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정병욱,박동일,이준희,서정욱,원유홍,김웅,신현종,권영무 동국대학교 경주대학 1996 東國論集 Vol.15 No.-
합병증이 동반된 Meckel씨 게실을 가진 환자의 치료에 대한 필요성은 과정이 문제이다. 하지만 우연히 만나는 게실의 처치는 논란 중이다. 부수적인 게실 절제술(incidental diverticulectomy)의 제안자는 증상이 있는 게실의 외과적 처치는 중요한 이환 및 사망률은 지적한다. 이를 반대하는 사람들은 전 생애를 통해 합병증의 위험성이 낮게 나타나므로 필요가 없다고한다. 게실의 예방적 제거는 개복술시 우연히 발견 될 때 시행한다. 이는 남아있는 게실이 나중에 합병증을 일으키는 것보다 술후 합병증의 위험성이 매우 적음을 알 수 있다. 저자들은 합병증이 동반된 Meckel씨 게실 2예를 경험하였기에 문헌 고찰과 더불어 보고하는 바이다. The necessity for therapy with complicated Meckel's diverticular is a matter of course.However, management of the incidentally encountered diverticulum is controversial. Proponents of incidental diverticulectomy point to the significant morbidity and mortality rates of surgical treatment of symptomatic divenicular. Other authors base their opposition to incidental diveniculectomy on the low risk of complications developing during lifetime. Prophyillctic removal of the diveniculum is indicated when it is found incidentally at laparotomy, because there are few postoperative complications and the risk exists that the remaining diverticulum may be the cause of later complication. The 2 cases of complicated Meckel's diverticulum are reported with a brief review of literature.
Transcriptional Activities of Two Different forms of Human TFIIS
Yoo, Ook Joon,Cho, Nam Young,Hahn, Bum Soo,Baek, Kwang Hee,Park, Heung Rok 한국유전학회 1993 Genes & Genomics Vol.15 No.2
Transcription Factor IIS(TFIIS) exerts influence on the transcript elongation by RNA polymerase II. Two different cDNA clones of human TFIIS have been found. If we compare the amino acid sequence in the coding region of these two clones, we can find one of the cDNA clone carry extra 21 amino acids at the N-terminal region of TFIIS. To identify the functional role of these additional amino acid sequence, we have expressed and purified two different forms of TFIIS in E. coli. The results of the comparison between these two proteins in the transcription elongation activities indicate that 21 amino acid sequence is not crucial for the function of TFIIS in our in vitro assay system. But we cannot rule out the possibility of their functional role(s) in vivo.
Monoclonal Antibody CFC - 6 , which Binds to Helix Ⅱ , Inhibits Erythropoietin - Induced Bioactivity
Kim, Suk Joon,Yoo, Ook Joon,Ha, Byung Jhip,Oh, Myung Suk,Kim, Hyun Su,Yoo, Ree Ann,Lee, Dong Eok,Park, Ji Sook,Woo, Koo 생화학분자생물학회 1998 BMB Reports Vol.30 No.5
It was discovered that monoclonal anti -erythropoietin (EPO) antibody CFC-6 can neutralize EPO-induced cell activation. To know the binding site of CFC-6, recombinant human erythropoietin (rhEPO) was digested with Glu-C. followed by a separation using high performance liquid chromato graphy (HPLC). Each HPLC fraction was blotted on the nitrocellulose membrane and the membrane was treated with anti-EPO antibody CFC-6 and anti-mouse antibody which is modified with peroxidase. Only one spot showed the color and the fraction was sequenced by Edman degradation. The results suggest that CFC-6 recognizes amino acid sequence V63-W-Q-G-L-A-L-L-S-E72 which is a part of helix II of the EPO molecule. Binding of CFC-6 to EPO may inhibit EPO binding to its receptor. which implies that the antibody binding site and the receptor binding site are close or overlapping.
최준,백롱민,오재욱,윤용현,백세민,정영덕 大韓成形外科學會 1993 Archives of Plastic Surgery Vol.20 No.5
People with asymmetric face have many handicaps in their social life. Asymmetric face with soft tissue deficiency can be corrected by multiple autogenous tissue transfer. Between November of 1988 and June of 1992, authors have corrected asymmetric faces with various free flaps(n=16) with excellent results. In five cases, facial bone surgeries have been performed to correct skeletal asymmetry before free flap surgery. Deepithelized groin free flaps were used most commonly(n=11). Superficial temporal and facial vessels were used recipient vessels. Authors consider that free flap surgery is the best choice for the correction of various degree of facial depression deformity. It has several advantages as below. 1. It is one-stage operation and simpler than local or distant flap method. 2. The patients were comfortable and relieved from their long term hospitalization and disability. 3. Various types of free flap can be used according to the size of defect and the length of vascular pedicle.
증례 : 내분비-대사 ; 알도스테론 분비 부신샘종과 동측의 신장동맥혈관협착이 동반된 1예
진준 ( Joon Jin ),임철환 ( Chur Hoan Lim ),정진욱 ( Jin Ook Chung ),조동혁 ( Dong Hyeok Cho ),정동진 ( Dong Jin Chung ),정민영 ( Min Young Chung ),최유덕 ( Yoo Duk Choi ) 대한내과학회 2015 대한내과학회지 Vol.89 No.1
알도스테론 분비 부신샘종과 신장동맥협착을 동시에 보이는 예는 극히 드물다. 저자들은 약물로 조절되지 않은 고혈압을 주소로 내원한 52세 여자에게서 고알도스테론증을 시사하는 검사 소견이 있어 알도스테론 분비 부신샘종을 진단하였고 복강경하 좌측 부신절제술을 시행하였다. 수술로 제거하였음에도 불구하고 지속된 고혈압에 대해 평가하던 중 신장 동맥혈관조영술로 좌측 신장동맥협착을 진단하였고 풍선혈 관성형술을 시행하였다. 그 후 혈압은 항고혈압제 요구량이 감소하면서 조절된 양상을 보였다. 본 증례는 고알도스테론증을 보이는 환자를 평가하는 데 있어 신장동맥협착 동반 여부에 대한 평가가 필요함을 강조한다. The simultaneous occurrence of renovascular hypertension and an aldosterone-producing adrenal adenoma is a rare entity. Here, we report the case of a 52-year-old female who had a coexisting aldosterone-producing adrenal adenoma and ipsilateral renal artery stenosis. She was diagnosed with the aldosterone-producing adrenal adenoma and then underwent a laparoscopic left adrenalectomy. Her blood pressure was uncontrolled after the adrenalectomy. Selective renal angiography showed left renal artery stenosis; thus, she underwent balloon angioplasty at the same sitting. Subsequently, her blood pressure returned to normal after administration of a single antihypertensive drug. This case suggests that it is important to recognize the possible coexistence of renal artery stenosis in a patient with an aldosterone-producing adrenal adenoma. (Korean J Med 2015;89:97-101)
Acid Stable Trypsin Inhlbitor 에 대한 단일클론 항체의 제조와 위암조직에서의 발현양상
유욱준,정연태,문형배,김정중,이황희,장원희,노종섭,최완성 한국유전학회 1994 Genes & Genomics Vol.16 No.4
Monoclonal antibodies against human acid stable trypsin inhibitor (ASTI) was produced by hybridizing SP2/0-Ag14 mouse myeloma cells with spleen cells of Balb/c mouse immunized with ASTI. Western blotting analysis using purified ASTI and urinary proteins exhibited the specificity of the antibodies agains ASTI. The distribution and localization of ASTI in adenocarcinoma of stomach were examined using immunohistochemical techniques. ASTI immunoreactivity was detected from the tubular adenocarcinoma, but not from the signet ring cell carcinoma or mucinous adenocarcinoma.
안면거상술(Face Lift)을 이용한 안면노화(Aging face) 치험례(319례)
최 준,신명수,김동일,이영준,백세민,오재욱 大韓成形外科學會 1992 Archives of Plastic Surgery Vol.19 No.6
There are some differences between Orientals and Caucasians in the amount and type of aging. In general, Orientals have thicker facial skin with more subcutaneous adipose tissues than Caucasians. These differences result in characteristic Oriental aging face combined with round and flat facial contours. Many surgical techniques of face lift or rhytidectomy have been largely performed in Caucasians, but less in Orientals, therefore, we should consider modified principles and techniques in the surgery of the oriental aging face. First, postoperative incision scars are more prominent in Orientals than in Caucasians and this calls for a modified incision design n oriental patients. Second, wide dissection is mandatory for a good result because the skin is very thick and less pliable in oriental patients. Third, it is not necessary to perform cervicofacial platysmal surgery in most cases of oriental face lift. We experienced 171 cases of oriental patients with aging faces and performed 319face lifting procedures during recent 3 years(from Mar. 1988 to Feb. 1991). Combined procedures such as suction lipectomy, forehead augmentation, blepharoplasty, and facial bone contouring surgery were performed simultaneously case by case. Types of anesthesia were decided according to the psychologic states and wishes of patients and the types of combined procedures. Thirty-five cases of 171 patients(20.5%) were performed under local anesthesia. Subcutaneous forehead lifts with ultrasobic vibrator-dissection were our new interesting trials with good results. Complications were 11 cases of wound hematoma(6.4%) and 3 cases of focal wound dehiscence(1.8%). The patients with the complications were completely recovered 6 months later.