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- 저자 : Yuxia Xu (검색결과 4 건)
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Epithelial CST1 Promotes Airway Eosinophilic Inflammation in Asthma via the AKT Signaling Pathway
Du Lijuan,Xu Changyi,Tang Kun,Shi Jia,Tang Lu,Lisha Xiao,Lei Chengcheng,Liu Huicong,Liang Yuxia,Guo Yubiao 대한천식알레르기학회 2023 Allergy, Asthma & Immunology Research Vol.15 No.3
Purpose: Epithelial cystatin SN (CST1), a type 2 cysteine protease inhibitor, was significantly upregulated in asthma. In this study, we aimed to investigate the potential role and mechanism of CST1 in eosinophilic inflammation in asthma. Methods: Bioinformatics analysis on Gene Expression Omnibus datasets were used to explore the expression of CST1 in asthma. Sputum samples were collected from 76 asthmatics and 22 control subjects. CST1 mRNA and protein expression in the induced sputum were measured by real-time polymerase chain reaction, enzyme-linked immunosorbent assay, and western blotting. The possible function of CST1 was explored in ovalbumin (OVA)-induced eosinophilic asthma. Transcriptome sequencing (RNA-seq) was used to predict the possible regulated mechanism of CST1 in bronchial epithelial cells. Overexpression or knockdown of CST1 was further used to verify potential mechanisms in bronchial epithelial cells. Results: CST1 expression was significantly increased in the epithelial cells and induced sputum of asthma. Increased CST1 was significantly associated with eosinophilic indicators and T helper cytokines. CST1 aggravated airway eosinophilic inflammation in the OVA-induced asthma model. In addition, overexpression of CST1 significantly enhanced the phosphorylation of AKT and the expression of serpin peptidase inhibitor, clade B, member 2 (SERPINB2), while knockdown using anti-CST1 siRNA reversed the trend. Furthermore, AKT had a positive effect on SERPINB2 expression. Conclusions: Increased sputum CST1 may play a key role in the pathogenesis of asthma through involvement in eosinophilic and type 2 inflammation through activation of the AKT signaling pathway, further promoting SERPINB2 expression. Therefore, targeting CST1 might be of therapeutic value in treating asthma with severe and eosinophilic phenotypes.
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Zhang, Zhao,He, Yuxia,Tuteja, Dipika,Xu, Danyan,Timofeyev, Valeriy,Zhang, Qian,Glatter, Kathryn A.,Xu, Yanfang,Shin, Hee-Sup,Low, Reginald,Chiamvimonvat, Nipavan Ovid Technologies Wolters Kluwer -American Heart A 2005 CIRCULATION - Vol.112 No.13
<P>Previous data suggest that L-type Ca2+ channels containing the Cav1.3(alpha(1D)) subunit are expressed mainly in neurons and neuroendocrine cells, whereas those containing the Cav1.2(alpha1C) subunit are found in the brain, vascular smooth muscle, and cardiac tissue. However, our previous report as well as others have shown that Cav1.3 Ca2+ channel-deficient mice (Cav1.3(-/-)) demonstrate sinus bradycardia with a prolonged PR interval. In the present study, we extended our study to examine the role of the Cav1.3(alpha1D) Ca2+ channel in the atria of Cav1.3(-/-) mice.</P>
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Lingli Long,Jingnan Wang,Ningning Chen,Shuhui Zheng,Lanying Shi,Yuxia Xu,Canqiao Luo,Yubin Deng 한국식품영양과학회 2016 Journal of medicinal food Vol.19 No.6
The objective of our study was to investigate whether curcumin protects against reserpine-induced gastrointestinal mucosal lesions (GMLs) in rats and to explore the mechanism of curcumin’s action. Sprague-Dawley rats were randomly divided into four groups: control group, reserpine-treated group, reserpine treatment group with curcumin at high dose (200 mg/kg), and reserpine treatment group with curcumin at low dose (100 mg/kg). Rats in reserpine-treated group were induced by intraperitoneally administered reserpine (0.5 mg/kg) for 28 days. TUNEL staining and hematoxylin and eosin staining were used to evaluate the apoptotic cells and morphologic changes. In addition, to explore the mechanism of curcumin in protecting GMLs, we used serum of experimental rats to assess the level of vasoactive intestinal peptide (VIP), gastrin, interleukin-6, interleukin-10, tumor necrosis factor-α and interferon-γ by ELISA and radioimmunoassay. The protein levels of NF-κB, p-IκB-α, IκB-α, Bcl-2, Bax, and cleaved-caspase-3 were examined by western blot analysis. Data were analyzed with SPSS 19.0 software package. Curcumin treatment prevented tissue damage and cell death in the reserpinetreated rats and effectively decreased inflammatory response and balanced the expression of VIP and gastrin in the reserpinetreated rats. NF-κB, p-IκB-α, Bax, and cleaved-caspase-3 were increased in the reserpine group, but the curcumin high-dose group inhibited them. Curcumin can target the IκB-α/NF-κB pathway to inhibit inflammatory response and regulate the level of VIP and gastrin in reserpine-induced GML rats.
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Yu Xia,Jun-Yang Li,Yan-Kui Song,Jia-Xu Wang,Yan-Feng Han,Ke Xiao 제어·로봇·시스템학회 2023 International Journal of Control, Automation, and Vol.21 No.3
Due to the complexity of modeling and the strong transmission coupling, the rich background of rigid actuator control has not been transferred to variable stiffness actuator (VSA). Therefore, most model-based control techniques developed for VSA require feedback linearization first. Alternatively, VSA can use non-model-based control techniques such as PD control, but it does not show strong robustness under disturbances. This paper is concerned with designing a novel adaptive neural network backstepping control scheme without using feedback linearization for a special VSA with saturation inputs, output constraints, and disturbances. Firstly, for ensuring the VSA with lower tracking error and higher security, the prescribed performance-tangent barrier Lyapunov function (PP-TBLF) is introduced to handle the prescribed output performance constraints. Subsequently, the Chebyshev neural network and the Nussbaum-type function are exploited to approximate the unknown nonlinearities and unknown gains. Meanwhile, the inverse hyperbolic sine function tracking differentiator is utilized to solve the “explosion of complexity” caused by the differentiation of virtual inputs and also approximate the complex partial derivatives caused by the auxiliary control signals. Finally, the stability of the whole scheme is proved by the Lyapunov criterion. The simulation results illustrate the raised control scheme’s feasibility and show a better closed-loop behavior relative to that obtained using a classic PD controller.
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