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Irbesartan과 Lercanidipine의 병용요법이 고혈압 및 혈관재형성에 미치는 효과
이도형, 임태완, 조은지, 박현수, 정상혁, 한주희, 병창선 충남대학교 약학대학 의약품개발연구소 2017 藥學論文集 Vol.32 No.-
Hypertension is one of the major risk factor for cardiovascular disease and can lead to or make worse many complications, heart disease, atherosclerosis and diabetes. Thus, managing blood pressure effec tively using therapeutic drugs such as angiotensin II receptor blocker (ARB) and Ca2+ channel blocker (CCB) can be prevent other complications. Therefore, we investigated the synergistic effect of these two drugs, ir besartan and lercanidipine, for antihypertension, cardioprotection and antidiabetes. Irbesartan (28.74 mg/kg, 14.37 mg/kg) or lercanidipine (1.92 mg/kg, 0.96 mg/kg) alone or combination was administered to sponta-neously hypertensive rats (SHRs) and C57BL/6 mice. A two-week treatment of combination with irbesartan and lercanidipine significantly attenuated systolic blood pressure (SBP) and mean arterial pressure (MAP) compared with monotherapy. Futhermore. the combination therapy protected myocardial ischemia reperfusion injury more effectively than monotherapy. In vascular remodeling, combination therapy significantly diminished cuff -induced neointima formation and reduced serum -indllced vascular smooth muscle cells (VSMCs) pro-liferation compared with monotherapy. However, combination therapy had no significant synergistic effect of blood glucose regulation. Taken together, present study suggest that the combination therapy of irbesartan and lercanidipine may be more effective therapeutic strategy for the treatment of hypertension and related complications, myocardial infarction and arterial restenosis than monotherapy
최창주,서강성,박수강,조금배,백형래,임병옥 조선대학교 에너지.자원신기술연구소 2002 에너지·자원신기술연구소 논문지 Vol.24 No.2
Single phase induction motor(SPIM) is one of the most widely used type of low power AC motors in the world, especially for domestic or commercial applications where a three phase power supply is not available. Fractional horse power single phase induction motors have no starting torque their own. So there are several ways of starting single phase induction motors. The most common type is the starting capacitor installed in series with the auxiliary winding to increase the starting torque. Also, the auxiliary winding is disconnected once the speed of the motor reaches 70 to 80% of the rated speed. In the conventional systems, this function is conducted by a centrifugal switch. But the mechanical centrifugal switch has many problems such as switch malfunction. This paper presents the new methods of universal starting switch by digital controller to overcome these shortcomings of centrifugal switch.
위암수술 환자에서의 cp 개발과 cp적용에 따른 질 향상 활동에 관한 연구
임은주,황순휘,박도중,하광일,배현주,김형호 한국의료QA학회 2006 한국의료질향상학회지 Vol.13 No.2
Background : In an era of increasing medical costs, safe reduction in postoperative stay has become a major focus to optimize utilization of healthcare resources. The authors aimed to evaluate the clinical significance of the critical pathway(CP) for gastrectomy patients by implementing standardized postoperative management and electronic medical records. Method : From August 2006 to April 2007, critical pathways were introduced to inpatients and outpatients with gastric cancer. 60 consecutive patients undergoing distal gastrectomy were randomly divided into two groups; 30 CP group(A) and 30 non-CP group(B). Simultaneously, we also retrospectively reviewed the records of 438 patients(C:control group) who were able to be enrolled in CP program. We compared group(A) with (B), (C) in terms of hospital stay, complication rate, use of antibiotics and hospital costs. Patient satisfaction was surveyed by questionnaires. Result : There was no significant demographic difference between group(A) and (B). Of 30 patients in group(A), 5 drop-outs and 14 variances occurred. The mean postoperative hospital stays(Laparoscopy-assisted distal gastrectomy: LADG/Open distal gastrectomy: ODG) were 7.6/10.5 days for the group(A), 8.9/12.7 days for the group(B) and 12.6/14.5 days for the group(C) (p=0.02 in LADG). The total hospital cost of group(A) had a tendency to be less than that of group(B) and the amount of hospital cost per day in group(A) was significantly higher than that in group(B). The usage rates of the first generation antibiotics were 73.33%, 63.33%, and 59.2% in group(A), (B), and (C), respectively. Patients’ satisfaction had a tendency to be higher in the CP group than non-CP group. Conclusion : The mean hospital stay in LADG patients was shortened meaningfully and hospital cost per day was enlarged after introduction of clinical pathway. It is necessary to apply a number of patients to the critical pathway and to make an effort to reduce the variation and drop-out rates.
이경태,임형주,김상욱 강원대학교 정보통신연구소 2002 정보통신논문지 Vol.6 No.-
Radiologic images are widely used in hospitals for diagnosing and treating patients' diseases. The radiologist accurately reads radiologic images, and thus helps diagnose patients correctly. The number of radiologists is much smaller than is necessary, however. In some small or rural hospitals, there are no radiologists residing there. In these cases, correct diagnosis and treatment are infeasible. Also, radiologists are not resident at hospitals all day long[1][2][3]. Thus, emergency patients would suffer from the absence of radiologists at night. XRay21 Inc. and Data & Knowledge Engineering Lab. at Kang won National University have been working together since 2000 in order to alleviate the problems above. Currently, the advances of the computer and network technology make it possible to connect a lot of radiologists and hospitals together through the Internet. By fully utilizing the Internet environment, we have developed a telemedicine system, thus permitting remote diagnosis of radiologic images. This paper presents the technical experiences obtained in developing the system.
최성용,이주형,임홍범,윤경구 강원대학교 산업기술연구소 2003 産業技術硏究 Vol.23 No.A
The properties of mechanics and durability of LMC have been performed actively. However. little studies on analysis and properties of thermal expansion has been on the temperature variation. Especially. the low of bonding strength and tensile cracking are caused by difference of thermal expansion between LMC and the substrate concrete Therefore, this study focused on effect of thermal expansion behavior and properties of LMC according to temperature variation. To identify the property of thermal expansion of LMC. tests of modulus of thermal expansion were carried out at 28 days after casting specimen. subjected to temperature variation between 10℃ and 60℃ The results of this study showed the modulus of elastic of LMC was similar to that of ordinary portland concrete(OPC) It means that stresses caused by difference of modulus of elastic did not occur on interface between LMC and existing concrete The modulus of thermal expansion of LMC had a little smaller than that of OPC The modulus of thermal expansion of polymer modified concrete is generally larger than OPC. but the result of this test IS disagree with the fact. which may be due to the humidity evaporation difference and aggregate properties
대퇴박근 근피판을 이용한 Fournier's gangrene치험례
이석기,이종원,이형주,임풍 大韓成形外科學會 1991 Archives of Plastic Surgery Vol.18 No.1
Fournier's gangrene is a progressive tissue necrosis of scrotum, this disease commonly occured in alcoholics and diabetic patients. 60 year old patient shows toxic symptom and even sepsis, but the scrotal content is to be spared. The treatment of this disease is adequate debridement and administration of sensitive antibiotics. If the scrotal content is exposed, the defect can be covered with skin graft, local flap, etc. But, when the scrotum shows marked fibrosis or inflammation, myocutaneous flap is inevitable. We experienced one case of scrotal defect due to Fournier's gangrene, which was successfully covered with gracilis myocutaneous flap.
Joo, Hyung Joon,Cho, Sang-A,Cho, Jae-Young,Lee, Seunghun,Park, Jae Hyung,Yu, Cheol Woong,Hong, Soon Jun,Lim, Do-Sun Human Kinetics 2017 Journal of physical activity & health Vol.14 No.9
<B>Background:</B><P>Although the relationship between physical activity and arterial stiffness has been shown in healthy persons, it remains controversial in obese persons.</P><B>Methods:</B><P>From January 2014 to September 2014, we evaluated 795 obese subjects from 25 public health centers in Seoul, Korea. We compared physical activity and brachial-ankle pulse wave velocity (baPWV) between obese subjects with metabolic syndrome (MetS) (MO) and obese subjects without MetS (NMO).</P><B>Results:</B><P>The MO group had more men, higher body mass index (BMI), higher fasting glucose level, lower high-density lipoprotein-cholesterol level, and higher triglyceride level. The mean physical activity levels were similar between the 2 groups. baPWV was higher in the MO group than the NMO group. MO group showed positive correlation between baPWV and physical activity (<I>P</I>trend = 0.04). Interestingly, baPWV was significantly higher in the MO group than in the NMO group in subjects with moderate and vigorous physical activity (1403.4 cm/sec vs 1349 cm/sec [95% CI 21.4 to 87.4], <I>P</I> < .05). Multivariate regression analysis demonstrated that brachial-ankle pulse wave velocity was apparently associated with age, BMI, blood pressure, and glucose level.</P><B>Conclusions:</B><P>In a community-based population, baPWV was higher in obese MetS group compared with obese non-MetS group. Physical activity showed different association with baPWV depending on metabolic status.</P>