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심한 낙타혹(Hump)의 형성을 동반한 제 2 형 막증식성 사구체신염(Dense Deposit Disease) 1예
오희정,유민아,이영숙,김미연,김승정,강덕희,윤견일,최규복,성순희 이화여자대학교 의과대학 2004 EMJ (Ewha medical journal) Vol.27 No.1
Dense deposit disease (DDD), known as type Ⅱ MPGN, is an uncommon form of glomerulonephritis. It is an acquired primary glomerular disease, characterised by electron microscopic evidence of a continous, dense membrane deposition replacing the lamina densa. There is associated alternative pathway complement activation and a C3 nephritic factor maybe present. Patients with dense deposit disease tend to be young at clincal onset and more commonly have persistent nephrotic syndrome, gross hematuria, and acute nephritis episode and persistent depression of the serum complement level. The prognosis of dense deposit disease is worse than that of typeⅠMPGN. We experienced a patient with dense deposit disease that presenting persistent nephrotic syndrome, gross hematuria and having subepithelial hump. It is a first report of dense deposit disease having subepithelial hump in Korea, therefore we report this case with the review of relevant literatures.
김원일,왕덕현,이윤경,이재만,신경오 경남대학교 신소재연구소 1997 論文集 Vol.9 No.-
다방향 적층구조 중합체 목합재료의 드릴가공시 발생하는 적층분리 현상에 대해서 절삭속도 및 이송속도의 변화시키면서 실험적 연구를 진행하였다. 드릴가공시 발생되는 재료거동의 탄성파의 변형을 시편의 측면에서 음향방출신호로 측정하였으며, 광학현미경과 전자현미경으로 적층분리된 측정값과 표면거칠기 측정에서 얻은 결과를 얻어 비교하였다. 음향방출 신호로 측정한 결과와 공구현미경의 실제측정값 및 표면거칠기에서 적층분리가 발생한 지점이 거의 일치함을 확인하였다. 본 실험결과 드릴공구로 사용된 소결합금 공구는 이송속도가 낮고 절삭속도를 큰 경우 적층분리 현상을 억제하여 양호한 가공면을 얻을 수 있었다. An experimental study on the delamination phenomena during drilling of laminate polymer composites, was conducted according t o the change of cutting speed and feed rate. The analysis of acoustic emission signals was in good agreement with measured values by optical microscopy. And also the surface roughness characteristics of workpiece in drilling was accumulated and compared. It was found that the delamination location measured by AE signals and real measurement values by tool microscope are almost same. The better surface and prevention of delamination was obtained by the slight increase of cutting speed and the decrease of feed rate when sintered tool was used.
Il Tae Son,Duck-Woo Kim,Min Hyun Kim,Young-Kyoung Shin,Ja-Lok Ku,Heung-Kwon Oh,Sung-Bum Kang,Seung-Yong Jeong,Kyu Joo Park 대한외과학회 2021 Annals of Surgical Treatment and Research(ASRT) Vol.101 No.1
Purpose: Long-term oncologic differences in outcome between groups of patients with Lynch syndrome (LS) colorectal cancer (CRC) and sporadic CRC with microsatellite instability-high (MSI-H) are the focus of investigation in the current study. Methods: Patients registered in the Korean Hereditary Tumor Registry and 2 tertiary referral hospitals treated for stage I–III CRC between 2005 and 2015 were retrospectively analyzed. Detection for both groups was performed using pedigree, microsatellite instability, and mismatch repair (MMR) gene testing. Multivariate analyses for overall survival (OS) and disease-free survival (DFS) were conducted. Results: Cases of LS (n = 77) and sporadic CRC with MSI-H (n = 96) were identified. LS CRC patients were younger in age and displayed tumor sidedness, typically involving left-sided colon and rectum, compared to patients with sporadic CRC with MSI-H. OS and DFS were lower for LS CRC relative to CRC with MSI-H (OS, 72.7% vs. 93.8%, P = 0.001; DFS, 71.4% vs. 88.5%, P = 0.001). In multivariate analyses, tumor sidedness, stage, and chemotherapy were independent factors for OS and DFS. LS CRC was a prognostic factor for poorer OS (hazard ratio, 2.740; 95% confidence interval, 1.003–7.487; P = 0.049), but not DFS. Conclusion: Our findings indicate that LS CRC is associated with poorer outcomes compared to sporadic CRC with MSI-H, presenting distinct clinical features. In view of the current lack of knowledge on genetic and molecular mechanisms, appropriate management taking into consideration the difficulty of identification of CRC with hypermutable tumors harboring heterogeneity is essential.
Process Integration for a High Performance 0.35mm Merged Logic and DRAM Devices
Oh,Young Sun,Kim,Young Pil,Jun,In Kyun,Chang,Ju Woen,Kim,Dong Woo,Park,Ho Woo,Seo,Young Woo,Kwon,Chul Soon,Yu,Sun Il,Lee,Duck Hyung,Yoon,Jong Shik,Choi,Chang Sik 대한전자공학회 1997 ICVC : International Conference on VLSI and CAD Vol.5 No.1
This paper desicribes a process integration of 0.35 ㎛ Logic LSIs merged with DRAMS. In this study, 16 megabits of DRAM was embedded in 0.35 ㎛ logic chip without sacrifice of transistor performance of logic circuitry. The aluminum alloy layer shared with 1st level metal in the logic part was employed as a bit line in DRAM core. The cell size of DRAM produced was 2.1 ㎛². The process developed in the work has been proven by successful implementation of commercial graphic product which power consumption is far less than 50% of discrete solution.
Changes of Transepidermal Water Loss ( TEWL ) in Psoriatic Plaques during D - PUVA Therapy
Kwon, Oh Sang,Kim, Sang Duck,Cho, Kwang Hyun,Park, Kyoung Chan,Kim, Kyu Han,Eun, Hee Chul,Suh, Dae Hun,Youn, Jai Il,Kwon, Tae Eun,Park, Seok Bum 대한피부과학회 2001 Annals of Dermatology Vol.13 No.1
Background: Psoriatic lesions have reduced water-holding capacity and show increased transepidermal water loss (TEWL). The effect of D-PUVA therapy, which combines topical calcipotriol and PUVA therapy, on epidermal barrier function has not yet been evaluated. Objective: The purpose of this study was to verify the change of TEWL in lesional and normal skin according to D-PUVA therapy in psoriasis patients. Methods: TEWL was measured consecutively by TEWAMETER TM210^ⓡ in 13 psoriasis patients who received D-PUVA therapy. Clinical grading was done according to psoriasis severity index (PSI). Results: TEWL of psoriatic lesian decreased as D-PUVA continued. TEWL of normal-looking skin gradually increased, although the increase was trivial. Clinical grading of scale and infiltration followed the pattern of PSI in the decrease of TEWL, while that of erythema did not. Conclusion: In psoriatic plaques, TEWL was decreased according to the improvement. In normal-looking skin, D-PUVA therapy caused only a little effect on TEWL.
정모 두부 방사선 규격 사진을 이용한 안면 비대칭 환자의 분석
김일곤,이영미,오용덕,양희상,박금석,박관수,김중한,윤영주,김광원 朝鮮大學校 口腔生物學硏究所 1997 口腔生物學硏究 Vol.21 No.1
Since Broadbent, lateral cephalometric radiographs have been popularized as one of the most important diagnostic data. In case of asymmetric patients, however, lateral cephalometric radiographs can't give useful information because it just depends on sagittal and vertical analysis. While posteroanterior cephalometric radiographs can give useful information to us especially in case of vertical growth difference or lateral deviation and help making STO. Because appropriate diagnosis and treatment plan are very important in orthodontic treatment, clinician should pay more attention to use it for asymmetric patients.
Original Article : Factors influencing the severity of acute viral hepatitis A
( Joo Il Kim ),( Yun Soo Kim ),( Young Kul Jung ),( Oh Sang Kwon ),( Yeon Suk Kim ),( Yang Suh Ku ),( Duck Joo Choi ),( Ju Hyun Kim ) 대한간학회 2010 Clinical and Molecular Hepatology(대한간학회지) Vol.16 No.3
Background/Aims: Most patients with acute viral hepatitis A have a favorable course, but a few of them suffer from severe forms of hepatitis such as fulminant hepatitis. This study was carried out to identify the factors influencing the severity of acute viral hepatitis A. Methods: We retrospectively reviewed the medical records of 713 patients with acute hepatitis A, who were divided into two groups: severe hepatitis A (N=87) and non-severe hepatitis A (N=626). Severe hepatitis was defined as fulminant hepatitis or prolongation of prothrombin time (INR≥1.5). Clinical variables were compared between the two groups. Results: The incidence of fulminant hepatitis was 1.4 % (10/713) in patients with acute hepatitis A. Thirty-three (4.6 %) cases exhibited HBsAg positivity. In multivariate analyses, significant alcohol intake and the presence of HBsAg were significant predictive factors of fulminant hepatitis A, and significant alcohol intake and age were significant predictive factors of severe hepatitis A. HBeAg and HBV-DNA status did not affect the clinical course of hepatitis A in chronic hepatitis B carriers. Conclusions: While most patients with acute hepatitis A have an uncomplicated clinical course, our data suggest that a more-severe clinical course is correlated with being older, significant alcohol intake, and chronic hepatitis-B-virus infection. (Korean J Hepatol 2010;16:295-300)