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Cutaneous hemangiopericytoma in a dog : Cytologic and Histopathologic findings
Tae-Woo Kim, Min-Hee Kang, Soon-Wuk Jung, Hee-Myung Park 충북대학교 동물의학연구소 2013 Journal of Biomedical and Translational Research Vol.14 No.1
A 10-year-old, castrated male, English cocker spaniel dog was presented for evaluation of a mass in the left forelimb. Physical examination revealed a solitary subcutaneous mass measuring 2.7 × 2.1 × 1 cm in size. Radiographs and ultrasonography showed a well-circumscribed, focally mineralized, non-invasive to muscle layer mass without signs of further bone invasion and periosteal reaction. Cytologic evaluation of the mass through fine needle aspiration revealed a mesenchymal cell type malignant tumor without distant metastasis. An excisional biopsy was performed for definitive diagnosis and the mass was diagnosed as cutaneous hemangiopericytoma. This case report presents disagreement between fine needle aspiration and histopathology during diagnostic procedures of cutaneous hemangiopericytoma in a dog.
The histone methyltransferase, NSD2, enhances androgen receptor-mediated transcription
Kang, Hee-Bum,Choi, Youngsok,Lee, Jae Myun,Choi, Kyung-Chul,Kim, Han-Cheon,Yoo, Jung-Yoon,Lee, Yoo-Hyun,Yoon, Ho-Geun Elsevier 2009 FEBS letters Vol.583 No.12
<P><B>Abstract</B></P><P>In this study, we discovered that NSD2 specifically interacts with the DNA-binding domain of androgen receptor (AR) via its HMG domain, and the nuclear translocation of both NSD2 and AR is enhanced in the presence of ligand. Furthermore, we also demonstrated that the over expression of NSD2, but not of NSD2 (ΔSET) HMT-activity defective mutant, enhanced the mRNA level of PSA in a dose-dependent manner. A chromatin immunoprecipitation assay showed that NSD2 protein is recruited to the enhancer region of the PSA gene by AR in an agonist-enhanced manner. Taken together, these results uncover a potential role for NSD2 in AR-mediated transcription, implicating NSD2 in prostate carcinogenesis.</P><P><B>Structured summary</B></P><P>MINT-7103766: <I>NSD2</I> (uniprotkb:O96028) <I>physically interacts</I> (MI:0914) with <I>alpha AR</I> (uniprotkb:P10275) by <I>anti tag coimmunoprecipitation</I> (MI:0007)</P><P>MINT-7103748: <I>NSD2</I> (uniprotkb:O96028) <I>physically interacts</I> (MI:0915) with <I>alpha AR</I> (uniprotkb:P10275) by <I>two hybrid</I> (MI:0018)</P><P>MINT-7103800, MINT-7103819: <I>alpha AR</I> (uniprotkb:P10275) <I>binds</I> (MI:0407) to <I>NSD2</I> (uniprotkb:O96028) by <I>pull down</I> (MI:0096)</P><P>MINT-7103785: <I>NSD2</I> (uniprotkb:O96028) <I>colocalizes</I> (MI:0403) with <I>alpha AR</I> (uniprotkb:P10275) by <I>fluorescence microscopy</I> (MI:0416)</P><P>MINT-7103733: <I>P53</I> (uniprotkb:P04637) <I>physically interacts</I> (MI:0915) with <I>alpha AR</I> (uniprotkb:P10275) by <I>two hybrid</I> (MI:0018)</P>
症例(증례) : 류마티스 곤절염과 동반된 IgA 신병증 1례
고강석 ( Kang Suk Ko ),조양동 ( Yang Tong Cho ),김희정 ( Hui Jung Kim ),이원석 ( Won Seok Lee ),김형일 ( Hyoung Il Kim ),송민주 ( Min Ju Song ),손지연 ( Ji Youn Sohn ),류완희 ( Wan Hee Yoo ),강경표 ( Kyung Pyo Kang ),강명재 ( Myun 전북대학교 의과학연구소 2007 全北醫大論文集 Vol.31 No.2
IgA nephropathy is a common primary glomerulonephritis characterized by the deposition of IgA in glomerular mesangium. At clinical presentation the disorder may be macroscopic hematuria, often recurring in association with viral upper respiratory illness or with microscopic hematuria or proteinuria. Although the cause of primary IgA nephropathy is unknown, IgA nephropathy can be associated with systemic diseases, such as ankylosing spondylitis, Reiters`s syndrome, liver disease, and Sicca syndrome. We report a case of IgA nephropathy associated with rheumatoid arthritis. A 49-year-old woman, who has complaint of multiple joint swelling and pain, was presented with microscopic hematuria and proteinuria. Light microscopy showed mesangial and segmental endocapillary proliferative glomerulonephritis and immunofluorescence microscopy demonstrated segmental positive mesangial stainings for IgA and C3, consistent with IgA nephropathy. Treatment with anti-rheumatic medications and angiotensin converting enzyme inhibitor resulted in gradual disappearance of microscopic hematuria and proteinuria. Therefore, we suggest that IgA nephropathy may be associated with rheumatoid arthritis.
이종면,강중신,조희웅 啓明大學校 醫科大學 1982 계명의대학술지 Vol.1 No.1
The introduction of central venous catheter placement and parenteral untrition during the past few years have significantly improved the prognosis of critically ill infants with multiple or complex gastrointestinal diseases. With the use of a technique of central venous catheterization which includes meticulous attention to asepsis and antisepsis in insertion and regular care of the catheter, good results have been obtained. The technique, indication and complications of central venous catheterization are described herein.
만성 호중구성 백혈병(Chronic Neutrophilic Leukemia) 1예
정재면,홍택원,고동희,강준구,김태종,이웅수,최정혜,안명주,김인순,최일영,이영열 한양대학교 의과대학 2002 한양의대 학술지 Vol.22 No.2
Chronic neutrophilic leukemia is a very rare myeloproliferative disorder characterized by splenomagaly, persistent neutrophilia, bone marrow granulocyte hyperplasia, elevated leukocyte alkaline phosphatase, the absense of philadelphis cheomosome. Recently we have experienced a case of chronic neutrophilic leukemia in a 73 years old woman who complained of general weakness. On admission, peripheral blood examination showed leukocytosis with mature neutrophil: Hb 10.5g/㎗, WBC 33,200/㎣, platelet 751,000/㎣ and neutrophoil 93% in differential count. The underlying disease for leukemoid reaction has not been detected. Leukocyte alkaline phospatase score was elevated. Bone marrow study revealed hypercellular marrow with prominent neutrophilic hyperplasia and without myelofibrosis. The cytogenic study shows normal bone marrow cell karyotype without philadephia chromosome.
MRP1 Polymorphisms Associated With Citalopram Response in Patients With Major Depression
Lee, Sung Hee,Lee, Min-Soo,Lee, Ji Hyun,Kim, So Won,Kang, Rhee-Hun,Choi, Myoung-Jin,Park, Sang Jin,Kim, Se Joo,Lee, Jae Myun,Cole, Susan P.C.,Lee, Min Goo Lippincott Williams Wilkins, Inc. 2010 JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY Vol.30 No.2
Multidrug resistance protein 1 (MRP1, ABCC1) transports antidepressive agents in the endothelial cells of the blood-brain barrier. Therefore, polymorphisms in the MRP1 gene may affect the treatment response of antidepressants. This study was aimed to identify the association between genetic variations in MRP1/ABCC1 and the therapeutic response to the antidepressant citalopram. One hundred and twenty-three patients who had been treated with citalopram monotherapy to control their major depressive disorder were recruited, and genotype data from 64 patients who had completed their 8-week follow-up were evaluated together with those from 100 controls. Nine MRP1 single nucleotide polymorphisms (SNPs) showing more than 5% allele frequency in the Korean population were analyzed. The c.4002G>A, a synonymous SNP in exon 28, showed a strong association with the remission state at 8 weeks (P = 0.005, odds ratio [OR], 4.7, 95% confidence interval [CI], 1.5∼14.7). The c.4002G>A forms a linkage disequilibrium block with 3 other SNPs including c.5462T>A in the 3' untranslated region. Accordingly, the haplotype showed a significant association with the remission state (P = 0.014). Subsequent molecular studies also supported the association between these MRP1 polymorphisms and the citalopram response. Thus, kinetic studies using MRP1-enriched membrane vesicles revealed that citalopram is a substrate of MRP1 (Km = 1.99 μM, Vmax = 137 pmol/min per milligram protein). In addition, individuals with c.4002G>A or c.5462T>A polymorphisms showed higher MRP1 mRNA levels in peripheral blood cells. These results suggest that MRP1 polymorphisms may be a predictive marker of citalopram treatment in major depression.
안상호,이강희,장성호,안면환,최창열,박승한 대한스포츠의학회 1999 대한스포츠의학회지 Vol.17 No.2
Objective : To compare isokinetic trunk muscle strength and endurance between control and elite athletes groups(wrestlers, baseball players, judo players, ssireum players) and among athletes, to come up with a trunk strengthening program for poorly trained athletes. Method : We have conducted out study using a CYBEX 7000 Trunk Extension Flexion(TEF) unit (Lumex, inc., Reonkonkoma, NY, U.S.A) to measure peak toruque per body weight trunk flexor and extensor, endurance and conentric flexor/extensor ratio. Results : The trunk flexor peak torque per body weight of the athletes groups excepte baseball players was significantly higher than that of the control group at nearly all the angle velocities (p<0.05). The trunk flexor peak torque per body weight of wrestlers was significantly higher than that of baseball, ssireum and judo players. The trunk extensor peak torque per body weight of wrestlers was significantly higher than that of the control group(p<0.05) and ssireum players. The trunk extensor peak torque per body weight of judo players was significantly higher than that of control group at rapid velocities(p<0.05). Conclusion : To strengthen trunk muscle in poorly trained athletes, sports-specific trunk muscle strengthening exercise may be helpful.