Oxygen vacancies assisted LaFeO3 derived from metal organic frameworks endows a practical HCHO sensor with excellent sensing characteristics

Lulu Guo,Shushu Zhao,Guimao Yang,Lifeng Gao,Yanhong Wu,Xuguang Zhang 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.126 No.-

Perovskite oxide semiconductors have attracted tremendous interest in gas sensing due to their promisingproperties of tunable active sites, excellent catalytic ability and good structural stability. Nevertheless, the rapid synthesis of perovskite oxides and controlled regulation of their surface oxygenvacancies remains a great challenge. Herein, we report a novel metal–organic frameworks (MOFs) selftemplatestrategy for the rapid and large-scale preparation of LaFeO3 nanoparticles (MLaFeO3) withabundant oxygen vacancies. Benefit from the introduction of oxygen vacancies, the resultantMLaFeO3 gas sensor exhibit excellent formaldehyde (HCHO) sensing performance at a low operatingtemperature of 160 C, including high sensitivity (Rg/Ra = 8.9 @ 100 ppm), fast response/recovery rate(53 s/32 s), low detection limit (1 ppm) and excellent selectivity. Comprehensive density functional theory(DFT) calculation and spectral characterizations reveal that oxygen vacancies play a vital role in promotingthe adsorption and activation of O2 and HCHO molecules, and accelerate the chemical reaction onthe sensing materials surface. Most importantly, it proves the promising application of MLaFeO3 sensorin food safety assessment. This work not only provides a simple strategy for constructing oxygen vacanciesenriched LaFeO3, but also demonstrates the application potential of LaFeO3-based gas sensors in thefield of formaldehyde detection.

Transiting test method for galloping of iced conductor using wind generated by a moving vehicle

Pan Guo,Dongwei Wang,Shengli Li,Lulu Liu,Xidong Wang 한국풍공학회 2019 Wind and Structures, An International Journal (WAS Vol.28 No.3

This paper presents a novel test method for the galloping of iced conductor using wind generated by a moving vehicle which can produce relative wind field. The theoretical formula of transiting test is developed based on theoretical derivation and field test. The test devices of transiting test method for aerodynamic coefficient and galloping of an iced conductor are designed and assembled, respectively. The test method is then used to measure the aerodynamic coefficient and galloping of iced conductor which has been performed in the relevant literatures. Experimental results reveal that the theoretical formula of transiting test method for aerodynamic coefficient of iced conductor is accurate. Moreover, the driving wind speed measured by Pitot tube pressure sensors, as well as the lift and drag forces measured by dynamometer in the transiting test are stable and accurate. Vehicle vibration slightly influences the aerodynamic coefficients of the transiting test during driving in ideal conditions. Results of transiting test show that the tendencies of the aerodynamic coefficient curve are generally consistent with those of the wind tunnel tests in related studies. Meanwhile, the galloping is fairly consistent with that obtained through the wind tunnel test in the related literature. These studies validate the feasibility and effectiveness of the transiting test method. The present study on the transiting test method provides a novel testing method for research on the wind-resistance of iced conductor.

Folate-decorated Polysaccharide-doxorubicin Polymer: Synthesis, Characterization, and Activity in HeLa Cells

Lei Zhang,Lulu Guo,Jingna Ding,Yongming Lu,Yaping Zhang,Yan Chen 대한화학회 2015 Bulletin of the Korean Chemical Society Vol.36 No.8

In order to develop the application of the natural polysaccharide lentinan (LNT) and decrease the side effects of doxorubicin, we successfully synthesized a novel folate-modified maleilated lentinan-doxorubicin (FA-M.LNT-DOX) polymer and used it for tumor-targeted drug delivery. The release efficiency and cytotoxicity of the prodrugs were evaluated in vitro. Although DOX release from FA-M.LNT-DOX was quite slow in a neutral buffer, it was particularly fast in an acidic solution with a pH of 5.0. Compared with DOX, FA-M.LNT-DOX showed higher cytotoxicity in HeLa cells and significantly lower cytotoxicity in normal cells. These results suggested that FA-M.LNT-DOX could be considered as a potential drug delivery candidate for folate receptor-positive cancer therapy.

Natural wind impact analysis of transiting test method to measure wind pressure coefficients

Shengli Li,Lulu Liu,Pan Guo,Xidong Wang 한국풍공학회 2020 Wind and Structures, An International Journal (WAS Vol.30 No.2

Building wind pressure coefficient transiting test is a new method to test the building wind pressure coefficient by using the wind generated by a moving vehicle, which is susceptible to natural wind and other factors. In this paper, the Commonwealth Advisory Aeronautical Research Council standard model with a scale ratio of 1:300 is used as the test object, and the wind pressure coefficient transiting test is repeated under different natural wind conditions to study the influence of natural wind. Natural wind is measured by an ultrasonic anemometer at a fixed location. All building wind pressure coefficient transiting tests meet the test conditions, and the vehicle’s driving speed is 72 km/h. The mean wind pressure coefficient, the fluctuating wind pressure coefficient, and the correlation coefficient of wind pressure are used to describe the influence of natural wind on the building wind pressure coefficient transiting test qualitatively and quantitatively. Some rules, which can also help subsequent transiting tests, are also summarized.

Effects of surface materials of self-draining beds on cattle behavior in a temperate climate

Liu Ping,Guo Lulu,Zhang Fulan,Li Lin,Mao Huaming,Gu Zhaobing 아세아·태평양축산학회 2020 Animal Bioscience Vol.33 No.11

Objective: The objective of the present experiment was to construct self-draining beds to keep surface bedding materials clean and dry for beef cattle comfort in a temperate climate. Methods: In Experiment 1, a self-draining bed was covered with sand at depths of 10 cm (S-10a), 15 cm (S-15), and 20 cm (S-20) respectively. In Experiment 2, self-draining beds of different sizes were covered with 10 cm of sand (S-10b) and wood shavings (WS) at depths of 15 cm and 20 cm (WS-15 and WS-20). Fifteen cattle were engaged to evaluate the comfort of self-draining beds covered with different bedding materials. Results: No cattle lay in the feed alley and cattle spent more time lying on S-10a than S-15 or S-20 in Experiment 1 (p<0.01). No difference in lying time was detected between S-15 and S-20 (p>0.05). In Experiment 2, no cattle selected the feed alley as the lying area. Cattle preferred WS-15 as the lying area and time spent lying on WS-20 was slightly higher than on S-10b (p<0.05). Feces weight was higher in the feed alley than in the different bedding areas in both Experiments 1 and 2 (p<0.01). Conclusion: Sand-bedding depth at 10 cm and WSs at 15 cm above the self-draining bed can provide for the lying comfort of beef cattle. Design of a special feed alley to hold most of the feces to keep bedding materials clean and dry is desirable for organic beef cattle in a loose barn.

Impact of NR1I2, adenosine triphosphateebinding cassette transporters genetic polymorphisms on the pharmacokinetics of ginsenoside compound K in healthy Chinese volunteers

Luping Zhou,Lulu Chen,Yaqin Wang,Jie Huang,Guo Ping Yang,Zhi-Rong Tang,Yicheng Wang,Jianwei Liao,Gan Zhou,Kai-hua Wei,Zhenyu Li,Dongsheng Ouyang 고려인삼학회 2019 Journal of Ginseng Research Vol.43 No.3

Background: Ginsenoside compound K (CK) is a promising drug candidate for rheumatoid arthritis. Thisstudy examined the impact of polymorphisms in NR1I2, adenosine triphosphateebinding cassette (ABC)transporter genes on the pharmacokinetics of CK in healthy Chinese individuals. Methods: Forty-two targeted variants in seven genes were genotyped in 54 participants using SequenomMassARRAY system to investigate their association with major pharmacokinetic parameters of CK and itsmetabolite 20(S)-protopanaxadiol (PPD). Subsequently, molecular docking was simulated using theAutoDock Vina program. Results: ABCC4 rs1751034 TT and rs1189437 TT were associated with increased exposure of CK anddecreased exposure of 20(S)-PPD, whereas CFTR rs4148688 heterozygous carriers had the lowestmaximum concentration (Cmax) of CK. The area under the curve from zero to the time of the lastquantifiable concentration (AUClast) of CK was decreased in NR1I2 rs1464602 and rs2472682 homozygouscarriers, while Cmax was significantly reduced only in rs2472682. ABCC4 rs1151471 and CFTR rs2283054influenced the pharmacokinetics of 20(S)-PPD. In addition, several variations in ABCC2, ABCC4, CFTR, andNR1I2 had minor effects on the pharmacokinetics of CK. Quality of the best homology model of multidrugresistance protein 4 (MRP4) was assessed, and the ligand interaction plot showed the mode of interactionof CK with different MRP4 residues. Conlusion: ABCC4 rs1751034 and rs1189437 affected the pharmacokinetics of both CK and 20(S)-PPD. NR1I2 rs1464602 and rs2472682 were only associated with the pharmacokinetics of CK. Thus, thesehereditary variances could partly explain the interindividual differences in the pharmacokinetics of CK.

Overexpressing fusion proteins of 4-coumaroyl-CoA ligase (4CL) and stilbene synthase (STS) in tobacco plants leading to resveratrol accumulation and improved stress tolerance

Xuancheng He,Feiyan Xue,Lulu Zhang,Hui-Li Guo,Lan-Qing Ma,Mingfeng Yang 한국식물생명공학회 2018 Plant biotechnology reports Vol.12 No.5

Resveratrol (trans-3,4′,5-trihydroxystilbene) is a phytoalexin produced in plants in response to pathogen attack as a part of plant defense response and it is also a highly bioactive substance of pharmaceutical interest. To obtain transgenic plants with a high level of resveratrol, two enzymes in the last two steps of resveratrol synthesis, 4-coumaroyl-CoA ligase (4CL) and stilbene synthase (STS), were fused together by a glycine–serine–glycine (GSG) tripeptide linker, and the 4CL-GSGSTS construct driven by a CaMV35S promoter was transformed into tobacco (Nicotiana benthamiana) by Agrobacteriummediated method. In the transgenic plants, a high resveratrol level was detected (21.05 μg/g fresh weight) by high-pressure liquid chromatography (HPLC), which is higher than previous transgenic plants with only STS gene overexpression. In addition to resistance to pathogen, transgenic plants showed improved tolerance to salt and osmotic stresses, and the lower level of malondialdehyde (MDA) in transgenic plants suggested that resveratrol could protect plant membrane lipid from peroxidation under abiotic stresses.

Ultrastructural changes of Haematococcus pluvialis (Chlorophyta) in process of astaxanthin accumulation and cell damage under condition of high light with acetate

He, Bangxiang,Hou, Lulu,Zhang, Feng,Cong, Xiaomei,Wang, Zhendong,Guo, Yalin,Shi, Jiawei,Jiang, Ming,Zhang, Xuecheng,Zang, Xiaonan The Korean Society of Phycology 2020 ALGAE Vol.35 No.3

Haematococcus pluvialis is a commercial microalga that can produce high quantities of astaxanthin. Under induced conditions, some important changes in the subcellular structures related to astaxanthin accumulation were observable. For example, a large number of astaxanthin granules, oil structures and starch granules appeared in the thick-walled cells; Astaxanthin granules gradually dissolved into the oil structures and spread throughout the entire cell with the fusion and diffusion process of oil structures during the middle and late stages of induction; The plastoglobules were closed to the newly formed structures, and some plastoglobules would abnormally increase in size under stress. Based on observations of cell damage, the degradation of membrane structures, such as chloroplasts, was found to be the primary form of damage during the early stage of induction. During the middle stage of induction, some transparent holes were exposed in the dissolving astaxanthin granules in the cytoplasm. In thick-walled cells, these transparent holes were covered by oil substances dissolving astaxanthin, thereby avoiding further damage to cells. Given the relatively few oil structures, in non-thick-walled cells, the transparent holes expanded to form multiple transparent areas, eventually resulting in the rupture and death of cells. These results suggested that the high level of synthesis and the wide range diffusion of oil explained the expansion of astaxanthin in H. pluvialis.

Experimental-based optimization of polymer injection molding process parameters using anfis-ga method

Yanli Cao,Xi-ying Fan,Yong-huan Guo,Xin Liu,Chunxiao Li,Lulu Li 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.3

Compared with ordinary injection-molded parts, the slender, cantilevered, and thin-walled plastic parts are harsh on the injection molding process conditions. For complexity and particularity, it is difficult to form such parts. It is also more likely to cause excessive warpage deformation, affecting the molding quality and performance. The automobile audio shell is a typical slender, cantilevered, thin-walled plastic part. When the mold structure and material are determined, optimizing its injection molding process is the most economical and effective method to manufacture the products with the optimum properties. In order to minimize the warpage deformation, the adaptive network based fuzzy inference system (ANFIS) and genetic algorithm (GA) were adopted to optimize the injection molding process parameters. In particular, considering the high-dimensional nonlinear relationship between the process parameters and the warpage, the ANFIS is constructed as the prediction model of the warpage. Then, the GA is used to globally optimize the prediction model to determine the optimal process parameters. The results show that the optimization method based on ANFIS-GA has a good performance. The warpage is reduced to 0.0925 mm while reduced by 88.25 %. The optimal injection molding process parameters are used for simulation and manufacture, verifying the effectiveness and reliability of the optimization method.