유방선암의 유형에 따른 c-erbB-2, p53, bcl-2, 그리고 c-myc의 발현

강영근,조현득,오미혜,김의한,양승하 순천향의학연구소 2006 Journal of Soonchunhyang Medical Science Vol.12 No.2

Breast carcinoma is a common malignant tumor in female of the korea. Various oncogenes have been found in malignant tumor cells. There were many reports or correlation between the prognosis of patients and c-erbB-2, p53, bcl-2, and c-myc, but is controversial. We performed immunohistochemical stain for above antigenic protein for 80 cases of breast carcinoma and evaluated expression rate of each antigens, and we compared their correlation with prognosis of patients. The results were as follow; 1) The expression rates in breast carcinoma was c-erbB-2 80%, p53 56.3%, bcl-2 51.3% and c-myc 53.8%. 2) c-erbB-2 showed no significant difference according to histologic types, grade, and lymph node metastatic status of breast carcinoma. 3) p53 showed higher expression rate in metastatic cases compared to non-metastatic cases, and it showed higher expression rate according to increasing of grade without significant difference. There is no significant difference according to types. 4) The expression rate of bcl-2 in breast carcinoma be lowed according to increasing of grade. There was no significant difference according to types, side, and status of lymph node metastasis. 5) c-myc showed higher expression rate in non-metastatic cases compared to and metastatic cases, and it showed decreasing expression rate according to increasing of grade without significant difference. There is no significant difference according to types. 6) p53 and bcl-2 in breast carxinoma showed reverse corre1ation(P < 0.05), and bc1-2 and c-myc showed close correlation without statiscally significance. Above results showed that p53 may be related to poor prognosis of the patients and c-myc may be related good prognosis in breast carcinoma. There was reverse correlation between p53 and bcl-2 and bcl-2 and c-myc may be correlated closely. c-erbB-2 and bcl-2 showed no interrelation to prognosis.

여름에 비정형 폐렴으로 발현한 쯔쯔가무시병 1예

박상돈,정문현,이혜명,김미경,강재승 대한감염학회 2008 감염과 화학요법 Vol.40 No.4

Scrub typhus usually occurs in October and November in Korea. Its typical clinical manifestations are fever, rash, eschar, and lymphadenopathies. Pneumonitis may occur, however it occurs as a complication at the late phase of scrub typhus, when it is inappropriately treated. We encountered a case of pneumonitis that was an initial manifestation of scrub typhus which was confirmed by rickettsial culture, Positive seroconversion, and polymerase chain reaction. The case was a 16-year-old high school adolescent who presented with fever and headache that lasted for 1 day in July, 2007, He denied of any outdoor activities. A chest radiograph showed patchy infiltrates in the left lower lung, which improved with the administration of cefotaxime and azithromycin for empirical treatment of community-acquired pneumonia. Blood taken on the second febrile day showed a positive culture for Orientia tsutsugamushi and was also positive for O. tsutsugamushi DNA polymerase chain reaction. Immunofluorescent antibody (IFA) test for O. tsutsugamushi showed that the initial antibody was negative, but convalescent serum tested positive with an antibody titer of 1:80. IFA for Coxiella burnetii showed false positive results; the initial IgM and IgG liters were 1:128 and 1:256, respectively, and the IgM and IgG titers in convalescent serum were 1:128 and 1:128, respectively.

Regional disparities in major cancer incidence in Korea, 1999-2018

Eun Hye Park(Eun Hye Park),Mee Joo Kang(Mee Joo Kang),Kyu-Won Jung(Kyu-Won Jung),Eun Hye Park(Eun Hye Park),E Hwa Yun(E Hwa Yun),Hye-Jin Kim(Hye-Jin Kim),Hyun-Joo Kong(Hyun-Joo Kong),Chang Kyun Choi(C 한국역학회 2023 Epidemiology and Health Vol.45 No.-

OBJECTIVES: This study investigated regional disparities in the incidence of 8 major cancers at the municipal level in Korea during 1999-2018 and evaluated the presence or absence of hot spots of cancer clusters during 2014-2018. METHODS: The Korea National Cancer Incidence Database was used. Age-standardized incidence rates were calculated by gender and region at the municipal level for 4 periods of 5 years and 8 cancer types. Regional disparities were calculated as both absolute and relative measures. The possibility of clusters was examined using global Moran’s I with a spatial weight matrix based on adjacency or distance. RESULTS: Regional disparities varied depending on cancer type and gender during the 20-year study period. For men, the regional disparities of stomach, colon and rectum, lung, and liver cancer declined, and those of thyroid and prostate cancer recently decreased, despite an overall increasing incidence. For women, regional disparities in stomach, colon and rectum, lung, liver, and cervical cancer declined, that of thyroid cancer recently decreased, despite an overall increasing incidence, and that of breast cancer steadily increased. In 2014-2018, breast cancer (I, 0.61; 95% confidence interval [CI], 0.53 to 0.70) showed a high probability of cancer clusters in women, and liver cancer (I, 0.48; 95% CI, 0.40 to 0.56) showed a high probability of cancer clusters in men. CONCLUSIONS: Disparities in cancer incidence that were not seen at the national level were discovered at the municipal level. These results could provide important directions for planning and implementing local cancer policies.

CACNA1A Gene Polymorphism is Associated with Hypertension in Korean Population

Hye Kyung Kim,Kang Hyun Leem,Sena Lee,Mee Sook Hong,Kyung Hee Jung,Su Kang Kim,Sung Wook Kang,Joo-Ho Chung 대한의생명과학회 2009 Biomedical Science Letters Vol.15 No.1

High blood pressure (BP) is the most frequent risk factor among metabolic syndrome components. The control of hypertension is very important to prevent the cardiovascular risk in metabolic syndrome. The dysfunction of calcium channel is responsible in the regulation of the vascular muscle contribution to hypertension. Calcium channel, voltagedependent, P/Q type, alpha-1A subunit (CACNA1A) gene is located in brain and known to control the intracranial hypertension. In this study, we investigate whether the polymorphisms of CACNA1A gene is associated with hypertension. The 49 CACNA1A genotypes were determined using the Affymetrix Genotyping chip array in 92 hypertension and 279 control individuals from a Korean population. Logistic and multiple regression models were employed to analyze the genetic contributions of polymorphisms. Out of 49 polymorphisms, six SNPs (rs12611029, rs16035, rs7259944, rs10419472, rs17777900, and rs4926294) showed a significant association with hypertension in three alternative models (codominant, dominant, and recessive models; P<0.05 after adjusting for age and sex). Our results suggest that the CACNA1A gene may be associated with hypertension in the Korean population.

Insights into Test Construction Practices of Native English Speaking Teachers in College Conversation Courses

Mee Hye Kang,Daniel James Cuffey,Myeong-Hee Seong 한국영어어문교육학회 2017 영어어문교육 Vol.23 No.3

This study aims to analyze the college English conversation tests of native English teachers to see if the tests complied with program goals. Also, problems with current test construction practices were highlighted and improvements for similar conversation courses were suggested. In order to do this, we examined the test construction practices of seven native English teachers who taught an English conversation course at a university in Gyeonggi province near Seoul. The teachers’ mid-term and final tests were collected and they also expressed their views on testing through a survey and interviews. The teachers’ tests were analyzed in terms of the types of assessments used, question types, number of test items, language skills targeted, and task types. The results showed that despite having a standardized course goal and using the same textbook, the testing methods utilized by teachers varied widely and teachers typically employed written tests which varied extensively due to non-standardization. However, the teachers believed oral exams should be employed in various ways: a 1:1 interview, individual presentations, group discussions or role plays. The implications of these assessment methods, along with the future direction of this study were discussed.

Review : 2014 Clinical Practice Guidelines for Overweight and Obesity in Korea

( Mee Kyoung Kim ),( Won Young Lee ),( Jae Heon Kang ),( Jee Hyun Kang ),( Bom Taeck Kim ),( Seon Mee Kim ),( Eun Mi Kim ),( Sang Hoon Suh ),( Hye Jung Shin ),( Kyu Rae Lee ),( Ki Young Lee ),( Sang Y 대한비만학회 2014 The Korean journal of obesity Vol.23 No.4

The dramatic increase in the prevalence of obesity and its accompanying comorbidities are major health concerns in Korea. Obesity is defined as a body mass index (BMI) ≥25 kg/m2 in Korea. Current estimates are that 32.8% of adults are obese: 36.1% of men and 29.7% of women. The prevalence of being overweight and obese in national surveys is increasing steadily. Early detection and the proper management of obesity are urgently needed. Weight loss of 5-10% is the standard goal. In obese patients, control of cardiovascular risk factors deserves the same emphasis as weight-loss therapy. Since obesity is multifactorial, proper care of obesity requires a coordinated multidisciplinary treatment team, as a single intervention is unlikely to modify the incidence or natural history of obesity.

직업여성과 비취업 주부의 의복행동 연구 : 20, 30대 디자이너, 연예인, 교사 주부를 중심으로

강지혜,권선미,김수경,김지언,김혜진,백민현,백정희,오경애,윤성원,이미현,최선미 연세대학교 생활과학대학 1993 婦學 Vol.26 No.-

한국노인의 성공적 노후에 대한 경험

김미혜(Mee-Hye Kim),신경림(Kyung-Rm Shin),강미선(Mi-Sun Kang),강인(In Kang) 한국노년학회 2004 한국노년학 Vol.24 No.2

본 연구는 노인들이 체험하고 있는 노후의 삶을 이해하고 그 체험의 본질을 탐색하여 성공적인 노후에 대한 한국 노인들의 의식을 심층적으로 파악하기 위하여 질적 연구방법을 적용하였다. 연구 참여자는 서울시에 거주하는 노인 40명이었으며, 이들을 2003년 3월부터 5월까지 2회에 걸쳐 개별적으로 심층면담을 하여 자료를 수집하였다. 수집된 자료를 분석한 결과 연구 참여자들이 체험한 한국노인의 성공적 노후의 공통의 속성은 복(福)이었으며, 본질적 범주는 9가지로 나타났다. 9가지 범주는 '부부 복', '자식 복', '친구 복', '여가생활 복', '거처 복', '재산 복', '건강 복', '마음 복', '죽음 복'이었다. 노인은 자식과 가족의 연계 속에서 자신의 삶과 죽음을 인식하고, 자신의 노후에 자식에 대한 의존을 극도로 자제하려는 모습을 보여 죽음마저도 자식을 배려할 수 있고 깨끗하게 맞이할 수 있다면 그것이 하늘이 내려준 복이며 곧 성공적 노후라고 인식하고 있었다. 이러한 결과는 한국적 문화 안에서 노년기 삶을 이해함에 있어서 통합적인 시각을 제공하고, 노년기 삶에 대한 지식을 제공함으로써, 다양한 분야의 전문가들이 노인의 욕구에 맞는 개입방향 및 방법을 마련함에 있어서 기초 자료로 활용될 것이다. The purposes of this study are to understand the meanings and to explore the nature of successful aging experiences of Korean elderly. 40 elderly aged 65 and over participated in this study. Data of the experiences of successful aging were collected by using in-depth interviews with respondents from March, 2003 to May 2003. The analysis of data was made phenomenological analytic method by suggested by Colaizzi. Meaning of experience was categorized as '9 fortune'. This is consisted of nine theme-cluster: The couples live in health; They live happily in their neighbor which is familiar and convenient for them; They can even participate in daily activity such as doing volunteer work and doing some sports; Their children live better life than they did; They have a friend who can talk to and share their emotions with; They keep their health condition as good as now; They afford their daily living expense; They will die in peace; They accept current situation and live their life in a more positive way for the rest of their life. Significance of this study is that by understanding elderly's successful aging experience it will help the researchers, educators and practitioners to develop appropriate social services for them.

고령화 한국사회의 부양체계 구축을 위한 연구

김미혜(Kim, Mee Hye),신경림(Shin, Kyung Rim),강미선(Kang, Mi Sun),강인(Kang, In) 한국노년학회 2006 한국노년학 Vol.26 No.3

본 연구는 한국 노인들의 성공적 노후 삶의 유형별로 경제적 부양, 서비스 부양, 정서적 부양에 있어서의 주부양제공자와 대체부양제공자를 분석하였다. 이를 통하여 가족, 사회, 국가 간의 부양역할을 조화롭게 조정, 보완하는 부양체계 구축을 모색하여 노인들이 성공적 노후에 근접할 수 있도록 돕고자 한다. 서울시와 경기도에 거주하는 노인 483명을 대상으로 지난 6개월 내에 부양을 받은 경험이 있는지 여부와 부양 종류별로 가장 도움이 되는 주부양제공자와 주부양제공자로부터의 부양이 어려울 때 부양을 대신 제공해주길 기대하는 대체부양제공자를 조사하였다. 한국 노인에게 있어서 중요한 부양제공자는 배우자, 장남과 기타 자녀, 친구, 이웃 등의 순서로 드러났다. 다만 성공적 노후 삶의 유형에 따라 부양의 종류별로 노인들이 선호하는 부양제공자들의 순위에 있어서 약간의 변동이 있는데, 이는 배우자, 장남, 기타 자녀 등의 가족 구성원의 존재 여부, 그들의 부양과 관련된 재정적 능력 등의 요인이 작용하기 때문이었다. 이러한 가족에 의한 부양을 선호하는 노인들의 부양실태를 반영하여 경제적 부양을 하는 가족에 대한 재정적 지원, 재가노인복지서비스를 위한 고령친화산업의 활성화, 그리고 노년기 부부관계와 친구관계 관리를 위한 프로그램 개발 등이 요구된다. The purposes of this study were to analyze the care system in aged Korea and make the suggestions which can harmonize the care roles between family and government. The survey was done to 483 elderly living in Seoul and Kyung-gi province with a standardized questionnaire during October 2004. The elderly was asked whether s/he had received financial, daily living activity and emotional cares during last 6 months, who had been the main care-giver, and whom s/he had expected the alternative care-giver. As a result, we found the primary care-giver in order from spouse, the first son, other adult children, friends and neighborhood and public service. The small differences among the successful life types were found in the order of the primary care-giver due to existence of family members such as spouse, first son, and other children as well as the financial ability to pay for care. Reflecting these results, we suggested to support financially to adult children who provide financial care; to activate 60+ market industry for service ; to develop the marriage encounter and friendship program.

한국노인의 성공적 노후 삶의 유형에 영향을 미치는 요인

김미혜(Kim, Mee Hye),신경림(Shin, Kyung Rim),최혜경(Choi, Hye Kyoung),강미선(Kang, Mi Sun) 한국노년학회 2006 한국노년학 Vol.26 No.1

본 연구의 목적은 성공적 노후 관점에 따른 한국노인의 삶을 분석하고, 성공적 노후의 4가지 요인-'자기 효능감을 느끼는 삶', '자녀의 성공을 통해 만족하는 삶', '부부간의 동반자적인 삶', '자기 통제를 잘하는 삶'-을 통해 한국노인의 삶의 유형을 분류하고자 하였다. 이를 위해 질문지를 통한 조사를 실시하였고, 군집분석 결과 4가지 삶의 유형-'이상근접형', '배우자 결핍형', '적당유지형', '성공적 노후 요소 결핍형'-이 나타났다. 이러한 성공적인 노후를 이루기 위한 현 한국 노인의 삶의 유형의 예측요인을 살펴본 결과 사회인구학적인 특성으로 인해 유형의 이동이 일어날 수 있음을 살펴볼 수 있다. 즉, 성별, 소득, 배우자유무, 연령, 남아자녀수, 주관적 건강상태에 따라 이상근접형은 배우자 결핍형, 그리고 적당유지형으로, 또한 적당유지형에서 성공적 노후 요소 결핍형으로 이동할 수 있다는 것이다. 한국 노인들이 성공적 노후를 이루기 위해 성공적인 노후 관점에 따른 삶의 유형별 주요 변인들의 부정적인 영향력을 줄여주고 보완해줄 수 있는 대책을 마련하여 이러한 이동경로를 차단하거나 이동의 속도를 늦추는 것이 필요하다. The purposes of this study were to analyse the concept of successful aging for Korean elderly and to classify the successful aging types by four factors; (1)self efficacy, (2)satisfaction with adult children's success, (3) companionate couple life, (4)self-control. In order to explore successful aging types of Korean elderly, the survey was done with a standardized questionnaire during October 2004. As a result, four types of successful aging emerged: ideal, insufficient in spouse, moderate, and needy. We found demographic differences among four types and three transitions from 'ideal' to 'insufficient in spouse', from 'ideal' to 'moderate', and from 'moderate' to 'needy'. Based on three transitions-from 'ideal' to 'insufficient in spouse', from 'ideal' to 'moderate', and from 'moderate' to 'needy', we come to a conclusion of the importance of delaying or breaking off the transitions. It will be necessary (1) for 'ideal' to prepare home care service network for spouses, to promote marriage encounter programs that supports emotionally, (2) for 'insufficient' to provide information on social services and to expand cost sale services, (3) for 'moderate' to extend social welfare benefits for middle class and to expand cost sale services. (4) for 'needy' to improve the quality of public welfare service.