加味香砂六君子湯이 생쥐 小腸에서 放射線照射 後 保護效果와 Apoptosis에 미치는 影響

이태업,김진성,윤상협,류봉하,박동원,류기원 대한한방종양학회 2000 대한한방종양학회지 Vol.6 No.1

The present study was performed in order to evaluate the effects of the gamihyangsayukgunjatang on radioprotection and apoptoss in small intestines of mice after whole bdy irradiation. Two hundred forty mice were divided into 40 groups according to the radiation dose and the gamihyangsayukgunjatang treatment. The extracts of the herbal medicines were orally administered to each group differently before and/or after irradiation. The gamihyangsayukgunjatang treated groups were divided into 3 groups. Sample Ⅰ was the group treated with the gamihyangsayukgunjatang for 3 days before the radiation, sample Ⅱ was the group treated with the gamihyangsayukgunjatang for 3 days after the radiation. Sample Ⅲ was the group treated with the gamihyangsayukgunjatang for both 3 days before and after the radiation. To analyze the crypt survival, the micradony survival assay was used according to the Withers and Elind's method. To analyze the apptosis, the TUNEL assay was done. The reslts obtained are a follows : 1. From the microcolony survival assay, the gamihyangsayukgunjatang treated groups showed theradioprotective effect with a statistical ignificance(p<0.05), as compared to the control group. Comparing the radioprotective effect among the 3 groups, sample Ⅲ was statistically more significant than sample Ⅰand Ⅱ (p<O.O5). Sample Ⅰ showed no effect. In accordance with the research mentioned above, it is suggested that the radioprotective effect of the gamihyangsayukgunjatang is more useful for the treatment of the radiation injury rather that the prevention. 2. The results of the TUNEL assay showed that the apoptotic index in the gamihyangsayukgunjatang treaed group was slightly decreased with no effectiveness, as compared to the control group. According to the above results, it could be suggested that the gammyangsayukgummang has a prominent protective effect in mice intestines against the radiation damage. However, the radioprotective effect does not seem to be related to inhibition of the apoptosis.

혈청 C-peptide치와 비만도에 의한 한국인 당뇨병의 병형 분류

이기업 ( Lee Gi Eob ),류진숙 ( Lyu Jin Sug ),김용태 ( Kim Yong Tae ),송영기 ( Song Yeong Gi ),김기수 ( Kim Gi Su ),이문호 ( Lee Mun Ho ),박성우 ( Park Seong U ) 대한내과학회 1992 대한내과학회지 Vol.42 No.3

연구배경 : 한국인에서의 당뇨병 발생이 서구인에서와 차이가 있다는 것은 일반적으로 인정된 사실이며 이제까지 이에 대하여 많은 연구가 진행되어왔다. 그러나 임상적으로 전형적인 IDDM이나 NIDDM으로 구분하기 힘든 비전형적인 환자가 상당수 존재함으로 인해, 당뇨병의 병형분류에 어려움이 있었으며 한국인 당뇨병의 특징을 규명하는데 있어서도 논란의 여지가 많았다. 저자들은 인슐린분비능을 반영하는 혈청 C-Peptide치에 의해 당뇨 병형을 분류하고 한국인 당뇨병의 발생양상의 특징을 알아보았다. 방법 : 서울중앙병원과 한강성심병원에 내원한 일차성 당뇨병 환자 257명에서 공복시 혈청 C-peptide를 측정하여 병형을 분류하였고, 비만도, 가족력 및 발병연령에 따른 임상적 특징을 조사하였다. 결과 1) IDDM으로 분류된 환자는 27예로 25세이하에서 발병한 예가 8예, 26∼40세가 9예, 40세 이상에서 10예였다. 이들중 성인연령에 발병한 IDDM 환자의 대부분에서는 최소한 1년이상 인슐린 투여를 하지 않은 기간이 있었다. 2) 발병전 최고체중을 확인할 수 있었던 NIDDM환자 158예 중 발병이전 체중과다(BMI>25)이었던 경우는 73%였으나, 현재에도 계속 체중과다인 경우는 37%에 불과하였다. 한편 NIDDM 환자의 28%는 40세 이전에 발병하였으며, 발병연령이 젊을수록 가족력이 강하였다. 결론 : 대부분의 한국인 NIDDM의 경우에도 발병전 체중과다가 발병원인으로 작용하였을 것으로 추정되나 많은 경우에 발병후 심한 체중감소를 보여 계속 체중과다를 보이는 경우는 전체환자의 1/3에 불과하였다. 이상의 결과는 일반적으로 한국인에서의 췌장 베타세포 기능이 서구인에 비하여 비만증을 지속적으로 유지하거나 증가시킬 만큼 충분하지 못할 가능성을 시사하고 있다. 한편 IDDM 환자의 상당수는 성인연령에 발병하며 NIDDM 환자의 일부는 젊은 연령에 발병하였는데, 성인연령에 발병한 IDDM의 대부분은 상당기간 인슐린 투여를 필요로 하지 않았으며, 젊은 연령에 발병한 NIDDM은 가족력이 매우 강하였다. 이상으로부터 한국인 당뇨병 환자의 일부에는 소위 지진성 인슐린 의존형 당뇨병 및 MODY로 분류될 수 있는 환자가 있는 것으로 생각된다. Background : Despite many previous studies, clinical characteristics of Korean diabetic patients have not been precisely defined yes. Although it is generally assumed that typical IDDM and obese NIDDM patients are relatively rare in Korean diabetics, the actual prevalence of those subpopulations among diabetic patients have not been properly evaluated, because of the lack of a definite clinical critria to distinguish IDDM from NIDDM, and the scarcity of the information about previous and present degree of obesity in Korean diabetic patients. Recently, we reported that fasting plasma C-peptide level gives a good distinction between IDDM and NIDDM. Method : Two hundred fifty seven patients with diabetes mellitus who visited Diabetes Clinics of Asan Medical Center and Hankang Sacred Hospital during the period from May 1989 to June 1990 were included in this study. By a premade protocol, inquiry was made about family history, onset age, present weight and maximum previous weight before the disease onset. Patients were classified into IDDM and NIDDM by their fasting plasma C-peptide levels (IDDM if the C-peptide level is less than 0.6 ng/㎖; NIDDM if the C-peptide level is higher than 1.0 ng/㎖), Body mass index (wt/ht¹; ㎏/㎡) greater than 25 was defined as overweight. 1)Ratients classified as IDDM were 27 cases. Age(yr) of onset was less than 25 in 8 cases, 26∼40 in 9 cases, and more than 40 in 10 cases. Most of the adult-onset IDDM patients have not required insulin for more than l year. 2) Seventy three percent of the NIDDM patients were overweight previously, but only 37% remained persistently overweight. 3) There was a strong family history in NIDDM patients who were diagnosesd at young ages. Our data show that obesity is one of the mojor determinants of diabetes in most Korean NIDDM patients, but only 1/3 of the patients remain persistently overweight after the onset of disease. The data also show that there are some atypical NIDDM patients who develop diabetes early in life and have a strong family history. From these data, we suggest that most Korean diabetic patients have limited insulin secretory capacity and thus cannot maintain their obesity after the onset of disease. It is also suggested that there are subgroups of patients who can be classified as slowly progressive IDDM and MODY.

인천 인현동 호프집 화재 피해자 분석

최정태,안무업,안희철,최영미,정재봉,서정열,유기철,이삼우,박석현,조준휘,김성환,김아진,송근정 대한응급의학회 2001 대한응급의학회지 Vol.12 No.4

Purpose : This study was conducted to develop field triage, transportation, distribution, and prehospital care at a fire disaster by analyzing the victims of the fore that broke out at a bar in Incheon. Method : We analyzed the cases of the victims of a fire in Incheon in Oct. 1999. We determined the primary care hospital, the arrival time, the burn size, the outcome, and the injury type from the medical records, the concerned organ records, and interviews with concerned persons. Result : The total number of victims was 137: 56 prehospital deaths, 1 hospital death, and 80 survivals. The Pearson correlation coefficient between the burn size and the severity was -0.175. There were 121(89.6%) cases of inhalation injury, 59 (43.7%) cases of flame burns, 66 (48.9%) cases of hypoxic brain damage, and 16 (11.9%) cases involving other types of injury. Conclusion : The causes of death of the fire victims were inhalation injury and hypoxic brain damage due to CO poisoning and other toxic inhalants. We propose the use of a simple triage and rapid treatment(START) system and a reassessment the delayed category in fire disasters.

Seismicity of the Korean Peninsula : 4. Seismicity of the Okcheon Zone

Kihwa Lee(이기화),Byung Doo Kwon(권병두),Chang Eob Baag(박창업),Tae Woo Chang(장태우) 대한지질학회 1988 지질학회지 Vol.24 No.4

The Analysis of Liquid Metal Flow Characteristics in the Annular Passage of an Electromagnetic Pump

Chang Eob Kim,Mun Ho Jeon,Jeong Tae Kwon,Hyo Jae Lim,Suk Won Lee 대한전기학회 2010 Journal of Electrical Engineering & Technology Vol.5 No.2

An electromagnetic pump using a tubular induction motor (TLIM) has been proposed to pump liquid metal fluids. TLIM has been designed for liquid metal flow systems with a motor with a thrust force of 40~77[N]. The flow characteristics have been investigated by solving the Navier-Stokes equation, where the Lorentz force was included simply by considering it as a constant in the Navier-Stokes equation. A wood metal was chosen to simulate the liquid metal. The effect of Lorentz force on the flow rate was investigated. An experiment was conducted and its results were compared with those of the simulation. The simulation result showed an overestimation of about 17% compared with the experimental one.

The Analysis of Liquid Metal Flow Characteristics in the Annular Passage of an Electromagnetic Pump

Kim, Chang-Eob,Jeon, Mun-Ho,Kwon, Jeong-Tae,Lim, Hyo-Jae,Lee, Suk-Won The Korean Institute of Electrical Engineers 2010 Journal of Electrical Engineering & Technology Vol.5 No.2

An electromagnetic pump using a tubular induction motor (TLIM) has been proposed to pump liquid metal fluids. TLIM has been designed for liquid metal flow systems with a motor with a thrust force of 40~77[N]. The flow characteristics have been investigated by solving the Navier-Stokes equation, where the Lorentz force was included simply by considering it as a constant in the Navier-Stokes equation. A wood metal was chosen to simulate the liquid metal. The effect of Lorentz force on the flow rate was investigated. An experiment was conducted and its results were compared with those of the simulation. The simulation result showed an overestimation of about 17% compared with the experimental one.

The Type Analysis for Safety Accident of Water Sports Happening in River

( Nam Eui Kim ),( Moo Eob Ahn ),( Jeong Yeol Seo ),( Dong Won Kim ),( Jeong Hyeok Kim ),( Hyung Ki Kim ),( Jae Hyun Han ),( Tae Hun Lee ) 대한외상학회 2017 大韓外傷學會誌 Vol.30 No.4

Purpose: Recently, as the number of people who enjoy water sports life in river or lake easy to accessible are increasing, that of the patients who are injured in water sports also does gradually. We intend to investigate the type of the injured patients of water sports and the riskiness of the sports in this study. Methods: We retrospectively looked into the medical records of the patients who were injured in water sports and visited a general hospital in Gangwondo-province from 2010 to 2015. Results: Total 146 patients came to the hospital during six years. Patients mostly occurred at younger ages, in summer, and on holidays, rather than weekdays. The most common lesions of injuries were faces (53 patients). The most common types of injuries were contusions (62 patients), followed by fractures (32 patients) and lacerations (26 patients). The most frequent fracture sites were the upper extremities (11 patients). Most of the trauma patients were mild, but a small number of patients with aspiration pneumonia occurred and their severity was higher than trauma patients. Conclusions: In this study, facial injuries were most frequent in water sports injuries. In the fractures, upper extremities were the most common fractured lesions. In addition, even if there is no direct trauma, aspiration pneumonia is serious, so caution should be taken with protective equipment suitable for water sports.

외상환자의 전산화 단층촬영소견에서 나타난 달무리 소견의 임상적 유용성

이승용 ( Seung Yong Lee ),손유동 ( You Dong Sohn ),안희철 ( Hee Cheol Ahn ),강구현 ( Gu Hyun Kang ),최정태 ( Jung Tae Choi ),안무업 ( Moo Eob Ahn ),서정열 ( Jeong Youl Seo ) 대한외상학회 2007 大韓外傷學會誌 Vol.20 No.2

Purpose: The management of hemorrhagic shock is critical for trauma patients. To assess hemorrhagic shock, the clinician commonly uses a change in positional blood pressure, the shock index, an estimate of the diameter of inferior vena cava based on sonography, and an evaluation of hypoperfusion complex shown on a CT scan. To add the finding for the hypoperfusion complex, the ``halo sign`` was introduced recently. To our knowledge, this ``halo sign`` has not been evaluated for its clinical usefulness, so we designed this study to evaluate its usefulness and to find the useful CT signs for hypoperfusion complex. Methods: The study was done from January 2007 to May 2007. All medical records and CT images of 124 patients with trauma were reviewed, of which 103 patients were included. Exclusion criteria was as follows: 1) age < 15 year old and 2) head trauma score of AIS ≥ 5. Results: The value of kappa, to assess the inter-observer agreement, was 0.51 (p < 0.001). The variables of the halo-sign-positive group were statistically different from those of the halo-sign-negative group. The rate of transfusion for the halo-sign-positive group was about 10 times higher than that of the halo-sign-negative group and the rate of mortality was about 6 times higher. Conclusion: In the setting of trauma, early abdominal CT can show diffuse abnormalities due to hypoperfusion complex. Recognition of these signs is important in order to prevent an unwanted outcome in hemorrhagic shock. We conclude that the halo sign is a useful one for hypoperfusion complex and that it is useful for assessing the degree of hemorrhagic shock. (J Korean Soc Traumatol 2007;20:144-148)

가미향사육군자탕(加味香砂六君子湯)이 생쥐 소장(小腸)에서 방사선조사(放射線照射) 후(後) 보호효과(保護效果)와 Apoptosis에 미치는 영향(影響)

이태업,김진성,윤상협,류봉하,박동원,류기원,Lee, Tae-Eob,Kim, Jin-Sung,Yoon, Sang-Heup,Ryu, Bong-Ha,Park, Dong-Won,Ryu, Ki-Won 대한암한의학회 2000 大韓癌韓醫學會誌 Vol.6 No.1

The present study was performed in order to evaluate the effects of the gamihyangsayukgunjatang on radioprotection and apoptosis in small intestines of mice after whole body irradiation. Two hundred forty mice were divided into 40 groups according to the radiation dose and the gamihyangsayukgunjatang treatment. The extracts of the herbal medicines were orally administered to each group differently before and/or after irradiation. The gamihyangsayukgunjatang treated groups were divided into 3 groups. Sample Ⅰ was the group treated with the gamihyangsayukgunjatang for 3 days before the radiation, sample Ⅱ was the group treated with the gamihyangsayukgunjatang for 3 days after the radiation. Sample Ⅲ was the group treated with the gamihyangsayukgunjatang for both 3 days before and after the radiation. To analyze the crypt survival, the micradony survival assay was used according to the Withers and Elind's method. To analyze the apptosis, the TUNEL assay was done. The results obtained are a follows : 1. From the microcolony survival assay, the gamihyangsayukgunjatang treated groups showed the radioprotective effect with a statistical significance(p<0.05), as compared to the control group. Comparing the radioprotective effect among the 3 groups, sample III was statistically more significant than sample I and II (p<0.05). Sample I showed no effect. In accordance with the research mentioned above, it is suggested that the radioprotective effect of the gamihyangsayukgunjatang is more useful for the treatment of the radiation injury rather that the prevention. 2. The results of the TUNEL assay showed that the apoptotic index in the gamihyangsayukgunjatang treated group was slightly decreased with no effectiveness, as compared to the control group. According to the above results, it could be suggested that the gamihyangsayukgujatang has a prominent protective effect in mice intestines against the radiation damage. However, the radioprotective effect does not seem to be related to inhibition of the apoptosis.

한약(韓藥) 복합제제(複合製劑)의 투여(投與)가 돼지의 성장(成長) 및 성장(成長)호르몬 분비(分泌)에 미치는 영향(影響)

구본홍,이태업,이병우,Koo Bon-Hong,Lee Tae-Eob,Lee Byung-Woo 대한한방소아과학회 1998 대한한방소아과학회지 Vol.12 No.1

The present study is designed that the herb medicines which are returned to kidney, pancreas and are known by efficacy in growth are supplied to pigs, thereafter the effects to growth and secretion of growth hormone in serum is investigated. For this purpose the 24 days old pigs, which are crossbreeding, castrated are used. The conclusions are that after 4 weeks' supply of herb medicinal compounds, pigs' weight gain has increased in low nutritional group with statistical meaning(p〈0.05). And one day's weight gain has increased with statistical meaning(p〈0.05) in all groups. Regarding food take, the second nutritional group has more significant increase than control group. Utilization rate of nutrition doesn't have any statistical meaning in all groups, but it has the tendency that as herb medicinal compounds are added, utilization rate of nutrition is increased. Increase of vertebra lengths and level of growth hormone in serum according to supply of herb medicinal compound don't have any statistical meaning because of small sample size, but 10 - 20 % increase of vertebra lengths and 10 - 30 % increase of level of growth hormone are observed.