HCV-Specific Interleukin-21+CD4+ T Cells Responses Associated with Viral Control through the Modulation of HCV-Specific CD8+ T Cells Function in Chronic Hepatitis C Patients

Guo-Hua Feng,Fu-Sheng Wang,Ji-Yuan Zhang,Qing-Lei Zeng,Lei Jin,Junliang Fu,Bin Yang,Ying Sun,Tianjun Jiang,Xiangsheng Xu,Zheng Zhang,Jinhong Yuan,Liyuan Wu 한국분자세포생물학회 2013 Molecules and cells Vol.36 No.4

Interleukin-21 (IL-21)+CD4+ T cells are involved in the immune response against hepatitis B virus (HBV) by secreting IL-21. However, the role of IL-21+CD4+ T cells in the immune response against chronic hepatitis C (CHC) virus infection is poorly understood. This study aimed to investigate the role of IL-21+CD4+ T cells in CHC patients and the potential mechanisms. The study subjects in-cluded nineteen CHC patients who were grouped by viral load (low, < 106 RNA copies/ml, n = 8; high, > 106 RNA copies/ml, n = 11). The peripheral frequency of HCV-specific IL-21+CD4+ T cells was higher in the low viral load group and was negatively correlated with the serum HCV RNA viral load in all CHC patients. Meanwhile, IL-21+ cells accumulated in the liver in the low viral load group. In vitro, IL-21 treatment increased the expression of proliferation markers and cytolytic molecules on HCV-specific CD8+ T cells. In summary, these findings suggest that HCV-specific IL-21+CD4+ T cells might contribute to HCV control by rescuing HCV-specific CD8+ T cells in CHC patients.

Exploring the low PM2.5 exposure routes for bicycle commuters in Taipei and Seoul by machine learning models - a pilot study

Tzong-Gang Wu(Tzong-Gang Wu),Bang-Hua Chen(Bang-Hua Chen),Kiyoung Lee(Kiyoung Lee),Chang-Fu Wu(Chang-Fu Wu) 한국환경보건학회 2021 한국환경보건학회 학술대회 자료집 Vol.2021 No.2

EXPERIMENTAL STUDIES ON SPONGE ALUMINUM ALLOY BY SUCTION CASTING PROCESS

Hua, Hua, Xiang,Wu, Wu, Binyao,Yan, Yan, Xiaolong 한국재료학회 1995 Fabrication and Characterization of Advanced Mater Vol.1 No.2

Spomge metal with 3-dimensionally interconnected fine pores is a kind of functional material used in the areas of shock attenuation, noise elimination, filtration, decoration, fire-proof, etc. Currently most of them are produced by penetrating casting process, limited shaping size due to its penetrating resistance and difficulties in controlling it's complicated procedure are two main problems. Using soulble granules as fillings, applying the suction casting method with self-made devices, the effect of preheating temperature of granules, pouring temperature metal and vacuum on the shaping size, porosity and the uniformity of pores at every distinct filling sizes are systematically investigated. Experimental results show tha the preheating temperature of granules is the key fat, while the e pouring temperature of metal and negative pressure are the second at a fixed grain size ; the nearer the preheating temperature of fillings to pouring temperature of the metal, the better the suction casting moulding. For the eurectiv Al-Si alloy, a speong-like cylinder, with the porosity of 70-80%, 200mm in height and 120mm in diameter, can be formed when the temperature of liquid metal gets 750 centigrade and preheating temperature reaches 420 centigrade. The Minimum size of the proes reaches ${\phi}0.05mm$.

Association of Oral Contraceptives Use and Lung Cancer Risk among Women: an Updated Meta-analysis Based on Cohort and Case-control Studies

Wu, Wei,Yin, Zhi-Hua,Guan, Peng,Ren, Yang-Wu,Zhou, Bao-Sen Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.3

Background: Previous studies on the association of oral contraceptives (OC) use and lung cancer generated inconsistent findings. The aim of this study was to confirm any definite correlation between OC use and lung cancer risk. Methods: Publications were reviewed and obtained through PubMed and EMBASE databases literature search up to November, 2013. Reference lists from retrieved articles were also reviewed. The language of publication was restricted to English. A meta-analysis was performed to evaluate the association by calculating pooled odds ratios (ORs) and 95% confidence intervals (CIs). Results: A total of 14 studies consisting of 9 case-control studies and 5 cohort studies were finally included in this meta-analysis. There was no significant association observed between OC use and lung cancer risk in the overall analysis (OR=0.91; 95% CI=0.81-1.03). There was a significant protective effect in Europe (OR=0.74; 95% CI=0.60-0.91) and a borderline significant protective effect with an adenocarcinoma histology (OR=0.90; 95% CI=0.80-1.01) in subgroup analyses. No association was observed for methodological quality of study, study design, smoking status and case number of study. Conclusion: This meta-analysis suggests that OC use is not likely to be associated with the risk of lung cancer at all. While a significant protective effect of OC use on lung cancer was observed in Europe, interpretation should be cautious because of the potential biases of low-quality studies. At the same time, more attention should be paid to the possible association of OC use with adenocarcinoma of lung. Our findings require further research, with well-conducted and large-scale epidemiological studies to confirm effects of OC use on lung cancer.

Improved Production of Caffeic Acid Derivatives in Suspension Cultures of Echinacea purpurea by Medium Replenishment Strategy

Wu, Chun-Hua,Murthy, Hosakatte Niranjana,Hahn, Eun-Joo,Paek, Kee-Yoeup 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.8

The aim of this study was to produce caffeic acid derivatives from adventitious root cultures of Echinacea purpurea, which are of high pharmaceutical value. The effects of both media optimization and replenishment strategies were adopted to achieve improved production of E. purpurea adventitious roots and caffeic acid derivatives. Of the different media strengths (0.25 MS, 0.5 MS, 0.75 MS and 1 MS) tested for the culturing of adventitious roots in 5 L bioreactors, 0.5 MS medium was found to be most suitable for the growth of adventitious roots. The optima accumulation of biomass (73.6 g $L^{-1}$ FW and 10.03 g $L^{-1}$ DW), phenolics (61.14 mg $g^{-1}$ DW) and flavonoids (38.30 mg $g^{-1}$ DW) were achieved in this medium. Furthermore, fed batch cultivations (media replenishment with 0.25 MS, 0.5 MS, 0.75 MS and 1 MS at the end of $2^{nd}$ and $3^{rd}$ weeks) to further enhance the production of adventitious root biomass and metabolites were also attempted. High adventitious root biomasses (83.1 g $L^{-1}$ FW and 15.30 g $L^{-1}$ DW) were achieved with feeding of the 0.5 MS medium at the end of $2^{nd}$ week. This led to slight decreases in the total production of phenolics and flavonoids; however, this feeding was responsible for increases in the accumulation of caftaric acid (5.76 mg $g^{-1}$ DW) and cichoric acid (26.12 mg $g^{-1}$ DW).

Soft Hemirings Related to Fuzzy Set Theory

Wu, Hua-Jun,Zhan, Jianming Department of Mathematics 2012 Kyungpook mathematical journal Vol.52 No.1

In this paper, we investigate soft hemirings by fuzzy theory. Some characterizations of hemirings are introduced by means of soft sets. In particular, the $h$-hemiregular hemirings and $h$-intra-hemiregular hemirings are also characterized.

High-efficiency Hybrid Surface-normal Coupler Design

Hua Wu,Xia Guo,Ming-Fu Han 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.63 No.5

Based on an analysis of the grating coupler, a high-efficiency hybrid surface-normal coupler, which is a combination of a coupler grating, reflector grating and a bottom mirror, was designed to couple a planar waveguide and a single-mode fiber. The negative second-order reflection was reduced by destructive interference by selecting a reasonable spacing between the reflector and the coupler grating. The negative first-order diffraction to the substrate was reflected by the bottom mirror,which was realized by Au-Au bonding. The etch depth of the coupler grating was optimized to increase the coupling efficiency between the grating and the fiber. The highest coupling efficiency of 89.5% at 1550 nm was achieved for surface normal coupling.

PROGRAMMABLE INDUCTANCE AND CAPACITANCE GENERATOR

Hua, Shang Qing,Hua, Wu Li,Sheng, Qu Yan,Jian, Ma Huai 대한전자공학회 1992 HICEC:Harbin International Conference on Electroni Vol.1 No.1

This paper introduces an impedance converter principle of simulated pure inductance and capacitance by using operational amplifiers, in addition, it provides the circuitry configurations according to this principle. The generator can produce equivalent inductance from 0.1H to 6553500H or equivalent capacitance from 10^(-10) F to 65535 × 10^(-7) by programming control. Its circuit is very simple, this generator can be programmed control conveniently and integrated easily. It especially has certain advantages in simulating large inductance or capacitance and programming control.

A Study of the Efficiency of Futures Research Institutes of China

WU, Guo-Hua,YAO, Tian-Yin,ZHANG, Bao-Ping Korea Distribution Science Association 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.12

The purpose of this study is to analyze the efficiency of research institutes of futures companies, and to promote the development of futures market and real economy. This study employs DEA-solver software to conduct super-efficiency data envelopment analysis (SE-DEA), and also selects 40 representative futures research institutes in China as decision-making units (DMUs). For data of input and output indicators, we collect from the China Futures Association, Futures Daily, Hexun.com and Webstock.com respectively, and the time duration is the 103 trading days between from October 2019 to February 2020. Then the indicator for the strategy accuracy rate is calculated separately by analyzing the strategies published by each DMUs in public media. In conclusions, most institutes have excessive investment in human resources, and also have insufficient strategy accuracy rate and insufficient published research reports. The findings of this study suggest that Chinese futures companies need to improve the efficiency of research institutes, and better meet the demand of the financial market. In fact, the analysis of the efficiency of the futures company research institute has not been found in the literature worldwide, Application of DEA model in efficiency analysis of securities and futures research institutions and establishment of indicators are the innovations of this paper.

Clinical Application of Endoscopic Inguinal Lymph Node Resection after Lipolysis and Liposuction for Vulvar Cancer

Wu, Qiang,Zhao, Yi-Bing,Sun, Zhi-Hua,Ni, Jing,Wu, Yu-Zhong,Shao, Heng-Hua,Qu, Jun-Wei,Huang, Xin-En Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12

Aim: To examine lymph nodes obtained after lipolysis and liposuction of subcutaneous fat of the inguinal region of female vulvar cancer patients to explore the feasibility of clinical application. Methods: The field of operation was on the basis of the range of the conventional resection of inguinal lymph nodes. We injected lipolysis liquid fanwise, started liposuction after 15-20 minutes; then the subcutaneous fatty tissue was sucked out clearly by suction tube. We selected the first puncture holes located on 2-3 cm part below anterior superior spine, the others respectively being located 3cm and 6cm below the first for puncturing into the skin, imbedding a trocar to intorduce $CO_2$ gas and the specular body, and excise the lymph nodes by ultrasonic scalpel. The surgical field chamber was set with negative pressure drainage and was pressured with a soft saline bag after surgery. Results: A lacuna emerged from subcutaneous of the inguinal region after lipolysis and liposuction, with a wide fascia easily exposed at the bottom where lymph nodes could be readily excised. The number of lymph nodes of ten patients excised within the inguinal region on each side was 4-18. The excised average number of lymph nodes was 11 when we had mature technology. Conclusion: Most of adipose tissue was removed after lipolysis and liposuction of subcutaneous tissue of inguinal region, so that the included lymph nodes were exposed and easy to excise by endoscope. This surgery avoided the large incision of regular surgery of inguinal region, the results indicating that this approach is feasible and safe for used as an alternative technology.