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- 검색키워드
- 저자 : P. S. Kulkarni (검색결과 11 건)
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Protective Effect of Quercetin on Alcohol Abstinence-Induced Anxiety and Convulsions
S.K. Kulkarni,D. Joshi,P.S. Naidu,A. Singh 한국식품영양과학회 2005 Journal of medicinal food Vol.8 No.3
Chronic administration of ethanol (2 g/kg, p.o.) on days 16 and its withdrawal produced an anxiogenic reac-tion in mice as assessed in the mirrored-chamber test. Daily administration of quercetin (25 or 50 mg/kg, p.o.) prior to ethanolfor 6 days prevented withdrawal-induced anxiety in mice. However, acute administration of a single dose of quercetin (50mg/kg) to animals withdrawn from ethanol, i.e., on day 7, did not prevent withdrawal-induced anxiety. Ethanol withdrawalalso induced a significant increase in the locomotor activity of mice indicating an anxiogenic response. Daily administrationof quercetin (25 or 50 mg/kg, p.o.) prior to ethanol for 6 days prevented withdrawal-induced increased locomotor activity.Ethanol withdrawal also sensitized the convulsogenic reaction to pentylenetetrazole (PTZ). A non-convulsive dose (4060mg/kg) of PTZ produced full-blown convulsions and increased mortality in ethanol-withdrawn mice. Both acute and chronicadministration of quercetin (25 or 50 mg/kg, p.o.) produced a significant protection against ethanol withdrawal-induced re-duction in PTZ threshold in mice. The result suggests the protective effect of this safe drug, quercetin, in the management ofethanol withdrawal reactions.
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Shukla, S.T.,Kulkarni, V.H.,Habbu, P.V.,Jagadeesh, K.S.,Patil, B.S.,Smita, D.M. 경희한의학연구센터 2012 Oriental Pharmacy and Experimental Medicine Vol.12 No.2
Endophytic fungi are a rich source of novel organic compounds with interesting biological activities and a high level of biodiversity. In the present investigation, an attempt has been made to isolate, characterize and screen the Tulsi (Ocimum sanctum Linn.) root fungal endophytic fractions (TRF) for hepatoprotective and antioxidant activities. Endophytic fungi from Ocimum sanctum Linn. roots were isolated and cultured aseptically in PDA media. The full fledged grown fungus cultures were fermented in potato dextrose broth and fractionated using ethyl acetate. TRF-1 and TRF-2 were subjected free radical scavenging activities against 2,2-diphenyl-1-picrylhydrazyl, hydroxyl free radicals and reducing power assay. TRF-1 was found to be potential free radical scavenger with $IC_{50}$ values of $71.83{\mu}g/ml$ for DPPH and $110.85{\mu}g/ml$ for hydroxyl radical respectively. TRF-1 and TRF-2 were further assessed for hepatoprotective activity in $CCl_4$ induced hepatotoxicity in-vivo. Results showed that TRF-1 (200 mg/kg p.o.) and TRF-2 (200 mg/kg p.o.) significantly reversed the actions of carbon tetrachloride induced hepatotoxicity, as evident by restoration of serum AST, ALT, ALP, bilirubin, triglycerides and protein level to normal values as compared to $CCl_4$ treated group. Restoration of altered LPO (p<0.001), GSH (p<0.01) and catalase (p<0.01) by TRF-1 suggests that the hepatoprotective activity may be attributed to its antioxidant action. This was further supported by histopathological studies. TRF-1 was subjected to rDNA sequencing studies by PCR technique. Based on the morphological and molecular characterization, the fungus was identified as Paecilomyces variotti Bain. Therefore, endophytes from medicinal plants represent great potential for the discovery of new pharmacologically active metabolites.
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THERMAL AND STRUCTURAL ANALYSIS OF CALANDRIA VESSEL OF A PHWR DURING A SEVERE ACCIDENT
Kulkarni, P.P.,Prasad, S.V.,Nayak, A.K.,Vijayan, P.K. Korean Nuclear Society 2013 Nuclear Engineering and Technology Vol.45 No.4
In a postulated severe core damage accident in a PHWR, multiple failures of core cooling systems may lead to the collapse of pressure tubes and calandria tubes, which may ultimately relocate inside the calandria vessel forming a terminal debris bed. The debris bed, which may reach high temperatures due to the decay heat, is cooled by the moderator in the calandria. With time, the moderator is evaporated and after some time, a hot dry debris bed is formed. The debris bed transfers heat to the calandria vault water which acts as the ultimate heat sink. However, the questions remain: how long would the vault water be an ultimate heat sink, and what would be the failure mode of the calandria vessel if the heat sink capability of the reactor vault water is lost? In the present study, a numerical analysis is performed to evaluate the thermal loads and the stresses in the calandria vessel following the above accident scenario. The heat transfer from the molten corium pool to the surrounding is assumed to be by a combination of radiation, conduction, and convection from the calandria vessel wall to the vault water. From the temperature distribution in the vessel wall, the transient thermal loads have been evaluated. The strain rate and the vessel failure have been evaluated for the above scenario.
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Thermal and Structural Analysis of Calandria Vessel of a PHWR during a Severe Accident
P.P. KULKARNI,S. V. Prasad,A. K. Nayak,P. K. Vijayan 한국원자력학회 2013 Nuclear Engineering and Technology Vol.45 No.4
In a postulated severe core damage accident in a PHWR, multiple failures of core cooling systems may lead to the collapse of pressure tubes and calandria tubes, which may ultimately relocate inside the calandria vessel forming a terminal debris bed. The debris bed, which may reach high temperatures due to the decay heat, is cooled by the moderator in the calandria. With time, the moderator is evaporated and after some time, a hot dry debris bed is formed. The debris bed transfers heat to the calandria vault water which acts as the ultimate heat sink. However, the questions remain: how long would the vault water be an ultimate heat sink, and what would be the failure mode of the calandria vessel if the heat sink capability of the reactor vault water is lost?In the present study, a numerical analysis is performed to evaluate the thermal loads and the stresses in the calandria vessel following the above accident scenario. The heat transfer from the molten corium pool to the surrounding is assumed to be by a combination of radiation, conduction, and convection from the calandria vessel wall to the vault water. From the temperature distribution in the vessel wall, the transient thermal loads have been evaluated. The strain rate and the vessel failure have been evaluated for the above scenario.
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S.L. Kadam,S.M. Mane,P.M. Tirmali,S.B. Kulkarni 한국물리학회 2018 Current Applied Physics Vol.18 No.4
In the present work flower like Mn-Co mixed metal oxide electrode materials were successfully synthesized by simple, low cost electrodeposition method on stainless steel substrates. Different volume ratio of Mn-Co was used to attempt enhancement in the supercapacitive properties of electrode material. Structural, morphological and wettability properties of synthesized electrodes were carried out using XRD, RAMAN, FE-SEM and Contact Angle Measurement techniques. Electrochemical properties of electrodeposited Mn-Co mixed metal oxide at three different volume variation such as 50-50, 60-40 and 70- 30 electrodes were analyzed by using cyclic voltammetry, galvonostatic charge discharge and electrochemical impedance spectroscopy in 1M NaOH aqueous electrolyte. The Mn-Co:60-40 composition shows maximum specific capacitance which is 679 F/g at scan rate 5mV/sec. Charge discharge studies gives 95% columbic efficiency. Impedance spectroscopy reveals capacitive behavior and gives series resistance ~0.19 ohm and combined internal resistance ~0.89 ohm. The 80% retention of specific capacitance after the 1000 cycles. The synergistic effect of Mn-Co mixed metal oxide electrode having good conductivity, large surface area and improved charge transportation than individual electrode material leads to enhancing supercapacitor performance of electrode material for its practical application.
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Kulkarni, A,Ha, S,Joshirao, P,Manchanda, V,Bak, M S,Kim, T American Institute of Physics 2015 Review of scientific instruments Vol.86 No.6
<P>A sensitive radioactive aerosols sensor has been designed and developed. Its design guidance is based on the need for a low operational cost and reliable measurements to provide daily aerosol monitoring. The exposure of diethylene-glycol bis (allylcarbonate) to radiation causes modification of its physico-chemical properties like surface roughness and reflectance. In the present study, optical sensor based on the reflectance measurement has been developed with an aim to monitor real time presence of alpha radioactive aerosols emitted from thorium nitrate hydrate. The results shows that the fabricated sensor can detect 0.0157 kBq to 0.1572 kBq of radio activity by radioactive aerosols generated from (Th(NO3)4 ??? 5H2O) at 0.1 ml/min flow rate. The proposed instrument will be helpful to monitor radioactive aerosols in/around a nuclear facility, building construction sites, mines, and granite polishing factories.</P>
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Vilarinho, S.,Choi, M.,Jain, D.,Malhotra, A.,Kulkarni, S.,Pashankar, D.,Phatak, U.,Patel, M.,Bale, A.,Mane, S.,Lifton, R.P.,Mistry, P.K. Elsevier Science Publishers 2014 Journal of hepatology Vol.61 No.5
Background & Aims: In children with liver failure, as many as half remain of indeterminate aetiology. This hinders timely consideration of optimal treatment options. We posit that a significant subset of these children harbour known inherited metabolic liver diseases with atypical presentation or novel inborn errors of metabolism. We investigated the utility of whole-exome sequencing in three children with advanced liver disease of indeterminate aetiology. Methods: Patient 1 was a 10year-old female diagnosed with Wilson disease but no detectable ATP7B mutations, and decompensated liver cirrhosis who underwent liver transplant and subsequently developed onset of neurodegenerative disease. Patient 2 was a full-term 2day-old male with fatal acute liver failure of indeterminate aetiology. Patient 3 was an 8year-old female with progressive syndromic cholestasis of unknown aetiology since age 3months. Results: Unbiased whole-exome sequencing of germline DNA revealed homozygous mutations in MPV17 and SERAC1 as the disease causing genes in patient 1 and 2, respectively. This is the first demonstration of SERAC1 loss-of-function associated fatal acute liver failure. Patient 1 expands the phenotypic spectrum of the MPV17-related hepatocerebral mitochondrial DNA depletion syndrome. Patient 3 was found to have syndromic cholestasis due to bi-allelic NOTCH2 mutations. Conclusions: Our findings validate the application of whole-exome sequencing in the diagnosis and management of children with advanced liver disease of indeterminate aetiology, with the potential to enhance optimal selection of treatment options and adequate counselling of families. Moreover, whole-exome sequencing revealed a hitherto unrecognized phenotypic spectrum of inherited metabolic liver diseases.
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Kulkarni, Sachnin A.,Sawadh, P.S.,Palei, Prakash K. Korean Chemical Society 2014 대한화학회지 Vol.58 No.1
Magnetite nanoparticles were prepared by co-precipitation method and then silica was coated onto the surface of $Fe_3O_4$ by hydrolysis of TEOS. The silica coated magnetite nanoparticles were characterized for its structural, microstructural, optical, vibrational and magnetic properties by X-ray diffraction analysis, Scanning electron microscopy, UV-visible spectroscopy, Infrared spectroscopy and Vibration sample magnetometer, respectively. XRD study confirmed the presence of $SiO_2$ on the surface of magnetite nanoparticles. SEM study indicated that with increase in TEOS content the particles become bigger and mono-disperse. It was also found that the silica coating prevents magnetic particles from aggregation and imparts excellent stability.
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