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- 저자 : Mengjie Liu (검색결과 5 건)
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Mengjie Du,Jun Liu,Wenbin Ye,Fan Yang,Gao Lin 국제구조공학회 2022 Structural Engineering and Mechanics, An Int'l Jou Vol.81 No.2
The bending, buckling and free vibration responses of functionally graded material (FGM) beams are investigated semi-analytically by the scaled boundary finite element method (SBFEM) in this paper. In the concepts of the SBFEM, the dimension of computational domain can be reduced by one, therefore only the axial dimension of the beam is discretized using the higher order spectral element, which reduces the amount of calculation and greatly improves the calculation efficiency. The governing equation of FGM beams is derived in detail by the means of the principle of virtual work. Compared with the higherorder beam theory, fewer parameters and simpler control equations are used. And the governing equation is transformed into a first-order ordinary differential equation by introducing intermediate variables. Analytical solutions of the governing equation can be obtained by padé series expansion in the direction of thickness. Numerical example are compared with the numerical solutions provided by the previous researchers to verify the accuracy and applicability of the proposed method. The results show that the proposed formulations can quickly converge to the reference solutions by increasing the order of higher order spectral elements, and high accuracy can be achieved by using a small number of the elements. In addition, the influence of the structural sizes, material properties and boundary conditions on the mechanical behaviors of FG beams subjected to different load types is discussed.
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Mengjie Zhao,Qiong Zhao,Zhiwei Guan,Qianwei Liu,Hongyun Zhou,Qinwan Huang,Bixiu Huo 한국식품영양과학회 2023 Journal of medicinal food Vol.26 No.3
Panax ginseng and Fructus mume (Renshen Wumei in Chinese, RW) are natural medicines with high nutritional and pharmacological value. They have been widely used together in China to treat gastrointestinal diseases, especially persistent diarrhea, but the potential mechanisms remain elusive. In this study, a diarrhea model was established in rats using a 30% aqueous extract of senna. The therapeutic effects of RW were evaluated by recording the prevalence of loose stools, the diarrhea index, and histopathological changes in colon tissue. The levels of mucins, tight junction (TJ) proteins, inflammatory cytokines, and phosphoinositide 3-kinase/Akt/nuclear factor-κB (PI3K/Akt/NF-κB) signaling pathway proteins were measured. Metagenomic sequencing was used to analyze the gut microbiota. Treatment with RW alleviated injury to the intestinal barrier in rats with diarrhea and also upregulated levels of Muc2 and TJ proteins, such as occludin, zonula occludens-1, and claudin-1. Administration of RW regulated the structure of the gut microbiota in diarrheal rats. Furthermore, RW suppressed levels of interleukin (IL), tumor necrosis factor (TNF)-α, IL-1, PI3K, Akt, and p-NF-κB p65 and also increased IL-4 levels. Our study indicates that P. ginseng and Fructus mume help improve the symptoms of diarrhea, possibly by alleviating the intestinal barrier injury, regulating intestinal flora composition, and inhibiting the PI3K/Akt/NF-κB signaling pathway.
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The miR-145-5p/CD36 pathway mediates PCB2-induced apoptosis in MCF-7 cells
Yuan Yuan,Caihua Xue,Qiang Wu,Mengjie Wang,Jiahua Liu,Longfei Zhang,Qianwen Xing,Jingyan Liang,Hua Wu,Zhi Chen 한국유전학회 2021 Genes & Genomics Vol.43 No.2
Background Procyanidin B2 (PCB2) can increase the levels of anti-infammatory and immune mediators. Objectives However, its molecular mechanism in human breast cancer remains unclear. This study aimed to investigate the antitumor efect of PCB2 on MCF-7 cells and to examine the underlying mechanism. Methods The fow cytometry and EdU incorporation assays were measured the PCB2-induced BMECs. The expression levels of infammatory factors and immune response genes were upregulated in MCF-7 cells, high-throughput sequencing was used to detect diferentially expressed genes in blank and PCB2-treated MCF-7 cells. Results The results showed that PCB2 induced the apoptosis of MCF-7 cells. CD36 profles were afected in MCF-7 cells. Additionally, prediction software identifed a miR-145-5p binding site in the CD36 sequence. Luciferase reporter assays and Western blot analysis were used to verify the regulatory relationships between the diferentially expressed miRNA miR145-5p and CD36. MiR-145-5p and its key target (CD36) constitute a potential miRNA-mRNA regulatory pair. Functional studies in MCF-7 cells revealed that CD36 promotes but miR-145-5p inhibits apoptosis. Conclusion Overall, these data suggest that miR-145-5p inhibits the enhancing efect of PCB2 on CD36 expression by binding CD36 and subsequently regulating apoptosis, the immune response and anti-infammatory pathways. These results provide theoretical and experimental support for the treatment of breast cancer.
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Saisai Duan,Wei Wang,Chenglei Yu,Mengjie Liu,Longyu Yu 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2019 NANO Vol.14 No.5
A practical sensor based on a glassy carbon electrode (GCE) modified with exfoliated graphene (GR) and poly (3,4-ethylenedioxythiophene): poly (styrene sulfonate) (PEDOT:PSS) was prepared to determine L-tryptophan (L-Trp) via differential pulse voltammetry (DPV). Optical microscopy was utilized to characterize the surface morphology of the composite electrode. Electrochemical behaviors of the composite electrodes were carried out via cyclic voltammetry (CV). According to DPV results, there are linear relationships between the peak currents and the concentrations in the ranges of 0.1–100 μmol L -1 and 100–1000 μmol L -1 for L-Trp, with the detection limit of 0.015 μmol L -1 for L-Trp. Moreover, the modified electrode can eliminate the interference effects of Ca2+, Mg2+, K+, Na+, L-tyrosine and ascorbic acid, which exhibit excellent stability and reproducibility.
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Yajing Tang,Sunwei Qiu,Haimei Li,Feifei Si,Mengjie Zhao,Min Dong,Meirong Pan,Xinxin Yue,Lu Liu,Qiujin Qian,Yufeng Wang 대한신경정신의학회 2023 PSYCHIATRY INVESTIGATION Vol.20 No.9
Objective Subthreshold attention-deficit/hyperactivity disorder (ADHD) has been suggested to be a “morbid condition” which also needs medical attention.Methods The present study recruited 89 children with subthreshold ADHD (sADHD), 115 children with diagnosed ADHD (cADHD), and 79 healthy controls (HC) to explore the clinical manifestation, executive functions (EFs) of sADHD, and the caregiver strain. The clinical manifestation was evaluated through clinical interviews and parent-reports. Executive functions were assessed both experimentally and ecologically. Caregiver strain was measured by a parent-reported questionnaire.Results For the clinical manifestation, both sADHD and cADHD indicated impairments when compared with HC. The comorbidities and the scaled symptoms indicated that the externalizing behaviors were relatively less serious in sADHD than cADHD, whereas the internalizing behaviors between two groups were comparable. For ecological EFs, sADHD scored between cADHD and HC in inhibition and working memory. For experimental EFs, sADHD was comparable to cADHD in inhibition, shifting, and was worse than cADHD in verbal working memory. For the caregiver strain, all scores of sADHD were between that in cADHD and that in HC.Conclusion Our present findings supported the suggestion of subthreshold ADHD as “morbid condition,” which should be treated with caution in clinical practice, especially for the internalizing behaviors and some key components of EFs.
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