http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Chen, Wenjing,Zhao, Yumin The Institute for Far Eastern Studies, Kyungnam Un 1998 人文學硏究 Vol.23 No.-
Whether trade and investment liberalization contribute to sustainable development or sabotage the basis of sustainable development is a question yet to be answered sufficiently, since the countries in the Asia-Pacific region are inclined to rely on foreing trade and foreign direct investment for their economic success. APEC has made remarkable achievements in advancing its trade and investment liberalization agenda due to its flexible mechanism and unique cooperative approach. With the same approach it has much to contribute to sustainable-development endeavors in the region. With the repid pace of integration into the world economy and liberalization of trade and investment, particularly in Asia-Pacific, developing countries and regions are facing tough choices as to how to achieve economic development on an environmentally sustainable basis. This study reviews and analyzes the state of the region's economies and challenges for the developing economies; and we identify opportunities for regional cooperation throgh APEC to reduce, simultaneously, the impediments to promoting trade liberalization, environmental improvement, and economic development.
Wang, Yina,Zhang, Fangfang,Zhao, Guoyan,Zhao, Yingao,Ren, Yangyang,Zhang, Huijun,Zhang, Linyu,Du, Jimin,Han, Yumin,Kang, Dae Joon Elsevier 2019 CERAMICS INTERNATIONAL Vol.45 No.6
<P><B>Abstract</B></P> <P>We report a successful fabrication of low-cost, high-efficient, structurally-rigid, porous WO<SUB>3</SUB> photoelectrochemical (PEC) catalysts using polystyrene as the template by a sol-gel method and a high-temperature annealing treatment. The scanning electron microscopy and Brunauer-Emmett-Teller surface analysis results indicate that such WO<SUB>3</SUB> monoliths possess a porous structure and a large specific surface area, which can supply lots of photogenerated charge transfer pathways as well as more surface PEC active sites. Compared with a commercially available WO<SUB>3</SUB>, our highly porous WO<SUB>3</SUB> PEC catalysts show an excellent PEC water splitting activity. Particularly, the porous WO<SUB>3</SUB> photoanodes calcinated in the presence of oxygen atmosphere at 450 °C for 7 h show the best PEC performance exhibiting the photocurrent density of 0.97 mA/cm<SUP>2</SUP> at 1.23 V versus reversible the hydrogen electrode and the incident photon-to-current conversion efficiency up to 48.9% at 420 nm in 0.5 M Na<SUB>2</SUB>SO<SUB>4</SUB> electrolyte under AM 1.5 G irradiation. Such excellent PEC performance is due to the high porosity of the WO<SUB>3</SUB>, promoting the fast transfer and the separation rate of photogenerated carriers during the PEC water splitting process.</P>
Effects of puerarin on the Akt signaling pathway in bovine preadipocyte differentiation
Yun, Jinyan,Yu, Yongsheng,Zhou, Guoli,Luo, Xiaotong,Jin, Haiguo,Zhao, Yumin,Cao, Yang Asian Australasian Association of Animal Productio 2020 Animal Bioscience Vol.33 No.1
Objective: Puerarin has the potential of regulating the differentiation of preadipocytes, but its mechanism of action has not yet been elucidated. Adipocytes found in adipose tissue, the main endocrine organ, are the main sites of lipid deposition, and are widely used as a cell model in the study of in vitro fat deposition. This study aimed to investigate the effects of puerarin on adipogenesis in vitro. Methods: Puerarin was added to the culture medium during the process of adipogenesis. The proliferation and differentiation of bovine preadipocytes was measured through cell viability and staining with oil red O. The content of triacylglycerol was measured using a triglyceride assay kit. The mRNA and protein expression levels of adipogenic genes, peroxisome proliferator-activated receptor-γ (PPARγ) and CCAAT/enhancer-binding protein-α, were measured using quantitative real-time polymerase chain reaction and western blotting, respectively. Results: The addition of puerarin significantly increased adipogenesis of bovine preadipocytes and enhanced the mRNA and protein level expression of PPARγ (p<0.01). The expression of P-Akt increased after adipogenic hormonal induction, whereas puerarin significantly increased PPARγ expression by promoting the Akt signaling component, P-Akt. The mechanism of adipogenesis was found to be related to the phosphorylation level of Ser473, which may activate the downstream signaling of the Akt pathway. Conclusion: Puerarin was able to promote the differentiation of preadipocytes and improve fat deposition in cattle. The mechanism of adipogenesis was found to be related to the phosphorylation level of Ser473.
Kei Muro,Takatsugu Ogata,Yukiya Narita,Zev A. Wainberg,Eric Van Cutsem,Kensei Yamaguchi,Yongzhe Piao,Yumin Zhao,Patrick M. Peterson,Sameera R. Wijayawardana,Paolo Abada,Anindya Chatterjee 대한위암학회 2023 Journal of gastric cancer Vol.23 No.2
Purpose: Liver metastasis (LM) is reported in approximately 40% of patients with advanced/metastatic gastric/gastroesophageal junction adenocarcinoma (metastatic esophagogastric adenocarcinoma; mGEA) and is associated with a worse prognosis. This post-hoc analysis from the RAINBOW trial reported the efficacy, safety, and biomarker outcomes of ramucirumab and paclitaxel combination treatment (RAM+PAC) in patients with (LM+) and without (LM−) LM at baseline. Materials and Methods: Patients (n=665) were randomly assigned on a 1:1 basis to receive either RAM+PAC (LM+: 150, LM−: 180) or placebo and paclitaxel (PL+PAC) (LM+: 138, LM−: 197). The overall survival (OS) and progression-free survival (PFS) were evaluated using stratified Kaplan–Meier and Cox regression models. The correlation of dichotomized biomarkers (VEGF-C, D; VEGFR-1,2) with efficacy in the LM+ versus LM− subgroups was analyzed using the Cox regression model with reported interaction P-values. Results: The presence of LM was associated with earlier progression than those without LM, particularly in patients receiving PL+PAC (hazard ratio [HR], 1.68). RAM+PAC treatment improved OS and PFS irrespective of LM status but showed greater improvement in LM+ than that in LM− (OS HR, 0.71 [LM+] vs. 0.88 [LM−]; PFS HR, 0.47 [LM+] vs. 0.76 [LM−]). Treatment-emergent adverse events were similar between patients with and without LM. No predictive relationship was observed between biomarker levels (VEGF-C, D; VEGFR-1,2) and efficacy outcome (OS, PFS) (all interaction P-values >0.05). Conclusions: RAM provided a significant benefit, irrespective of LM status; however, its effect was numerically stronger in patients with LM. Therefore, RAM+PAC is a clinically meaningful therapeutic option for patients with mGEA and LM.