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Li, Rong,Liang, Hong-Ying,Li, Ming-Yong,Lin, Chun-Yan,Shi, Meng-Jie,Zhang, Xiu-Juan Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.22
Fisetin is an effective compound extracted from lacquer which has been used in the treatment of various diseases. Preliminary data indicate that it also exerts specific anti-cancer effects. However, the manner in which fisetin regulates cancer growth remains unknown. In this study, we elucidated interference of fisetin with targets of the nuclear factor ${\kappa}B$ signal transduction pathway activated by Epstein-Barr virus encoding latent membrane protein 1 (LMP1)in nasopharyngeal carcinoma (NPC) cells, Results showed that fisetin inhibited the survival rate of CNE-LMP1 cells and NF-${\kappa}B$ activation caused by LMP1. Fisetin also suppressed nuclear translocation of NF-${\kappa}B$ (p65) and $I{\kappa}B{\alpha}$ phosphorylation, while inhibiting CyclinD1, all key targets of the NF-${\kappa}B$ signal transduction pathway. It was suggested that interference effects of fisetin with signal transduction activated by LMP1 encoded by the Epstein-Barr virus may play an important role in its anticancer potential.
Rong Jie Zha,Zheng Lin Zhao,Xiu Feng Zhao,Guang Wen Zha,Meng Quan Li,Yi Yan Wu,Jing Qiu Li,Li Xin Guan,김상찬 대한한의학방제학회 2009 大韓韓醫學方劑學會誌 Vol.17 No.2
The effects of aqueous extract of Schizandrae Fructus (AESC) on lead (Pb)-induced changes of monoamine neurotransmitters in the hippocampus (HIP) of adult rats were investigated. Male Sprague-Dawley rats were received intraperitoneal (i.p.) administration of Pb acetate (5 mg/kg/d) for 28 days and sacrificed 7 days after the last administration. Concentrations of norepinephrine (NE), dopamine (DA), serotonin (5-HT), 5-hydroxyindole acetic acid (5-HIAA) in HIP were measured by HPLC. There were significant decreases of NE, DA, 5-HT and 5-HIAA in Pb treated rats (P < 0.05), while pretreatment with AESC (100 mg/kg/d or 300 mg/kg/d, p.o., 2 h before Pb) greatly inhibited the decrease of monoamine transmitters, respectively (P < 0.05). Also, AESC (300 mg/kg/d) significantly increased the reduction of glutathione contents and superoxide dismutase activities in HIP induced by chronic Pb. These results suggest that AESC ameliorates Pb-induced depletion of monoamine neurotransmitters in HIP through its antioxidant activity.
Meng-Meng Lv,Ming-Hui Tan,Li-Wen Lu,Rong-Hua Zhang,Zhi-Yong Guo,Cheng-Xiong Liu,Jin Yang,Kun Zou,Peter Proksch 한국생약학회 2018 Natural Product Sciences Vol.24 No.3
Two new polyketides, chinoketides A and B (1 - 2) with a known compound xylarphthalide A (3), were isolated from the solid medium of the endophytes from the leaves of the relic plant Distylium chinense with the "black-box" co-culture method, and the structures of two new compounds were elucidated by NMR, MS and CD spectra. And the absolute configurations of chinoketides A (1) and B (2) were determined as 2R,3R,8S and 5R,6S by calculating their ECD spectra to compare with the experimental CD spectra. Finally, the antimicrobial activities were evaluated to Erwinia carotovora sub sp. Carotovora (Jones) Bersey et al, and the results showed that compounds 1 - 3 displayed the antimicrobial activities with MIC value at 20.5, 30.4 and 10.2 mg/mL.
A Rapid Life Cycle Assessment Method based on Green Features in Supporting Conceptual Design
Qiang Meng,Fang-yi Li,Li-rong Zhou,Jing Li,Qin-qin Ji,Xiaodong Yang 한국정밀공학회 2015 International Journal of Precision Engineering and Vol.2 No.2
A Rapid Life Cycle Assessment (RLCA) method based on Green features is proposed in order to solve the inherent limitations of conventional Life Cycle Assessment (LCA), such as long period, massive data requirement, which result in difficulties in supporting product conceptual design. Firstly, Green Feature is proposed in supporting the LCA in conceptual design, where a mapping relationship is established between green feature and design information to achieve the transformation from the design information to green features. Secondly, product conceptual design model is proposed based on modular configuration. The approximate products program will be obtained through retrieval and matching of each module of product using the knowledge base and case base. Thirdly, Intuitionistic Fuzzy theory and Monte Carlo method are respectively used to process the qualitative and quantitative uncertain information of green features in order to ensure the accuracy of the evaluation results. Besides, the appropriate life cycle impact assessment method is selected to complete the life cycle impact assessment and obtain the LCA results. Consequently, the RLCA of product design program is completed to support product green design. Finally, a fan of a ventilation system is studied as an example to verify the proposed RLCA theory.
Zhao, Rong Jie,Zhao, Zheng Lin,Zhao, Xiu Feng,Zhao, Guang Wen,Li, Meng Quan,Wu, Yi Yan,Li, Jing Qiu,Guan, Li Xin,Kim, Sang-Chan The Korean Medicine Society for the Herbal Formula 2009 大韓韓醫學方劑學會誌 Vol.17 No.2
The effects of aqueous extract of Schizandrae Fructus (AESC) on lead (Pb)-induced changes of monoamine neurotransmitters in the hippocampus (HIP) of adult rats were investigated. Male Sprague-Dawley rats were received intraperitoneal (i.p.) administration of Pb acetate (5 mg/kg/d) for 28 days and sacrificed 7 days after the last administration. Concentrations of norepinephrine (NE), dopamine (DA), serotonin (5-HT), 5-hydroxyindole acetic acid (5-HIAA) in HIP were measured by HPLC. There were significant decreases of NE, DA, 5-HT and 5-HIAA in Pb treated rats (P < 0.05), while pretreatment with AESC (100 mg/kg/d or 300 mg/kg/d, p.o., 2 h before Pb) greatly inhibited the decrease of monoamine transmitters, respectively (P < 0.05). Also, AESC (300 mg/kg/d) significantly increased the reduction of glutathione contents and superoxide dismutase activities in HIP induced by chronic Pb. These results suggest that AESC ameliorates Pb-induced depletion of monoamine neurotransmitters in HIP through its antioxidant activity.
Ru-ren Li,Qun-li Yu,Ling Han,Liang-yan Rong,Meng-meng Yang,Mai-rui An 한국화학공학회 2014 Korean Journal of Chemical Engineering Vol.31 No.11
A novel hyaluronidase (BgHya1) from Yak testis was isolated and shown to have compara-tively high activity on sodium hyaluronate. However, surveys on BgHya1 are still limited. The enzyme was purifiedthrough gel filtration on Sephacryl S-100 and cation-exchange on SP Sepharose fast flow; the purity was confirmedby a reverse phase FPLC Shodex C4 column. The specific activity of the purified BgHya1 was 20.4 U/mg assayed bythe colorimetric method against 0.85 U/mg for the crude enzyme, representing a 24-fold purification. It was a monomericprotein of 55 kDa estimated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and SephacrylS-200. It exhibited maximum activity in the presence of 0.15 M NaCl at 37 oC, pH 3.8, and a specificity to sodiumhyaluronate higher than that of chondroitin-4-sulfate, chondroitin-6-sulfate, and dermatan. The Km value for BgHya1,using sodium hyaluronate as substrate, was 0.106 mg/mL. Activity of BgHya1 was inhibited mildly by Ca2+and Fe2+,and significantly by Fe3+, Mg2+, EDTA, urea, heparin, and 0.5 M NaCl. It was not affected by Cu2+,Zn2+,Co2+, ascorbicacid, PMSF, DTT, glutathione (reduced), or L-cysteine. BgHya1 was shown to be heat unstable in the range of 4-45 oC. In terms of storage stability, 92% of the activity was retained after four weeks at 4 oC, and 58% at room temperature. In addition, adding BSA (1.0 mg/mL) to the enzyme sample prior to freezing resulted in complete retention of enzymeactivity. This work yielded a high purity hyaluronidase, the first one isolated from by-product.
Zheng Lin Zhao,Guang Wen Zhao,Li Li,Meng Quan Li,Li Xin Guan,Xu Dong Yang,Hou Zhong Li,Feng Lin,Jong Rok Lee,Rong Jie Zhao 한국독성학회 2009 Toxicological Research Vol.25 No.1
The effects of aqueous extract of Schizandra Chinensis Fruit (AESC) on cadmium-induced changes of monoamine neurotransmitters in the different brain regions of adult rats were investigated. Male rats were received intraperitoneal (i.p.) administration of CdCl₂ (0.6 ㎎/㎏/d) for 21 days and sacrificed 7 days after the last administration. Concentrations of norepinephrine (NE), dopamine (DA) in striatum and serotonin (5-HT), 5-hydroxyindole acetic acid (5-HIAA) in cortex were measured by HPLC. There were significant decreases of NE, DA, 5-HT and 5-HIAA in Cd intoxicated rats (P < 0.05), while pretreatment with AESC (20 ㎎/㎏/d or 60 mg/kg/d, p.o., 30 min before CdCl₂) greatly inhibited the decrease of monoamine transmitters, respectively (P < 0.05). Also, AESC significantly increased the reduction of glutathione contents and superoxide dismutase activities in cortex induced by CdCl₂. These results suggest that AESC ameliorates Cd-induced depletion of monoamine neurotransmitters in brain through its antioxidant activity.
Zhao, Zheng Lin,Zhao, Guang Wen,Li, Li,Li, Meng Quan,Guan, Li Xin,Yang, Xu Dong,Li, Hou Zhong,Lin, Feng,Lee, Jong-Rok,Zhao, Rong Jie Korean Society of ToxicologyKorea Environmental Mu 2009 Toxicological Research Vol.26 No.1
The effects of aqueous extract of Schizandra Chinensis Fruit (AESC) on cadmium-induced changes of monoamine neurotransmitters in the different brain regions of adult rats were investigated. Male rats were received intraperitoneal (i.p.) administration of CdCl2 (0.6 mg/kg/d) for 21 days and sacrificed 7 days after the last administration. Concentrations of norepinephrine (NE), dopamine (DA) in striatum and serotonin (5-HT), 5-hydroxyindole acetic acid (5-HIAA) in cortex were measured by HPLC. There were significant decreases of NE, DA, 5-HT and 5-HIAA in Cd intoxicated rats (P < 0.05), while pretreatment with AESC (20 mg/kg/d or 60 mg/kg/d, p.o., 30 min before $CdCl_2$) greatly inhibited the decrease of monoamine transmitters, respectively (P < 0.05). Also, AESC significantly increased the reduction of glutathione contents and superoxide dismutase activities in cortex induced by $CdCl_2$. These results suggest that AESC ameliorates Cd-induced depletion of monoamine neurotransmitters in brain through its antioxidant activity.
Meng-Yuan Hu,Kuan-Kuan Xiong,Jian-Rong Li,Xing-Bin Jing,Pei-Hua Zhao 한국섬유공학회 2019 Fibers and polymers Vol.20 No.9
A new P/N/Si/S-containing mononickel complex NiS, which can be regarded as a rare type of the metal-basedintumescent flame retardant, has been prepared through the condensation reaction of precursor NiCl with 1, 2-ethanedithiolin the presence of triethylamine as acid-binding agent. Its molecular structure is well characterized by elemental analysis,infrared (IR) and nuclear magnetic resonance (NMR) spectroscopies. The target flame retardant NiS has been successfullyapplied to cotton fabrics through a pad-dry-cure method. Thermal degradation properties of neat and treated cotton fabricswith 10.7 wt% NiS are studied by thermogravimetric analysis (TGA). Flammability behaviors of neat and treated cotton with10.7 wt% NiS are evaluated using vertical burning test, limiting oxygen index (LOI) and microscale combustion calorimeter(MCC). Meanwhile, to further investigate the flame retardancy of NiS for cotton fabrics, the char layers of neat and treatedsamples after combustion are analyzed by SEM image and Raman spectroscopy. As a result, the improved thermal andflammability performance for cotton fabrics by introduction of NiS might be due to the metal-assisted catalytic charringeffect of NiS on the formation of the compact char layer and the release of the flammable gas.
An efficient method to improve the stability of submerged functionally graded cylindrical shell
Rong Li,Linxia Liu,Bin Liang,Meng Yang 대한기계학회 2019 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.33 No.6
An efficient method is presented to improve the stability of a submerged functionally graded (FG) cylindrical shell which is subjected to external hydrostatic pressure. To improve stability while satisfying the application requirements for shell thickness, we focused on the optimum value of the power-law exponent to maximize the critical hydrostatic pressure. The optimum value of the power-law exponent is obtained from an analysis of the influence factors on critical pressure. The results show that the critical pressure can be greatly increased by using the optimum value of the power-law exponent, and the growth rate of critical pressure is almost constant independent of the shell geometry and boundary condition. The advantage of the present method in reducing the shell thickness is illustrated by examples. In addition, the present method is applicable to all kinds of material combinations.