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원전 고등제어 알고리즘 설계를 위한 소규모 시뮬레이터 개발
나만균,심영록,신선호,노희천 조선대학교 에너지.자원신기술연구소 2003 에너지·자원신기술연구소 논문지 Vol.25 No.2
There has been a difficulty in implementing control algorithms (including even proportional-integral-derivative control algorithms) designed to verify and test to many small-scale simulators. In particular, it was almost impossible to implement advanced control algorithms to them. Therefore, it is required to develop a new simulator that facilitates the implementation of advanced control algorithms and the interface between different kinds of application programs. The objective of this work is to improve the existing small-scale simulator (FISA-2/WS) for the Kori unit 2 nuclear power plant and thus enable advanced control algorithms to be tested and verified by being applied to it. The developed simulator consists of FORTRAN, Visual C++, and MATLAB programs and an advanced control method using a receding horizon control method was applied to it to control the steam generator water level.
윤헌영,정순욱,박희명,박철,정만복,김준영,한현정,황민,노병국,박상혁,장하영,박정윤 한국임상수의학회 2004 한국임상수의학회지 Vol.21 No.1
A ten months old, female Yorkshire terrier weighing 2.88 kg referred to veterinary teaching hospital of college of veterinary medicine, Konkuk University because of syncope, cough and dyspnea. First hematological and serum chemical test revealed thrombocytopenia, mild anemia, and increase of concentration of ALP (195 U/L). On 57 days later, second hematological and serum chemical test revealed polycythemia, increase of concentration of ALP (211 U/L), and Tchol (387 mg/dl). Right atrium enlargement, main pulmonary artery bulge and cardiomegaly (VHS = 11.5) were observed in radiographic findings. Ultrasonographic images showed both right and left ventricular dilation and turbulent flow between the descending aorta and the main pulmonary artery in color Doppler imaging. ECG showed left ventricular enlargement, SA block, and electrical alternant. Thoracotomy was performed through left fourth intercostal incision under isoflurane anesthesia. Patent ductus arteriosus was double ligated with 1-0 silk. Cough and dyspnea disappeared on 5 days after operation. Turbulent flow was not found in color doppler imaging of ultrasonography on 10 days after operation. Ten months later after the operation, syncope could not exist any more.
MONITORING SEVERE ACCIDENTS USING AI TECHNIQUES
No, Young-Gyu,Kim, Ju-Hyun,Na, Man-Gyun,Lim, Dong-Hyuk,Ahn, Kwang-Il Korean Nuclear Society 2012 Nuclear Engineering and Technology Vol.44 No.4
After the Fukushima nuclear accident in 2011, there has been increasing concern regarding severe accidents in nuclear facilities. Severe accident scenarios are difficult for operators to monitor and identify. Therefore, accurate prediction of a severe accident is important in order to manage it appropriately in the unfavorable conditions. In this study, artificial intelligence (AI) techniques, such as support vector classification (SVC), probabilistic neural network (PNN), group method of data handling (GMDH), and fuzzy neural network (FNN), were used to monitor the major transient scenarios of a severe accident caused by three different initiating events, the hot-leg loss of coolant accident (LOCA), the cold-leg LOCA, and the steam generator tube rupture in pressurized water reactors (PWRs). The SVC and PNN models were used for the event classification. The GMDH and FNN models were employed to accurately predict the important timing representing severe accident scenarios. In addition, in order to verify the proposed algorithm, data from a number of numerical simulations were required in order to train the AI techniques due to the shortage of real LOCA data. The data was acquired by performing simulations using the MAAP4 code. The prediction accuracy of the three types of initiating events was sufficiently high to predict severe accident scenarios. Therefore, the AI techniques can be applied successfully in the identification and monitoring of severe accident scenarios in real PWRs.
Inhibitory Regulation of Chicken Mx against Avian Viruses in Chicken Spermatogonial Stem Cells
Ju-Young Ji,Kuppannan Gobianand,Jong-Ju Park,Jin-Gu No,Ju Sung Yang,Man Sung Park,Dong Kee Jeong,Dong-Hoon Kim,Jin Ki Park,Sung-June Byun,Chang Sun Song,Jae Gyu Yoo 한국동물생명공학회(구 한국동물번식학회) 2013 Reproductive & Developmental Biology(Supplement) Vol.37 No.2s
Mx is regulated by type I interferons and contains a typical GTP-binding motif like other members of the GTPase dynamin family. However, the functions and working mechanisms of the Mx protein in chicken spermatogonial stem cells (SSCs) are not well documented. In the present study, Mx-overexpressing chicken SSCs (chMx-SSCs) were established and the antiviral activity of chMx-SSCs against Newcastle disease virus, avian influenza viruses was investigated in vitro. For chicken SSCs isolation, day 20 fetal males derived testes were initially subjected to digestion by collagenase IV followed by 0.25% trypsin–EDTA. After discarding the supernatant, the cells were cultured in SSC medium. SSC colonies expressed pluripotent markers such as stagespecific embryonic antigen-1, Oct-4, Nanog, and Sox-2. Chicken Mx gene was constructed in plasmid DNA vector (pcDNA3.1/V5-His A-chMX) and ChMx-SSCs lines were established with chMX constructs. The antiviral activity of ChMx-SSCs was determined by real-time RT-PCR, flow cytometry, and western blot analyses after infection with Newcastle disease virus-green fluorescent protein (GFP) and avian influenza viruses (H9N2 and H1N1). ChMx-SSCs inhibited recombinant Newcastle disease virus (rNDV)- GFP replication as determined by the calculation of the proportion GFP signal- positive cells by FACS analysis. When SSCs showed 100% GFP expression, chMx- SSCs had only 3.6% GFP expression. At 24 h after avian influenza virus infection, chMx-SSCs had a lower hemagglutinin protein level and a higher level of Mx protein. When the number of released virion particles was estimated by plaque-formation assay, chMx-SSCs had significantly fewer stained visible plaques in the MDCK layer than SSCs. Our results suggest that overexpression of chicken Mx directly stimulates antiviral activity resulting in downregulation of viral progeny release. Chicken Mx overexpression in chicken SSCs can be applied for the production of virus resistant transgenic chicken via direct transplantation of chMx-SSCs into the testis.
김만선 ( Man Sun Kim ),김원식 ( Wuon Shik Kim ),노기용 ( Gi Young No ),이상태 ( Sang Tae Lee ) 한국감성과학회 2003 춘계학술대회 Vol.2003 No.-
본 논문에서는 심근허혈 질환을 효율적으로 분류하기 위한 신경망을 설계하였다. European ST-T DB의 심전도로부터 ST 분절의 특징을 추출하여 입력노드를 결정하고 10개의 학습률과 학습 횟수에 따른 신경망의 MES를 계산하였다. 실험 결과 특징 파라미터의 조합을 ST0, ST80, Slope, Area로 하였을 때 MSE를 가장 작았다. 이러한 특징 파라미터를 이용하여 신경망의 입력으로 학습시킨 경우 학습 횟수의 증가에 따라 MSE가 지수합수적으로 감소하였으며 1,000회 이상에서는 둔하게 감소하였다. 또한 학습 횟수가 5,000회, 10,000회, 15,000회 각각의 경우에 대하여 학습률을 0.01부터 0.7까지 증가시키면서 MSE를 계산한 결과 학습 횟수가 증가할수록 MSE를 최소로 하는 최적학습률이 0.1부터 0.04까지 감소하였다.
정만호 ( Man Ho Chung ),강춘원 ( Chun Won Kang ),노용기 ( Young Ki No ),반진열 ( Jin Yeal Park ) 한국가축위생학회 1990 韓國家畜衛生學會誌 Vol.13 No.1
The immune responses of commercial layer chickens against Newcastle disease(ND) were compared among different administration methods and times of vaccination during 4 weeks of age. A total of 372 day-old chickens were divided into 4 groups of 93 birds each. Each of 3 groups was received a commercially available B live vaccine via drinking water, eye instillation or spray method at one, 14 and 2 8 days of age. One group was used as an unvaccinated control. At two and 4 weeks after each time of vaccination, 15 birds from each group were collected randomly out and challenged with virulent ND virus at the dose of 105EID per bird. Ten to 15 birds from each group were bled at two weeks intervals from day old to 8 weeks of age for hemagglutination inhibition antibody titer. The protection rate was generally low regardless of the times of vaccination although two or more times vaccination gave higher protection than once vaccination. The low protection was considered due to low titer of the vaccine used since the vaccine titer was less than 103 5EID50 per bird. Spray method gave better protection compared to eye instillation or drinking water method which resulted in lowest response. Majority of birds showed clinical 5igns of ND between 3 and 6 days after challenge. Death occured one or two days after onset of symptoms. Major clinical signs observed were depression (94%), anorexia (84%), diarrhoea (29%), difficult breath (15%) and torticollis(10%). Hemorrhagic lesions on post mortem were seen in duodenum (51%), trachea (36%), illeum (13%), ceacal tonsil(11%), proventriculus(10%) and some other odrgans.