난소암의 조기진단

남주현,목정은 울산대학교 의과대학 1993 울산의대학술지 Vol.2 No.2

Ovarian cancer is the leading cause of death from gynecologic malignancies. In 1992, it has been reported that the incidence of ovarian cancer was 3% of all female malignancies in Korea. During the last decade, the incidence of cervical cancer which is the most common one of female malignancies was gradually declining, however that of ovarian cancer tended to be slightly increasing probably because of changes in socioeconomic status of this country. Despite of aggressive debulking operation and intensive platinum-based combination chemotherapy, the overall survival rate for ovarian cancer has not changed appreciably over the last twenty years. One of the reasons for poor prognosis of ovarian cancer is that greater than 70% of patients with ovarian cancer is unfortunately detected after the disease has already spreaded beyond the pelvis because of the lack of early symptoms. The cure rate for these patients with advanced ovarian cancer is only 15-20%, This low survival rate is in marked contrast to that of as high as 90% with stage I disease. Therefore, development of early detection method for ovarian cancer would be the best way to reduce the mortality rate of this disease. Ultrasonography and serum tumor marker, CA 125 have been extensively studied for early detection of ovarian cancer. Recently, combined use of transvaginal color Doppler technique is studied to increase the specificity of the screening test. However, the value of these methods as a screening test is still debating. So far, unfortunately there is no conclusive method which has cost-effectiveness and perfect sensitivity and specificity for ovarian cancer screening. Moreover, the optimal population and interval for ovarian cancer screening are not currently defined. In this review, recent data of studies using ultrasound and serum marker, CA 125 and debating issues for ovarian cancer screening are discussed.

한국 Drosophila아속 10종에 대한 유전적 유연관계

주은영,이양숙,김남우 경산대학교 기초과학연구소 2001 基礎科學 Vol.5 No.2

한국산 Drosophila아속 10종(D. virilis, D. tsigana, D. lacertosa, D. angularis, D. brachyephros, D. curvispina, D. kuntzei, D. nigromaculata, D. takadai, D. unispina)의 계통관계를 알아보기 위하여 동위효소와 수용성 단백질 분석을 실시하였다. 15종류의 동위효소 분석에서 18개의 loci가 검출되었다. 18개 loci중 Mdh-2, Got, Me, Ao, G6pd, Adh, Fum은 종내 변이가 없었으며, 특히 Ao, Fum은 종간에서도 변이가 없이 monomorpic하였다. 이 동위효소 분석에서 D. lacertosa와 D. nigromaculata가 가장 낮은 유연관계를 보였다. 2DE에 의한 수용성단백질 분석에서는 D. nigromaculata와 D. brachynephros가 가장 낮은 유연관계를 보였으며, D. angularis와 D. brachynephros가 가장 높은 유연관계를 보였다. 이상의 결과를 종합하여 보면 한국산 Drosophila아속 10종은 D. virilis, D. tsigana, D. lacertosa의 group과 D. angularis, D. brachynephros, D. curvispina, D. kuntzei, D. nigromaculata, D. takadai, D. unispina의 group으로 나눌 수 있으며, D. virilis가 속한 group이 더 primitive하다고 하겠다. 그러나 이 group이 다른 group에 직접적인 ancestor는 아니며 다른 ancestor가 있었을 것으로 생각된다. Phylogenetic relationships among the 10 species of the subgenus Drosophila in Korea, which is D. virilis, D. lacertosa, D. tsigana, D. angularis D. brachnephros, D. curvispina, D. kuntzei, D. nigromaculata, D. takadai and D. unispina were investigated using 18 loci found from analysis of 15 allozymes and soluble proteins analysis. Mdh-2, Got, Me, Ao, G6pd, Adh and Fum showed monomorphic patterns in each species, and specially Ao and Fum are the same alleles. As for the genetic relationships based on the results from the allozymes analysis, D. curvispina and D. unisina were found to have the closest relationship (0.851), and D. lacertosa and D. kuntzei showed the reverse (0.198). the average genetic similarity of the 10 species by allozyme analysis was 0.458. Soluble proteins from the 10 species of subgenus Drosophila were analyzed by 2DE method. Genetic distance between D. angularis and D. brachynephros was closer (0.168) than any other species. D. curvispina and D. unispina, and D. kuntzei and D. takadai were grouped as related species. The allozyme and soluble protein analysis showed similar. The average genetic distance of the 10 species by 2DE analysis was 0.386, indicating that the subgenus Drosophila can be grouped into two classes; the one class in D. virilis, D. lacertosa, D. tsigana and the other D. angularis, D. brachynephros, D. curvispina, D. kuntzei, D. nigromaculata, D. takadai and D. unispina.

한국의 당뇨병 관리를 위한 건강증진정책 연구

남은우,사카마키 히로유키,조은주,조혜전 고신대학교 보건과학연구소 2002 보건과학연구소보 Vol.12 No.-

This research is based on the drastically increased occurrence and death rate of diabetes recorded within the past ten years and the analysis of the Korean government's Diabetes Mellitus Management system in Korea in handling this alarming problem. The information used for this analysis is based on documents and statistics from the Ministry of Health and Welfare Statistics(2001, 2002) and also, health insurance statistics and documents from the National Health Insurance Corporation, 2001. The analysis of Health Plan 2010 will also be a key issue discussed in this paper. The Korean government's Diabetes Mellitus Management Plan's aim of increasing the life and healthy life expectancy while decreasing the medical costs at the same time is considered as a vital link in the government's Chronic Disease Management Plan. The main aim is to decrease the death rate, due to diabetes, from 22.6 people in 2000 to 19.0 by the year 2010. Health Plan 2010 plans to increase the role of public health centers. It also plans to form a system that will be used as a device in decreasing chronic diseases such as high blood pressure, diabetes and increasing general health by using the strategies of Health Plan 2010 against diabetes -to increase the government's role in public health. Korea's death rate, due to diabetes, is 2.2 times higher than that of Japan. Korea's being 22.6% compared to that of Japan which is only 10.1%. From now on our concerns should be directed in education and manpower. We need to have more specialized personnel who can be responsible for the nutrition, exercise, prevention and care of the public. Education is the fundamental basis for the control of Diabetes and is known throughout the world as the most cost-effective treatment. From this point on, the Government should concentrate on educating the people on the importance of healthy life styles. To do this it needs to provide the necessary funds needed in Health promotion and health education, and also to provide for professional personnel(eg. health educator).

영아 천식의 임상적 고찰 : Asthma prospective score에 의한 Based on Asthma Prospective Score

양은석,노영일,문경래,박영봉,박상기,변주남 조선대학교 부설 의학연구소 1999 The Medical Journal of Chosun University Vol.24 No.1

A Clinical study was made on 40 patients for infantile asthma less than 2 years old who had been admitted to the Department of Pediatrics of Chosun University Hospital from January 1997 to December 1998. We evaluated family history of allergic diseases, clinical features, serum IgE level, eosinophilia, chest radiologic findings and response to bronchodilator. The results obtained were as follows ; 1) The male to female ratio of patients studied was 4 : 1. 2) Eighteen of the 40 patients (45.0%) had a family history of allergic diseases, of which 10 patients had maternal allergic diseases. 3) Atopic dermatitis was the most common disease (37.5%) among the associated allergic diseases. 4) Thirty two of the 40 patients (80.0%) showed high serum total 19E levels. 5) Only 5 of the 20 patients who were examined by MAST showed positive reaction. 6) The frequency of chest radiologic findings observed in these patients was as follows ; hyperinflation (52.5%), increased bronchovascular marking(30.0%), no pathologic findings(25.0%), and pneumonic infiltration(25.0%). 7) In response to bronchodilator 28 cases(70.0%) were effective. 8) When we divided the 40 patients into two groups by the diagnostic criteria of Asthma prospective score (AP score), 30 patients(75.0%) were included in a compatible group. On the basis of AP score, family history of major or minor allergic dieases and the responsiveness to bronchodilator were important factors for the diagnosis of asthma.

한국노인약물역학코호트에서 폐암 발생률, 사망률 및 생존율, 1994-1998

최남경,윤경은,허대석,김윤이,이승미,박병주 한국역학회 2002 Epidemiology and Health Vol.24 No.2

Purpose : This study was conducted to estimate incidence, mortality and survival rate of lung cancer in the elderly people in Korea. Methods : Study population was Korean Elderly Phamacoepidemiologic Cohort (KEPEC). The lung cancer incidence cases were detected from three different sources, medical utilization database of the Korea Medical Insurance Corporation (KMIC), the database from the National Cancer Registry, and the database from the Regional Cancer Registry. The hospital survey to confirm the final diagnosis of the potential cases was conducted. A specialist on lung cancer reviewed the abstracted data to confirm the final diagnoses. The lung cancer death cases were detected from the mortality database at National Statistical Office. Incidence rate, survival rate and mortality rate of lung cancer and their 95% confidence intervals were estimated with SAS Window ver.8.1. Results : There were 213 confirmed lung cancer cases in KEPEC between Jan. 1994 and Dec. 1998. Age-standardized incidence rate of lung cancer to the Korean population was estimated to be 316.9 per 100,000 person-years in male and 65.2 per 100,000 person-years in female. Age-standardized mortality rate of lung cancer to the Korean population was estimated to be 342.3 per 100,000 person-years in male and 84.8 per 100,000 person-years in female. One years survival rate was 17% in male and 11% in female. Two year survival rate was 2% in male and 4% in female. Conclusion : Age-standardized incidence rate, age-standardized mortality rate and survival rate of lung cancer in the elderly Korean may be useful for further study and making health policy for managing lung cancer in the elderly.

풍력발전의 설비이용율 특성연구

이계주,이은학,김유남 한라대학교 2009 論文集 Vol.12 No.-

The scheme described checking the change transition for annual average plant factor month and season respectively as standard with measuring power exchange on Korea Power Exchange (KPX) from 2003 to 2006 and analysis of characteristic of output of wind power on a huge Wind Power Plant Complex which is selected for evaluating capacity of wind pover The result of the change transition for annual average plant factor will carry out good place construction plan and Long-term Electric Power Development Plan It can find that Wind Energy will be very useful when comparison between the value of data for long-term operating of wind power and the value of data for real wind

코오넬의학지수(Cornell Medical Index)에 의한 남·녀 대학생의 건강실태 조사연구

이기남,이종섭,유은주 圓光大學校 醫科學硏究所 1987 圓光醫科學 Vol.3 No.2

This study was conducted to evaluate the Health Status of 584 students enrolled in WonKwang University by Cornell Medical Index Questionaire from March to May 1987. The conclusion is as follows ; 1. Inaducacy, eyes and ears, fatigue in CMI items was showed high Complaints rate of more than 30% 2. For the purpose of understanding the Health Problem according to the general characteristics of students implemented Analysis of Variance Test. The results that according to sex, age, marital status, income, native place, medical institution looking for firstly, college are significant difference appeared. 1) Sex ; Female students shows higher complaints rate than male students. 2) Age; The younger, the higher complaints rate appeared. 3) Marital Status ; Single shows higher complaints rate than married. 4) Native Place ; Students who grown in middle, small city and large city shows higher complaints rate than rural students. 5) College ; Medical college, the others (humanistic, sociological arts college), Herb medical college, in regular sequence high complaints rate appeared.

수도 계량기 검침 자동화 시스템 구현

백남수,이은주 大田産業大學校 2002 한밭대학교 논문집 Vol.19 No.-

In this paper, we proposed a new method for automatic inspection of water gauge, and implemented it. We decided meter area for inspection using intensity of input image, and noise removed by labeling and size of label. The numbers were overlapped or not, it was decided by characteristics of numbers, and recognition area was decided by size of area. Finally, we computed the similarity between area of numbers and reference pattern by double template matching, and the number that similarity is the highest with area of numbers was result of recognition.

수리분석에 의한 한국 Drosophila 아속 10종에 대한 계통학적 연구

김남우,주은영,이양숙 慶山大學校 2000 論文集 Vol.18 No.1

Systematic relationships among the 10 species (D. virilis, D. lacertosa, D. tsigana, D. angularis D. brachynephros, D. curvispina, D. kuntzei, D. nigromaculata, D. takadai, D. unispina) of the subgenus Drosophila in Korea were investigated by taximetrical analysis. The taximetrical analysis of the 10 species according to the30 morphological characters were performed using UPGMA and cladistic analysis. The similarity coefficient (Gower's) between D. angularis and D. brachynephros was the highest value 0.941, and between D. curvispina and D. takadai was relatively high over 0.88. On the other hand, that between D. virilis and D. takadai was lowest value of 0.271. A dendrogram was constructed by cladistic analysis among 10 species with 30 morphological characters. The result of cladistic analysis D. virilis has the most primitive characters. The 10 species seem to be cladisted into three groups (D. virilis, D. lacertosa, P2). D. tsigana and P3 were derived from P2. Three derivative groups were cladisted from primitive species (P3). One derivative group included D. nigromaculata and next group included D. brachynephros, D. angularis, D. kuntzei, D. takadai, and the other group comprised D. unispina, D. curvispina. These results might suggest that the subgenus Drosophila consist of two section; the 1st section of D. virilis, D. lacertosa, D. tsigana and 2nd section of D. angularis, D. brachynephros, D. curvispina, D. kuntzei, D. nigromaculata, D. takadai, D. unispina. The group to which D. virilis belonged was considered as the primitive. However, it could not be the direct primitive to the another group, Instead it was presumed that there had been another ancestor.

삼각법을 기반으로한 구조화된 격자 캘리브레이션

김은석,주기세,왕지남 한국경영과학회 2002 한국경영과학회 학술대회논문집 Vol.- No.1(1)

Many sensors such as a structured grid pattern generator, a laser, and CCD camera to information have been used, but most of algorithms for a calibration are inefficient memory and experiment data are required. In this paper, the calibration algorithm of a structured grid pattern based on triang is introduced to calculate 3D information in the real world. The beams generated from str pattern generator established horizontally with the CCD camera are projected on the calibr CCD camera observes the intersection plane of a light and an object plane. The 3D infor calculated using observed and calibration data. This proposed method in this paper has advantages such as a memory saving and an e experimental data since the 3D information are obtained simply triangulation method.