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뢰영성 ( Yong Sung Loi ),권영모 ( Kwon Yeong Mo ),박종흠 ( Park Jong Heum ),박선동 ( Park Seon Dong ) 대한본초학회 2003 大韓本草學會誌 Vol.18 No.3
N/A objectives: Exposure to oxidant molecules can generate reactive oxigen species(R0S; for example, H₂O₂, O₂-, OH .). These free radicals can alter DNA, proteins and membrane phospholipids. ROS are responsible for aging and many diseases including cancer, neurodegenerative diseases and cardiovascular diseases. Thus, to prevent against celluar damages associated with oxidative stress, antioxidants are important and many research about antioxidants are being conducted over the world. methods: This study was performed to research the antioxidant activities of Insamgobonwhan(IG) and its component groups in vitro, so intended to know the possibility of Insamgobonwhan(1G) as drug which can prevent aging. The experimental group was divided into 4 groups: Imsamgobonwhan(IG), two dong-two jiwhang(IG-1; 麥門冬, 天門冬, 熱地黃, 生地黃), two dong(IG-2; 麥門冬, 天門冬) and two jiwhang(IG-3; 熱地黃, 生地黃). results: 1. All experimental groups had significant antioxidant activity in linoleic acid system on concentration dose--dependently in comparison with control group. But IG and IG-2 have more effect than IG-1 and IG-3 relatively. 2. DPPH radical scavenging experiment and inhibitory effect experiment on superoxide generation in xanthine-xanthine oxidase system showed that all experimental groups had a dose-dependent effect. But IG and IG--1 had more effect than IG-2 and IG-3. 3. Inhibitory effect experiment on superoxide generation induced by xanthine-xanthine oxidase system showed that all experimental groups had a dose-dependent effect. But IG and IG-1 had more effect than IG-2 and IG-3. 4. Inhibitory effect experiment on lipid peroxidation reaction in H₂O₂-Fe²system showed that all experimental groups had a dose--dependent effect. But IG and IG--1 had more effect than IG-2 and IG-3. 5. Experiment on lipid peroxidation removal effect showed that all experimental groups had a dose-dependent effect. But IG and IG-2 have more effect than IG-1 and IG-3. 6. Experiment on glutathion activity effect showed that all experimental groups had some effect. But each groups had no significant difference. 7. Experiment on catalase activity effect showed that all experimental groups had some effect. But each groups had no significant difference. conclusion: These results showed that IG has an antioxidant activity, so it seems to have some anti-aging effect. From comparisons of each experimental groups, IG`s antioxidant effect is likely to be associated with IG-1 mostly.
E. coli 과량발현을 통한 B형 간염 바이러스 preS1 유도체의 안정한 동위원소 N의 치환
박병관,김세하,한규훈,김선영,홍요정,이시형,한동설,김순종,박진구 木浦大學校基礎科學硏究所 1997 基礎科學硏究誌 Vol.15 No.-
We have used molecular biology technique to label the side chains and backbone of HBV preS1(1-56) with stable isotope (??) during E. coli over-expression and purified the protein to near homogeneity. The expression level of ?? labelled preS1(1-56) seems to be ∼15% of the total protein. to characterize the secondary structure of the labelled protein, circular dichroism was used. In different buffer conditions including pH 3.3 and pH 7.4 the protein seems to be devoid of any stable secondary structure probably suggesting that the N-terminal portion (preS1(1-56)) of HBV preS1 might be unstructured before binding to its target cells.
펄스 코로나 방전 반응기를 이용한 NOx 제거 효율 및 입자 성장 분석
박정환,김동주,김교선 江原大學校 産業技術硏究所 2001 産業技術硏究 Vol.21 No.B
In this study, we analyzed the NOx removal efficiency and particle size distribution by the pulsed corona discharge process and investigated the effect of several process variables. The NO removal efficiencies and the particle characteristics were measured and analyzed as the function of initial concentrations of NO, H2O and NH3, applied voltage, pulse frequency and residence time. As the frequency of applied voltage increases, or as the applied voltage increases or as the residence time increases, the NO removal efficiency increases. The change of initial NH3 and H2O concentrations do not affect the NO removal efficiency significantly. The particle concentration and size increases with the increases of initial NO concentration, residence time and applied voltage.
3-Chloromethyl-3-Methyl Oxetane의 합성
박정환,한도수,허선아,조성동 조선대학교 기초과학연구소 1993 自然科學硏究 Vol.16 No.1
3-chloromethyl-3-methyl oxetane(CMMO) was synthesized with 3-methy-3-methoxytosyl oxetane(MMTO) and LiCI in 68% yield.
저온 플라즈마 공정에 의한 NO_x 제거시 공정 변수의 영향
박정환,김동주,김교선 江原大學校 産業技術硏究所 2001 産業技術硏究 Vol.21 No.A
In this study, we analyzed the NOx removal effiency by the low temperature plasma process and investigated the effect of several process variables. Most of NO is converted into NO2 and, later, into HNO3 which reacts with NH3 to form NH4NO3 particles. As the frequency of appling voltage increases, as the applied voltage increases or as the residential time increases, removal efficiency of the NO supplied initially increase. The removal efficiency of NOx also increases with the increase of NH3 supplied.
정선우,김인택,박중석,이동준 7개 국립대학교 환경연구 논문집 공동발행 위원회 2004 공업기술연구 Vol.4 No.-
The community structure of benthic macroinvertebratcs in the stream of Mt. Kajisan was studied. The surveyed sites were streams of Seoknamsa area and Backyconsa area. The Collection was per-formed from May to October of 2004. as a result, total macroinvertabates collecter in the stream of Mt. Kajisan were 4 phyla, 5 classes, 15 orders, 42 families, 62 genera, 79 species and 806 individuals. From the Seoknamsa area, 4 phyla, 5 classes 14 orders, 38 families 54 genaera, 69 species and 429 individuals were identified. From the Backyconsa area, 4 phyla, 5 classes,14 order, 36 families 48 genera, 58 species and 377 individuals were found. The community analysis showed higher species diversity and species richness in Seaoknamsa area than those of Backyeonsa area. The dominant species of both areas were Semisulco-spira libertina and it occupied 10% of total individuals or more. The total species richness and species diversity of benthic macroivertcbratcs in the stream of Mt. Kajisan was 26.98 and 1.68 respectively.
카드뮴이 인간 단핵구 세포주(THP-1)에서 cytokine 유전자 발현에 미치는 영향
신동훈,박관규,강미정,서석권,정인성,양선희 大韓産業醫學會 1997 대한직업환경의학회지 Vol.9 No.2
Cadmium, a potent toxic metal, posses a serious environmental threat but the mechanism of its toxicity remains unclear. Also, cadmium is a known immunotoxic agent in animal studies and induces pathophysiological effects by modulating components of immune system. Cytokines are being increasingly recognized as essential mediators of normal and pathologic immune response. Cells of mononuclear phagocytic system are strategically located at portals of entry in humans and therefore may be particularly at risk for cadmium exposure through contaminated air, food, and drinking water. In the present study, we investigated the effect of cadmium cytotoxicity for the monocyte and expression of cytokine gene in the control and cadmium treated human monocytic cell lines using RT-PCR method. The results showed that cadmium inhibited cell proliferation at 0.1mM cadimium treated cells for 24 hours. The TNF-α mRNA was expressed in both control and cadmium treated cells but not IL-6 and IL-1β. The mRNA levels of TNF-αwere examined during 24 hours culture period, at different time points. The expression of TNF-αmRNA increased in both 0.01mM and 0.1mM cadmium treated cells, but did not show dose-response relationship. According to cadimium treated duration, expression of TNF-αmRNA was more decreased in 24 hours than 6 hours. The decreased levels of mRNA of TNF-α suggest that cadmium suppresses its production at the transcription level.