Carpenter 所要人員策定에 對한 考察

李鍾萬 慶北工業專文大學 1966 論文集 Vol.3 No.-

Multiloop Edgewise Arch Wire를 이용한 정중변위 밍 전치부 개방교합을 동반한 제3급 부정교합의 치료증례

이흥교,이상호,유종만 大韓小兒齒科學會 1993 大韓小兒齒科學會誌 Vol.20 No.2

The purpose of early orthodontic treatment is to guide the dentitions toward the development of a functionally and morphologically harmonious occlusion. Early treatment of CI.Ⅲ malocclusion is useful to establish the normal occlussion and induce to proper seating for the condyle in the fossa. CI.Ⅲ malocclusion is treated with 3 categories of methods, such as orthodontic tooth movement, modification of growth and orthognathic surgery. This report presents a case of classⅢ malocclusion accompanying the midline shift and anterior openbite treated with Multiloop Edgewise Arch Wire(MEAW) mechanics. Treatment resulted in normal classⅠ molar relationship and functional overbite& overjet. Extrusion of anterior teeth and distal uprighting of posterior teeth were also observed. Further observation is needed to evaluation the stability or recurrence of these cases treated with MEAW.

단일클론 항 γ-Glutamyltrasferase(GCT) 항체를 이용한 혈뇌장벽 내 GGT의 분포에 관한 연구

이병규,김명곤,신규만,류총근 대한신경외과학회 1995 Journal of Korean neurosurgical society Vol.24 No.3

γ-Glutamyltransferase(GGT: E.C. 2.3.2.2.) is a glycoprotein enzyme which is involved in glutathione metabolism and amino acid transport through the plasma membrane. It is distributed widely in several organs including liver, kidney, pancrease and brain. GGTs derived from the brain of Wister rats and BALB/c mice were biochemically purified to a specific activity of 4246.2, 862.1 units per mg of protein, a purification folds 93.7, 43.8 and the final yield 65.8, 44.0% respectively. Electrophoretic pattern of purified GGTs from rats and mice brain shows very similar protein fraction each other. We have produced six monoclonal antibodies(GGT-MAb 1-6) against 2-acetamidofluorene treated rat liver GGT. Using these GGT-MAb 1-6 we performed immunohistochemistry(IHC) to study the distribution of GGY isozymes in normal tissues of rat brain and in ncoplastic tissues of human brain. The results indicated that human brain GGT was localized in pericytes of blood-brain barrier, especially in the blood-rich portion of the brain(e.g. cerebellum of rat, meningioma and craniopharyngioma of human). Therefore these MAbs may be used to evaluate the distribution of GGT isozymes in different tissues.

Micelle형성에 미치는 소수성 결합의 영향

이종만 誠信女子大學校 1981 硏究論文集 Vol.14 No.-

새로운 계면활성제인 dodecyl m-picolinium chloride(D m-PC)를 합성 확인하고 이 합성된 활성제의 수용액에서의 온도 변화에 따른 cmc와 서로 유사한 물질인 guanidinium chloride(GuCl), urea 및 thiourea를 첨가제로 사용하여 이들의 농도 변화와 온도 변화에 따른 cmc를 표면장력 자료로부터 결정하였다. 또한 각 경우에 대해 온도에 대한 cmc의 대수치의 온도방정식을 3차 polynomial로 구하여 각 경우의 micelle형성에 대한 열역학 변수를 구하고 정성, 정량적 방법으로 micelle의 안정도, 즉 소수성 결합의 안정도 및 micelle형성에 관한 지식을 얻었으며 단백질 변성제의 일종인 각 첨가제의 소수성 결합에 대한 영향을 조사한 결과, 그 효과가 GuCl> urea >thiourea의 순서가 됨을 알았다. For studying the effect of guanidinium chloride, urea and thiourea on the stability of micelle, a new cationic surfactant, dodecyl m-picolinium chloride(D m-PC) was synthetized and identified. The effect of temperature on the critical micelle concentration(cmc) of D m-PC in the aqeous solutions of guanidinium chloride, urea and thiourea has been determined by the surface tension method over the range from 20℃ to 50℃. The values of the change in enthalpy, ΔHm and the other thermodynamic parameters of micellization have been estimated using the equation of temperature dependence on the cmc for the same temperature range. Qualitatively, correlations are observed between hydrophobic nature of the additives and their micelle-breaking power. In this experiment, we found that the order of effectiveness in breaking up micelles is GuCl> urea >thiourea.

실험적 간암의 전암병변에 관한 면역 조직화학적 및 유세포 계측 연구 : C-ras, C-erb B2, Proliferating Cell Nuclear Antigen 및 C-myc의 변동 Expression of C-ras, C-erb B2, PCNA, and C-myc

이중달,김종만,고영혜,김재영 한양대학교 의과대학 1994 한양의대 학술지 Vol.14 No.1

To investigate the role of oncogenes in the hepatocarcinogenesis, author had undertaken an experimental study of hepatic carcinogenesis induced in 50 rats by feeding 2-acetylaminofluorene(2-AAF) in diet. The animals were sacrificed at 2, 4, 6, 8, 12, 16, 27, and 36 weeks after 2-AAF administration, and each liver was immunostained with monoclonal antibodies for c-ras, c-erb B2, and proliferating cell nuclear antigen(PCNA), and analysed by flow cytometry for c-myc oncoprotein. 1.The control livers were negative for expression of c-ras, c-erb B2, and c-myc oncoprotein, and positive for PCNA in 0.2% of hepatic cells. 2.The oval cells were markedly proliferated at 4 weeks after 2-AAF administration. They eventually became differentialted into bile ductular cells and small hepatocytes. 3.The oval cells and small hepatocytes showed high positive rate for PCNA with strong reaction for c=ras, c-erb B2, and c-myc oncoprotein whereas bile ductular cells failed to react for c-ras and c-erb B2. 4.Most hepatocytes in regenerative nodules lost the expression for c-myc, c-ras, and c-erb B2, although the oncoproteins persisted in some hepatocytes in the nodules. 5.Hepatocellular carcinoma of trabecular type and undifferentiated carcinoma were induced by 36 weeks after 2-AAF administration. The undifferentiated carcinoma cells expressed both PCNA and c-erb B2 oncoprotein rather strongly. Above results suggested that in the early phase of the experiment, c-ras, c-erb B2, and c-myc oncogenes were activated and stimulated to proliferation makes the oval cells to e transformed into malignant cells. However, the findings that most oval cells were differented into reversible cells in regenerating nodules suggested that overexpression of these oncogenes might not be sufficient to obtain irreversible phenotype of malignant cells. Also strong expression of oncoproteins and high PCNA positive rate in small hepatocytes and in a few cells of the hyperplastic nodules suggested that the pathway of the cancer might go through the development of oval cells to small hepatocytes to nodules and eventually to cancer. However, the results that most hepatocytes in the nodules lost oncoproteins and development of undifferentiated carcinoma in the absence of nodule formation suggested that the hepatocellular carcinoma arose from oval cells directly without a morphologic intermediate.

유리 광배근피판을 이용한 하지의 재건

이규윤,김용배,이영만,양순재,박종섭 大韓成形外科學會 1991 Archives of Plastic Surgery Vol.18 No.1

Significant soft-tissue defects in the lower extremity including the tibia and the foot are best managed with free skin-muscle of skin-grafted free muscle transfers. While free flap donor sites useful for lower exremity reconstruction include the latissimus dorsi, the rectus abdominis, the gracilis, and the scapular flaps, the latissimus dorsi seems ideal. This muscle has a reliably long vascular pedicle of wide diameter, making microsurgical anastomosis of the thoracodorsal vessels straightforward. Because it is so large, it can cover virtually and size defect. Furthermore, its flat configuration makes it especially easy to fold on itself to that it can be used to closure wounds with complex three-dimensional geometry and dead space. Although the gracilis and rectus abdominis muscles have their roles, in most cases the latissimus dorsi should serve well. We described technical considerations in each case and the advantages of free latissimus dorsi myocutaneous flap on the reconstruction of the soft tissue defect in the lower extremity.

댐건설에 따른 국지기후의 변화실태

이종범,봉종헌,조하만 江原大學校 附設 環境硏究所 1990 環境硏究 Vol.7 No.-

Local climatic change due to the artificial lakes formed by dams was studied for 5 areas in Korea. At the lake side station there were remarkable increase of frequency of fog and decreases of sunshine du-ration and summertime air temperature. At the down stream area of dam. for frequency was increased while sunshine duration was decreased as those at the lake side. Analysis of hourly solar radiation and cloud amount data shows that at Chunchon. amount of solar radiation is less and cloud amount is more than those at the iniand areas in the morning time in autumn. The reason for these considered to be due to the evaporation from the relatively warm water surface discharged from the Lake soyang in autumn.

주기적 침전반응에 관한 이론적 고찰

이종만 誠信女子大學校 1993 硏究論文集 Vol.33 No.-

From an examination of the various theories proposed to a account for the formation of Liesegang rings, it appears that the application of the ordinary diffusion law is quite adequate. Up to now, no completely rigorous solution of the diffusion euqations under proper boundary condition has been carried out. This is due principally to the mathematical difficulties involved. The revised coagulation theory has been surveyed to explain the periodic precipitation, taking Adair's solution for Pick's law of diffusion. The estimations of the reduced concentration of the sol(C_30) and the flocculation value(Γ) have been made by this theory. The time law of Mores and Pierce, and the spacing law of Jablczynski have been critically reviewed and derived by taking Riemann's solution for Fick's diffusion equation. It has been assumed that the distribution of the concentration product of the ions is represented a simple harmonic curve whose amplitude diminishes exponentially to zero with increasing distance. The condition for the precipitation is that the ionic product should exceed or be equal to the solubility roduct of the sparingly soluble compound at the point.

림프구성 간질을 동반한 위선암종의 임상-병리학적 및 면역조직화학적 연구

김종만,김남훈,이중달 한양대학교 의과대학 1994 한양의대 학술지 Vol.14 No.1

Various clinicopathologic and immunologic parameters to determine the prognosis of gastric adenocarcinoma have been proposed. It has been reported that lymphocytes around tumor cells may play a role in determination of the prognosis. Among them gastric adenocarcinoma with lymphoid stroma(GALS), which is characterized by 1) a sparese population of small nests consisting of poorly differentiasted carcinoma cells widely separated by the intervening lymphocytic infiltration, and 2) the presence of a nondesmoplastic stroma infiltrated uniformly iwth abundant lymphocytes throughout the tumor frequently accompanied by lymph follicles, has been proven to show good prognosis. To evaluate the correlation between the pathologic patterns and immunologic expression of lymphocytes, the author reviewed clinical data and pathologic specimens from 13 cases of GALS. Immunohistochemical study on lymphocytes in GALS was performed. In comparison with ordinary gastric carcinomas GALS had the growth pattern of Borrmann type Ⅱ in 7 of 13(54%), and occured predominantly in the body. No correlation between the degree of lymphocytic infiltration and the metastases to the regional lymph nodes was noted. The less invasive tumors had a tendency to the more expanding in growth pattern, and more invasive tumor, more infiltrative. Immunohistochemical study revealed stromal lymphocytes of predominantly T-cell expression. T-cells were frequently seen in intimate contact with individual carcinoma cells. In contrast, B-cellls was sparsely scattered throughout apart from carcinoma cell nests.

ATYPICAL MESOBLASTIC NEPHROMA 1례

박만수,이중화,윤율로,설종구 충남대학교 의과대학 지역사회의학연구소 1991 충남의대잡지 Vol.18 No.1

Atypical mesoblastic nephroma is a rare infantile renal tumor that may behave aggressively in older infants. The features that distinguish atypical mesoblastic nephroma from congenital mesoblastic nephrorma are as follows; (1) atypical gross features consisting of one or more of the follwing: flesh areas, foci of hemorrhage, necrosis, involvement of adjacent structures; and (2) high cellularity and mitotic index. Treatment is not established whether additional modes of therapy are indicated in completely resected atypical mesoblastic nephroma. A close and regular periodic follow-up is indicated in all cases of atypical mesoblastic nephroma. A case of atypical mesoblastic nephroma in 45-day-old-male is presented with brief review of literatures.