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      • 분산 및 병렬처리 : Relaxed min-max 힙을 병합하는 병렬 알고리즘

        민용식(Min Yong Sik) 한국정보처리학회 1998 정보처리학회논문지 Vol.5 No.5

        본 논문에서는 relaxed min-max heap을 병합시키기 위하여 새로운 자료구조인 개선된 relaxed min-max-pair 힙을 제시함과 동시에, 두개의 relaxed min-max 힙, 즉 크기가 n인 relaxed min-max nheap과 크기가 k인 relaxed min-max kheap으로 구성된 우선 순위 큐를 병합시키기 위한 병렬 알고리즘을 제시하고자 한다. 본 논문에서는 [9]의 방법으로부터 relaxed min-max 힙을 병합 시키기 위해서 이용된 blossomed tree와 lazying 방법을 제거하여도 병합되는 새로운 방법을 제시하였다. 결과적으로 본 논문에 제시된 방법은 max(2^i-1,[(m+1/4)])개의 프로세서를 이용할 경우, 시간 복잡도가 O(log(log(n/k))?og(k))임을 볼 수가 있다. 그리고 크기가 서로 다른 두 개의 relaxed min-max heap으로 구성된 8백만개의 데이터를 병합시키기 위해서, MasPar 머쉰에서 64개의 프로세서를 이용하여 실행시킨 결과 35.205의 Speedup을 얻었다. This paper presents a data structure that implements a mergable double-ended priority queue : namely an improved relaxed min-max-pair heap. By means of this new data structure, we suggest a parallel algorithm to merge priority queues organized in two relaxed heaps of different sizes, n and k, respectively. This new data-structure eliminates the blossomed tree and the lazying method used to merge the relaxed min-max heaps in [9]. As a result, employing max(2^i-1,[(m 1/4)]) processors, this algorithm requires O(log(log(n/k))?log(k)) time. Also, on the MarPar machine, this method achieves a 35.205-fold speedup with 64 processors to merge 8 million data items which consist of two relaxed min-max heaps of different sizes.

      • KCI등재

        Merging Algorithm for Relaxed Min-Max Heaps Relaxed min-max 힙에 대한 병합 알고리즙

        민용식,Min,,Yong-Sik The Acoustical Society of Korea 1995 韓國音響學會誌 Vol.14 No.e1

        본 논문은 relaxed min-max heap을 병합시키기 위하여 이용된 새로운 자료구조인 개선된 relaxed min-max-pair 힙으로서, 두개의 relaxed min-max 힙 즉, 크기가 n인 relaxed min-max nheap과 크기가 k인 relaxed min-max kheap으로 구성된 우선 순위 큐를 병합시키기 위한 순차적 알고리즘을 제시하고자 한다. 본 논문에서 제시된 방법은 [8]에 제시된 방법에서 relaxed min-max 힙을 병합시키기 위해서 이용된 blossomed tree와 lazying 방법을 제거하여도 병합이 되는 새로운 기법을 제시하였다. 결과적으로 본 논문에서 제세된 방법은 두개의 relaxed min-max 힙의 크기가 서로 다른 경우로서, 이때 크기 $k{\leq}{\lfloor}log(size(nheap)){\rfloor}$인 경우, 시간 복잡도가 O(log(log(n/k))*log(k)) 이고 공간복잡도가 O(n+k)임을 볼수가 있다. This paper presents a data structure that implements a mergeable double-ended priority queue ; namely, an improved relaxed min-max-pair heap. It suggests a sequential algorithm to merge priority queues organized in two relaxed min-max heaps : kheap and nheap of sizes k and n, respecrively. This new data sturuture eliminates the blossomed tree and the lazying method used to merge the relaxed min-max heaps in [8]. As a result, the suggested method in this paper requires the time complexity of O(log(log(n/k))*log(k)) and the space complexity of O(n+), assuming that $k{\leq}{\lfloor}log(size(nheap)){\rfloor}$ are in two heaps of different sizes.

      • SCIESCOPUSKCI등재

        Coconut-derived D-xylose affects postprandial glucose and insulin responses in healthy individuals

        Yun,,Jung-Bae,Bak,,Youn-Kyung,Kim,,Bum-Sik,Kim,,Min-Sun,Lee,,Jin-Hee,Sung,,Mi-Kyung The Korean Nutrition Society 2011 Nutrition Research and Practice Vol. No.

        Metabolic alterations including postprandial hyperglycemia have been implicated in the development of obesity-related diseases. Xylose is a sucrase inhibitor suggested to suppress the postprandial glucose surge. The objectives of this study were to assess the inhibitory effects of two different concentrations of xylose on postprandial glucose and insulin responses and to evaluate its efficacy in the presence of other macronutrients. Randomized double-blind cross-over studies were conducted to examine the effect of D-xylose on postprandial glucose and insulin response following the oral glucose tolerance test (OGTT). In study 1, the overnight-fasted study subjects (n = 49) consumed a test sucrose solution (50 g sucrose in 130 ml water) containing 0, 5, or 7.5 g D-xylose powder. In study 2, the overnight-fasted study subjects (n = 50) consumed a test meal (50 g sucrose in a 60 g muffin and 200 ml sucrose-containing solution). The control meal provided 64.5 g of carbohydrates, 4.5 g of fat, and 10 g of protein. The xylose meal was identical to the control meal except 5 g of xylose was added to the muffin mix. In study 1, the 5 g xylose-containing solutions exhibited significantly lower area under the glucose curve (AUCg) and area under the insulin curve (AUCi) values for 0-15 min (P < 0.0001, P < 0.0001), 0-30 min (P < 0.0001, P < 0.0001), 0-45 min (P < 0.0001, P < 0.0001), 0-60 min (P < 0.0001, P < 0.0001), 0-90 min (P < 0.0001, P < 0.0001) and 0-120 min (P = 0.0071, P = 0.0016). In study 2, the test meal exhibited significantly lower AUCg and AUCi values for 0-15 min (P < 0.0001, P < 0.0001), 0-30 min (P < 0.0001, P < 0.0001), 0-45 min (P < 0.0001, P = 0.0005), 0-60 min (P = 0.0002, P = 0.0025), and 0-90 min (P = 0.0396, P = 0.0246). In conclusion, xylose showed an acute suppressive effect on the postprandial glucose and insulin surges.

      • SCOPUSKCI등재

        동맥혈 채혈후 시간 경과 및 온도 변화가 가스분압 및 PH 에 미치는 영향에 관한 연구

        김동수,이승환,김건식,강화자,신광일,여민구 대한마취과학회 1989 Korean Journal of Anesthesiology Vol.22 No.6

        Blood gas samples are highly susceptible to preanalytic error due to improper methods of obtaining or handling the sample prior to delivery to the laboratory. The errors in the measurement of blood gas analysis are currently derived from the exposure of sample to atmosphere, effects of anticoagulant itself, temperature difference between the measuring electrode and drawn blood and the delay in running the sample. To study the effects of the delay in measuring the sample and the temperature difference between the measuring electrode and drawn blood on values of blood gases and pH, we analyzed the arterial sampling from the 24 patients who were taking elective surgery or on his/her recovery period with indwelling arterial catheter. The plastic sampling syringes were kept at 4。C (refrigerator) or 22。-24。C (room temperature) and analyzed at regular intervals (1, 10, 30, 60,120 min) for 120 minutes. The following results were obtained: 1) When the arterial blood drawn from the anesthetized patients were stored 4。C, partial pressure of oxygen (PaO₂) decreased significantly after 20 min, whereas those stored at room temperature decreased significantly after 10 min. 2) When the arterial blood drawn from the recovery patients were stored at 4。C, PaO₂ did not decrease significantly through the experimental period of 120 min. Although those stored at room temperature did not decrease significantly through the period of 120 min. 3) Partial pressure of carbon dioxide in the arterial blood (PaCO₂,) drawn from the anesthetized patients increased significantly by 120 min. at 4。C, whereas those at room temperature increased significantly after 20 min. 4) PaCO₂, of the recovery patients increased signigicantly by 120 min. at 4。C, whereas those at room temperature increased significantly after 30 min. 5) pH of the arterial blood drawn from either anesthetized or recovery patients decreased significantly by 120 min. at 4。C, whereas those at room temperature decreased significantly after 60 min. 6) No significant changes al oxygen saturation (SaO₂) and content (CaO₂) were noted in either anesthetized or recovery. patients in accordance with time elapsed at 4。C or room temperature. In summary, as the changes of PO₂ in particular higher than physiologic PO₂ and PCO₂ in the arterial blood stored at room temperature are significant in accordance with the delay in measuring, it would be advisable to analyze the sample in a short period of time or to store it in a cool place when the measuring will be delayed.

      • KCI등재

        묽은황산 및 Cellulase에 의한 목재당화(木材糖化)에 관한 연구

        민두식,정인표,김홍은 한국임학회 1979 한국산림과학회지 Vol.41 No.1

        1. The study was conducted on the optimum condition of the treated substrate with dilute sulphuric acid solution and cellulase for saccharification. The wood (saw dust) of Alnus hirsuta Rupr. (10∼15 years) was treated with 0.3%, 0.6%, 0.9%, 1.2%, 1.5%, H₂SO₄ solution at 1.5㎏/㎠ for 15min., 30min., 45min., and 60min., followed by thermal treatment at 190℃ for 30min., and screening with 60 mesh sieve, after which to 0.5 grams of each sample was added 0.5㎖ cellulase solution, and 50㎖ 0.1M acetic acid buffer solution (pH 5.0), after incubating at 40℃ for 96hr. 2. The crude cellulase of Trichoderma viride Perx. ex. Fr. SANK 16374 was produced by the submerged culture process and produced in the culture fluid was salted out quantitatively by the use of ammonium sulfite. 3. Reducing sugar was determined by the 3.5-dinitrosalicylic acid (DNS) method. 4. The reducing sugar was increased with increase of the sulphuric acid concentration and saw dust was treated with 1.5% H₂SO₄ solution at 1.5㎏/㎠ for 45min. showed the best saccharification (16.0%). The reducing sugar formation did not show statistically significant in 5% levels by thermal treatment time 45min. and 60min. 5. The substrate for cellulase which was treated with 0.9% H₂SO₄ solution at 1.5㎏/㎠ for 60min. showed the best reducing sugar formation (23.6%). And did not show significant difference in 5% levels at 0.9%, 1.2%, and 1.5% H₂SO₄ solution.

      • Relaxed min-max 힘에 대한 병합 알고리즘

        민용식(Yong sik Min) 호서대학교 중앙도서관 1994 호서대학교 논문집 Vol.2 No.-

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

        This paper presents a data structure that implements a mergeable double-ended priority queue; namely, an improved relaxed min-max-pair heap. It suggests a sequential algorithm to merge priority queues organized in two relaxed min-max heaps: kheap and nheap of sizes k and n, respectively. This new data structure eliminates the blossomed tree and the lazying method used to merge the relaxed min-max heaps in [8]. As a result, the suggested method in this paper requires the time complexity of O(log(log(n/k))*log(k)) and the space complexity of O(n+k), assuming that k≤[log(size(nheap))] are in two heaps of different sizes.

      • SCIESCOPUSKCI등재

        Efffects of Fluoxetine on ATP-induced Calcium Signaling in PC12 Cells

        Yeo-Min,Lee,Hee,Jung,Kim,Sun,Hwa,Hong,Myung-Jun,Kim,Do,Sik,Min,Duck-Joo 대한생리학회-대한약리학회 2004 The Korean Journal of Physiology & Pharmacology Vol.8 No.1

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

        Fluoxetine, a widely used anti-depressant compound, has several additional effects, including blockade of voltage-gated ion channels. We examined whether fluoxetine affects ATP-induced calcium signaling in PC12 cells by using fura-2-based digital calcium imaging and assay for [<SUP>3</SUP>H]-inositol phosphates (IPs). Treatment with ATP (100μM) for 2 min induced [Ca<SUP>2⁢</SUP>]<SUB>i</SUB> increases. The ATP-induced [Ca<SUP>2⁢</SUP>]<SUB>i</SUB> increases were significantly decreased by removal of extracellular Ca<SUP>2⁢</SUP> and treatment with the inhibitor of endoplasmic reticulum Ca<SUP>2⁢</SUP> ATPase thapsigargin (1μM). Treatment with fluoxetine for 5 min blocked the ATP-induced [Ca<SUP>2⁢</SUP>]<SUB>i</SUB> increase concentration-dependently. Treatment with fluoxetine (30μM) for 5 min blocked the ATP-induced [Ca<SUP>2⁢</SUP>]<SUB>i</SUB> increase following removal of extracellular Ca<SUP>2⁢</SUP> and depletion of intracellular Ca<SUP>2⁢</SUP> stores. While treatment with the L-type Ca<SUP>2⁢</SUP> channel antagonist nimodipine for 10 min inhibited the ATP-induced [Ca<SUP>2⁢</SUP>]<SUB>i</SUB> increases significantly, treatment with fluoxetine alone blocked the ATP-induced responses. Treatment with fluoxetine also inhibited the 50 mM K<SUP>⁢</SUP>-induced [Ca<SUP>2⁢</SUP>]<SUB>i</SUB> increases completely. However, treatment with fluoxetine did not inhibit the ATP-induced [<SUP>3</SUP>H]-IPs formation. Collectively, we conclude that fluoxetine inhibits ATP-induced [Ca<SUP>2⁢</SUP>]<SUB>i</SUB> increases in PC12 cells by inhibiting both an influx of extracellular Ca<SUP>2⁢</SUP> and a release of Ca<SUP>2⁢</SUP> from intracellular stores without affecting IPs formation.

      • SCOPUSKCI등재

        Sevoflurane 흡입마취의 임상적 평가

        신양식,김종래,최미영,홍정연,민경태 대한마취과학회 1993 Korean Journal of Anesthesiology Vol.26 No.3

        This study was aimed to evaluate the clinical usefulness of sevaflurane including an adjustability for anesthetic depth and an efficacy in 30 healthy patients who had no previous anesthetic complications or have not experienced general anesthesia within 1 month. After premedication with intramuscular administration of midazolam and glycopyrrolate, anesthesia was induced with thiopental sodium and succinylcholine and endotracheal intubation was done for all the patients. Anesthesia was maintained with 0.5 to 2.0 vol% of sevoflurane according to changes of blood pressure in response to surgical stimuli in N₂O(2 L/min)-O₂(2 L/min) following 4∼5 vo1% inhalation for initial 5 minutes. For the muscle relaxation, vecuronium or pancuronium bromide 0.08 mg/kg was injected initially with additional doses in needed. At the end of operation, administration of N₂O and sevoflurane was discontinued. Pure oxygen with 5 L/min- flow rates was inhaled until full recovery. The emergence time interval from the discontinuation sevoflurane to the response of verbal command was about 10 minutes. The systolic blood pressure during operation reduced by 10 mmHg from preinduction value (from 126 to 116 mmHg). And the heart rate just before incision inereased by 14 beats/min from the preinduction value (from 83 beats/min to 97 beats/min). Arterial blood gas study showed mild hyperventilation with PaCO₂ of 30 torr during operation, but PaCO returned normocapneic state during spontaneous breathing after recovery from anesthesia. There was no evidence of respiratory depression during perianesthetic periods. Complete blood counts, biochemical studies, serum electrolytes, and urinalysis at the preanesthetic period, the 1st and 7th postoperative days revealed clinically nonisgnificant changes. However SGPT increased to 30 IU/L in the 7th postoperative day from the preoperative value of 13 IU/L. No arrhythmia did occur during anesthesia, and no complaint including headache, nausea and vomiting ect, was seen after recovery.

      • SCIESCOPUSKCI등재

        KR-31762, a Novel $K_{ATP}$ Channel Opener, Exerts Cardioprotective Effects by Opening $SarcK_{ATP}$ Channels in Rat Models of Ischemia/reperfusion-induced Heart Injury

        Lee,,Sung-Hun,Yang,,Min-Kyu,Lim,,Jong-Hyun,Seo,,Ho-Won,Yi,,Kyu-Yang,Yoo,,Sung-Eun,Lee,,Byung-Ho,Won,,Hyung-Sik,Lee,,Chang-Soo,Choi,,Wahn-Soo,Shin,,Hwa-Sup 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.4

        The cardioprotective effects of KR-31762, a newly synthesized $K^+_{ATP}$ opener, were evaluated in rat models of ischemia/reperfusion (I/R) heart injury. In isolated rat hearts subjected to 30-min global ischemia followed by 30-min reperfusion, KR-31762 (3 and 10 ${\mu}M$) significantly increased the left ventricular developed pressure (LVDP) and double product (heart rate ${\times}$ LVDP) after 30-min referfusion in a concentration-dependent manner, while decreasing the left ventricular end-diastolic pressure (LVEDP). KR-31762 also significantly increased the time to contracture (TIC) during ischemic period (20.0, 22.4 and 26.4 min for control, 3 and 10 ${\mu}M$, respectively), while decreasing the release of lactate dehydrogenase (LDH) from the heart during 30 min reperfusion (30.4, 14.3 and 19.7 U/g heart weight, respectively). All these parameters except LDH release were reversed by glyburide (1 ${\mu}M$), a nonselective blocker of $K^+_{ATP}$ channel, but not by 5-hydroxydecanoate, a selective blocker of $mitoK^+_{ATP}$ channel. In anesthetized rats subjected to 45-min occlusion of left anterior descending coronary artery followed by 90-min reperfusion, KR-31762 significantly decreased the infarct size (60.8, 40.5 and 37.8% for control, 0.3 and 1.0 mg/kg, iv, respectively). KR-31762 slightly relaxed the isolated rat aorta precontracted with methoxamine ($IC_{50}:\;23.5\;{\mu}M$). These results suggest that KR-31762 exerts potent cardioprotective effects through the opening of sarcolemmal $K_{ATP}$ channel in rat hearts with the minimal vasorelaxant effects.

      • Activation by Combined Treatment with Cyclobeximide and Electrical Stimulation of In-Vitro Matured Porcine Oocytes Improves Subsequent Parthenogenetic Development

        Naruse,,Kenji,Kim,,Hong,Rye,Shin,,Young,Min,Chang,,Suk,Min,Lee,,Hye,Ran,Tarte,,Vaishali,Quan,,Yan,Shi,Kim,,Beak,Chul,Park,,Tae,Young,Choi,,Su,Min,Park,,Chang,Sik,Jin,,Dong,Il 충남대학교 형질전환복제돼지연구센터 2007 논문집 Vol. No.10

        Electrical treatment has been widely used for porcine oocytes activation However, developmental rates following electrical activation of porcine oocytes is relatively inefficient compared to other domestic animals. To investigate the effects of porcine oocytes on combined activation by both chemical and electrical treatment, in-vitro matured oocytes were activated by combined cycloheximide and electrical pulses treatment. Cumulus-free oocytes were exposed with NCSU-23 medium containing cycloheximide (10 μg/ml) for 0, 5, 10, 20, 30 min and then activated by electrical pulse treatment and cultured in PZM-3 for 8 days. Also effects of exposure to 6.25 μM calcium ionophore for 2 min for cumulus-free oocytes were tested. The percentage of blastocyst formation in 10 min exposure to 10 μg/ml cycloheximide and electrical pulse treatment was significantly increased (P<O.05) than in the control group. And exposure to 6.25 μM calcium ionophore for 2 min with 10 μg/ml cycloheximide for 10min and electrical pulse treatment significantly increased (P<O.05) the percentage of blastocyst developmental rates than the control group. In conclusion, activation by combined cycloheximide and electrical stimulation treatment promoted the subsequent development of porcine oocytes and improved the subsequence blastocyst development.

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