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RISS 인기검색어
- 검색키워드
- 저자 : Lifei Hou (검색결과 3 건)
- 무료
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- 유료
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Wang, Chong-Zhi,Hou, Lifei,Wan, Jin-Yi,Yao, Haiqiang,Yuan, Jinbin,Zeng, Jinxiang,Park, Chan Woong,Kim, Su Hwan,Seo, Dae Bang,Shin, Kwang-Soon,Zhang, Chun-Feng,Chen, Lina,Zhang, Qi-Hui,Liu, Zhi,Sava-Se The Korean Society of Ginseng 2020 Journal of Ginseng Research Vol.44 No.2
Background: Ginseng is a commonly used herbal medicine in treating various medical conditions. Chronic gut inflammation is a recognized factor for the development of colorectal cancer (CRC). In this project, Asian ginseng berry polysaccharide preparations were used to assess their effects on CRC and related immune regulation mechanisms. Methods: Ginseng berry polysaccharide extract (GBPE) and purified ginseng berry polysaccharide portion (GBPP) were used to evaluate their activities on human HCT-116 and HT-29 CRC cell proliferation. Interleukin-8 secretion analysis was performed on HT-29 cells. Naive CD4 cell isolation and T-helper cell differentiation were performed and determined using flow cytometry for Th1 and Treg in addition to cell cycle and apoptotic investigation. Results: GBPE and GBPP significantly inhibited interleukin-8 secretion and cancer cell proliferation, inhibited CD4<sup>+</sup>IFN-γ<sup>+</sup> cell (Th1) differentiation, and decreased CD4<sup>+</sup>FoxP3<sup>+</sup> cell (Treg) differentiation. Compared to the GBPE, GBPP showed more potent antiinflammatory activities on the malignant cells. This is consistent with the observation that GBPP can also inhibit Th1-cell differentiation better, suggesting that it has an important role in antiinflammation, whereas Treg cells hinder the body's immune response against malignancies. Supported by cell cycle and apoptosis data, GBPE and GBPP, at various degrees, remarkably enhanced the anticancer activities of 5-fluorouracil. Conclusion: Data from this project suggested that Asian ginseng berry potentially has clinical utility in managing enteric inflammation and suppressing CRC through immunomodulation mechanisms.
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Chong-Zhi Wang,Lifei Hou,Jin-Yi Wan,Haiqiang Yao,Jinbin Yuan,Jinxiang Zeng,Chan Woong Park,Su Hwan Kim,Dae Bang Seo,Kwang-Soon Shin,Chun-Feng Zhang,Lina Chen,Qi-Hui Zhang,Zhi Liu,Clara Sava-Segal,Chun 고려인삼학회 2020 Journal of Ginseng Research Vol.44 No.2
Background: Ginseng is a commonly used herbal medicine in treating various medical conditions. Chronic gut inflammation is a recognized factor for the development of colorectal cancer (CRC). In thisproject, Asian ginseng berry polysaccharide preparations were used to assess their effects on CRC andrelated immune regulation mechanisms. Methods: Ginseng berry polysaccharide extract (GBPE) and purified ginseng berry polysaccharideportion (GBPP) were used to evaluate their activities on human HCT-116 and HT-29 CRC cell proliferation. Interleukin-8 secretion analysis was performed on HT-29 cells. Naive CD4 cell isolation and T-helper celldifferentiation were performed and determined using flow cytometry for Th1 and Treg in addition to cellcycle and apoptotic investigation. Results: GBPE and GBPP significantly inhibited interleukin-8 secretion and cancer cell proliferation,inhibited CD4þIFN-gþ cell (Th1) differentiation, and decreased CD4þFoxP3þ cell (Treg) differentiation. Compared to the GBPE, GBPP showed more potent antiinflammatory activities on the malignant cells. This is consistent with the observation that GBPP can also inhibit Th1-cell differentiation better, suggestingthat it has an important role in antiinflammation, whereas Treg cells hinder the body’s immuneresponse against malignancies. Supported by cell cycle and apoptosis data, GBPE and GBPP, at variousdegrees, remarkably enhanced the anticancer activities of 5-fluorouracil. Conclusion: Data from this project suggested that Asian ginseng berry potentially has clinical utility inmanaging enteric inflammation and suppressing CRC through immunomodulation mechanisms.
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Hua Zhang,Xiaoqing Bai,Minjian Hou,Lifei Wang,Qiang Zhang,Jianfeng Fan,Weiguo Li,Hongbiao Dong,Bingshe Xu 대한금속·재료학회 2019 METALS AND MATERIALS International Vol.25 No.5
Influence of pre-introducing {10–12} extension twins on compressive deformation behavior of AZ31Mg alloy at differenttemperature was investigated. The compression tests were conducted along the normal direction of AZ31Mg alloy at roomtemperature, 100 °C, 200 °C and 300 °C with a strain rate of 1 × 10−3 s−1. The results indicated that the pre-introducing{10–12} extension twins strongly affected the yield strength, the peak strength and the strain hardening rate at middle-lowtemperature (≤ 200 °C). The twinned samples containing pre-introducing {10–12} extension twins exhibited smaller yieldstrength and larger peak strength than the as-received samples without {10–12} extension twins at temperature ≤ 200 °C. Forthe as-received samples, the strain hardening rate decreased gradually at different temperature. While for the twinned samples,the strain hardening behavior exhibited three distinct stages at temperature ≤ 200 °C. When compressing at 300 °C, the asreceivedand twinned samples exhibited similar compression flow curves and strain hardening rate curves. The continuousdynamic recrystallization (CDRX) was the main dynamic recrystallization (DRX) mechanism in the as-received sample whencompressing at 200 °C. The twin assisted DRX besides CDRX was also initiated in the twinned sample when compressingat 200 °C. While the DRX mechanism was transformed into the discontinuous dynamic recrystallization (DDRX) in boththe as-received and twinned samples when compressing at 300 °C.
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