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- 저자 : Bingshe Xu (검색결과 3 건)
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Han, Bingshe,Wei, Wei,Hua, Fangyuan,Cao, Tingming,Dong, Hua,Yang, Tao,Yang, Yang,Pan, Huazhen,Xu, Caimin Korean Society for Biochemistry and Molecular Biol 2007 Journal of biochemistry and molecular biology Vol.40 No.2
Our previous study has shown that sodium selenite can cause apoptosis in acute promyelocytic leukemia-derived NB4 cells in a caspase-dependent manner, but the detailed mechanism is unknown. Here we demonstrate a requirement for extracellular signal-regulated protein kinase (ERK) in mediating sodium selenite -induced apoptosis in NB4 cell. Though no apparent elevation of ERK activity was observed during the apoptosis in NB4 cells caused by 20 μM sodium selenite treatment, PD98059 and U0126, specific chemical inhibitors of the MEK/ERK signaling pathway, were shown to strongly prevent the apoptosis process, while ERK activator TPA enhanced the process. It is also known that p38 MAPK inhibitor SB203580 and JNK inhibitor SP600125 had slight effects on apoptosis. Further study indicated that ERK exerted its proapoptotic effect only at the early stage of apoptosis and played an antiapoptotic role at the later stages. Taken together, our findings suggest that ERK plays an active role in mediating sodium seleniteinduced apoptosis in NB4 cells .
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Hao Yuying,Lei Junfeng,Fang Xiaohong,Fan Wenhao,Xu Bingshe 한국물리학회 2010 Current Applied Physics Vol.10 No.3
The studies on geometrical and electronic structure of electroplex (NPB+PBD-), which is formed by NPB+and PBD-, were carried out by simulation calculation. The calculation results indicate that the (NPB+PBD-) is formed efficiently when the positions of PBD- and NPB+ are appropriate. The (NPB+PBD-)is energetically favored compared to isolated ions NPB+ and PBD-. So the ionic state NPB+ and PBD- at the interface NPB/PBD inside organic light-emitting diode (OLED) tend to form electroplex. The analysis of geometrical structure data of the (NPB+PBD-) suggests that the electron transfer occurs from the PBD-side to the NPB+ side. The lowest unoccupied molecular orbital (LUMO) of (NPB+PBD-) is localized on the PBD- side and the highest occupied molecular orbital (HOMO) of (NPB+PBD-) on the NPB+ side. The energy gap of the (NPB+PBD-) is 1.61 eV, which approximately equals to the energy difference of 1.63 eV between the LUMO of PBD and the HOMO of NPB. The emission of electroplex is theoretically intermolecular optical transition from the LUMO of PBD to the HOMO of NPB. Because of little overlap probability between LUMOs of PBD and NPB at the NPB/PBD interface inside OLED, the exciplex of PBD and NPB is not efficiently produced.
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Hua Zhang,Xiaoqing Bai,Minjian Hou,Lifei Wang,Qiang Zhang,Jianfeng Fan,Weiguo Li,Hongbiao Dong,Bingshe Xu 대한금속·재료학회 2019 METALS AND MATERIALS International Vol.25 No.5
Influence of pre-introducing {10–12} extension twins on compressive deformation behavior of AZ31Mg alloy at differenttemperature was investigated. The compression tests were conducted along the normal direction of AZ31Mg alloy at roomtemperature, 100 °C, 200 °C and 300 °C with a strain rate of 1 × 10−3 s−1. The results indicated that the pre-introducing{10–12} extension twins strongly affected the yield strength, the peak strength and the strain hardening rate at middle-lowtemperature (≤ 200 °C). The twinned samples containing pre-introducing {10–12} extension twins exhibited smaller yieldstrength and larger peak strength than the as-received samples without {10–12} extension twins at temperature ≤ 200 °C. Forthe as-received samples, the strain hardening rate decreased gradually at different temperature. While for the twinned samples,the strain hardening behavior exhibited three distinct stages at temperature ≤ 200 °C. When compressing at 300 °C, the asreceivedand twinned samples exhibited similar compression flow curves and strain hardening rate curves. The continuousdynamic recrystallization (CDRX) was the main dynamic recrystallization (DRX) mechanism in the as-received sample whencompressing at 200 °C. The twin assisted DRX besides CDRX was also initiated in the twinned sample when compressingat 200 °C. While the DRX mechanism was transformed into the discontinuous dynamic recrystallization (DDRX) in boththe as-received and twinned samples when compressing at 300 °C.
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