Against AIDS : Economic Analysis on Chinese Rural Women

Deng Dasong,Ling Zhang Research Institute of Asian Women Sookmyung Women' 2005 Asian Women Vol.21 No.-

The Chinese government has realized that the spread of HIV/AIDS will finally set off the fruits of economic development. The disease begins from the weak, and then spreads quickly to every stratum of the population, which leads to irremediable shortage of human resources and eventually the stagnation and even retrogression of economic growth. The difficulty to control it is that this incurable disease will go into human social behavior, grow in the weak links of the society and entangle many other problems into a complicated vicious circle. Poverty, ignorance and indifference upon the weak have become the main reasons for the rapid spread of AIDS. Therefore, AIDS is regarded as the adjunct of social injustice, and consequently the protection of the weak has been attached unprecedented importance. At present, the spread of AIDS in China is wide spread in some places and among special groups. The AIDS patients are mainly from the rural areas, since drug abusers, prostitutes and those who sell blood are also mainly concentrated in the rural areas. Women, the most vulnerable group, are at the beginning of the vicious circle. The vulnerable position of rural women makes them the group most easily infected by AIDS and then the new source of infection. To effectively control the spread of the disease, it is necessary to attach great attention to this vulnerable group and provide them with effective help. This paper, after analyzing the vulnerability of Chinese rural women, points out the importance of maintaining social justice and protecting the vulnerable groups in preventing the spread of HIV/AIDS in China.

ASPEN PLUG SIMULATION OF MOVING-BED CHAR GASIFICATION USING FOUR TYPES OF MODELS

Ling Yan DENG,Hyung Taek KIM 한국신재생에너지학회 2015 AFORE Vol.2015 No.11

Prevalence and Prognostic Role of PIK3CA/AKT1 Mutations in Chinese Breast Cancer Patients

Ling Deng,Xuehua Zhu,Yun Sun,Jiemin Wang,Xiaorong Zhong,Jiayuan Li,Min Hu,Hong Zheng 대한암학회 2019 Cancer Research and Treatment Vol.51 No.1

Purpose The prevalence of PIK3CA in Chinese breast cancer patients may be underestimated. Therefore, we investigated the distribution of somatic PIK3CA/AKT1mutations in Chinese breast cancer patients and explored their roles in tumor phenotypes and disease prognosis. Materials and Methods Tumors from 507 breast cancer patients were prospectively collected from the West China Hospital between 2008 and 2013. Whole exons of AKT1 and PIK3CAwere detected in freshfrozen tumors using next-generation sequencing, and correlations between PIK3CA/AKT1 mutations and clinicopathological features were analyzed. Results The AKT1mutation was found in 3.6% (18/507) of patients. Tumors from patients that carried the AKT1mutation were estrogen receptor (ER)+/progesterone receptor (PR)+/human epidermal growth factor receptor 2 (HER2) and were more likely to have high expression levels of Ki67. The prevalence of the PIK3CA mutation was 46.5% (236/507), and 35 patients carried two or three variants of the PIK3CA gene. PIK3CA mutations were associated with ER+/PR+/HER2 status. The prognosis of patients with one mutation in PIK3CA (or PIK3CA/AKT1) was not significantly different than that of patients with wild-type PIK3CA (or PIK3CA/AKT1), while patients with two or three variants in PIK3CA (or PIK3CA/AKT1) exhibited poorer outcomes in the entire group and in all three subgroups (ER+, HER2, Ki67 high), particularly with respect to overall survival. Conclusion A high frequency of somatic PIK3CA mutations was detected in Chinese breast cancer patients. In addition to the mutation frequency, the tumor mutational burden of the PIK3CA and AKT1 genes should also be of concern, as they may be associated with poor prognosis.

Against AIDS: Economic Analysis on Chinese Rural Women

Deng Dasong & Ling Zhang 숙명여자대학교 아시아여성연구원 2005 Asian Women Vol.21 No.-

The Chinese government has realized that the spread of HIV/AIDS will finally set off the fruits of economic development. The disease begins from the weak, and then spreads quickly to every stratum of the population, which leads to irremediable shortage of human resources and eventually the stagnation and even retrogression of economic growth. The difficulty to control it is that this incurable disease will go into human social behavior, grow in the weak links of the society and entangle many other problems into a complicated vicious circle. Poverty, ignorance and indifference upon the weak have become the main reasons for the rapid spread of AIDS. Therefore, AIDS is regarded as the adjunct of social injustice, and consequently the protection of the weak has been attached unprecedented importance. At present, the spread of AIDS in China is wide spread in some places and among special groups. The AIDS patients are mainly from the rural areas, since drug abusers, prostitutes and those who sell blood are also mainly concentrated in the rural areas. Women, the most vulnerable group, are at the beginning of the vicious circle. The vulnerable position of rural women makes them the group most easily infected by AIDS and then the new source of infection. To effectively control the spread of the disease, it is necessary to attach great attention to this vulnerable group and provide them with effective help. This paper, after analyzing the vulnerability of Chinese rural women, points out the importance of maintaining social justice and protecting the vulnerable groups in preventing the spread of HIV/AIDS in China.

사교육 현상의 미디어 재현과 사회문화적 함의: 텔레비전 드라마 <스카이 캐슬>의 사례를 중심으로

등령(DENG LING) 한국언론정보학회 2019 한국언론정보학회 학술대회 Vol.2019 No.11

Curcumin Ameliorates Reserpine-Induced Gastrointestinal Mucosal Lesions Through Inhibiting IκB-α/NF-κB Pathway and Regulating Expression of Vasoactive Intestinal Peptide and Gastrin in Rats

Lingli Long,Jingnan Wang,Ningning Chen,Shuhui Zheng,Lanying Shi,Yuxia Xu,Canqiao Luo,Yubin Deng 한국식품영양과학회 2016 Journal of medicinal food Vol.19 No.6

The objective of our study was to investigate whether curcumin protects against reserpine-induced gastrointestinal mucosal lesions (GMLs) in rats and to explore the mechanism of curcumin’s action. Sprague-Dawley rats were randomly divided into four groups: control group, reserpine-treated group, reserpine treatment group with curcumin at high dose (200 mg/kg), and reserpine treatment group with curcumin at low dose (100 mg/kg). Rats in reserpine-treated group were induced by intraperitoneally administered reserpine (0.5 mg/kg) for 28 days. TUNEL staining and hematoxylin and eosin staining were used to evaluate the apoptotic cells and morphologic changes. In addition, to explore the mechanism of curcumin in protecting GMLs, we used serum of experimental rats to assess the level of vasoactive intestinal peptide (VIP), gastrin, interleukin-6, interleukin-10, tumor necrosis factor-α and interferon-γ by ELISA and radioimmunoassay. The protein levels of NF-κB, p-IκB-α, IκB-α, Bcl-2, Bax, and cleaved-caspase-3 were examined by western blot analysis. Data were analyzed with SPSS 19.0 software package. Curcumin treatment prevented tissue damage and cell death in the reserpinetreated rats and effectively decreased inflammatory response and balanced the expression of VIP and gastrin in the reserpinetreated rats. NF-κB, p-IκB-α, Bax, and cleaved-caspase-3 were increased in the reserpine group, but the curcumin high-dose group inhibited them. Curcumin can target the IκB-α/NF-κB pathway to inhibit inflammatory response and regulate the level of VIP and gastrin in reserpine-induced GML rats.

Finite Element Analysis and Test Study on Restraint of High-energy Pipe Whip in Conventional Island

Ling-yun Peng,Yu-ke Deng,Hua-ting Chen,Ying-jie Kang,Xiang-xiu Li 대한토목학회 2019 KSCE JOURNAL OF CIVIL ENGINEERING Vol.23 No.4

The effects of high-energy pipe whipping after rupturing are very important in an AP1000 nuclear power plant's conventional island and restraints of pipe whipping should be considered in the design. It is the first time in the country when reinforced concrete shear walls are used as restraint services. In this paper, the behaviors of walls and restraint services subjected to pipe whipping are analyzed through static and dynamic methods in the finite element software (ABAQUS), in which all kinds of nonlinearities are considered. In addition, a test study on the restraint of pipe whipping is conducted. The results show that the wall and the restraint service can prevent pipe whipping effectively under the design load, and anchor plates arranged around the wall opening can improve the local concrete compression performance of concrete to reduce the damage of concrete. Meanwhile, the study also provides the valuable reference for wall designing to prevent from pipe whipping.

Roles of E-Cadherin (CDH1) Genetic Variations in Cancer Risk: a Meta-analysis

Deng, Qi-Wen,He, Bang-Shun,Pan, Yu-Qin,Sun, Hui-Ling,Xu, Ye-Qiong,Gao, Tian-Yi,Li, Rui,Song, Guo-Qi,Wang, Shu-Kui Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.8

E-Cadherin (CDH1) genetic variations may be involved in invasion and metastasis of various cancers by altering gene transcriptional activity of epithelial cells. However, published studies on the association of CDH1 gene polymorphisms and cancer risk remain contradictory, owing to differences in living habits and genetic backgrounds. To derive a more better and comprehensive conclusion, the present meta-analysis was performed including 57 eligible studies of the association between polymorphisms of CDH1 gene promoter -160 C>A, -347 G>GA and 3'-UTR +54 C>T and cancer risk. Results showed that these three polymorphisms of CDH1 were significantly associated with cancer risk. For -160 C>A polymorphism, -160A allele carriers (CA and CA+AA) had an increased risk of cancer compared with the homozygotes (CC), and the similar result was discovered for the -160A allele in the overall analyses. In the subgroup analyses, obvious elevated risk was found with -160A allele carriers (AA, CA, CA+AA and A allele) for prostate cancer, while a decreased colorectal cancer risk was shown with the AA genotype. For the -347 G>GA polymorphism, the GAGA genotype was associated with increased cancer risk in the overall analysis with homozygous and recessive models. In addition, results of subgroup analysis indicated that the elevated risks were observed in colorectal cancer and Asian descendants. For +54 C>T polymorphism, a decreased risk of cancer was found in heterozygous, dominant and allele models. Moreover, +54T allele carriers (CT, CT+TT genotype and T allele) showed a potential protective factor in gastric cancer and Asian descendants.

Study on the Flexural Fatigue Performance of CFRP-OFBG Plate Reinforced Damaged Steel Beams

Langni Deng,Mengjun Zhong,Yang Liu,Ling Liao,Shijin Lai,Lizhen Lei,Zheng Zhou 대한토목학회 2021 KSCE Journal of Civil Engineering Vol.25 No.12

This paper studies the flexural fatigue performance of damaged steel beams strengthened by carbon fiber reinforced plastic-optical fiber bragg grating (CFRP-OFBG) plates. By analyzing the test beam's failure mechanism under cyclic loading and the strain data monitored by the CFRP-OFBG panel in real-time, a life prediction model based on cumulative fatigue damage is proposed. The test results show that CFRP-OFBG plate reinforcement effectively reduces the fatigue crack growth rate of damaged steel beams and increases the fatigue life of damaged steel beams by 22.46%. The analysis and test results show that the minimum error between the calculated value of the life prediction model and the test value is -24.13%, and the maximum error is -5.61%. This study provides some suggestions for improving the service life of existing fatigue-damaged steel beams and establishing a simple fatigue life evaluation model.

Dimethyl Sulfoxide Suppresses Mouse 4T1 Breast Cancer Growth by Modulating Tumor-Associated Macrophage Differentiation

Rui Deng,Shi-min Wang,Tao Yin,Ting-hong Ye,Guo-bo Shen, Ling Li,Jing-yi Zhao,Ya-xiong Sang,Xiao-gang Duan,Yu-Quan Wei 한국유방암학회 2014 Journal of breast cancer Vol.17 No.1

Purpose: The universal organic solvent dimethyl sulfoxide (DMSO)can be used as a differentiation inducer of many cancer cells andhas been widely used as a solvent in laboratories. However, itseffects on breast cancer cells are not well understood. The aimof this study is to investigate the effect and associated mechanismsof DMSO on mouse breast cancer. Methods: We appliedDMSO to observe the effect on tumors in a mouse breast cancermodel. Tumor-associated macrophages (TAMs) were tested byflow cytometry. Ex vivo tumor microenvironment was imitated by4T1 cultured cell conditioned medium. Enzyme-linked immunosorbentassays were performed to detect interleukin (IL)-10 andIL-12 expression in medium. To investigate the cytotoxicity ofDMSO on TAMs, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide (MTT) assays were performed. Results: We foundthat DMSO produced tumor retardation when injected into mouseperitoneal cavities in a certain concentration range (0.5–1.0 mg/g). Furthermore, as detected by flow cytometry, TAM subtypeswere found to be transformed. We further imitated a tumor microenvironmentin vitro by using 4T1 cultured cell conditionedmedium. Similarly, by using low concentration DMSO (1.0%–2.0% v/v), TAMs were induced to polarize to the classically activatedmacrophage (M1-type) and inhibited from polarizing intothe alternatively activated macrophage (M2-type) in the conditionedmedium. IL-10 expression in tumors was reduced, whileIL-12 was increased compared with the control. Furthermore, wereported that 2.0% (v/v) DMSO could lead to cytotoxicity in peritonealmacrophages after 48 hours in MTT assays. Conclusion:Our findings suggest that DMSO could exert antitumor effects in4T1 cancer-bearing mice by reversing TAM orientation and polarizationfrom M2- to M1-type TAMs. These data may providenovel insight into studying breast cancer immunotherapy.