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세포질내 정자주입법(ICSI)에 있어서 정자흡입 및 난자내 주입방법에 관한 연구
이택후,김항진,송건호,김대근,전상식,박윤규,서태광,전병균,류은경,이은숙,문진수,김광철 경북대학교 의학연구소 2000 경북대학교병원의학연구소논문집 Vol.4 No.1
Study on Method of Sperm Aspiration and Injection into an Oocyte in Intracytoplasmic Sperm Injection(ICSI) Immobilization of spermatozoa prior to intracytoplasmic sperm iniection(ICSI) sometimes results in crooked tail and this makes it difficult to aspirate sperm into an injection pipette tail first. Head-first sperm aspiration into an injection pipette avoid this problem due to the bigger size of the sperm head. The effect of head or tail-first sperm injection into an oocyte on fertilization cleavage, percentage of grade I embryos and development to blastocyst stage in ICSI program has been studied. A single living immobilized spermatozoa from oligoasthenozoospermic patient was injected into an oocyte head-first or tail-first according to the treatment. Eighteen hours after microinjection, oocytes ware inspected for survival and fertilization Fertilized oocytes with two pronuclei were cultured in 30μl drop of mHTF supplemented with 10% heat-inactivated follicular fluid(FF) at 37℃. On day 2. embryo transfer was performed with cleaved embryos. The remaining 2-8 cell stage embryos were co-cultured with BRL cells in mHTF + 10% FF for 72 hours and the developmental stage was observed. The data were analyzed by Analysis of Variance. A total of 164 oocytes from 36 cycles were assigned to earth treatment and ICSI was performed(88 head-first, tail-first). The rates of normal fertilization were 81.8% and 76.3% for head-first and tail-first, respectively. Of the fertilized oocytes, the percentage of cleaved embryos and the percentage of grade 1 embryo among cleaved embryos were 88.9% and 68.8%, 93.1% and 74.1% for head-first and tail-first, respectively. Of the 2-8 cell embryos cultured, 44.4%(16/36) and 50.0%(10/20) for head first and tail first, respectively developed to blastocyst stage. There were no differences in fertilization, cleavage, rates of grade 1 embryos, and development to blastocyst stage. In conclusion, head-first or tail-first sperm injection into an oocyte in ICSI program does not affect fertilization and subsequent embryo development to blastocyst stage in vitro.
이상태,이후성,정윤교 國立 昌原大學校 産業技術硏究所 2000 産技硏論文集 Vol.14 No.-
The accuracy of machinindg using grinding wheels depend upon the combined parameters that are depth of cut, the speed of workpiece and wheel, the state of wheel surface and kinds of grinding wheel. If this parameters apply inadequately for grinding work, it'll break out the abnormal states such as grinding crack and grinding burn. Therefore, this paper aims at analysing the variations of grinding forces that are closely concerned this abnormal states, proposing the normal and proper conditions of grinding work, an making up the economic grinding.
Lee, Sea-Won,Hwang, Tae-Kon,Hong, Sung-Hoo,Lee, Ji-Youl,Chung, Mi Joo,Jeong, Song Mi,Kim, Sung Hwan,Lee, Jong Hoon,Jang, Hong Seok,Yoon, Sei Chul The Korean Society for Radiation Oncology 2014 Radiation Oncology Journal Vol.32 No.3
Purpose: This single institutional study is aimed to observe the outcome of patients who received postoperative radiotherapy after radical prostatectomy. Materials and Methods: A total of 59 men with histologically identified prostate adenocarcinoma who had received postoperative radiation after radical prostatectomy from August 2005 to July 2011 in Seoul St. Mary's Hospital of the Catholic University of Korea, was included. They received 45-50 Gy to the pelvis and boost on the prostate bed was given up to total dose of 63-72 Gy (median, 64.8 Gy) in conventional fractionation. The proportion of patients given hormonal therapy and the pattern in which it was given were analyzed. Primary endpoint was biochemical relapse-free survival (bRFS) after radiotherapy completion. Secondary endpoint was overall survival (OS). Biochemical relapse was defined as a prostate-specific antigen level above 0.2 ng/mL. Results: After median follow-up of 53 months (range, 0 to 104 months), the 5-year bRFS of all patients was estimated 80.4%. The 5-year OS was estimated 96.6%. Patients who were given androgen deprivation therapy had a 5-year bRFS of 95.1% while the ones who were not given any had that of 40.0% (p < 0.01). However, the statistical significance in survival difference did not persist in multivariate analysis. The 3-year actuarial grade 3 chronic toxicity was 1.7% and no grade 3 acute toxicity was observed. Conclusion: The biochemical and toxicity outcome of post-radical prostatectomy radiotherapy in our institution is favorable and comparable to those of other studies.
이정희,박성수,김홍근,이동후,이중달,김태화,이민교,류우진,전석철 대한내과학회 1987 대한내과학회지 Vol.32 No.1
Percutaneous needle biopsy is the most reliable nonoperative method of obtaining the definitive diagnosis of peripheral pulmonary lesion. Needle aspiration combined with cytologic examination is being used with increasing frequency in the diagnosis of pulmonary nodules and masses. Diagnostic needle aspiration of 59 localized pulmonary lesions was performed with 20 and 22 gauge needles between the beginning of November 1983 and the end of August 1986 at the Department of Internal Medicine of Hanyang University Hospital. Cough was the most common chief complaint. Next in order were chest pain, dyspnea, no symptoms, blood tinged sputum, production of mucus, generalized weakness. hoarseness, weight loss, and fever. The obtainability of the tissue was 91.5%, and diagnostic accuracy was 84.7%. Complications of percutaneous needle lung aspiration were: pneumothorax in 5 cases (8.5%), all of which were not required chest tube evacuation; minor hemoptsis ($lt;50ml) in 2 (3.4%), and hemnthorax in 1 (1.7%). We think that needle biopsy represents a minor, inexpensive and safe procedure, which-with a simple technique-permits a direct approach to all kinds of localized lung lesion with a high degree of accuracy.
Synthesis and COX Inhibitory Activities of Rutaecarpine Derivatives
Lee, Eung-Seok,Kim, Seung-Ill,Lee, Seung-Hoo,Jeong, Tae-Cheon,Moon, Tae-Chul,Chang, Hyeun-Wook,Jahng, Yurng Dong Korean Chemical Society 2005 Bulletin of the Korean Chemical Society Vol.26 No.12
A series of substituted rutaecarpines were prepared by employing Fischer indole synthesis as key step and their inhibitory activities on COX-1 and 2 as well as selectivity on COX-2 were evaluated. The compounds with a methanesulfonyl and a bromo group at C10 showed promising inhibitory activity ($IC_{50}$ = 0.27, 0.35 $\mu$M, respectively) with selectivity.
이후경(Hoo-Kyeong Lee),윤태원(Tae-Won Yun),윤성철(Sung-Chul Yoon),박상군(Sang-Kun Park),김태우(Tae-Woo Kim),안현주(Hyun-Joo Ahn),김선재(Sun-Jae Kim),최영숙(Young-Sook Choi) 대한사회정신의학회 2003 사회정신의학 Vol.8 No.2
연구 목적: 본 연구는 가벼운 비행을 저지른‘훈방대상 비행청소년’을 대상으로 사회인구학적 특징, 사회심리적 특성, 성별에 따른 차이를 파악하기 위하여 시행되었다. 방법: 본 연구의 대상자는 서울시‘사랑의 교실’ (비행예방 프로그램)에 참석한 비행청소년 290명(남자 192명, 여자 98명)과 서울 시내 중고등학교 일반학생 391명(남자 189명, 여자 202명)이었으며, 이들에게 사회인구학적 설문지와 K-YSR(Youth Self Report) 척도를 실시하였다. 결과: 1) 사회인구학적 자료에서 비행청소년이 일반학생보다 부모 사망률이 더 높았고, 부모의 이혼과 별거가 더 많았으며, 부모의 학력이 더 낮았고, 경제수준이 더 낮았으며, 부모가 맞벌이거나 어머니만 직업이 있는 경우가 더 많았다. 2) 문제행동증후군척도에서 남녀 모두 비행청소년이 일반학생보다 비행, 공격성, 외현화, 총문제행동 점수가 더 높았으며, 반면 사회적 미성숙의 경우 비행청소년이 일반학생보다 더 낮았다. 그 외 위축, 신체증상, 우울/불안, 사고의 문제, 주의집중 문제, 내재화는 유의미한 차이가 없었다. 3) 사회능력척도에서 남자비행청소년이 남자학생보다 사회성, 학업수행, 총사회능력 모두 낮았다. 그러나 여자비행청소년은 여자학생보다 학업수행만 낮았고 사회성과 총사회능력은 차이가 없었다. 비행청소년의 남녀비교에서 여자군이 남자군보다 사회 성, 학업수행, 총사회능력 모두 높았다. 결론: ‘훈방대상 비행청소년’의 비행은 낮은 사회경제적 상태 및 부모와 관련된 다양한 요인과 연관이 있었다. 이들은 정신병리적인 면에서 공격성과 충동성이 높은 것 외에는 일반학생과 유사하였다. 이들의 학업수행은 일반학생보다 낮았다. 이들의 사회성은 여자가 남자보다 더 높았다.