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MinSoo Byun,Dahyun Yi,JunHo Lee,YoungMin Choe,BoKyung Sohn,JunYoung Lee,HyoJung Choi,Hyewon Baek,YuKyeong Kim,YunSang Lee,ChulHo Sohn,Inhee MookJung,Murim Choi,YuJin Lee,DongWoo Lee,SeungHo Ryu,ShinGy 대한신경정신의학회 2017 PSYCHIATRY INVESTIGATION Vol.14 No.6
Objective-The Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer’s disease (KBASE) aimed to recruit 650 individuals, aged from 20 to 90 years, to search for new biomarkers of Alzheimer’s disease (AD) and to investigate how multi-faceted lifetime experiences and bodily changes contribute to the brain changes or brain pathologies related to the AD process. Methods-All participants received comprehensive clinical and neuropsychological evaluations, multi-modal brain imaging, including magnetic resonance imaging, magnetic resonance angiography, [11C]Pittsburgh compound B-positron emission tomography (PET), and [18F]fluorodeoxyglucose-PET, blood and genetic marker analyses at baseline, and a subset of participants underwent actigraph monitoring and completed a sleep diary. Participants are to be followed annually with clinical and neuropsychological assessments, and biannually with the full KBASE assessment, including neuroimaging and laboratory tests. Results-As of March 2017, in total, 758 individuals had volunteered for this study. Among them, in total, 591 participants-291 cognitively normal (CN) old-aged individuals, 74 CN young- and middle-aged individuals, 139 individuals with mild cognitive impairment (MCI), and 87 individuals with AD dementia (ADD)-were enrolled at baseline, after excluding 162 individuals. A subset of participants (n=275) underwent actigraph monitoring. Conclusion-The KBASE cohort is a prospective, longitudinal cohort study that recruited participants with a wide age range and a wide distribution of cognitive status (CN, MCI, and ADD) and it has several strengths in its design and methodologies. Details of the recruitment, study methodology, and baseline sample characteristics are described in this paper.
애플 앱 스토어의 앱 스크린샷이 앱 설치에 미치는 영향
변민수(Minsoo Byun),주광일(Kwangil Joo),최준호(Junho Choi) 한국HCI학회 2013 한국HCI학회 학술대회 Vol.2013 No.1
본 연구의 목적은 앱 스크린샷이 지닌 정보특성 즉, 다양한 스크린샷 유형이 사용자 앱 다운로드 행위에 어떠한 영향을 미치는가를 살펴보는 것이다. 분류된 5가지 유형의 앱 스크린샷을 토대로 각 유형에 따라 사용자가 앱을 설치하기까지 중요한 변수가 무엇인가를 밝혀낼 것이다. The purpose of this study is to figure out what types of app screenshots can make app installation more of not based on app screenshots classified five types of each.
Byun, Mi Ran,Sung, Mi Kyung,Kim, A Rum,Lee, Cham Han,Jang, Eun Jung,Jeong, Mi Gyeong,Noh, Minsoo,Hwang, Eun Sook,Hong, Jeong-Ho American Society for Biochemistry and Molecular Bi 2014 The Journal of biological chemistry Vol.289 No.14
<P>Osteoporosis is a degenerative bone disease characterized by low bone mass and is caused by an imbalance between osteoblastic bone formation and osteoclastic bone resorption. It is known that the bioactive compounds present in green tea increase osteogenic activity and decrease the risk of fracture by improving bone mineral density. However, the detailed mechanism underlying these beneficial effects has yet to be elucidated. In this study, we investigated the osteogenic effect of (−)-epicatechin gallate (ECG), a major bioactive compound found in green tea. We found that ECG effectively stimulates osteoblast differentiation, indicated by the increased expression of osteoblastic marker genes. Up-regulation of osteoblast marker genes is mediated by increased expression and interaction of the transcriptional coactivator with PDZ-binding motif (TAZ) and Runt-related transcription factor 2 (RUNX2). ECG facilitates nuclear localization of TAZ through PP1A. PP1A is essential for osteoblast differentiation because inhibition of PP1A activity was shown to suppress ECG-mediated osteogenic differentiation. Taken together, the results showed that ECG stimulates osteoblast differentiation through the activation of TAZ and RUNX2, revealing a novel mechanism for green tea-stimulated osteoblast differentiation.</P>
Synthesis and Anticonvulsant Evaluation of N-Cbz-α-amino-N-alkoxysuccinimides
Aesun Byun,Minjeong Kim,Jongwon Choi,Kyung Ho Moon,Chung Kyu Lee,Minsoo Park 대한약학회 2004 Archives of Pharmacal Research Vol.27 No.3
In previous studies for the development of new anticonvulsants, we found that N-Cbz-a-amino- N-alkylsuccinimides exhibited significant anticonvulsant activities in the Maximal electroshock seizure (MES) and Pentylenetetrazole induced seizure (PTZ) tests, and also their anticonvulsant activities were dependent on the N-alkyl substituents existent in their structures. Based on these estimations, N-Cbz-a-amino-N-hydroxysuccinimide and various N-Cbz-a-amino-Nalkoxysuccinimides were prepared in order to develop more active anticonvulsants and to examine the effects of N-hydoxy or N-alkoxy groups on their anticonvulsant activities. The (R)- or (S)-N-Cbz-a-amino-N-hydroxysuccinimide and N-Cbz-a-amino-N-alkoxysuccinimides were prepared from the corresponding (R)- or (S)-N-Cbz-aspartic acid through the known synthetic procedures. Their anticonvulsant activities in the MES and PTZ test were evaluated. All of these compounds except 3a showed significant anticonvulsant activities against the PTZ test, but these compounds were not active in the MES test. The most active compound in the PTZ test was (R)-N-Cbz-a-amino-N-benzyloxysuccinimide (ED50=62.5 mg/kg). In addition, the anticonvulsant activities of these compounds were dependent on their N-substited groups. The order of anticonvulsant activity against the PTZ test , as judged from the ED50 values for (R) series was N-benzyloxy > N-hydroxy > N-isopropoxy > N-methoxy > N-ethoxy; for the (S) series N-ethoxy > N-benzyloxy > N-methoxy > N-isopropoxy.
Yoonsik Uhm,Minsoo Lee,Jinsung Byun,Yong Kim,Sehyun Park IEEE 2010 IEEE transactions on consumer electronics Vol.56 No.1
<P>Intelligent gateway systems have evolved to seamlessly offer location-aware and multimedia services, allowing multi users to roam among multi service domains. In the past decade intelligent gateways have been implemented to support context-aware multimedia services with network convergence and service reasoning mechanisms in multi domains. However, recent researches have to consider multiple events and service management according to the user's movements and requirements. Therefore, we propose a Portable Intelligent Gateway System (PIGS) to offer seamless device-independent multimedia services and location-aware push services. Using heterogeneous network convergence and utilizing cooperation between other gateways, the PIGS interconnects users (user devices) who want to be offered multimedia services and Service Providers (SPs). Furthermore, our system dynamically offers differential services to multiple users with respect to the user, device and location characteristics. The PIGS also collects events using embedded sensors and generates events used for service configuration along with service predictions by using light-weight middleware. In this paper we implement real testbed, a house and a car, and verify the effectiveness of the service reconfiguration. The portable gateway structure using the PIGS achieves a 22% faster service response time in comparison to a fixed gateway-based structure.</P>
JeeWook Kim,MinSoo Byun,BoKyung Sohn,Dahyun Yi,EunHyun Seo,YoungMin Choe,ShinGyeom Kim,HyoJung Choi,JunHo Lee,IkSeung Chee,JongInn Woo,DongYoung Lee 대한신경정신의학회 2017 PSYCHIATRY INVESTIGATION Vol.14 No.4
Objective-This study aimed to examine the usefulness of each subscale score of the Clinical Dementia Rating (CDR) for predicting Alzheimer’s disease (AD) dementia progression in amnestic mild cognitive impairment (MCI) elderly subjects. Methods-Fifty-nine elderly MCI individuals were recruited from a university dementia and memory disorder clinic. Standardized clinical and neuropsychological tests were performed both at baseline and at the time of 2 years follow-up. Logistic regression analyses were conducted to examine the ability of various clinical measures or their combinations to predict progression to AD dementia in MCI individuals. Results-MCIp individuals showed significantly higher CDR Orientation subscale and CDR sum-of-boxes (SOB) score than MCInp ones, while there were no significant differences in other CDR subscale scores between the two. MCIp individuals also showed marginally higher MMSE scores than MCInp ones. A series of logistic regression analyses demonstrated that the model including CDR Orientation subscale had better AD dementia prediction accuracy than either the model with either MMSE or CDR-SOB. Conclusion-Our findings suggest that CDR Orientation subscale score, a simple and easily available clinical measure, could provide very useful information to predict AD dementia progression in amnestic MCI individuals in real clinical settings.
운영체제 수준에서 QoS를 보장하기 위한 우선순위 기반 네트워크 프로토콜 처리
김동수 ( Dongsoo Kim ),변재희 ( Jaehee Byun ),유민수 ( Minsoo Ryu ) 한국정보처리학회 2005 한국정보처리학회 학술대회논문집 Vol.12 No.1
본 논문에서는 운영체제 측면에서 QoS를 보장하기 위해 우선순위 기반의 네트워크 프로토콜 처리 기법을 제안한다. 제안된 기법에서는 우선순위에 따라 네트워크 패킷을 분류하고 프로토콜을 처리한다. 이를 위해 패킷분류기(Packet Classifier)와 프로토콜엔진(Protocol Engine)을 포함하는 QPF(QoS Provisioning Framework)를 설계하고 리눅스 커널 내부에 구현하였다. 과거의 인터럽트 기반의 방식에서는 네트워크 패킷이 선착순(first-in first-out)으로 처리되어 응용 프로그램에서 요구하는 QoS를 보장하기 어려우며, 또한 항상 네트워크 패킷의 처리가 응용 프로그램보다 우선적으로 처리되어 수신교착상태(Receive Livelock) 등의 문제가 발생한다. 본 논문에서 제안하는 QPF는 네트워크 패킷을 우선순위에 따라 처리함은 물론 네트워크 처리에 사용되는 CPU 시간을 조절할 수 있어 위와 같은 문제를 효과적으로 해결할 수 있다.
이은규(Eunkyu Lee),변상익(Sang-Ick Byun),김명철(Myungchul Kim),김민수(Minsoo Kim) 한국정보과학회 2002 한국정보과학회 학술발표논문집 Vol.29 No.2Ⅲ
인터넷에서 멀티미디어 서비스 및 고품질의 서비스를 제공하기 위한 다양한 모델들이 제시되고 있다. 기존의 통합화 서비스(Intserv)나 차별화 서비스(Diffserv)가 확장성과 종단간의 QoS 보장 측면에서 문제점을 보이면서 최근에는 이들을 통합하려는 시도가 나오고 있다. 그러나 각 모델의 기본 구조가 다르기 때문에 자연스럽게 연결되는 (Seamless) 통합 네트워크을 제시하는데 상당한 어려움이 있다. 본 논문에서는 인터넷에서 종단간의 QoS을 보장하기 위해 통합 모델의 형태를 보이고, 이를 구현하기 위한 프로토콜 변환기를 제안한다. 프로토콜 변환기는 리눅스 기반으로 구현되었다. 프로토콜 변환기를 포함하는 통합 모델에서 패킷 손실율, 데이터 전송율과 같은 네트워크 성능이 향되었음을 실험을 통해서 보여진다.