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Single Pleural Relapse of a Nasal-Type Extranodal Natural Killer/T-Cell Lymphoma: A Case Report
Kim, Keunmo,Oh, Youngmin,Lim, Sung-Nam,Choi, Song-Yi,Lee, Ok-Jun,Choe, Kang-Hyeon,Lee, Ki-Man,An, Jin-Young The Korean Academy of Tuberculosis and Respiratory 2014 Tuberculosis and Respiratory Diseases Vol.76 No.4
A nasal-type extranodal natural killer/T-cell lymphoma is considered an aggressive form of non-Hodgkin's lymphoma, with approximately half of all patients relapsing during the follow-up period, and most relapses occurring within the first 2 years of remission. Here we report an unusual case of a 42-year-old man who experienced recurrence in single pleura after 8 years of remission.
Aspergillus Tracheobronchitis in a Mild Immunocompromised Host
Cho, Byung Ha,Oh, Youngmin,Kang, Eun Seok,Hong, Yong Joo,Jeong, Hye Won,Lee, Ok-Jun,Chang, You-Jin,Choe, Kang Hyeon,Lee, Ki Man,An, Jin-Young The Korean Academy of Tuberculosis and Respiratory 2014 Tuberculosis and Respiratory Diseases Vol.77 No.5
Aspergillus tracheobronchitis is a form of invasive pulmonary aspergillosis in which the Aspergillus infection is limited predominantly to the tracheobronchial tree. It occurs primarily in severely immunocompromised patients such as lung transplant recipients. Here, we report a case of Aspergillus tracheobronchitis in a 42-year-old man with diabetes mellitus, who presented with intractable cough, lack of expectoration of sputum, and chest discomfort. The patient did not respond to conventional treatment with antibiotics and antitussive agents, and he underwent bronchoscopy that showed multiple, discrete, gelatinous whitish plaques mainly involving the trachea and the left bronchus. On the basis of the bronchoscopic and microbiologic findings, we made the diagnosis of Aspergillus tracheobronchitis and initiated antifungal therapy. He showed gradual improvement in his symptoms and continued taking oral itraconazole for 6 months. Physicians should consider Aspergillus tracheobronchitis as a probable diagnosis in immunocompromised patients presenting with atypical respiratory symptoms and should try to establish a prompt diagnosis.
멀티페이즈 컨버터 기반 3㎾급 연료전지용 계통연계 PCS 개발
한동화(Donghwa Han),최규하(Gyuha Choe),채영민(Youngmin Chae),조준석(Junseok Cho),임정민(Jungmin Lim) 전력전자학회 2010 전력전자학술대회 논문집 Vol.2010 No.7
본 논문은 연료전지를 이용한 가정용 발전시스템의 계통 연계를 위한 3㎾급 전력변환 시스템의 개발에 관한 것이다. 저전압 대전류 출력특성을 갖는 연료전지의 전류리플 최소화를 위해 멀티페이즈 컨버터를 적용한 DC/DC 승압 컨버터를 제안하고자 한다. 특히 고밀도 전력변환 시스템의 스위칭 손실 극소화를 위해 고효율 ZVS Soft-Switching 동작을 구현하였다. 또한 본 연구에서는 높은 승압비로 변환된 전압을 통해 계통운전 동작을 수행하기 위한 DC/AC 단상 인버터와 고효율 무결점 기능을 갖는 디지털 방식의 DSP를 적용한 제어기 개발도 병행하여 수행되었다. 제안하는 3㎾급 멀티페이즈 컨버터 및 계통연계형 인버터의 Proto-Type을 제작하고 실험을 통해 본 방식의 타당성을 검증하였다.
Bae, Seunghee,Ha, Tae-Su,Yoon, Youngmin,Lee, Joonyoung,Cha, Hwa Jun,Yoo, Hoesook,Choe, Tae-Boo,Li, Shunhua,Sohn, Insook,Kim, Ji-Young,Kim, Cha-Soon,Jin, Hyeon-Ok,Lee, Hyung-Chahn,Park, In-Chul,Kim, Ch D.A. Spandidos 2008 International journal of molecular medicine Vol.21 No.3
<P>Apoptosis executed by the mammalian caspase family plays a fundamental role in cellular homeostasis. Deregulation of this process is associated with several human diseases. The multimerization of ligand-induced death receptors results in the recruitment of the death inducing signaling complex and autocatalytic activation of initiator caspases, including caspase-8 and -10. However, it is still unclear how initiator caspases trigger and control the early apoptotic signaling pathways, partly because the downstream proteolytic cleavage targets of the initiator caspases are not completely known. Although it is known that a number of proteins are cleaved by various members of the caspase family, the identification of specific cleavage substrates of the initiator caspases 8 and 10, has been hindered by a lack of systematic and broadly applicable strategies for substrate identification. In the present study we constructed a mouse cDNA library and used it to perform a systematic, genome-wide screen for novel in vitro substrates of caspase-8 and -10. From this, we successfully identified six putative caspase substrates, including five novel proteins (ABCF1, AKAP1, CPE, DOPEY1 and GOPC1) that may be targeted specifically by the initiator caspases 8 and 10 during the early stages of apoptosis. These findings may provide useful information for elucidating the apoptotic signaling pathways downstream of the death receptors.</P>