Notes on preverbation in contemporary Italian

Alessio Muro 한국이탈리아어문학회(구 한국이어이문학회) 2016 이탈리아어문학 Vol.0 No.47

The present contribution aims to provide a synthetic description of the main morphological and syntactic phenomena linked to preverbation in contemporary Italian, paying special attention to the phenomenon of preverb stacking, which so far has not received any attention, as far as Italian is concerned. Preverbs are defined as a subset of verbal prefixes, namely those bearing semantic values pertaining to the domains of space, temporal/aspectual meanings, or quantification. Such prefixes are mainly spatial in their original uses, the other meanings being the outcomes of grammaticalization paths. There is, in Italian and other Indo-European languages, a certain formal overlap between the class of preverbs and that of adpositions (i.e. prepositions, in the case of Italian). The first part of the paper is devoted to a discussion of the relationship between prepositions and preverbs, with special attention being paid to the effects of preverbation on argument structure and transitivity. After introducing the temporal/actional meanings of Italian preverbs, the main features of preverb stacking are outlined. Two types of stacking are identifiable in Italian: the type termed ‘preverbazione incrementale’ (incremental preverbation) features the stacking of individual preverbs, each of which contributes a clearly identifiable meaning. This type allows for the stacking of up to three preverbs; those positioned in the second and third layers normally cannot express spatial meanings. This phenomenon is common in the formal register of the language. The other type is termed ‘polipreverbazione intensiva’ (intensifying preverb stacking): its characteristics are the opposite of those identified for incremental preverbation. In this type, the preverbs are all intensifiers and come in lexicalized blocks commonly composed of three morphemes. Intensifying stacking is a feature of the colloquial language (especially of younger generations).

Anisotropic c − f Hybridization in the Kondo Semiconductor CeFe2Al10

Yuji Muro,Keiske Yutani,Jumpei Kajino,Takahiro Onimaru,Toshiro Takabatake 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.63 No.3

We report a single-crystal study on the Kondo semiconductor CeFe2Al10 in which we measuredthe magnetic susceptibility, electrical resistivity, thermopower and thermal conductivity. The highlyanisotropic behavior in all measurements indicates an anisotropic electronic structure that couldoriginate from a c−f hybridization in an orthorhombic YbFe2Al10-type structure. The anisotropicc−f hybridization effect is manifested in the different peak temperatures of the electrical resistivityand the thermopower along the three principal axes.

Exploratory Analysis of Patients With Gastric/Gastroesophageal Junction Adenocarcinoma With or Without Liver Metastasis From the Phase 3 RAINBOW Study

Kei Muro,Takatsugu Ogata,Yukiya Narita,Zev A. Wainberg,Eric Van Cutsem,Kensei Yamaguchi,Yongzhe Piao,Yumin Zhao,Patrick M. Peterson,Sameera R. Wijayawardana,Paolo Abada,Anindya Chatterjee 대한위암학회 2023 Journal of gastric cancer Vol.23 No.2

Purpose: Liver metastasis (LM) is reported in approximately 40% of patients with advanced/metastatic gastric/gastroesophageal junction adenocarcinoma (metastatic esophagogastric adenocarcinoma; mGEA) and is associated with a worse prognosis. This post-hoc analysis from the RAINBOW trial reported the efficacy, safety, and biomarker outcomes of ramucirumab and paclitaxel combination treatment (RAM+PAC) in patients with (LM+) and without (LM−) LM at baseline. Materials and Methods: Patients (n=665) were randomly assigned on a 1:1 basis to receive either RAM+PAC (LM+: 150, LM−: 180) or placebo and paclitaxel (PL+PAC) (LM+: 138, LM−: 197). The overall survival (OS) and progression-free survival (PFS) were evaluated using stratified Kaplan–Meier and Cox regression models. The correlation of dichotomized biomarkers (VEGF-C, D; VEGFR-1,2) with efficacy in the LM+ versus LM− subgroups was analyzed using the Cox regression model with reported interaction P-values. Results: The presence of LM was associated with earlier progression than those without LM, particularly in patients receiving PL+PAC (hazard ratio [HR], 1.68). RAM+PAC treatment improved OS and PFS irrespective of LM status but showed greater improvement in LM+ than that in LM− (OS HR, 0.71 [LM+] vs. 0.88 [LM−]; PFS HR, 0.47 [LM+] vs. 0.76 [LM−]). Treatment-emergent adverse events were similar between patients with and without LM. No predictive relationship was observed between biomarker levels (VEGF-C, D; VEGFR-1,2) and efficacy outcome (OS, PFS) (all interaction P-values >0.05). Conclusions: RAM provided a significant benefit, irrespective of LM status; however, its effect was numerically stronger in patients with LM. Therefore, RAM+PAC is a clinically meaningful therapeutic option for patients with mGEA and LM.

Competencia Políticay Gasto Social en México

Cristina Tapia Muro,Leonardo Gatica Arreola 한국라틴아메리카학회 2014 라틴아메리카연구 Vol.27 No.2

Who are the voters who have benefited from a tactical distribution of budget of the political class? There is an important literature which seeks to explain the political criteria that underlies the distribution of the public spending. This article provides a study of the Mexican case. Specifically, a panel data model is estimated, providing evidence for the incidence of political criteria in the expansion of the “Oportunidades” social program during the period 2002-2010. The result of our model shows that political turnover and a high degree of political competition could partially explain the municipal assignations from “Oportunidades”.

Prognostic Factor Analysis of Overall Survival in Gastric Cancer from Two Phase III Studies of Second-line Ramucirumab (REGARD and RAINBOW) Using Pooled Patient Data

Fuchs, Charles S.,Muro, Kei,Tomasek, Jiri,Van Cutsem, Eric,Cho, Jae Yong,Oh, Sang-Cheul,Safran, Howard,Bodoky, Gyorgy,Chau, Ian,Shimada, Yasuhiro,Al-Batran, Salah-Eddin,Passalacqua, Rodolfo,Ohtsu, Ats The Korean Gastric Cancer Association 2017 Journal of gastric cancer Vol.17 No.2

Purpose: To identify baseline prognostic factors for survival in patients with disease progression, during or after chemotherapy for the treatment of advanced gastric or gastroesophageal junction (GEJ) cancer. Materials and Methods: We pooled data from patients randomized between 2009 and 2012 in 2 phase III, global double-blind studies of ramucirumab for the treatment of advanced gastric or GEJ adenocarcinoma following disease progression on first-line platinum- and/or fluoropyrimidine-containing therapy (REGARD and RAINBOW). Forty-one key baseline clinical and laboratory factors common in both studies were examined. Model building started with covariate screening using univariate Cox models (significance level=0.05). A stepwise multivariable Cox model identified the final prognostic factors (entry+exit significance level=0.01). Cox models were stratified by treatment and geographic region. The process was repeated to identify baseline prognostic quality of life (QoL) parameters. Results: Of 1,020 randomized patients, 953 (93%) patients without any missing covariates were included in the analysis. We identified 12 independent prognostic factors of poor survival: 1) peritoneal metastases; 2) Eastern Cooperative Oncology Group (ECOG) performance score 1; 3) the presence of a primary tumor; 4) time to progression since prior therapy <6 months; 5) poor/unknown tumor differentiation; abnormally low blood levels of 6) albumin, 7) sodium, and/or 8) lymphocytes; and abnormally high blood levels of 9) neutrophils, 10) aspartate aminotransferase (AST), 11) alkaline phosphatase (ALP), and/or 12) lactate dehydrogenase (LDH). Factors were used to devise a 4-tier prognostic index (median overall survival [OS] by risk [months]: high=3.4, moderate=6.4, medium=9.9, and low=14.5; Harrell's C-index=0.66; 95% confidence interval [CI], 0.64-0.68). Addition of QoL to the model identified patient-reported appetite loss as an independent prognostic factor. Conclusions: The identified prognostic factors and the reported prognostic index may help clinical decision-making, patient stratification, and planning of future clinical studies.

Fruit Quality of Seedless Watermelon Produced by Pollination with Inactivated Pollen in an Extender Medium

Keita Sugiyama,Takato Muro 한국원예학회 2006 한국원예학회 기타간행물 Vol.- No.-

Exposure-Response Analyses of Ramucirumab from Two Randomized, Phase III Trials of Second-line Treatment for Advanced Gastric or Gastroesophageal Junction Cancer

Tabernero, Josep,Ohtsu, Atsushi,Muro, Kei,Van Cutsem, Eric,Oh, Sang Cheul,Bodoky, Gyorgy,Shimada, Yasuhiro,Hironaka, Shuichi,Ajani, Jaffer A.,Tomasek, Jiri,Safran, Howard,Chandrawansa, Kumari,Hsu, Yan American Association for Cancer Research 2017 Molecular cancer therapeutics Vol.16 No.10

<P>Ramucirumab is an IgG1 monoclonal antibody specific for the vascular endothelial growth factor receptor-2. Ramucirumab, 8 mg/kg every 2 weeks, administered as monotherapy (REGARD) or in combination with paclitaxel (RAINBOW), was safe and effective in patients with previously treated advanced gastric or gastroesophageal junction (GEJ) cancer. We evaluated exposure-efficacy and exposure-safety relationships of ramucirumab from two randomized, placebo-controlled phase III trials. Sparse pharmacokinetic samples were collected, and a population pharmacokinetic analysis was conducted to predict ramucirumab minimumtrough concentration at steady state (C-min,C-ss). Kaplan-Meier methods and Cox proportional hazards models were used to evaluate the ramucirumab exposure (C-min,C-ss)-efficacy relationship to overall survival (OS) and progression-free survival (PFS). Logistic regression analyses were used to evaluate exposure-safety relationships. Analyses included 321 ramucirumab + paclitaxel and 335 placebo + paclitaxel patients from RAINBOW and 72 ramucirumab and 35 placebo patients from REGARD. Exposure-efficacy analysis showed ramucirumab C-min,C-ss was a significant predictor of OS and PFS in both trials. Higher ramucirumab exposure was associated with longer OS and PFS. In RAINBOW, grade >= 3 hypertension, leukopenia, and neutropenia, but not febrile neutropenia, significantly correlated with Cmin, ss, with increased exposure leading to increased incidence. Exploratory exposure-response analyses suggest a positive relationship between efficacy and ramucirumab exposure with manageable toxicities at exposures generated from a dose of 8 mg/kg ramucirumab given every 2 weeks for patients with advanced gastric/GEJ cancer. These findings suggest an opportunity to further optimize benefit versus risk profiles of ramucirumab treatment in patients with gastric/GEJ cancer. (C) 2017 AACR.</P>

Unconventional Magnetic Order and Superconductivity in Cage Compounds Encapsulating Rare-Earth Ions

T. Takabatake,Y. Muro,T. Onimaru,D. T. Adroja 한국자기학회 2010 한국자기학회 학술연구발표회 논문개요집 Vol.2010 No.12

Prognostic Factor Analysis of Overall Survival in Gastric Cancer from Two Phase III Studies of Second-line Ramucirumab (REGARD and RAINBOW) Using Pooled Patient Data

Charles S. Fuchs,Kei Muro,Jiri Tomasek,Eric Van Cutsem,조재용,오상철,Howard Safran,György Bodoky,Ian Chau,Yasuhiro Shimada,Salah-Eddin Al-Batran,Rodolfo Passalacqua,Atsushi Ohtsu,Michael Emig,David Ferry,Ku 대한위암학회 2017 Journal of gastric cancer Vol.17 No.2

The identified prognostic factors and the reported prognostic index may help clinical decision-making, patient stratification, and planning of future clinical studies.

Ce(Fe{0.7}Co{0.3})2 화합물에 대한 전자구조 연구

조은진,최병희,정재관,정란주,박제근,Takayuki MURO,Shigemasa SUGA 한국물리학회 2017 New Physics: Sae Mulli Vol.67 No.7

The Ce $4f$ spectra for CeFe$_{2}$ and Ce(Fe$_{0.7}$Co$_{0.3}$)$_{2}$ compounds were obtained using resonant photoemission spectroscopy, and the Ce $4f$ spectra were theoretically analyzed by using the impurity Anderson Hamiltonian. For the bulk Ce $4f$ spectrum of the Ce(Fe$_{0.7}$Co$_{0.3}$)$_{2}$ compound, we obtained $n_{f}$ = 0.87, $T_{K}$ = 318 K, and $\chi_{m} (0)$ = 1.97 $\times 10^{-3}$ emu/mol with $\epsilon_{f} (B) $ = -0.90 eV and $\Delta_{av} (B)$ = 47.9 meV, where for the surface Ce $4f$ spectrum, $n_{f}$ = 0.98 with $\epsilon_{f} (S) $ = -0.90 eV and $\Delta_{av} (S) $ = 40.1 meV. The intensity ratio of the surface Ce $4f$ spectrum relative to the bulk Ce $4f$ spectrum was about 25%. For the bulk Ce $4f$ spectrum of CeFe$_{2}$, we obtained $n_{f}$ = 0.88, $T_{K}$ = 311 K, and $\chi_{m} (0)$ = 10 $\times$ 10$^{-3}$ emu/mol by using $\epsilon_{f} (B) $ = -0.90 eV and $\Delta_{av} (B)$ = 49.2 meV. For the surface Ce $4f$ spectrum, we obtained $n_{f}$ = 0.98 with $\epsilon_{f} (S) $ = -0.90 eV and $\Delta_{av} (S) $ = 40.1 meV. The intensity ratio of the surface to the bulk Ce $4f$ spectra was about 22%. 공명광전자분광 실험으로CeFe$_{2}$ 화합물과 Ce(Fe$_{0.7}$Co$_{0.3}$)$_{2}$ 화합물의 Ce $ 4f$ 전자 스펙트럼을 얻었고, 불순물 앤더슨 해밀토니안 (Anderson Hamiltonian)을 사용해서 Ce $4f$ 전자 스펙트럼을 이론적으로 분석하였다. Ce(Fe$_{0.7}$Co$_{0.3}$)$_{2}$ 화합물의 덩어리 Ce $4f$ 전자 스펙트럼을 분석할 때, $\epsilon_{f} (B) $ = -0.90 eV와 $\Delta_{av} (B)$ = 47.9 meV를 사용해서 $n_{f}$ = 0.87, $T_{K}$ = 318 K 및 $\chi_{m} (0)$ = 1.93 $\times$ 10$^{-3}$ emu/mol을 얻었다. 표면 Ce $4f$ 전자 스펙트럼에서 $\epsilon_{f} (S) $ = -0.90 eV와 $\Delta_{av} (S) $ = 40.1 meV를 이용해서 $n_{f}$ = 0.98을 얻었다. 덩어리 성분에 대한 표면 Ce $4f$ 전자 스펙트럼 세기 비는 약 25%이다. CeFe$_{2}$ 화합물의 덩어리 Ce $4f$ 전자 스펙트럼에서 $\epsilon_{f} (B) $ = -0.90 eV와 $\Delta_{av} (B)$ = 49.2 meV을 사용해서 $n_{f}$ = 0.88, $T_{K}$ = 311 K와 $\chi_{m} (0)$ = 1.97 $\times$ 10$^{-3}$ emu/mol을 얻었다. 표면 Ce $4f$ 전자 스펙트럼에서 $\epsilon_{f} (S) $ = -0.90 eV와 $\Delta_{av} (S) $ = 40.1 meV를 사용해서 $n_{f}$= 0.98을 얻었다. 덩어리 성분에 대한 표면 Ce $4f$ 전자 스펙트럼 세기 비는 약 22%이다.