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( Myung Jin Lee ),( Kye Hyung Kim ),( Jong Youn Yi ),( Su Jin Choi ),( Chung Jong Kim ),( Nak Hyun Kim ),( Kyoung Ho Song ),( Pyoeng Gyun Choi ),( Ji Hwan Bang ),( Wan Beom Park ),( Eu Suk Kim ),( San 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
In Vitro Antiviral Activity of Ribavirin Against Severe Fever with Thrombocytopenia Syndrome Virus Myung Jin LEE1, Kye-Hyung KIM1, Jongyoun YI2, SuJin CHOI1, Chung-Jong KIM1, Nak- Hyun KIM1, Kyoung-Ho SONG1, Pyoeng Gyun CHOI1, Ji-Hwan BANG1, Wan Beom PARK1, Eu Suk KIM1, Sang-Won PARK1, Hong Bin KIM1, Nam Joong KIM1, Myoung- Don OH1 Seoul National University College of Medicine, Korea1, Pusan National University School of Medicine, Korea2 Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel Bunyavirus, severe fever with thrombocytopenia syndrome virus (SFTSV). No effective antiviral therapy is proven yet, but clinical use of ribavirin (RBV) has been tried. We investigated the antiviral effect of RBV against SFTSV in vitro. Methods: To test for cytotoxicity of RBV, Vero cells were treated with different concentrations of RBV (3.90 to 500 μg/mL, two-fold dilution) and analyzed by cell viability MTS assay 48h post-infection. To determine antiviral activity of RBV against SFTSV, Vero cells were infected with SFTSV strain Gangwon/Korea/2012 at 100 TCID50 (50% tissue culture infective dose) per well in a 96-well plate, and RBV was added at the concentrations showing no or minimal cytotoxicity. Viral RNAs were extracted from the culture supernatants and quantifi ed using one-step real-time reverse transcription- PCR to amplify the partial large segment of SFTSV. Statistical analysis was done by one-way ANOVA with Tukey`s post hoc test. Results: Cytotoxicity due to RBV was not observed at RBV concentration =31.3 μg/ mL. Viral RNAs at 24h post-RBV treatment were reduced with increasing RBV concentrations (1-32 μg/mL), compared with those of mock-treated cells (P <0.01, Figure). Half maximal inhibitory concentration (IC50) of RBV was 3.69 μg/mL at 24h post-RBV treatment. Conclusions: Our study shows that RBV has antiviral effect against SFTSV in a dose-dependent manner. Further studies are required to evaluate the effi cacy of RBV in SFTS.
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이영섭,엄정현,김완진 서울産業大學校 2005 논문집 Vol.54 No.1
In the modern society, job stresses are the one of the causes of diseases related to the job, such as the cardiovascular diseases, the musculoskeletal diseases and so on. An investigation study of job stresses in the construction industry has not been conducted yet in Korea, even though job stresses are the causes of significant job-related diseases. An investigation study in the job stresses are carried out through questionaire and analyzed statistically with being Appeared by Stress Index. The Stress level is calculated by statistical analysis of each stressor through interrelationship between variables, The result of this study could be contributed to the control management of job stresses of construction industry with basic data for job stresses of work-related diseases.
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Jin-Yi Han3*, Xu Zi Guang, Jyung-Sik Kwak, Ki-Wan Oh, Han-Ik Bae 충북대학교 동물의학연구소 2012 Journal of Biomedical and Translational Research Vol.13 No.1
The anti-inflammatory effect of PHBV/Collagen (PHCP) was examined in a mouse model of lipopolysaccharide (LPS)-induced skin inflammation. Vascular permeability on the back skin was measured by the local accumulation of Evan’s blue dye after subcutaneous injection of LPS (30 μg site-1). Dye leakage in the skin showed a significant increase at 2 h after injection of LPS. This LPS-induced dye leakage was also completely inhibited by HO-1 inhibitor, ZnPP, and antioxidants, including methyl gallate, trolox, and mannitol. To study the possible mechanisms underlying the in vivo anti-inflammatory effect of PHCP against LPS-induced inflammation, we also examined the effects of PHCP on malondialdehyde (MDA) and glutathione levels in skin tissues and found that pretreatment with PHCP resulted in inhibited MDA elevation and a remarkable reduction of glutathione level. In addition, similar results were obtained after pretreatment with antioxidants, including trolox and mannitol, and HO-1 inhibitor, ZnPP. Histopathologically, an influx of neutrophils into the skin dermis was detected between 24 h and 72 h after LPS injection (30, 100 μg site-1), compared to control animals after injection of saline. This increase was greater in mice treated with 100 μg of LPS than in those treated with 30 μg of LPS and was significantly suppressed by pretreatment with PHCP, antioxidants, and HO-1 inhibitor. These results collectively suggest that PHCP has an anti-inflammatory effect against LPS-induced inflammation model in vivo and may be a good candidate for the skin tissue engineering biomedical application primarily through manipulation of the redox state.
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Jin-Yi Han,Xu Zi Guang,Jyung-Sik Kwak,Ki-Wan Oh,Han-Ik Bae 충북대학교 동물의학연구소 2012 Journal of Biomedical and Translational Research Vol.13 No.1
The anti-inflammatory effect of PHBV/Collagen (PHCP) was examined in a mouse model of lipopolysaccharide (LPS)-induced skin inflammation. Vascular permeability on the back skin was measured by the local accumulation of Evan’s blue dye after subcutaneous injection of LPS (30 µg site<sup>-1</sup> ). Dye leakage in the skin showed a significant increase at 2 h after injection of LPS. This LPS-induced dye leakage was also completely inhibited by HO-1 inhibitor, ZnPP, and antioxidants, including methyl gallate, trolox, and mannitol. To study the possible mechanisms underlying the in vivo anti-inflammatory effect of PHCP against LPS-induced inflammation, we also examined the effects of PHCP on malondialdehyde (MDA) and glutathione levels in skin tissues and found that pretreatment with PHCP resulted in inhibited MDA elevation and a remarkable reduction of glutathione level. In addition, similar results were obtained after pretreatment with antioxidants, including trolox and mannitol, and HO-1 inhibitor, ZnPP. Histopathologically, an influx of neutrophils into the skin dermis was detected between 24 h and 72 h after LPS injection (30, 100 µg site<sup>-1</sup>), compared to control animals after injection of saline. This increase was greater in mice treated with 100 µg of LPS than in those treated with 30 µg of LPS and was significantly suppressed by pretreatment with PHCP, antioxidants, and HO-1 inhibitor. These results collectively suggest that PHCP has an anti-inflammatory effect against LPS-induced inflammation model in vivo and may be a good candidate for the skin tissue engineering biomedical application primarily through manipulation of the redox state.
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중국의 선원법체계와 해기인력양성의 문제점 및 개선논의에 관한 연구
金萬紅(Jin, Wan-Hong),최진이(Choi, Jin-Yi) 한국해양대학교 국제해양문제연구소 2020 해항도시문화교섭학 Vol.0 No.22
중국은 세계에서 가장 많은 선박을 보유하는 해운강국이다. 또한, 중국은 세계 10대 컨테이너항만 중에서 부동의 1위를 차지하고 있는 상하이항을 중심으로 10위권 이내의 항만이 7개나 있다. 항만과 해운은 중요한 중국의 중요한 기간산업이며, 국가경제는 해운의존도가 대단히 높다. 중국은 1978년 개혁과 개방정책을 추진함으로써 시장경제체제를 도입하였다. 그 결과 1980년대 이후 1990년대까지 높은 경제성장을 달성하였다. 그 과정에서 선원은 중국 내 가장 선호하는 직업 중의 하나였고, 정부 역시 외화획득수단으로 선원송출정책을 적극적으로 추진하였다. 대학 등 선원교육기관을 설립하여 고급선원(해기사)을 양성하는 정책을 적극 추진하였다. 이와 함께 해상근로의 특수성을 고려한 각종 입법과 함께 사회보장제도를 마련하기도 하였다. 법제도 측면에서 선원은 일반근로자에 비해 그 직업의 특수성으로 하여 선원의 법적 지위나 자격요건, 사회보장에 관하여 대부분의 국가들은 「선원법」과 같은 특별법을 제정하였다. 그러나 중국에는 「선원법」과 같은 특별법이 존재하지 않고 해상법에 포함되어 있다. 무엇보다 2022년까지의 입법계획에는 「선원법」이 포함되지도 않았다. 이 논문에서는 중국의 선원관련 법체계와 해기인력양성제도를 살펴보고, 중국의 자국 내 해기인력양성시스템에 대한 문제의식과 이를 개선하기 위한 정책방향에 관한 논의들을 고찰하였다. Ports and shipping are important industries in China, and the national economy is highly dependent on shipping. China has the world’s largest shipping power. In addition, China has seven ports within the top 10 with Shanghai Port, which ranks first among the world’s top 10 container ports. China introduced a market economy system in 1978 by promoting reform and open-door policy. As a result, high economic growth was achieved from the 1980s to the 1990s. In the process, crews were one of the most preferred jobs in China, and the government also actively promoted the overseas crew employment policy as a means of obtaining foreign currency. The government actively promoted the policy of nurturing high-quality crews by establishing crews education institutions such as universities. At the same time, the government also established a social security system with various legislation considering the specificity of maritime work. In terms of the legal system, most countries have enacted special laws such as the “Seafarers Act” concerning the legal status, qualifications and social security of crews, because sailors are a special occupation compared to land workers. But in China, no special laws such as the “Seafarers Act” exist and are included in the maritime law. Above all, the legislation plan until 2022 does not include the “Seafarers Act”. Sailors are very difficult jobs, but they do not have enough wages or welfare systems. People are reluctant to do difficult jobs as they become economically rich. For these reasons, social awareness of crew is getting worse. People are reluctant to become sailors because of the maritime risks as well as the characteristics of jobs that have to live away from their families. Therefore, the number of people who want to be crew has been greatly reduced. There are difficulties in cultivating advanced crews. A policy is needed to improve them. In this paper, I examined the awareness of the problems facing China’s Marine Officer’s education(training) in its own country and the direction of China’s Marine Officer’s education(training) policy being discussed to improve them.
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Han, Jin-Yi,Ahn, Sun-Young,Yoo, Jae Hyeon,Nam, Sang-Yoon,Hong, Jin Tae,Oh, Ki-Wan Hindawi Publishing Corporation 2015 BioMed research international Vol.2015 No.-
<P>This experiment was designed to investigate whether 4-O-methylhonokiol (MH), a principal ingredient of <I>Magnolia (M.) officinalis</I> bark, alleviated acute intraperitoneal (i.p.) kainic acid- (KA-) induced brain blood barrier dysfunction (BBBD) <I>via</I> pathological examination and cytological analyses of the brain tissues of mice. KA (10–30 mg/kg) time- and dose-dependently increased the water content of brain tissues and induced edema and encephalopathy. However, pretreatment with MH (5 and 20 mg/kg, i.p.) significantly reduced the water content of the brain compared to that observed in the KA control group. Furthermore, MH significantly and dose-dependently reversed the remarkable variations in evan's blue dye (EBD) staining and malondialdehyde (MDA) levels that were induced by KA (10 mg/kg, i.p.). MH also decreased the elevated seizure scores that were induced by KA (10 mg/kg, i.p.) in mice in a manner similar to scavengers such as DMTU and trolox. Additionally, MH significantly scavenged intracellular ROS and Ca<SUP>2+</SUP> within hippocampal cells. The tight junction seals mediated by claudin (Cld-5) were also found to be modulated by MH. MH efficiently reduced 1,1-diphenyl-2-picrylhydrazyl (DPPH) (IC<SUB>50</SUB>, 52.4 mM) and <SUP>•</SUP>OH with an electron spin resonance (ESR) signal rate constant of 4 × 10<SUP>9</SUP> M<SUP>−1</SUP> · S<SUP>−1</SUP>, which is close to the reactivity of the vitamin E analog trolox. Taken together, these results suggest that MH may enhance radical scavenging in lipid and hydrophobic environments, which may be important for the physiological activity of the barrier.</P>
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