백서 심근경색모델에서 시간경과와 경색의 크기에 따른 심자도의 변화

김미성(Mi Sung Kim),박영선(Young Sun Park),권순길(Sun Gil Kwon),지정훈(Jeong Hoon Ji),신종성(Jong Sung Shin),오광식(Kwang Sik Oh),양용모(Yong Mo Yang),연태진(Tae Jin Youn),김동운(Dong Woon Kim),조명찬(Myeong Chan Cho),이용호(Yong Ho 대한내과학회 2002 대한내과학회지 Vol.62 No.1

N/A Background: Magnetocardiogram (MCG), which records the changes of magnetic fields generated by the heart`s electrical activity, theoritically can provide unique data for clinical application. To date, MCG has been investigated only at a single time point after myocardial infarction (MI) with severe left ventricular dysfunction in rats. The purpose of the present study was to investigate sequential changes of MCG after MI and to evaluate effects of infarct size on MCG. Methods: Acute MI were induced by the permanent ligation of left coronary artery in 22 rats. Magnetic fields were recorded just above a rat with Nb Superconducting Quantum Interference Device (SQUID) gradiometer inside a magnetically shielded room. MCG was measured before and immediately after surgery and it was subsequently recorded at the time points of 1, 4 and 6 hours post operatively. MCG was also measured at 1, 3, 7 and 21 days after surgery. Results: Elevation of ST segment and appearance of pathological Q wave on the MCG were evident immediately after the ligation of coronary artery and persisted to 6 hours after MI. On MCG, ST segment was depressed and T wave was inverted from 1 day after MI. In rats with small-and moderate- sized MI (infarct size〈30%), ST depression returned to near the isoelectric level and Q wave disappeared from 7 days after MI. However, ST depression and Q wave were still present in rats with larger infarct (infarct size≥30%). Conclusion: Evolutional changes of MCG were well-recognized up to 21 days after MI. Furthermore, the infarct size can be expressed by the extent of Q wave and ST segment depression on MCG. Taken together, these data indicate that MCG is a helpful modality for the diagnosis, evaluation of infarct size and follow up after MI.(Korean J Med 62:42-48, 2002)

이용자간 만족도를 고려한 공원의 공간개선 방향연구 - 목포시 삼학도공원을 중심으로 -

박성현 ( Park Sung-hyun ),배현미 ( Bae Hyun-mi ) 한국도서(섬)학회 2020 韓國島嶼硏究 Vol.32 No.4

본 연구에서는 역사와 문화를 품고 있는 목포 삼학도공원의 재정비계획 수립과정에서 이용만족도를 높이기 위한 계획 및 설계에 필요한 기초자료를 제공하고자, 공원 이용자들을 대상으로 만족도 분석을 진행하였다. 구체적으로 먼저, 역사적인 측면에서 삼학도공원의 특징을 살펴본 후, 공원시설의 구성과 운용실태에 대해 살펴보았다. 다음으로 삼학도공원의 이용과 만족도 조사를 시민과 관광객을 대상으로 실시한 결과로는 첫째, 삼학도공원은 주말을 이용해서 가족 및 친구와 함께 여가를 즐기기 위한 공간으로서 근린공원의 특징을 보이고 있는데, 이는 시민들이 삼학도공원을 근린공원의 이미지로 인식하는 것과 맥락을 같이 하고 있다. 둘째, 삼학도공원을 찾는 관광객들은 전남지역에 거주하는 사람들이 많았고, 연령층은 시민과 비슷하게 40대와 50대가 가장 높은 것으로 나타났고, 이들은 가족과 함께 관광목적으로 방문한 것으로 나타났다. 셋째, 시민과 관광객 모두 삼학도공원의 이용 및 시설에 대해서는 대체로 만족하는 것으로 나타났으며, 시민은 그 이유로 편안한 쉼터와 좋은 자연환경이라고 응답하였다. 넷째, 시민과 관광객 모두 삼학도공원 이용 시 관리실, 화장실, 매점 등 안내 및 편의시설의 부족하다는 문제점을 제기하고 있으며, 삼학도에 새롭게 만들어졌으면 하는 시설과 사업에 대해시민과 관광객들은 섬의 정체성을 나타내기 위해 특색 없는 다리를 대신하여 육지와 삼학도를 이어주는 가동교 설치를 원하는 것으로 나타났다. 이용자간 만족도를 고려한 공원 공간개선 방향은 정리하면, 첫째 매립지의 기존 공원Zone(A)은 현재 공원시설을 최대한 활용함을 원칙으로 하고 이용측면에서 제기된 문제점을 개선하면서 지역 정체성을 살리고 최근의 트렌드에 맞는 새로운 아이템을 도입하는 방향으로 설계한다. 둘째, 삼학도 활용 Zone(B)은 복원된 삼학도를 적극적으로 활용하는 방향으로 설계한다. 셋째, 공원입구 Zone(C)는 공원의 위치 등 인지도 향상을 위한 안내 홍보 및 가동교 등 랜드마크 설치, 동선 유도책 등이 필요하다. 넷째, 목포내항 삼학도 해안 Zone(D)는 우수한 조망점이라는 특징을 적극 활용하고, 내륙과 내항측에서 접근이 용이한 동선 및 시선 유도계획 방향으로 설계한다. 본 연구의 결과를 통해 섬을 활용한 공원을 조성할 시 시설이용도 및 이용자 만족도를 높이 기 위해 일반적인 근린공원으로 그 역할을 제안하는 것보다는 해당 공원을 통해 지역의 문화와 정서를 담고 섬만의 정체성을 살리는 전략과 계획이 필요하며, 이러한 방식이 섬을 활용한 공원의 지속가능성을 보장할 수 있을 것이다. In this study, the author analyzed satisfaction with Samhak Island Park among park users with an aim to provide basic data essential to be applied in the planning and design phases in a way that enhances their satisfaction in the process of setting up the reorganization plan of this park entailing both the history and culture of Mokpo City. As a first step, the author first examined the characteristics of this park in terms of history and closely looked into the organization and features of park facilities. Secondly, the direction of space improvement plans was proposed based on the findings of the survey on satisfaction among residents and visitors at Samhak Island Park. To summarize the ways to improve park space considering satisfaction among park users, the current park Zone(A) at Mokpo landfill should be designed to address problems in terms of visiting, uphold the local identity, and introduce popular and trendy items, while maintaining the principle of making the best use of the present park facilities. Second, Zone(B) should be designed in a way that takes greater advantages of the restored Samhak Island. Third, Zone(C) representing an entrance requires tasks such as promotional activities to make public its location, landmark installments such as a movable bridge, and improved path guidance. Fourth, Zone(D) by the ocean of this island at the inner harbor should be designed to reflect its outstanding view point in the way that the users are allowed to have easier access from land as well as from the inner harbor as part of its view-attracting plan. The findings revealed that when it comes to building new parks using existing islands, strategies and plans to maintain its identity as an island while upholding its culture and feeling are needed rather than proposing its role as an ordinary neighborhood park to boost facility use and user satisfaction. This way is expected to successfully ensure sustainability related to parks using existing islands.

Interaction of <i>Veratrum nigrum</i> with <i>Panax ginseng</i> against Obesity: A Sang-ban Relationship

Park, Jinbong,Jeon, Yong-Deok,Kim, Hye-Lin,Lim, Hara,Jung, Yunu,Youn, Dong-Hyun,Jeong, Mi-Young,Kim, Hyun-Ju,Kim, Sung-Hoon,Kim, Su-Jin,Hong, Seung-Heon,Um, Jae-Young Hindawi Publishing Corporation 2013 Evidence-based Complementary and Alternative Medic Vol.2013 No.-

<P>Obesity has become a major health threat in developed countries. However, current medications for obesity are limited because of their adverse effects. Interest in natural products for the treatment of obesity is thus rapidly growing. Korean Medicine (KM) is characterized by the wide use of herbal formulas. However, the combination rule of herbal formulas in KM lacks experimental evidence. According to <I>Shennong's Classic of Materia Medica</I>, the earliest book of herbal medicine, <I>Veratrum nigrum</I> (VN) has antagonistic features against <I>Panax ginseng</I> (PG), and the PG-VN pair is strictly forbidden. In this study, we have shown the effects of PG, VN, and their combination on obesity in high-fat (HF) diet-induced obese mice and in 3T3-L1 cells. PG, VN, and PG-VN combination significantly reduced weight gain and the fat pad weight in HF diet-induced obese mice. They also significantly decreased lipid accumulation and the expressions of two major adipogenesis factors, PPAR<I><I>γ</I></I> and C/EBP<I><I>α</I></I>, in 3T3-L1 cells. In addition, the PG-VN combination had synergistic effects compared with the mixture of extracts of PG and VN on inhibition of PPAR<I><I>γ</I></I> and C/EBP<I><I>α</I></I> expressions at lower doses. These results indicate a new potential anti-obese pharmacotherapy and also provide scientific evidence supporting the usage of herbal combinations instead of mixtures in KM.</P>

Extension of Lance Life by Change of Height of Lances in the Smelting Furnace of Mitsubishi Process

Sung‑Mi Lim,Soo‑Sang Park,Kyung‑Woo Yi 대한금속·재료학회 2021 METALS AND MATERIALS International Vol.27 No.10

A Mitsubishi process, which pertains to continuous Cu production, involves a smelting furnace, cleaning furnace, and convertingfurnace connected in series. One of the main issues pertaining to the smelting furnace is the frequent interruption ofoperations required to allow the inspection and replacement of lances, because lances are frequently fractured. The presentstudy was aimed at modifying the operating conditions of the smelting furnace to suppress lance fractures. A numericalmodel was developed to simulate the transport phenomena in the furnace, including multi-phase behaviors. The simulationresults showed that the lances were exposed to a severely erosive atmosphere with high temperatures. Further calculationindicated that raising the positions of the lances could lower the temperature of the lances, and reducing the occurrence ofsplashed melt, which contains erosive sulfides. The smelting furnace was operated under the conditions of the raised lanceheight and attentively monitored for several months. It was confirmed that by implementing such a change of the lanceheights, the occurrence of lance failures has been considerably reduced without notably affecting the reaction ability of thesmelting furnace.

Could cluster of risk factors predict clinical outcome in patients with acute myocardial infarction?

( Sang Mi Park ),( Hong Nyun Kim ),( Se Yong Jang ),( Myung Hwan Bae ),( Dong Heon Yang ),( Hun Sik Park ),( Yongkeun Cho ),( Shung Chull Chae ),( Jang Hoon Lee ) 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1

Purpose: Conventional risk factors are differently contributed to short-term prognosis of acute myocardial infarction (AMI); hypertension and diabetes increase adverse outcome, whereas hyperlipidemia, smoking, and obesity paradoxically decrease adverse outcome of post-MI patients. The aim of this study is to assess whether cluster of conventional risk factors, PARADOCS (Pressure of ARtery Abnormality, Diabetes, Obesity, Cholesterol, Smoking) score, would improve the ability to predict major adverse cardiac events (MACEs) in patients with AMI. Methods: Between November 2005 and July 2011, 24,020 patients (17,232 men; mean age=63.0±12.8) with AMI were analyzed from Korean AMI registry. PARADOCS score was calculated as follows; [number of non-paradoxical risk factors (NRF) -number of paradoxical risk factors (PRF)]+3 in which non-paradoxical risk factors are hypertension and diabetes, and paradoxical risk factors are the rest. The 1-year MACEs were defined as death and non-fatal MI. Results: NRF including hypertension and diabetes were present in 49.6% and 27.0%, whereas PRF including hyperlipidemia, smoking, and obesity were present in 12.3%, 43.0%, and 34.6%, respectively. During the follow-up, 1,409 (5.9%) MACEs occurred. PARADOCS score was significantly higher in patients with 1-year MACEs (3.38±1.03 versus 2.81±1.08, p<0.001). In Cox proportional hazards model, PARADOCS score was an independent predictor of 1-year MACEs (hazards ratio 1.26, 95% confidence interval 1.18-1.34; p<0.001) after adjusting for confounding variables. Patients were categorized into 3 groups according to the PARADOCS score; PARADOCSLOW (0-1, n=2,446), PARADOCSMID (2-3, n=14,594), and PARADOCSHIGH (4-5, n= 6,980). Kaplan-Meier survival curve showed that there were significant differences in the 1-year MACEs among three groups including 3.5% in PARADOCSLOW, 8.5% in PARADOCSMID, and 16.4% in PARADOCSHIGH, respectively (long-rank p<0.001). Conclusions: In post-MI patients, conventional risk factors are differently associated with short-term prognosis, and score of these risk factors, PARADOCS score, can provide useful prognostic information to clinicians.

국립공원관리를 위한 위성영상 활용방안에 관한 연구 - 북한산 국립공원을 사례로 -

박경(Kyeong Park),장은미(Eun Mi Chang),신상희(Sang Hee Scene) 한국환경영향평가학회 2001 환경영향평가 Vol.10 No.3

National Parks in Korea occupy about four percents of South Korean land. This paper aims to prove the potentiality of the application of remotely sensed data for the effective management of National Parks. Different satellite images such as Landsat TM, IRS-1C, Alternative image, and IKONOS image are analyzed for the detection of changes, the extraction of degraded areas, and the comparison of Normalized Difference Vegetation Index (NDVI) in Bukhansan National Park. The artificial structures such as buildings and paved areas are overvalued in relatively higher resolution data. The result showed that the choice of images should be determined according to specific purposes and the combination of different resolution data may be the solution for the effective management of National Park.

보문 : Polyethylene Film포장이 포도 Sheridan의 저장력에 미치는 영향

남상영(Sang Young Nam),김경미(Kyoung Mi Kim),박종천(Jong Chun Park),주선종(Seon Jong Joo),정재현(Jai Hyun Jung) 한국식품저장유통학회(구 한국농산물저장유통학회) 1997 한국식품저장유통학회지 Vol.4 No.1

크론병으로 인한 십이지장-대장 누공의 Endoloop과 Hemoclip을 이용한 수술 전 내시경적 결찰 증례보고

박미성 ( Mi Sung Park1 ),김원진 ( Won Jin Kim ),허지혜 ( Ji Hye Huh ),박수정 ( Soo Jung Park ),홍성필 ( Sung Pil Hong ),김태일 ( Tae Il Kim ),김원호 ( Won Ho Kim ),천재희 ( Jae Hee Cheon ) 대한소화기학회 2013 대한소화기학회지 Vol.61 No.2

Duodeno-colonic fistula is an enterocolonic fistula that occurs as a complication of Crohn`s disease. Symptoms of duodeno colonic fistula are similar to those of Crohn`s disease, such as weight loss and diarrhea. The treatment of choice is surgery, although medical treatment may also be considered. However, surgery is recommended when all available medical therapies have been ineffective. In this case, we report a secondary duodeno-colonic fistula due to Crohn`s disease that was temporarily managed by an endoscopic procedure with a detached endoloop and hemoclips as a bridging therapy to final surgical repair.

코호트 효과를 고려한 주택연금 수요 추정

박상수(Sang-Soo Park),심미령(Mi-Ryung Sim),이충기(Chung-Ki Lee) 한국경제연구학회 2017 한국경제연구 Vol.35 No.3

2007년부터 시행되고 있는 한국의 주택연금제도는 정부가 보증하는 역모기지 프로그램이다. 한국주택금융공사가 매년 실시하고 있는 연간 설문 자료를 이용하여 미래에 주택연금을 이용할 의향이 있는 가구들에 대해 주택연금에 대한 수요를 추정하였다. 본 논문에서는 이충기․박상수(2014)의 연구를 확장하여 미래 기대와 코호트 효과를 고려하여 순서형 로짓 모형을 설정하였다. 설문에서 진술된 가구의 의향이 미래에 대한 기대에 근거하고 있다는 점을 적절하게 평가하기 위해 몇 가지의 가정을 바탕으로 미래의 기대형성 과정을 계량경제학적으로 모형화하여 주택연금 수요를 예측하고자 하였다. 주택연금에 대한 수요 추정 결과에 따르면, 주택연금 프로그램에 대해 후세대들이 보다 덜 긍정적인 경향이 나타난 반면 저소득 계층은 보다 긍정적으로 나타났다. The J ooTaekYeonKeum is the government guaranteed reverse mortgage program that Korean Government has been implementing since 2007. We extended Lee and Park’s(2014) demand estimation for the reverse mortgage loans in Korea using the yearly survey data, conducted by Korea Housing Financing Corporation, for household’s intention to use J ooTaekYeonKeum in the future. In order to appropriately appreciate the fact that the stated intentions in the survey were based on households’ expectations for their future, we adopted an econometric procedure that incorporated expectations explicitly as well as cohort effects. Our findings include: demands for reverse mortgage loans are estimated similar to that of Lee and Park(2014); later generations tend to be less positive for having the reverse mortgage program; lower income groups are more positive for the program.

Water-soluble Genistin Glycoside Isoflavones Upregulate Antioxidant Metallothionein Expression and Scavenge Free Radicals

Chung, Mi-Ja,Kang, Ah-Young,Jun, Hee-Jin,Kim Sang-Yeon,Moon, Tae-Hwa,Park, Kwan-Hwa,Lee, Sung-Joon 생명자원연구 2005 생명자원연구 Vol.13 No.-