. This is a rather rare form of conventional shoe construction. Changes in midsole geometry and material are only one of various strategies which can be used to alter the properties of a running shoe. Heel counters, heel stabilizers, insoles, inserts, additional wedges, and different lasts are some additional strategies used in running shoe construction. Many of them are used in combination with others which may introduce additional problems in quantifying their effects. An athlete can use external elements to influence load and stress on his body. The two most important ones are the running shoe and the surface. On the other hand, he or she can use internal elements which anre muscles, tendons, ligaments, and so forth, and his or her running style. Careful exercise and control of these elements is an important factor in the attempt to reduce running injuries.