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EFFECTS OF CHRONIC INGESTION OF ANTHRANILIC ACID ON LACTATION IN MICE
Nagasawa, H.,Suzuki, M.,Sakagami, N.,Inatomi, H.,Yamamoto, K. Asian Australasian Association of Animal Productio 1989 Animal Bioscience Vol.2 No.1
Treatment of mice with 0.04% anthranilic acid (AnA) as drinking water resulted in an apparent stimulation of pup's growth and food intake of mothers in their first lactations associated with an increased rearing rate and no alteration in plasma prolactin level. AnA showed no significant effects on the day of vaginal opening, the pattern of estrous cycles, plasma growth hormone level and endocrine organ weights of the female and male offspring. The growth of male offspring was significantly retarded by AnA, however, their reproductivity was quite normal. The results indicate the AnA can simulate lactation of mice through little modulation of endocrine systems.
EFFECTS OF CHRONIC INGESTION OF ANTHRANILIC ACID ON MAMMARY GLAND GROWTH IN SHN MICE
Nagasawa, H.,Konishi, R.,Sakagami, N.,Inatomi, H. Asian Australasian Association of Animal Productio 1988 Animal Bioscience Vol.1 No.3
Effects of anthranilic acid on normal mammary gland growth were examined in SHN/Mei female virgin mice. Anthranilic acid was given to the experimental groups as drinking water at the concentrations of 0.01, 0.02 or 0.04% for 21 days beginning 2-3 months of age. The control group received tap water only. RNA content and RNA/DNA ratio in mammary glands were significantly higher in mice given 0.04% anthranilic acid than in the control, while not mammary DNA content. The results indicate that chronic ingestion of anthranilic acid can induce an enhancement of proliferation and differentiation of mammary cells.
Nagasawa, H.,Suzuki, M.,Inatomi, H.,Hibino, A.,Yamamuro, Y.,Sensui, N. Asian Australasian Association of Animal Productio 1991 Animal Bioscience Vol.4 No.1
As a possible step to evaluate in the mammary gland the role of motherwort (Leonurus sibiricus L), a representative medicinal plant used traditionally for the therapy of gynecologic diseases, the effects of the agent on lactation which was suppressed by preganacy-dependent mammary tumors (PDMT) were studied in GR/A mice. Beginning the day of placing with males at 45-50 days of age, female mice were given 60% methanol-extract of the aerial part of motherwort as drinking water at the concentration of 0.5% throughout the experiment. Mice developing PDMT during pregnancy [PDMT(+)] and given motherwort were similar to mice developing no PDMT [PDMT(_)] with or without motherwort treatment and were significantly higher than PDMT(+) mice given tap water in litter growth and mammary RNA/DMA ratio on day 12 of the 2nd lactation. Mammary DNA and RNA contents were also elevated by motherwort in PDMT(+) mice. The results suggest that motherwort can ameliorate lactation suppressed by PDMT through its stimulation of both growth and function of the mammary glands.
Magnetic and Transport Properties of a New Caged Compound PrOs2Zn20
K. Wakiya,N. Nagasawa,K. T. Matsumoto,T. Onimaru,K. Umeo,T. Takabatake 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.62 No.12
The magnetic and transport properties of a Pr-encaged compound PrOs2Zn20 have been studiedby the electrical resistivity (T), magnetic susceptibility ρ(T), and specific heat C(T) measurementsdown to 2 K. The (T) and the C(T) show distinct anomalies at Ts = 87 K, which resemble theanomalies in the isostructural and isoelectronic compound PrRu2Zn20 with the structural phasetransition at Ts = 138 K. Above 50 K, the ρ(T) follows the Curie-Weiss law with the effectivemagnetic moment of 3.64 µB/f.u., which indicates the trivalent state of the Pr ion. The saturatedbehavior of ρ(T) below 5 K indicates the Van-Vleck paramagnetic state. Hence, the Pr3+ ion fallsin a nonmagnetic ground state under the crystalline electric field.
Diamond Conditioner Wear Characterization for a Copper CMP Process
Boruckia, L.,Zhuang, Y.,Kikuma, R.,Rikita, N.,Yamashita, T.,Nagasawa, K.,Lee, H.,Sun, T.,Rosales-Yeomans, D.,Philipossian, A.,Stout, T The Korean Institute of Electrical and Electronic 2007 Transactions on Electrical and Electronic Material Vol.8 No.1
Conditioner wear, copper polish rates, pad temperature and coefficient of friction (COF) are measured for two novel Mitsubishi Materials Corporation designs during an extended wear and polishing test. Both designs are coated with a $Teflon^{TM}$ film to reduce substrate wear and chemical attack. Using optical interferometry, changes in the coating that result in gradual changes in diamond exposure are measured. Theories of the COF, conditioning, and polishing are applied to explain the observed performance differences between the designs.
Diamond Conditioner Wear Characterizationfor a Copper CMP Process
L. Borucki,Y. Zhuang,R. Kikuma,N. Rikita,T. Yamashita,K. Nagasawa,H. Lee,T. Sun,D. Rosales-Yeomans,A. Philipossian,T. Stout 한국전기전자재료학회 2007 Transactions on Electrical and Electronic Material Vol.8 No.1
Conditioner wear, copper polish rates, pad temperature and coefficient of friction (COF) are measured for two novel Mitsubishi Materials Corporation designs during an extended wear and polishing test. Both designs are coated with a TeflonTM film to reduce substrate wear and chemical attack. Using optical interferometry, changes in the coating that result in gradual changes in diamond exposure are measured. Theories of the COF, conditioning, and polishing are applied to explain the observed performance differences between the designs.