Hashimoto thyroiditis with an unusual presentation of cardiac tamponade in Noonan syndrome

Mi Ji Lee,Byung Young Kim,Jae Sook Ma,Young Earl Choi,Young Ok Kim,조화진,Chan Jong Kim 대한소아청소년과학회 2016 Clinical and Experimental Pediatrics (CEP) Vol.59 No.no.sup1

Noonan syndrome is an autosomal dominant, multisystem disorder. Autoimmune thyroiditis with hypothyroidism is an infrequent feature in patients with Noonan syndrome. A 16-year-old boy was admitted because of chest discomfort and dyspnea; an echocardiogram revealed pericardial effusion. Additional investigations led to a diagnosis of severe hypothyroidism due to Hashimoto thyroiditis. The patient was treated with L-thyroxine at 0.15 mg daily. However, during admission, he developed symptoms of cardiac tamponade. Closed pericardiostomy was performed, after which the patient’s chest discomfort improved, and his vital signs stabilized. Herein, we report a case of an adolescent with Noonan syndrome, who was diagnosed with Hashimoto thyroiditis with an unusual presentation of cardiac tamponade.

DNA Topoisomerases I and II Inhibitory Activity and Cytotoxicity of Compounds from the Stems of Parthenocissus tricuspidata

Woo, Mi Hee,Zhao, Bing Tian,Tran, Manh Hung,Jeong, Su Yang,Ma, Eun Sook,Min, Byung Sun Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.9

Activity-directed isolation of the methylene chloride fraction from the stems of Parthenocissus tricuspidata have led to the identification of two new compounds (1-2): 1-(2',3',5'-trihydroxyphenyl)-2-(4"-hydroxyphenyl)-ethane-1,2-(E)-epoxide (1, tricuspidatin A) and erythro-1-(3',5'-dihydroxyphenyl)-2-(4"-hydroxyphenyl)-ethane-1,2-diol (2, tricuspidatin B), together with four known compounds (3-6): ${\beta}$-sitosterol (3), nonacosan-1-ol (4), 3-(4-hydroxy-3-methoxyphenyl)-2-propenoic acid hexacosyl ester (5) and betulinic acid (6). Their chemical structures were elucidated based on spectroscopic (IR, UV, MS, 1D and 2D NMR) and physicochemical analyses. Compounds 1 and 2 showed strong DNA topoisomerase II inhibitory activity at both concentrations of 20 and $100{\mu}M$. In addition, 3 exhibited strong cytotoxic activity against the HT-29 and HepG2 cancer cell lines, and 6 showed strong cytotoxicity against the HT-29 and MCF-7 ones.

Hashimoto thyroiditis with an unusual presentation of cardiac tamponade in Noonan syndrome

Lee, Mi Ji,Kim, Byung Young,Ma, Jae Sook,Choi, Young Earl,Kim, Young Ok,Cho, Hwa Jin,Kim, Chan Jong The Korean Pediatric Society 2016 Clinical and Experimental Pediatrics (CEP) Vol.59 No.no.sup1

Noonan syndrome is an autosomal dominant, multisystem disorder. Autoimmune thyroiditis with hypothyroidism is an infrequent feature in patients with Noonan syndrome. A 16-year-old boy was admitted because of chest discomfort and dyspnea; an echocardiogram revealed pericardial effusion. Additional investigations led to a diagnosis of severe hypothyroidism due to Hashimoto thyroiditis. The patient was treated with L-thyroxine at 0.15 mg daily. However, during admission, he developed symptoms of cardiac tamponade. Closed pericardiostomy was performed, after which the patient's chest discomfort improved, and his vital signs stabilized. Herein, we report a case of an adolescent with Noonan syndrome, who was diagnosed with Hashimoto thyroiditis with an unusual presentation of cardiac tamponade.

간접광고(PPL)의 차별적 규제에 대한 일반 시청자 인식 : Viewers’ perception of indirect advertising discriminatory regulation

천현숙(Hyun Sook Chun),마정미(Jung Mi Ma) 한국광고PR실학회 2021 광고PR실학연구 Vol.14 No.1

일반 시청자들은 과연 간접광고에 대해 어떤 생각을 하고 있을까? 이 의문을 해결하기 위해 실시간 설문조사를 해보았다. 조사 결과, 시청자들은 간접광고에 대해 잘 알고 있었고 주목해 보고 있었다. 그러나 시청자들은 간접광고를 불편하게 느끼고 있었다. 시청자들은 간접광고 자체에 대해서 뿐만 아니라 간접광고 규제에 대해서도 잘 알고 있었다. 지상파방송에 더 엄격한 간접광고 규제를 완화해야 한다고 답하였다. 절반 가까운 시청자가 그렇게 답하였다. 시청자가 지상파방송 간접광고 규제 완화 시 우려하고 있는 것은 프로그램의 선정·폭력성, 공공성 약화, 유료방송에 대한 부정적 영향이었다. 그러나 이러한 우려에도 불구하고 지상파방송 간접광고 규제를 완화해야 하는 이유로 꼽은 것은 방송 광고 시장 활성화, 형평의 원칙, 시장경제 원리, 탈규제의 세계적 흐름이었다. 반대로 지상파방송 간접광고 규제를 완화하지 않고 계속 유지할 경우 시청자들의 우려는 방송사들의 경쟁력 약화였다. 그러나 이러한 우려에도 불구하고 지상파방송 간접광고 규제를 완화하면 안 되는 이유로 꼽은 것은 시청자 주권, 균형 발전이었다. 시청자들이 지상파방송 간접광고 규제 완화 조건으로 생각하는 것은 간접광고 수익을 방송 프로그램 질 올리는 데 투자하는 것, 시청 흐름에 방해되지 않게 자연스러운 장면에 간접광고가 노출되는 것이었다. 시청자들이 광고 수익 투자 우선순위로 꼽은 것은 공익 프로그램 제작 확대, 프로그램 질 제고, 시청자 모니터링과 피드백 강화였다. 방송산업의 경쟁력 강화와 균형적 발전, 디지털 기술 등에 대한 투자는 그 다음 순위였다. 시청자들은 지상파방송 간접광고 규제를 어느 정도까지 완화해야 한다고 생각하는 것일까? 시청자들의 선택은 프로그램 시간의 6%였다. What are viewers thinking about indirect advertising? To solve this question, I did a real-time survey. As a result of the survey, viewers were well aware of and paying attention to indirect advertising. However, viewers were feeling uncomfortable with indirect advertising. Viewers were not only familiar with indirect advertising itself, but also about indirect advertising regulations. They replied that stricter regulations on indirect advertising should be relaxed for terrestrial broadcasting. Nearly half of the viewers answered so. What viewers are concerned about when deregulation on indirect advertising on terrestrial broadcasting is increasing violence, weakening of publicity, and negative effects on paid broadcasting. However, despite these concerns, the reasons for deregulation of indirect advertising on terrestrial broadcasting were revitalization of the broadcasting advertising market, the principle of equity, the principle of market economy, and the global trend of deregulation. On the contrary, if the regulations on indirect advertising for terrestrial broadcasting were not relaxed and maintained, viewers concerns were weakening of broadcasters competitiveness. However, despite these concerns, the reason why the regulation of indirect advertising on terrestrial broadcasting should not be relaxed was the sovereignty of viewers and balanced development. What viewers think as a condition for deregulation of indirect advertising on terrestrial broadcasting is to invest in indirect advertising revenue to improve the quality of broadcast programs, and to expose indirect advertising to natural scenes so as not to interfere with viewing flow. The top priority for investing in advertising revenue was to expand the production of public programs, improve the quality of the program, and strengthen viewer monitoring and feedback. Reinforcement of the competitiveness of the broadcasting industry, balanced development, and investment in digital technology were ranked next. To what extent do viewers think they should ease the regulation of indirect advertising on terrestrial broadcasting? Viewers choice was 6% of the program time.

간호대학생을 위한 신종감영병 간호교육 프로그램 효과

박인숙(In Sook Park),박미마(Mi Ma Park) 한국간호연구학회 2023 한국간호연구학회지 Vol.7 No.1

Purpose : The purpose of this study is to develop and apply an infection control education program and its effect on the knowledge, attitude, and the performance related Self confidence of nursing students. Method : The infection control education program was applied for session 6 from June 20 through July 30, 2021. The education program was developed by one infection control nurse and two professors of nursing department with reference to the previous studies. The educational program was consisted of 30 students in the experimental group and 27 students in the control group. The knowledge, attitude, and the performance related Self confidence about infection control were measured before and after the program for the students who participated in the educational program and those who did not. Result : The two groups were confirmed to be homogeneous as there was no significant difference among the homogeneity test results in all variables. After the education program, the experimental group was found to be statistically significantly higher than the control group in infection control related knowledge(t=19.60, p=.045) and attitude(t=57.00, p=.002). Conclusion : This study showed that the hospital infection control education program was effective for nursing college students who will become nurses who will perform infection control roles in the future, and confirmed the need for an education system to improve infection control practice competency to increase performance Self confidence.

일개 신설 대학교 병원 중환자실 신규 간호사의 적응 경험

박형숙(Park, Hyoung Sook),김경남(Kim, Kyoung Nam),강은희(Kang, Eun Hee),이전마(Lee, Jeon Ma),박순미(Park, Soon Mi) 기본간호학회 2011 기본간호학회지 Vol.18 No.2

The purpose of this study was to determine the meaning of the adaptation experiences of new ICU nurses who were working in a newly established university hospital. The study was based on phenomenological research methodology. Method: Data were collected over 3 months through in depth interview with 6 new nurses who had worked less than 1 year in a newly established ICU of university hospital of less than 1 year located in Y city. The Colaizzi analysis method was used for data analysis. Results: The themes were classified into 13 themes clusters. The 13 themes clusters were finally grouped into 6 categories, ‘The endlessness of a new beginning’, ‘Pressure of work due to lack of senior nurses’, ‘Wanting to quit’, ‘Attachment for the complete hospital and ICU’, ‘Preciousness of colleagues’, ‘Pride in self-growth’. Conclusion: New ICU nurses have a difficult time due to pressures of work and lack of expert knowledge, and anxiety adds to these problems making the situation more difficult. The study results indicate that professional knowledge and skills learned through repetition of difficult work, pride through self growth, recognition from others and good-fellowship are driving forces to overcome obstacles and with stand difficult daily work.

Annomolin and Annocherimolin, New Cytotoxic Annonaceous Acetogenins from Annona cherimolia Seeds

Kim, Dal Hwan,Ma, Eun Sook,Suk, Kui Duk,Son, Jong Keun,Lee, Jong Soon,Woo, Mi Hee 영남대학교 약품개발연구소 2001 영남대학교 약품개발연구소 연구업적집 Vol.11 No.-

Two new cytotoxic anonaceous acetogenis, annomolin (1) and annocherimolin (2), were iaoated from an ethanolic extract of the seeds of Annona cherimolia. Annomolin has a mono-THF ring with one flanking bydroxyl and possesses a 1,2-diol at C-7/8 of the aliphatic chain. Annocberimolin has a mono-THF ring with two flanking hydroxyls and possesses a double bond at C-21/22. Their structures were elucidated by spectral data and chemical derivatization. Compound 1 showed cytotoxic selectivity for the human prostate tumor cell line (PC-3), with a potency of over 10 000 times that of adriaraycin. Compound 2 showed cytotoxic potencies about 10 000 times those of adriamycin in the breast (MCF-7) and colon (HT-29) cancer cell lines.

산모에게 항부정맥제를 투여하여 치유된 태아 심박조동 ( atrial flutter ) 1 예

이지영(Ji Young Lee),김은미(Eun Mi Kim),송태복(Tae Bok Song),한수(Soo Han),김윤하(Yoon Ha Kim),마재숙(Jae Sook Ma) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.3

The incidence of fetal cardiac arrhythmia is approximately 1-3%. Sustatined fetal tachyarrhythmia may cause fetal hydrops and rnay lead to fetal death. We experienced a case of fetal atrial flutter without fetal hydrops at 34 weeks of gestation, which was diagnosed by fetal echocardiography. Transplacental fetal therapy with maternal digoxin administration resulted in restoration of normal fetal sinus rhythm. At birth, the infant showed normal electrocardiographic finding with normal Apgar scores.

Late adverse reactions to iopromide (Ultravist^®) diagnosed by the patch test: a case report

이순주,양은미,최우연,송은송,한동균,조영국,마재숙,Lee, Soon Joo,Yang, Eun Mi,Choi, Woo Yeon,Song, Eun Song,Han, Dong Kyun,Cho, Young Kuk,Ma, Jae Sook The Korean Pediatric Society 2009 Clinical and Experimental Pediatrics (CEP) Vol.52 No.4

요오드성 조영제는 즉각적인 부작용과 지연성 부작용을 일으킬 수 있다. 저자들은 컴퓨터 단층 촬영을 위해 요오드성 조영제인 iopromide ($Ultravist^{(R)}$)를 사용하고 2일 뒤에 전신에 반점 구진성 반점과 발열이 반복적으로 발생한 환아를 경험하였다. 이 환아에서 피부단자시험, 피내반응검사, 첩포검사를 포함한 피부반응검사를 시행하여 $Ultravist^{(R)}$에 지연성 반응임을 확인하고 다른 조영제인 ioversol ($Optiray^{(R)}$), iohexol ($Iobrix^{(R)}$), iobitridol ($Xenetix^{(R)}$) 에도 교차반응이 있음을 확인하였기에 보고하는 바이다. Iodinated contrast media (CM) can cause immediate and late reactions. We treated a patient with a recurrent generalized maculopapular rash and a fever that occurred within two days of exposure to iodinated CM, iopromide ($Ultravist^{(R)}$), for chest computed tomography. We performed skin testing including prick tests, intradermal tests, and patch tests. Our findings indicated a late skin reaction to $Ultravist^{(R)}$in addition to cross-reactions to other iodinated CM such as ioversol ($Optiray^{(R)}$), iohexol ($Iobrix^{(R)}$), and iobitridol ($Xenetix^{(R)}$). In this study, we report the case of a patient diagnosed with a late adverse reaction to $Ultravist^{(R)}$in addition to cross-reactions to other iodinated CM.

Serial evaluation of myocardial function using the myocardial performance index in Kawasaki disease

Song, Eun Song,Yoon, Somy,Cho, Joo Hyun,Yang, Eun Mi,Cho, Hwa Jin,Choi, Young Youn,Ma, Jae Sook,Eom, Gwang Hyeon,Cho, Young Kuk Springer-Verlag 2018 World journal of pediatrics Vol.14 No.3