Microstructure and property evolution of diamond-like carbon films co-doped by Al and Ti with different ratios

Zhou, Yong,Guo, Peng,Sun, Lili,Liu, Linlin,Xu, Xiaowei,Li, Wenxian,Li, Xiaowei,Lee, Kwang-Ryeol,Wang, Aiying Elsevier Sequoia 2019 Surface & coatings technology Vol.361 No.-

<P><B>Abstract</B></P> <P>Diamond-like carbon (DLC) films with weak carbide metal Al and carbide metal Ti co-doping (Al/Ti-DLC) were prepared by a hybrid ion beam deposition system. The atomic ratios of doped Al to Ti were tailored via designing the special Al/Ti combined sputtering target. The composition, microstructure, roughness, residual stress, hardness, toughness, and tribological behaviors of the deposited films were systematically evaluated to explore the dependence of structural properties on Al/Ti ratios. Results indicated that the high-throughput preparation of DLC films with different Al/Ti atomic ratios was achieved by tailoring the sputtering target and process parameters without the difference in both the film thickness and total Al/Ti content. With the Al/Ti ratios in the films decreased from 8.8 to 3.0, the residual stress, hardness, and toughness of Al/Ti-DLC films increased obviously, originating from the increased fraction of titanium carbide and the reduced Al content. However, the coefficient of friction and wear rate with decreasing the Al/Ti ratio were obviously improved, which was related with the transformation of underlying friction mechanism from the sliding interface graphitization to dangling bond-passivation. The present results not only suggest a high-throughput method to fabricate co-doped DLC films, but also promote the scientific understanding and engineering application of DLC films with high performance.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Ti/Al co-doped diamond-like carbon films were fabricated by a hybrid ion beam method. </LI> <LI> Different Al/Ti ratios were successfully achieved at one time using designed target. </LI> <LI> Al/Ti ratios had no effect on the chemical state of co-doped Ti and Al atoms. </LI> <LI> The mechanical and tribological properties were strongly dependent on Ti/Al ratios. </LI> <LI> Different friction mechanisms were observed with Al/Ti ratios ranged from 8.8 to 3.0. </LI> </UL> </P>

USP15 inhibits multiple myeloma cell apoptosis through activating a feedback loop with the transcription factor NF-κBp65

Lili Zhou,Hua Jiang,Juan Du,Lu Li,Rong Li,Jing Lu,Weijun Fu,Jian Hou 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-

USP15 has been shown to stabilize transcription factors, to be amplified in many cancers and to mediate cancer cell survival. However, the underlying mechanism by which USP15 regulates multiple myeloma (MM) cell proliferation and apoptosis has not been established. Here, our results showed that USP15 mRNA expression was upregulated in MM patients. USP15 silencing induced MM cell proliferation inhibition, apoptosis, and the expression of nuclear and cytoplasmic NF-κBp65, while USP15 overexpression exhibited an inverse effect. Moreover, in vivo experiments indicated that USP15 silencing inhibited MM tumor growth and NF-κBp65 expression. PDTC treatment significantly inhibited USP15 overexpression-induced cell proliferation, apoptosis inhibition, and NF-κBp65 expression. USP15 overexpression promoted NF-κBp65 expression through inhibition of its ubiquitination, whereas NF-κBp65 promoted USP15 expression as a positive regulator. Taken together, the USP15-NF-κBp65 loop is involved in MM tumorigenesis and may be a potential therapeutic target for MM.

Deep learning-based sensor fault detection using S-Long Short Term Memory Networks

Li, Lili,Liu, Gang,Zhang, Liangliang,Li, Qing Techno-Press 2018 Structural monitoring and maintenance Vol.5 No.1

A number of sensing techniques have been implemented for detecting defects in civil infrastructures instead of onsite human inspections in structural health monitoring. However, the issue of faults in sensors has not received much attention. This issue may lead to incorrect interpretation of data and false alarms. To overcome these challenges, this article presents a deep learning-based method with a new architecture of Stateful Long Short Term Memory Neural Networks (S-LSTM NN) for detecting sensor fault without going into details of the fault features. As LSTMs are capable of learning data features automatically, and the proposed method works without an accurate mathematical model. The detection of four types of sensor faults are studied in this paper. Non-stationary acceleration responses of a three-span continuous bridge when under operational conditions are studied. A deep network model is applied to the measured bridge data with estimation to detect the sensor fault. Another set of sensor output data is used to supervise the network parameters and backpropagation algorithm to fine tune the parameters to establish a deep self-coding network model. The response residuals between the true value and the predicted value of the deep S-LSTM network was statistically analyzed to determine the fault threshold of sensor. Experimental study with a cable-stayed bridge further indicated that the proposed method is robust in the detection of the sensor fault.

A Simulated Culture? : Cultural Learning Impact of the One-day Study Tour

Li-Jiuan Lilie Tsay,An-Wen Deng,Su-Yuan Lien 세계문화관광학회 2008 International Journal of Culture and tourism Resea Vol.1 No.1

One-day study tour in Taiwan began its establishment in early 2007, inspired by the An-San English Village in Seoul, in order to help students learn English quickly and efficiently. Different situational classrooms, such as a clinic, a hotel, a travel agency etc., are set up and manned with native teachers to teach students appropriate conversations accordingly. The main ideas of setting up such an English immersion program are to provide students with enough exposure to an English speaking environment and the culture related. In language learning, culture is one of the key elements which often determine students' learning interest and therefore cannot be neglected. In this study, based on the previous literature research, a model which suggests the relationships among learners' English ability (EA), learning interest (LI) and the situational classroom teaching (SCT) is discussed and explored. The purpose of the study is to investigate whether the simulated culture in different classroom settings could enhance students' English ability and their learning interest through the examination of the model suggested.

Serial Frozen Fecal Microbiota Transplantation in the Treatment of Chronic Intestinal Pseudo-obstruction: A Preliminary Study

( Lili Gu ),( Chao Ding ),( Hongliang Tian ),( Bo Yang ),( Xuelei Zhang ),( Yue Hua ),( Yifan Zhu ),( Jianfeng Gong ),( Weiming Zhu ),( Jieshou Li ),( Ning Li ) 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2017 Journal of Neurogastroenterology and Motility (JNM Vol.23 No.2

Background/Aims Chronic intestinal pseudo-obstruction (CIPO) is a serious, life-threatening motility disorder that is often related to bacterial overgrowth. Fecal microbiota transplantation (FMT) results in restoration of the normal intestinal microbial community structure. We investigated the efficacy of FMT in the treatment of CIPO patients. Methods Nine patients (age 18-53 years) with CIPO were enrolled in this prospective, open-label study. Patients received FMT for 6 consecutive days through nasojejunal (NJ) tubes and were followed up for 8 weeks after treatment. We evaluated the rate of clinical improvement and remission, feeding tolerance of enteral nutrition, and CT imaging scores of intestinal obstructions. Lactulose hydrogen breath tests were performed before FMT and 8 weeks after FMT to evaluate for the presence small intestinal bacterial overgrowth (SIBO). Results FMT significantly alleviated bloating symptoms, and symptoms of pain were relieved 2 weeks after FMT. Enteral nutrition administered through a NJ tube after FMT was well-tolerated by 66.7% (6/9) of patients. CT scores of intestinal obstructions were significantly reduced after FMT (P = 0.014). SIBO was eliminated in 71.0% (5/7) of patients. Conclusions This pilot study demonstrated the safety of using FMT. FMT may relieve symptoms in selected patients with CIPO. FMT may also improve patient tolerance of enteral nutrition delivered via a NJ tube. (J Neurogastroenterol Motil 2017;23:289-297)

Development of High-Current Sheet Beam Cathodes for Terahertz Sources

Lili Li,Yiman Wang,Wei Liu,Yanchun Wang,Jinshu Wang,Srivastava, A.,Jin-Kyu So,Gun-Sik Park IEEE 2009 IEEE transactions on electron devices Vol.56 No.5

<P>Generation of a sheet beam directly from a scandia-doped dispenser cathode has been investigated and optimized by means of beam-profile simulations and measurements. Rectangular beams 600 mum wide and 100 mum thick with current densities over 50 A/cm<SUP>2</SUP> have been generated. The beams are stable for at least several hundred hours with the cathodes operating at 950degC<SUB>b</SUB>, making them promising candidates for application in the next generation of terahertz vacuum electron devices such as a 0.5-THz superradiant Smith-Purcell radiation source.</P>

Synthesis of the crystalline porous copper oxide architectures derived from metal-organic framework for electrocatalytic oxidation and sensitive detection of glucose

Lili Li,Yaoyao Liu,Lunhong Ai,Jing Jiang 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.70 No.-

The porous CuO architectures have been successfully synthesize by the effective transformation of aCu-BTC metal-organic frameworks (MOFs) through a facile heating treatment. The as-synthesized porousCuO architectures exhibit high electrocatalytic activity toward the glucose oxidation. When evaluated asa nonenzymatic glucose biosensor, the porous CuO architectures manifest fast response within 1.3 s, widelinear range from 0.5 mM to 2.8 mM, low detection limit of 0.1 mM (signal-to-noise ratio of 3), highsensitivity up to 934.2 mA mM 1cm 2 as well as favorable reproducibility.

Choline supplementation improves the lipid metabolism of intrauterine-growth-restricted pigs

Li, Wei,Li, Bo,Lv, Jiaqi,Dong, Li,Zhang, Lili,Wang, Tian Asian Australasian Association of Animal Productio 2018 Animal Bioscience Vol.31 No.5

Objective: The objective of this study was to investigate the effects of dietary choline supplementation on hepatic lipid metabolism and gene expression in finishing pigs with intrauterine growth retardation (IUGR). Methods: Using a $2{\times}2$ factorial design, eight normal birth weight (NBW) and eight IUGR weaned pigs were fed either a basal diet (NBW pigs fed a basal diet, NC; IUGR pigs fed a basal diet, IC) or a diet supplemented with two times more choline than the basal diet (NBW pigs fed a high-choline diet, NH; IUGR pigs fed a high-choline diet, IH) until 200 d of age. Results: The results showed that the IUGR pigs had reduced body weight compared with the NBW pigs (p<0.05 from birth to d 120; p = 0.07 from d 120 to 200). Increased (p<0.05) free fatty acid (FFA) and triglyceride levels were observed in the IUGR pigs compared with the NBW pigs. Choline supplementation decreased (p<0.05) the levels of FFAs and triglycerides in the serum of the pigs. The activities of malate dehydrogenase and glucose 6-phosphate dehydrogenase were both increased (p<0.05) in the livers of the IUGR pigs. Choline supplementation decreased (p<0.05) malate dehydrogenase activity in the liver of the pigs. Gene expression of fatty acid synthase (FAS) was higher (p<0.05) in the IC group than in the other groups, and choline supplementation decreased (p<0.05) FAS and acetyl-CoA carboxylase ${\alpha}$ expression in the livers of the IUGR pigs. The expression of carnitine palmitoyl transferase 1A (CPT1A) was lower (p<0.05) in the IC group than in the other groups, and choline supplementation increased (p<0.05) the expression of CPT1A in the liver of the IUGR pigs and decreased (p<0.01) the expression of hormone-sensitive lipase in both types of pigs. The gene expression of phosphatidylethanolamine N-methyltransferase (PEMT) was higher (p<0.05) in the IC group than in the other groups, and choline supplementation significantly reduced (p<0.05) PEMT expression in the liver of the IUGR pigs. Conclusion: In conclusion, the lipid metabolism was abnormal in IUGR pigs, but the IUGR pigs consuming twice the normal level of choline had improved circulating lipid parameters, which could be related to the decreased activity of nicotinamide adenine dinucleotide phosphate-generating enzymes or the altered expressions of lipid metabolism-related genes.

ESTIMATING THE DOMAIN OF ATTRACTION VIA MOMENT MATRICES

Li, Chunji,Ryoo, Cheon-Seoung,Li, Ning,Cao, Lili Korean Mathematical Society 2009 대한수학회보 Vol.46 No.6

The domain of attraction of a nonlinear differential equations is the region of initial points of solution tending to the equilibrium points of the systems as the time going. Determining the domain of attraction is one of the most important problems to investigate nonlinear dynamical systems. In this article, we first present two algorithms to determine the domain of attraction by using the moment matrices. In addition, as an application we consider a class of SIRS infection model and discuss asymptotical stability by Lyapunov method, and also estimate the domain of attraction by using the algorithms.

Culture in a Day?

Li-Jiuan Lilie Tsay,Ruei King 세계문화관광학회 2008 Conference Proceedings Vol.9 No.0

Exposure to English culture and an authentic English speaking environment has always been regarded as one of the key elements to successful English language teaming. As a result, an increasing number of students go to English speaking countries to learn thc language as well as to explore the culture. For those who cannot afford the high tuition fees abroad, the parents of the students try all means to send their children to bilingual primary schools. In order to resolve this problem, and inspired by the An-San English Village in Seoul, Taiwan launched its "one-day study tour"English learning program in 2007. Different situational classrooms, such as airport customs, a hotel, a restaurant etc., are set up and manned with native speakers to teach students appropriate conversations within those scenarios. With the aim of providing an authentic English speaking environment and cultural settings, the learning results are expected to be boosted to optimum levels. The following questions therefore arise; what are the learning impacts of the one-day study tour upon the improvements of students' English abilities and levels of learning interest? Can culture and language be taught and learned in one day? The purposes of this research are to find out the answers to these questions through the analysis of 561 questionnaires from the students.