DJ-1/park7 modulates vasorelaxation and blood pressure via epigenetic modification of endothelial nitric oxide synthase

Won, Kyung Jong,Jung, Seung Hyo,Jung, Soo Hyun,Lee, Kang Pa,Lee, Hwan Myung,Lee, Dong-Youb,Park, Eun-Seok,Kim, Junghwan,Kim, Bokyung Oxford University Press 2014 Cardiovascular research Vol.101 No.3

<P><B>Aims</B></P><P>DJ-1/park7, a multifunctional protein, may play essential roles in the vascular system. However, the function of DJ-1/park7 in vascular contractility has remained unclear. The present study was designed to investigate whether the DJ-1/park7 is involved in the regulation of vascular contractility and systolic blood pressure (SBP).</P><P><B>Methods and results</B></P><P>Norepinephrine (NE) elevated contraction in endothelium-intact vessels in a dose-dependent manner, to a greater extent in DJ-1/park7 knockout (DJ-1/park7<SUP>−/−</SUP>) mice than in wild-type (DJ-1/park7<SUP>+/+</SUP>) mice. Acetylcholine inhibited NE-evoked contraction in endothelium-intact vessels, and this was markedly impaired in DJ-1/park7<SUP>−/−</SUP> mice compared with DJ-1/park7<SUP>+/+</SUP>. Nitric oxide (NO) production (82.1 ± 2.8% of control) and endothelial NO synthase (eNOS) expression (61.7 ± 8.9%) were lower, but H<SUB>2</SUB>O<SUB>2</SUB> production (126.4 ± 8.6%) was higher, in endothelial cells from DJ-1/park7<SUP>−/−</SUP> mice than in those from DJ-1/park7<SUP>+/+</SUP> controls; these effects were reversed by DJ-1/park7-overexpressing endothelial cells from DJ-1/park7<SUP>−/−</SUP> mice. Histone deacetylase (HDAC)-1 recruitment and H3 histone acetylation at the eNOS promoter were elevated and diminished, respectively, in DJ-1/park7<SUP>−/−</SUP> mice compared with DJ-1/park7<SUP>+/+</SUP> controls. Moreover, SBP was significantly elevated in DJ-1/park7<SUP>−/−</SUP> mice compared with DJ-1/park7<SUP>+/+</SUP> controls, but this elevation was inhibited in mice treated with valproic acid, an inhibitor of Class I HDACs including HDAC-1.</P><P><B>Conclusion</B></P><P>These results demonstrate that DJ-1/park7 protein may be implicated in the regulation of vascular contractility and blood pressure, probably by the impairment of NO production through H<SUB>2</SUB>O<SUB>2</SUB>-mediated epigenetic inhibition of eNOS expression.</P>

비매너 주차 단속시스템

박상민(Sang-min Park),손병수(Byung-Soo Son),김명식(Myung-sik Kim),최병윤 한국정보통신학회 2021 한국정보통신학회 종합학술대회 논문집 Vol.25 No.1

주차장에서 일어날 수 있는 비매너 주차로 인한 충돌을 사전에 예방하기 위한 단속시스템이다. 주차장에서 일어날 수 있는 장애인, 전기차 전용 주차구역에 일반차량 주차, 2개 차선을 물고 주차하는 차량이 있다. 위와 같은 차량을 딥러닝 객체인식 기능을 통해 비매너 주차를 감지하여 알려준다. 비매너 주차 상황이 찍힌 사진이나 영상을 학습데이터로 사용하여 상황을 인식할 수 있도록 학습데이터를 제작하고 그 상황을 인식하여 비매너 주차 유무를 판단한다. 주차장의 환경을 좀 더 쾌적하게 함으로써 주차장 이용자간 충돌을 줄이는데 목적이 있다. It is a enforcement system to prevent collisions caused by unmanageable parking that may occur in parking lots. There are handicapped people who can get up in parking lots, general vehicles parked in electric vehicle parking areas, and vehicles parked in two lanes. The vehicle above is detected and notified through the deep learning object recognition function. By using a picture or video of an unmanageable parking situation as learning data, the learning data is produced so that the situation can be recognized, and the situation is recognized to determine the presence or absence of unmanageable parking. The purpose is to reduce collisions between parking lot users by making the environment of the parking lot more comfortable.

아파트 주차장유형에 따른 선호도에 관한 조사연구 : 대구지역을 중심으로

박찬돈,이두진,이명권 경운대학교 산업기술연구소 2001 産業技術硏究論文誌 Vol.3 No.2(B)

This study begins analysis the parking situations in apartment complex. It originated from understanding of the preference of users about underground parking lot. The method of this study is based on field survey of parking demand and thoughts of users of underground parking lot. There are so many parking problems in apartment complex that is due to the absence of parking demand data. So the goal of this study is to provide a solution of parking problems in apartment complex through understanding of the actual condition of parking problems, the preference and the reason of users about underground parking lot in apartment complex.

門中文獻의 기록범위와 자료의 활용가능성

朴明姬(Park Myung-hee) 역사문화학회 2001 지방사와 지방문화 Vol.4 No.2

This study aims to investigate the range of documents in the lineage literature of 'O-han-gong' lineage among 'Ham-yang Park' clan in Gu-rim, Ri Yeong-am Province. Park Sung-gun who called himself as O-han, was the progenitor of 'Ham-yang Park' clan in Gu-rim. He settled in the area, getting married to the Park Jim-myong's daughter. Through the fact that his clan made its genealogy and established 'Seo-won', a private school, for its clan, it is presumed that is took two hundred years for the clan to settled down in the area. The representative lineage literature of 'O-han-gong' lineage is 『The Remains of 'O-han-gong' Lineage in 'Ham-yang Park' Clan』. The documents of those lineage literature largely cover people and remains. In those documents, the people were mostly who were of exceptional merit. And representative remains are 'Juk-jeong Seo-won' and 'Gan-juk Jeong' which both are symbolic place of present 'O-han-gong' lineage in 'Ham-yang Park' clan. It seems to be possible to use the result, from the study on the range of documents, in four aspects; as follows. First, it is possible for us to presume historically how the lineage moved into and settled in Gu-rim area. Second, we can find and introduce the people who were renowned in their area, but not nameless in central governments. Third, we can find how the people as above contacted with the people in center. Lastly, among 'O-han-gong' lineage, there were many people who actively participated in the wars in 1592 and 1636. The fact could be practical reference to study the movement of a righteous army in Ho-nam area.

대구시 아파트단지의 주차수요에 관한 연구

박찬돈,하재명,Park Chan-Don,Ha Jae-Myung 한국주거학회 2004 한국주거학회 논문집 Vol.15 No.5

After 1980's, the ratio of car possessions has been increased rapidly. Nowaday, most large cities have suffered a lot of problems about traffic and car parking. Specially in apartment complexes, they have parking problem which is caused by the parking demand. The ratio of parking demand at multi-family housing sites has been increased significantly, therefore several parking problems have occurred. The goal of this study is to investigate the parking demand per housing unit size of apartment complex in Daegu city. The results of this study is as follows. (1) The parking demand of 60 $m^2$ below sized housing unit is 1.09 car per the unit. (2) The parking demand of 60 $m^2$ over 85 $m^2$ below sized housing unit is 1.31 car per the unit. (3) The parking demand of 85 $m^2$ over 135 $m^2$ below sized housing unit is 1.74 car per the unit. (4) The parking demand of 135 $m^2$ over sized housing unit is 2.10 car per the unit.

도심에서 운전자 주차행동특성에 관한 연구

이상관,박찬돈,이명권 경운대학교 산업기술연구소 2001 産業技術硏究論文誌 Vol.3 No.2(B)

In this study, driver's parking behavior characteristics in C.B.D were analyzed by quantification theory Ⅱ, and the variables deeply correlate with parking behavior. And for developing parking choice model, binary logit model was applied to the case of that choice alternative were legal or illegal parking and on-road or off-road parking, and multinominal logit model that can predicts three alternatives simultaneously was applied to the case of that choice alternatives were on-road, off-road and illegal parking. Parking choice models developed in this study, are expected to generate available data in developing and validating parking policy.

Park's 벡터 패턴의 왜곡률을 이용한 고정자 권선 고장 자동진단

宋明現(Myung-Hyun Song),朴奎南(Kyu-Nam Park),韓東奇(Dong-Gi Han),梁哲午(Chul-Oh Yang) 대한전기학회 2008 전기학회논문지 P Vol.57 No.2

In this paper, an auto-diagnosis method of the stator winding fault for small induction motor is suggested. 3-phase stator currents are sampled, filtered, and transformed with Park's vector transformation. After then Park's vector patterns are obtained. To detect the stator winding fault automatically, a distortion ratio is newly defined and compared with the one of healthy motor, and the threshold levels of distortion ratio are suggested. The 2-turn, 4-tum, 8-turn winding fault are tested with no load, 25%, 50%, 75%, and 100% rated load. The distortion ratio of the Park's vector patterns are increased as the increase of the faulted turns. but are same as the increase of the load.

Slide Session : OS-IFD-07 ; Infectious Disease : In Vitro Antiviral Activity of Ribavirin Against Severe Fever with Thrombocytopenia Syndrome Virus

( Myung Jin Lee ),( Kye Hyung Kim ),( Jong Youn Yi ),( Su Jin Choi ),( Chung Jong Kim ),( Nak Hyun Kim ),( Kyoung Ho Song ),( Pyoeng Gyun Choi ),( Ji Hwan Bang ),( Wan Beom Park ),( Eu Suk Kim ),( San 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

In Vitro Antiviral Activity of Ribavirin Against Severe Fever with Thrombocytopenia Syndrome Virus Myung Jin LEE1, Kye-Hyung KIM1, Jongyoun YI2, SuJin CHOI1, Chung-Jong KIM1, Nak- Hyun KIM1, Kyoung-Ho SONG1, Pyoeng Gyun CHOI1, Ji-Hwan BANG1, Wan Beom PARK1, Eu Suk KIM1, Sang-Won PARK1, Hong Bin KIM1, Nam Joong KIM1, Myoung- Don OH1 Seoul National University College of Medicine, Korea1, Pusan National University School of Medicine, Korea2 Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel Bunyavirus, severe fever with thrombocytopenia syndrome virus (SFTSV). No effective antiviral therapy is proven yet, but clinical use of ribavirin (RBV) has been tried. We investigated the antiviral effect of RBV against SFTSV in vitro. Methods: To test for cytotoxicity of RBV, Vero cells were treated with different concentrations of RBV (3.90 to 500 μg/mL, two-fold dilution) and analyzed by cell viability MTS assay 48h post-infection. To determine antiviral activity of RBV against SFTSV, Vero cells were infected with SFTSV strain Gangwon/Korea/2012 at 100 TCID50 (50% tissue culture infective dose) per well in a 96-well plate, and RBV was added at the concentrations showing no or minimal cytotoxicity. Viral RNAs were extracted from the culture supernatants and quantifi ed using one-step real-time reverse transcription- PCR to amplify the partial large segment of SFTSV. Statistical analysis was done by one-way ANOVA with Tukey`s post hoc test. Results: Cytotoxicity due to RBV was not observed at RBV concentration =31.3 μg/ mL. Viral RNAs at 24h post-RBV treatment were reduced with increasing RBV concentrations (1-32 μg/mL), compared with those of mock-treated cells (P <0.01, Figure). Half maximal inhibitory concentration (IC50) of RBV was 3.69 μg/mL at 24h post-RBV treatment. Conclusions: Our study shows that RBV has antiviral effect against SFTSV in a dose-dependent manner. Further studies are required to evaluate the effi cacy of RBV in SFTS.

On the Identity of -Eykey in Korean Morphological Passives

Myung-Kwan Park,Euiyon Cho 한국생성문법학회 2018 생성문법연구 Vol.28 No.3

Park, Myung-Kwan and Cho, Euiyon. 2018. On the Identity of -Eykey in Korean Morphological Passives. Studies in Generative Grammar, 28-3, 513-525. This squib investigates the nature of –eykey in Korean morphological/lexical passives. We first argue that this type of passives derives from their causative counterparts. The former and the latter can have the same form of verb, but during passivization the zero passivizing morphology on the transitive complement verb of the matrix causative morpheme demotes the Dative -eyeky-marked Causee from an argument to an adjunct, besides the transitive verb losing the ability to value Accusative Case. The so-called animacy restriction on the subject NP with –eykey passives is ascribed to the requirement that it assume the Causer role in –eykey passives. In contrast, –ey uyhay passives are derived from the zero passivizing morpheme attached to the causativized verb complex, thus the matrix subject being realized by the particle –ey uyhay.

On English Verbal Anaphor: VP Replacement and VP Ellipsis

Myung-Kwan Park,Sunjoo Choi 현대문법학회 2017 현대문법연구 Vol.96 No.-

Myung-Kwan Park and Sunjoo Choi. 2017. On English Verbal Anaphor: VP Replacement and VP Ellipsis. Studies in Modern Grammar 96, 89-107. It has been noted that VP replacement do so is not allowed with verbal passives, though it is with unaccusatives (Hallman 2013). This paper develops an identity-based account for this contrast. Bruening (2016) recently reports that VP replacement is permitted even with passives in some restricted environments. Reformulating Miller's (2011) three options for VP anaphor (i.e., VP replacement and VP ellipsis), Bruening (2016) suggests two factors governing the choice of VP anaphor. Departing from Bruening (2016), however, this paper provides an identity-based account for the issue concerned, by demonstrating that VP replacement and VP ellipsis are derived in a similar way but they require different operational domains in tandem with the identity domain for VP replacement or ellipsis. Grounded on some key representative examples, we suggest that passives as well as unaccusatives require syntactic identity, but that they are distinguished in terms of the category where VP replacement or ellipsis applies. Furthermore, the difference between VP replacement and VP ellipsis concerning the size of operational domain can be extended to account for causative-inchoative alternations. In doing so, we argue that meeting the identity condition is crucial for VP replacement as well as VP ellipsis.