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Stable and Recyclable SERS Substrates Based on Au-Loaded PET Nanocomposite Superhydrophobic Surfaces
Hua-Xiang Chen,Yu-Ting Wang,Ting-Ting You,Jin Zhai,Peng-Gang Yin 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2018 NANO Vol.13 No.5
Novel surface-enhanced Raman scattering (SERS) substrates with stable and recyclable properties have been prepared by assembling gold nanoparticles-loaded PET (AuNPs/PET) nanocomposite superhydrophobic surfaces. After a physical vapor deposition process, the AuNPs/PET surfaces with vast plasmonic "hot spots" showed superhydrophobic properties, and it can hold target molecules droplets for rapid SERS detection. From blown off droplets and rinsed substrates with water after detection, we found that no probe molecules remained on the surfaces from Raman spectra. The prepared substrates were not contaminated in the detection process. Furthermore, the new SERS substrates were used for rapidly detecting droplets of crystal violet (CV) and the lowest detection concentration was about 1 x 10 -9 M. The as-prepared AuNPs/PET substrates also have good performance in terms of reproducibility and recyclability.
Hua-ting Chen,Shaomin Jia,Xuefeng He 국제구조공학회 2019 Structural Engineering and Mechanics, An Int'l Jou Vol.72 No.6
Based on the ball-screw mechanism, a tuned viscous mass damper (TVMD) has been proposed, which has functions of amplifying physical mass of the system and frequency tuning. Considering the sensitivity of a single TVMD’s effectiveness to frequency mistuning like that of the conventional tuned mass damper (TMD) and according to the concept of the conventional multiple tuned mass damper (MTMD), in the present paper, multiple tuned mass viscous dampers (MTVMD) consisting of many tuned mass dampers (TVMD) with a uniform distribution of natural frequencies are considered for attenuating undesirable vibration of a structure. The MTVMD is manufactured by keeping the stiffness and damping constant and varying the mass associated with the lead of the ball-screw type inerter element in the damper. The structure is represented by its mode-generalized system in a specific vibration mode controlled using the mode reduced-order method. Modal properties and fundamental characteristics of the MTVMD-structure system are investigated analytically with the parameters, i.e., the frequency band, the average damping ratio, the tuning frequency ratio, the total number of TVMD and the total mass ratio. It is found that there exists an optimum set of the parameters that makes the frequency response curve of the structure flattened with smaller amplitudes in a wider input frequency range. The effectiveness and robustness of the MTVMD are also discussed in comparison with those of the usual single TVMD (STVMD) and the results shows that the MTVMD is more effective and robust with the same level of total mass.
Qiu-Yan Chen,Shao-Yan Guo,Lin-Quan Tang,Tong-Yu Lu,Bo-Lin Chen,Qi-Yu Zhong,Meng-Sha Zou,Qing-Nan Tang,Wen-Hui Chen,Shan-Shan Guo,Li-Ting Liu,Yang Li,Ling Guo,Hao-Yuan Mo,Rui Sun,Dong-Hua Luo,Chong Zha 대한암학회 2018 Cancer Research and Treatment Vol.50 No.3
Purpose Little is known about combination of the circulating Epstein-Barr viral (EBV) DNA and tumor volume in prognosis of stage II nasopharyngeal carcinoma (NPC) patients in the intensity modulated radiotherapy (IMRT) era. We conducted this cohort study to evaluate the prognostic values of combining these two factors. Materials and Methods By Kaplan-Meier, we compare the differences of survival curves between 385 patients with different EBV DNA or tumor volume levels, or with the combination of two biomarkers mentioned above. Results Gross tumor volume of cervical lymph nodes (GTVnd, p < 0.001) and total tumor volume (GTVtotal, p < 0.001) were both closely related to pretreatment EBV DNA, while gross tumor volume of nasopharynx (GTVnx, p=0.047) was weakly related to EBV DNA. EBV DNA was significantly correlated with progress-free survival (PFS, p=0.005), locoregional-free survival (LRFS, p=0.039), and distant metastasis-free survival (DMFS, p=0.017), while GTVtotal, regardless of GTVnx and GTVnd, had a significant correlation with PFS and LRFS. The p-values of GTVtotal for PFS and LRFS were 0.008 and 0.001, respectively. According to GTVtotal and pretreatment EBV DNA level, patients were divided into a low-risk group (EBV DNA 0 copy/mL, GTVtotal < 30 cm3; EBV DNA 0 copy/mL, GTVtotal 30 cm3; or EBV DNA > 0 copy/mL, GTVtotal < 30 cm3) and a high-risk group (EBV DNA > 0 copy/mL, GTVtotal 30 cm3). When patients in the low-risk group were compared with those in the high-risk group, 3-year PFS (p=0.003), LRFS (p=0.010), and DMFS (p=0.031) rates were statistically significant. Conclusion Pretreatment plasma EBV DNA and tumor volume were both closely correlated with prognosis of stage II NPC patients in the IMRT era. Combination of EBV DNA and tumor volume can refine prognosis and indicate for clinical therapy.
Cui, Xiao-Bin,Peng, Hao,Li, Su,Li, Ting-Ting,Liu, Chun-Xia,Zhang, Shu-Mao,Jin, Ting-Ting,Hu, Jian-Ming,Jiang, Jin-Fang,Liang, Wei-Hua,Li, Na,Li, Li,Chen, Yun-Zhao,Li, Feng Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.22
Background: A number of studies have identified a shared susceptibility locus in phospholipase C epsilon 1 (PLCE1) for esophageal squamous cell carcinoma (ESCC) and gastric cardia adenocarcinomas (GCA). However, the results of PLCE1 expression in esophageal and gastric cancer remain inconsistent and controversial. Moreover, the effects on clinicopathological features remain undetermined. This study aimed to provide a precise quantification of the association between PLCE1 expression and the risk of ESCC and GCA through meta-analysis. Materials and Methods: Eligible studies were identified from PubMed, Wanfang Data, ISI Web of Science, and the Chinese National Knowledge Infrastructure databases. Using RevMan5.2 software, pooled odds ratios (ORs) with 95% confidence intervals (CIs) were employed to assess the association of PLCE1 expression with clinicopathological features relative to ESCC or GCA. Results: Seven articles were identified, including 761 esophageal and gastric cancer cases and 457 controls. Overall, we determined that PLCE1 expression was associated with tumor progression in both esophageal cancers (pooled OR=5.93; 95%CI=3.86 to 9.11) and gastric cancers (pooled OR=9.73; 95%CI=6.46 to 14.7). Moreover, invasion depth (pooled OR=3.62; 95%CI=2.30 to 5.70) and lymph node metastasis (pooled OR=4.21; 95%CI=2.69 to 6.59) were linked with PLCE1 expression in gastric cancer. However, no significant associations were determined between PLCE1 overexpression and the histologic grade, invasion depth, and lymph node metastasis in esophageal cancer. Conclusions: Our metaanalysis results indicated that upregulated PLCE1 is significantly associated with an increased risk of tumor progression in ESCC and GCA. Therefore, PLCE1 expression can be appropriately regarded as a promising biomarker for ESCC and GCA patients.
Experimental Study and Parameter Analysis of L-shaped Composite Column under Axial Loading
Ting Zhou,Minyang Xu,Xiaodun Wang,Zhi-Hua Chen,Ying Qin 한국강구조학회 2015 International Journal of Steel Structures Vol.15 No.4
A special-shaped column composed of concrete-filled steel tubes (SCFST column) is experimentally investigated in this paper. The SCFST column is composed of several small-sized concrete-filled square tubular columns (mono-columns) connected by connection plates. This kind of column is proposed because it can increase the usable space in residential buildings. The axial loading behavior of L-shaped SCFST columns is experimentally investigated. The failure mode, strain distribution, cooperation of mono-columns, bearing capacity, and the effect of a concrete core on column behavior were tested. As concluded, the SCFST column can be regarded as a useful kind of column. A finite element analysis model was proposed according to the experimental results, and the influence of connection plate size on bearing capacity was studied using the finite element model. Finally, proposed were the optimal width and thickness of connection plates for improving the design of the SCFST column.
Ting-Yu Chao,Cheng-Chu Hsieh,Shih-Min Hsu,Cho-Hua Wan,Guan-Ting Lian,Yi-Han Tseng,Yueh-Hsiung Kuo,Shu-Chen Hsieh 한국식품영양과학회 2021 Preventive Nutrition and Food Science Vol.26 No.1
Hepatic ischemia/reperfusion (IR) injury is a complication that occurs during liver surgery, whereby hepatic tissue is injured by oxygen deficiency during ischemia, then further damaged by a cascade of inflammatory and oxidative insults when blood is resupplied during reperfusion. Antrodia camphorata is an indigenous fungus in Taiwan and an esteemed Chinese herbal medicine with various bioactivities. This study examined the effect of ergostatrien-3β-ol (EK100), an active compound found in both the fruiting body and mycelia of A. camphorata, on IR injury pathologies in rats and cell models of oxidative and inflammatory stress. Male Sprague-Dawley rats were randomly assigned to receive a vehicle or 5 mg/kg EK100 prior to hepatic IR injury induced by 1 h ischemia followed by 24 h reperfusion, or a sham operation. RAW 264.7 murine macrophages and HepG2 hepatocytes were pretreated with EK100, then inflammation was induced with lipopolysaccharides in the former and oxidative stress was induced with hydrogen peroxide in the latter. EK100 decreased IR-induced elevation in serum levels of alanine aminotransferase and aspartate aminotransferase and lowered levels of the inflammatory cytokines tumor necrosis factor-α, interleukin (IL)-6, and IL-1β. In addition, EK100 significantly reduced hepatic mRNA levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2, as well as nitrite production and iNOS gene expression in both hepatocyte and macrophage cell lines. We demonstrated that EK100 exhibits potent protection against hepatic IR injury, which may be used to design strategies to ameliorate liver damage during liver surgery.
Calculating Method Study and Parameter Analysis of Slender LCFST Columns Under Axial Loading
Ting Zhou,Ziyang Ren,Baoqi Jiang,Minyang Xu,Zhiyong Lei,Zhi-Hua Chen 한국강구조학회 2019 International Journal of Steel Structures Vol.19 No.5
L-shaped columns composed of concrete-fi lled steel tubes (LCFST columns) connected by steel plates, which are important component to make sure the mono-column working together, were investigated under axial loading experiment with diff erent width and thickness of connection plates. The relationships between load and longitudinal displacement, lateral displacement, longitudinal strains and transverse strains as well as failure mode are presented. Load carrying capacity of LCFST columns increased with the width and thickness of the connection plates increasing. In addition, the integrity of the specimen was improved with increase of thickness and decrease of width of the connection plates. Failure modes obtained from the fi nite element model were consistent with the phenomenon observed in the test. Besides, the parameters of slenderness ratio, dimensions of connection plate, and transverse stiff ener spacing were analyzed. Finally, the calculating method of yield bearing capacity of axial compression was proposed based on the former analysis.
Experimental Study on Fire Resistance Performance of Concrete-Filled Steel Plate Composite Walls
Ting Zhou,Xueshan Liu,Hongbo Liu,Yixuan Li,Pengfei Zhang,Huazhou Chen,Zhi-Hua Chen 한국강구조학회 2023 International Journal of Steel Structures Vol.23 No.2
Concrete-filled steel plate composite walls are increasingly used in high-rise buildings; their mechanical properties at room temperature have produced fruitful results. However, research on their mechanical properties in fire and at high temperatures is scarce. Moreover, published studies on the fire resistance of concrete-filled steel plate composite walls have not considered the impact of fire protection measures. Based on previous fire resistance research, a fire resistance test was designed in this study for four walls under the combined action of axial compression and a single-sided fire under the ISO-834 standard heating curve. Apart from that, the existing fire protections have the disadvantages of too thick, easy falling off and cracking or difficult to install. In order to eliminate the disadvantages of existing fire prevention measures, new composite fireproof structure using a rock wool board and a thin fire-retardant coating is proposed. The effects of no fireproof structures, autoclaved lightweight concrete plate fireproof structures, thick-coated fire-retardant structures, and new composite fireproof structures on the fire resistance of concrete-filled steel plate composite walls were studied experimentally. The results show that the fire resistance of the four test specimens meets the 3 h fire resistance limit of the primary load-bearing component in the specification. Based on the experimental results, reasonable fire protection methods are suggested for concrete-filled steel plate composite walls in actual projects, and an experimental basis is provided for further numerical simulation.