中国河南省高校就业竞争力实证研究

王淼丹(Miaodan Wang),商敏(Min Shang),范国锋(Guofeng Fan),王梦洁(Mengjie Wang),彭丽玲(Liling Peng),尚莫依(Moyi Shang) YIXIN 출판사 2023 教育教学研究论丛 Vol.1 No.2

随着高校“扩招”的推行,中国高校毕业生数量骤增,就业市场遭受冲击,高校毕业生就业问题日益凸显。以高考大省河南省为例,结合当今时代教育的发展以及社会对人才的需求,首先通过灰色关联度模型确定 12 个指标与就业竞争力的关联程度;其次采用 G1-熵权组合赋权法对各指标赋予权值大小,然后采用 WRSR 综合评价法对省内本科院校就业竞争力进行分档和评价分析。结果表明,同档次学校具备着类似的问题,可以相互交流,对其相关重要指标,结合学科特点可开展组团式发展和提升。 With the implementation of “enrollment expansion” in universities, the number of college graduates in China has increased sharply, the job market has been impacted, and the employment problem of college graduates has become increasingly prominent. We take Henan Province, a major province of the college entrance examination, as an example to study employment competitiveness of undergraduate colleges and universities, combined with the development of education in the current era and the social demand for talents. Firstly, the correlation degree between 12 indicators and employment competitiveness was determined by the grey correlation degree model; Secondly, the G1-entropy weight combination weighting method was used to assign weights to each index; and then the WRSR comprehensive evaluation method was used to classify and evaluate the employment competitiveness of undergraduate universities in the province. The results show that colleges and universities of the same grade have similar problems and can communicate with each other, and can carry out group development and promotion of the relevant important indicators combined with subject characteristics.

Schisantherin B Improves the Pathological Manifestations of Mice Caused by Behavior Desperation in Different Ages-Depression with Cognitive Impairment

Mengjie Xu,Feng Xiao,Mengshi Wang,Tingxu Yan,Huilin Yang,Bo Wu,Kaishun Bi,Ying Jia 한국응용약물학회 2019 Biomolecules & Therapeutics(구 응용약물학회지) Vol.27 No.2

Depression is a major mood disorder. Abnormal expression of glial glutamate transporter-1 (GLT-1) is associated with depression. Schisantherin B (STB) is one bioactive of lignans isolated from Schisandra chinensis (Turcz.) Baill which has been commonly used as a traditional herbal medicine for thousands of years. This paper was designed to investigate the effects of STB on depressive mice induced by forced swimming test (FST). Additionally, we also assessed the impairment of FST on cognitive function in mice with different ages. FST and open field test (OFT) were used for assessing depressive symptoms, and Y-maze was used for evaluating cognition processes. Our study showed that STB acting as an antidepressant, which increased GLT-1 levels by promoting PI3K/AKT/mTOR pathway. Although the damage is reversible, short-term learning and memory impairment caused by FST test is more serious in the aged mice, and STB also exerts cognition improvement ability in the meanwhile. Our findings suggested that STB might be a promising therapeutic agent of depression by regulating the GLT-1 restoration as well as activating PI3K/AKT/mTOR pathway.

Naringenin ameliorates atopic dermatitis by inhibiting inflammation and enhancing immunity through the JAK2/STAT3 pathway

Tian Limin,Wang Mengjie,Wang Yangxingyun,Li Wei,Yang Yuenan 한국유전학회 2024 Genes & Genomics Vol.46 No.3

Objective Atopic dermatitis (AD) is an inflammatory skin disease. Naringenin (Nar) possesses an anti-inflammatory property. This paper attempts to discuss the functional mechanism of Nar in AD mice through the Janus kinase 2 (JAK2)/signal transducer and activation of transcription 3 (STAT3) pathway. Methods Mouse models of DNFB-induced AD were established and treated with Nar, followed by intraperitoneal injection with the JAK2/STAT3 pathway activator Coumermycin A1. Dermatitis severity was scored and the thickness of right ear was measured. The pathological changes in dorsal skin tissues were observed by HE staining. The number of infiltrated mast cells and eosinophilic granulocytes was counted by TB staining. The serum IgE level and levels of TNF-α, IL-6, IFN-γ, IL-12, and IL-5 in dorsal skin tissues were measured by ELISA. The levels of p-JAK2, JAK2, p-STAT3, and STAT3 were determined by Western blot. Results Nar decreased dermatitis scores and right ear thickness, alleviated skin lesions, and reduced the number of infiltrated mast cells and eosinophilic granulocytes in AD mice. The serum IgE level and levels of TNF-α, IL-6, IFN-γ, IL-12, and IL-5 in dorsal skin tissues of AD mice were diminished after Nar treatment in a dose-dependent manner. Nar inhibited the activation of the JAK2/STAT3 pathway. The activation of the JAK2/STAT3 pathway partially nullified the therapeutic function of Nar on AD mice. Conclusion Nar protects mice from AD by inhibiting inflammation and promoting immune responses through the inhibition of the JAK2/STAT3 pathway.

Development of Electrochemical Sensor for Detection of L-Tryptophan Based on Exfoliated Graphene/PEDOT:PSS

Saisai Duan,Wei Wang,Chenglei Yu,Mengjie Liu,Longyu Yu 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2019 NANO Vol.14 No.5

A practical sensor based on a glassy carbon electrode (GCE) modified with exfoliated graphene (GR) and poly (3,4-ethylenedioxythiophene): poly (styrene sulfonate) (PEDOT:PSS) was prepared to determine L-tryptophan (L-Trp) via differential pulse voltammetry (DPV). Optical microscopy was utilized to characterize the surface morphology of the composite electrode. Electrochemical behaviors of the composite electrodes were carried out via cyclic voltammetry (CV). According to DPV results, there are linear relationships between the peak currents and the concentrations in the ranges of 0.1–100 μmol L -1 and 100–1000 μmol L -1 for L-Trp, with the detection limit of 0.015 μmol L -1 for L-Trp. Moreover, the modified electrode can eliminate the interference effects of Ca2+, Mg2+, K+, Na+, L-tyrosine and ascorbic acid, which exhibit excellent stability and reproducibility.

Wrinkled rGO Sheets-Wrapped Carbon Fibers with High Tensile Strength and Excellent Electrochemical Stability as Anodes for Structural Li-Ion Battery

Huagen Li,Shubin Wang,Mengjie Feng,Jiping Yang,Boming Zhang 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2018 NANO Vol.13 No.08

Herein, we report a hierarchical structure formed by wrinkled reduced graphene oxide (rGO) sheets-wrapped carbon fiber via a facile and efficient electrostatic self-assembly method and subsequent annealing treatment. For this material, the Weibull scale parameter is 4.77 GPa. After 100 cycles, the rGO@CF retains 91% of its second charge capacity at 50mA· g -1, corresponding to a capacity fading of only 0.09% per cycle. Thus, this structural anode material exhibits enhanced capacity, high initial Coulombic efficiency and high tensile strength. Meanwhile, the carbon fiber and interweaved rGO sheets together form the whole conductive networks to provide multichannel highways for charge transfer (lithium-ion diffusion and electron transport) during discharge–charge processes, promising excellent electrochemical performance of this structural anode material.

Multielectrochromic Copolymers Based on Thiophene Derivatives: Tunable Optoelectronic Properties

Yafei Guo,Gaoyong Liang,Mengjie Dong,Meihui Wang,Xinmin Hao 한국섬유공학회 2022 Fibers and polymers Vol.23 No.9

In this study, a series of copolymers based on 3-methoxythiophene(MOT) and 3,4-ethylenedioxythiophene(EDOT) have been prepared by electrochemical method in boron trifluoride diethyl etherate (BFEE). The copolymers arecharacterized by FTIR, XPS, SEM and cyclic voltammograms. The MOT/EDOT ratio in the polymer chain decreases withthe decreasing MOT/EDOT feed ratio, and low polymerization potential incorporates more EDOT units into the polymerchain. The electrochromic properties of the copolymers can be greatly tuned by the applied MOT/EDOT feed ratio. Absorption peak of the neutral copolymer presents red-shift with increasing feed ratio, and each copolymer has multicolorelectrochromism. In addition, the copolymers present fast-switching response, reasonable coloration efficiency and goodstability. All these indicate that the copolymers based on facile, commercial MOT and EDOT are promising candidates forelectrochromic applications.

The miR-145-5p/CD36 pathway mediates PCB2-induced apoptosis in MCF-7 cells

Yuan Yuan,Caihua Xue,Qiang Wu,Mengjie Wang,Jiahua Liu,Longfei Zhang,Qianwen Xing,Jingyan Liang,Hua Wu,Zhi Chen 한국유전학회 2021 Genes & Genomics Vol.43 No.2

Background Procyanidin B2 (PCB2) can increase the levels of anti-infammatory and immune mediators. Objectives However, its molecular mechanism in human breast cancer remains unclear. This study aimed to investigate the antitumor efect of PCB2 on MCF-7 cells and to examine the underlying mechanism. Methods The fow cytometry and EdU incorporation assays were measured the PCB2-induced BMECs. The expression levels of infammatory factors and immune response genes were upregulated in MCF-7 cells, high-throughput sequencing was used to detect diferentially expressed genes in blank and PCB2-treated MCF-7 cells. Results The results showed that PCB2 induced the apoptosis of MCF-7 cells. CD36 profles were afected in MCF-7 cells. Additionally, prediction software identifed a miR-145-5p binding site in the CD36 sequence. Luciferase reporter assays and Western blot analysis were used to verify the regulatory relationships between the diferentially expressed miRNA miR145-5p and CD36. MiR-145-5p and its key target (CD36) constitute a potential miRNA-mRNA regulatory pair. Functional studies in MCF-7 cells revealed that CD36 promotes but miR-145-5p inhibits apoptosis. Conclusion Overall, these data suggest that miR-145-5p inhibits the enhancing efect of PCB2 on CD36 expression by binding CD36 and subsequently regulating apoptosis, the immune response and anti-infammatory pathways. These results provide theoretical and experimental support for the treatment of breast cancer.

An ABA triblock copolymer strategy for intrinsically stretchable semiconductors

Peng, Rui,Pang, Bo,Hu, Daqing,Chen, Mengjie,Zhang, Guobing,Wang, Xianghua,Lu, Hongbo,Cho, Kilwon,Qiu, Longzhen The Royal Society of Chemistry 2015 Journal of Materials Chemistry C Vol.3 No.15

<▼1><P>A novel semiconductor–rubber–semiconductor triblock copolymer has been designed and prepared according to the principle of thermoplastic elastomers (TPEs). It behaves as a TPE and exhibits good electrical properties.</P></▼1><▼2><P>A novel semiconductor–rubber–semiconductor (P3HT–PMA–P3HT) triblock copolymer has been designed and prepared according to the principle of thermoplastic elastomers. It behaves as a thermoplastic elastomer with a Young's modulus (<I>E</I>) of 6 MPa for an elongation at break of 140% and exhibits good electrical properties with a carrier mobility of 9 × 10<SUP>−4</SUP> cm<SUP>2</SUP> V<SUP>−1</SUP> s<SUP>−1</SUP>. This novel semiconductor may play an important role in low-cost and large-area stretchable electronics.</P></▼2>

Designing a Magnetically Controlled Soft Gripper with Versatile Grasping Based on Magneto-Active Elastomer

Rui Li,Xinyan Li,Hao Wang,Xianlun Tang,Penghua Li,Mengjie Shou 한국정보처리학회 2022 Journal of information processing systems Vol.18 No.5

A composite bionic soft gripper integrated with electromagnets and magneto-active elastomers is designed bycombining the structure of the human hand and the snake’s behavior of enhancing friction by actively adjustingthe scales. A silicon-based polymer containing magnetized hard magnetic particles is proposed as a soft finger,and it can be reversibly bent by adjusting the magnetic field. Experiments show that the length, width, andheight of rectangular soft fingers and the volume ratio of neodymium–iron–boron have different effects onbending angle. The flexible fingers with 20 vol% are the most efficient, which can bend to 90° when themagnetic field is 22 mT. The flexible gripper with four fingers can pick up 10.51 g of objects at the magneticfield of 105 mT. In addition, this composite bionic soft gripper has excellent magnetron performance, and itcan change surface like snakes and operate like human hands. This research may help develop soft devices formagnetic field control and try to provide new solutions for soft grasping.

The Clinical Manifestation, Executive Dysfunction, and Caregiver Strain in Subthreshold Attention-Deficit/Hyperactivity Disorder

Yajing Tang,Sunwei Qiu,Haimei Li,Feifei Si,Mengjie Zhao,Min Dong,Meirong Pan,Xinxin Yue,Lu Liu,Qiujin Qian,Yufeng Wang 대한신경정신의학회 2023 PSYCHIATRY INVESTIGATION Vol.20 No.9

Objective Subthreshold attention-deficit/hyperactivity disorder (ADHD) has been suggested to be a “morbid condition” which also needs medical attention.Methods The present study recruited 89 children with subthreshold ADHD (sADHD), 115 children with diagnosed ADHD (cADHD), and 79 healthy controls (HC) to explore the clinical manifestation, executive functions (EFs) of sADHD, and the caregiver strain. The clinical manifestation was evaluated through clinical interviews and parent-reports. Executive functions were assessed both experimentally and ecologically. Caregiver strain was measured by a parent-reported questionnaire.Results For the clinical manifestation, both sADHD and cADHD indicated impairments when compared with HC. The comorbidities and the scaled symptoms indicated that the externalizing behaviors were relatively less serious in sADHD than cADHD, whereas the internalizing behaviors between two groups were comparable. For ecological EFs, sADHD scored between cADHD and HC in inhibition and working memory. For experimental EFs, sADHD was comparable to cADHD in inhibition, shifting, and was worse than cADHD in verbal working memory. For the caregiver strain, all scores of sADHD were between that in cADHD and that in HC.Conclusion Our present findings supported the suggestion of subthreshold ADHD as “morbid condition,” which should be treated with caution in clinical practice, especially for the internalizing behaviors and some key components of EFs.