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Jiang, Lili,Zhang, Xiaolei,Choo, Kwang-Ho Elsevier 2018 Separation and purification technology Vol.198 No.-
<P><B>Abstract</B></P> <P>This study investigated the performance of a membrane photocatalytic reactor (MPR) with respect to the removal of bacteria from secondary effluents. The MPR achieved disinfection through several mechanisms: rejection by a membrane, inactivation by direct UV radiation, adsorption onto photocatalysts, and oxidation by reactive oxygen species. Bacterial removal by the MPR reached a maximum at a TiO<SUB>2</SUB> dose of 1.0g/L, with the TiO<SUB>2</SUB> dose ranging between 0 and 5g/L. The optimal TiO<SUB>2</SUB> dose for bacterial removal appeared to be the result of the trade-off between accelerated catalytic reactions and the light obstruction by surplus catalysts. Continuous aeration required for membrane fouling control had a negative impact on bacterial removal. Although intermittent backpulsing reduced bacterial removal, its impact was not as significant as that of continuous aeration. Backpulsing frequencies and durations did not play a significant role, but the dynamic cake layer formed on the membrane was responsible for the bactericidal behavior. An increase in membrane flux deteriorated the bacterial removal performance because it resulted in shorter reaction times, even though the formation of a thicker cake layer was possible at higher fluxes. The MPR can guarantee >2.5 log removal in total bacterial count, given that the right conditions are maintained. This is significantly larger than the removal achieved by microfiltration alone (ca. 0.5 log removal).</P> <P><B>Highlights</B></P> <P> <UL> <LI> The membrane photocatalytic reactor was investigated for bacterial inactivation. </LI> <LI> A hybrid of photocatalysis and microfiltration ensures >2.5 log bacterial removal. </LI> <LI> TiO<SUB>2</SUB> mediated reaction and adsorption played a key role in bactericidal behavior. </LI> <LI> Surplus TiO<SUB>2</SUB> dose reduced the disinfection efficiency due to light obstruction. </LI> <LI> Proper membrane operation is required for sustainable bacterial rejection. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Jiang Liu,Rong Xu,Xiaolei He,Reyina Wufuli,Ying Su,Lili Ma,Ru Chen,Zhongcheng Han,Fang Wang 대한위암학회 2019 Journal of gastric cancer Vol.19 No.4
Purpose: To study the efficacy of capecitabine or S-1 plus oxaliplatin (CAPOX or SOX) for treating thymidine phosphorylase (TP)- or dihydropyrimidine dehydrogenase (DPD)-positive advanced gastric cancer. Materials and Methods: Eighty-six patients with stage IIIC to IV gastric cancer were assessed for TP and DPD expression by immunohistochemistry. The association between CAPOX or SOX efficacy and TP/DPD expression was retrospectively analyzed. Results: There were no significant differences in the objective remission rate (ORR, 52.27% vs. 47.62%; P>0.05), disease control rate (72.73% vs. 73.81%, P>0.05), progression-free survival (hazard ratio [HR], 1.119; 95% confidence interval [CI], 0.739–1.741; P=0.586), and overall survival (OS; HR, 0.855; 95% CI, 0.481–1.511; P=0.588) between CAPOX and SOX. A higher number of stage IV patients showed TP positivity, while DPD-positive patients predominantly showed intestinal type of gastric cancer. In TP-positive patients, the ORRs associated with CAPOX and SOX treatments were 57.14% and 38.10%, respectively; OS was better with CAPOX than with SOX (HR, 0.447; 95% CI, 0.179–0.978; P=0.046). Among DPD-positive patients, the SOX treatment-associated ORR (60.87%) was significantly higher than the CAPOX treatment-associated ORR (43.48%). Furthermore, SOX treatment resulted in better OS than did CAPOX treatment (HR, 2.020; 95% CI, 1.019–4.837; P=0.049). Conclusions: No significant difference in clinical efficacy was found between CAPOX and SOX. TP-positive patients might respond better to CAPOX while DPD-positive patients may respond better to SOX. Our findings might serve as a guide for personalized chemotherapy for gastric cancer.
Antitumor and Immunomodulating Activity of Polysaccharides from Enteromorpha intestinalis
Lili Jiao,Liping Zhang,Peng Jiang,Mingjiang Wu 한국생물공학회 2010 Biotechnology and Bioprocess Engineering Vol.15 No.3
Two polysaccharides (WEA and WEB) were isolated from Enteromorpha intestinalis by hot water extraction, anion-exchange, and gel-permeation chromatography. The average molecular weights (Mw) of the two fractions were 72.03 kDa (WEA) and 60.12 kDa (WEB). WEA was composed of Rha, Xyl, Man, and Glc in a molar ratio of 1.39:1.00:0.13:3.23. WEB consisted of Rha, Xyl,Gal, and GlcA (glucuronic acid) in a molar ratio of 7.32:1.00:0.51:1.28. Both polysaccharides could inhibit tumor growth in S180 tumor-bearing mice, and increased the relative spleen and thymus weight. They also increased the expression of tumor necrosis factor-alpha (TNF-α) in serum. WEA and WEB induced lymphocyte proliferation,increased the production of TNF-α in macrophages, and stimulated macrophages to produce nitric oxide dosedependently through the up-regulation of inducible NO synthase activity. However, no direct cytotoxicity against Sarcoma 180 was investigated in vitro. These results indicate that the antitumor effects of these polysaccharides are associated with immunostimulation.
Lili Li,Yaoyao Liu,Lunhong Ai,Jing Jiang 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.70 No.-
The porous CuO architectures have been successfully synthesize by the effective transformation of aCu-BTC metal-organic frameworks (MOFs) through a facile heating treatment. The as-synthesized porousCuO architectures exhibit high electrocatalytic activity toward the glucose oxidation. When evaluated asa nonenzymatic glucose biosensor, the porous CuO architectures manifest fast response within 1.3 s, widelinear range from 0.5 mM to 2.8 mM, low detection limit of 0.1 mM (signal-to-noise ratio of 3), highsensitivity up to 934.2 mA mM 1cm 2 as well as favorable reproducibility.
Distortional Buckling Analysis of I-Steel Concrete Composite Beams Subjected to Hogging Moment
Lili Liu,Lizhong Jiang,Chun-dan Li,Wang-Bao Zhou,Lei-xin Nie 한국강구조학회 2022 International Journal of Steel Structures Vol.22 No.3
Bending-torsional distortion buckling is one of the most critical buckling modes of steel–concrete composite beams when they are working under hogging moment. The rotational and lateral restraint stiff ness provided by the steel web to the steel bottom fl ange are the key factors to determine this form of buckling. Firstly, the formula for solving the elastic rotational restraint stiff ness of the composite fl ange of steel beam upper fl ange and concrete slab to the steel web is derived. Then, the equivalent lateral and rotational restraint stiff ness of the steel bottom fl ange subjected to hogging moment are thoroughly studied. Considering the rotation restraint eff ect of the composite fl ange, this paper provides the calculation formula for the critical bending moment of I-steel concrete composite beams (I-SCCB) under hogging moment. Fifteen examples are considered to calculate the critical bending moment of the I-SCCB under hogging moment with the simplifi ed analytical method introduced in this paper. The results are compared with the ones derived by ANSYS numerical analyses and relevant research of other scholars. The infl uence of the arrangement of the shear studs on the critical bending moment of the I-SCCB is investigated. It is concluded that the results given by the simplifi ed analytical method are in good agreement with the ones obtained by the ANSYS fi nite element numerical method. Both methods show that the critical load of the distortional buckling of the I-SCCB under hogging moment is less aff ected by the member’s length. The critical bending moment of distortional buckling of the I-SCCB signifi cantly increases with the presence of shear studs. However, once shear studs are used, it tends to be stable with the increase of equivalent restrained torsional rotational stiff ness at the top edge of the steel web.
( Lili Tian ),( Xinliang Wu ),( Hangqian Yu ),( Fengying Yang ),( Jian Sun ),( Tiezhong Zhou ),( Hong Jiang ) 한국미생물생명공학회 2022 Journal of microbiology and biotechnology Vol.32 No.10
The rise of methicillin-resistant Staphylococcus aureus (MRSA) has resulted in significant morbidity and mortality, and clinical treatment of MRSA infections has become extremely difficult. Sortase A (SrtA), a virulence determinant that anchors numerous virulence-related proteins to the cell wall, is a prime druggable target against S. aureus infection due to its crucial role in the pathogenicity of S. aureus. Here, we demonstrate that isovitexin, an active ingredient derived from a variety of traditional Chinese medicines, can reversibly inhibit SrtA activity in vitro with a low dose (IC<sub>50</sub>=24.72 μg/ml). Fluorescence quenching and molecular simulations proved the interaction between isovitexin and SrtA. Subsequent point mutation experiments further confirmed that the critical amino acid positions for SrtA binding to isovitexin were Ala-92, Ile-182, and Trp-197. In addition, isovitexin treatment dramatically reduced S. aureus invasion of A549 cells. This study shows that treatment with isovitexin could alleviate pathological injury and prolong the life span of mice in an S. aureus pneumonia model. According to our research, isovitexin represents a promising lead molecule for the creation of anti-S. aureus medicines or adjuncts.
Photocatalytic oxidation of gas-phase Hg0 by carbon spheres supported visible-light-driven CuO–TiO2
Jiang Wu,Chaoen Li,Xiantuo Chen,Jing Zhang,Lili Zhao,Tianfang Huang,Tao Hu,Chong Zhang,Bu Ni,Xiao Zhou,Pankun Liang,Wenbo Zhang 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.46 No.-
A simplified approach for the fabrication of CuO/TiO2@C is demonstrated. In this study, low cost CuO/TiO2@C photocatalysts (CSs loading 0.25–2 wt.%) were prepared, characterized and evaluated for gasphaseHg0 oxidation. The obtained CuO/TiO2@C photocatalysts were used to remove gaseous elementalmercury under UV light and LED respectively, and the optimum doping of content of CSs was determined. The results showed that the CuO/TiO2@C photocatalysts were highly efficient in oxidizing Hg0, reachingabove 64% when the CSs doping reached 0.5 wt.%. We have proposed that the probable mechanism bywhich CuO/TiO2@C photocatalysts remove gaseous elemental mercury: with CSs doping, CSs can act assensitizer and transfer electrons to the semiconductors, triggering the formation of very reactive radicalsto improve photocatalytic efficiency.