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Novel Methylation Biomarker for Non-invasive Diagnostics in Lung Cancer
오태정,( Chang Hun Lee2 ),( Min Ki Lee ),( Yeul Hong Kim ),( Sang Yull Lee ),( Hyo Sung Jeon ),( Shin Yup Lee ),( Seung Soo Yoo ),( Jae Yong Park ),( Sung Whan An ) 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.-
To identify aberrantly hypermethylated DNA in lung cancer cells we established a genome-wide analysis for hypermethylation sites, namely Methyl DNA Isolation and Amplification (MeDIA) coupled-CpG microarray analysis. In the comprehensive methyaltion profiling analysis between human lung cancer, A549 cells and normal NHBE cells, we observed that several clusters of genes show a significant level of aberrancy in CpG island methylation pattern in cancer cells compared to normal cells. We further identified PCDHGA12 gene as a new marker of non-invasive diagnostics for lung cancer based on followings. 1) Transcription of PCDHGA12 gene is reactivated after treatment of A549 cells with demethylating agent. 2) Bisulfide clonal-sequencing reveals that CpG island of PCDHGA12 shows a distinctive differential methylation between two cell lines. 3) Pyrosequencing-based quantitative methylation assay for such region in tumor and non-tumorous tissues from lung cancer patients shows aberrant hypermethylation in 37 (92%) of the 40 tumor tissues. In clinical validation by pyrosequencingin induced-sputum of lung cancer patients (n=87) and healthy controls (n=51), we observed aberrant hypermethylation incident at significantly elevated level in samples derived from lung cancer patients. According to the optimal threshold calculated by ROC curve analysis, sensitivity and specificity of PCDHGA12 was 86.2% and 82.4%, respectively. PCDHGA12 methylation status could be a potential methylation biomarker alone or combined with others for the screen and the detection of relapse of lung cancer.
( Hyo-jung Park ),( Sang-mi Jung ),( Kyoung-bo Lee ) 대한신경치료학회 2017 신경치료 Vol.21 No.1
Purpose The purpose of this study was to investigate the effects of strengthening exercise of paretic lower limb extensors on the corticoreticulospinal tract in stroke. Methods The subjects were 8 stroke patients(4 male, 4 female), training performed a 30 minutes/day, 7 days/week, for 4-week. The motor function measured by TUG, BBS, Lower MI and tract volumes of CRST analysis by DTI. Results The pre and post-training showed TUG score was significant, but BBS, Lower MI was no significant. The tract volumes of CST was increase, but no significant. The tract volumes of CRST was decrease, but no significant. Conclusion It was changes of tract volumes showed no significant, but post training, motor function showed significant. These findings will be resourceful in providing various clinical impacts in actual treatments.
Stabilization of pressure solutions in four-node quadrilateral elements
Lee, Sang-Ho,Kim, Sang-Hyo Techno-Press 1998 Structural Engineering and Mechanics, An Int'l Jou Vol.6 No.6
Mixed finite element formulations for incompressible materials show pressure oscillations or pressure modes in four-node quadrilateral elements. The criterion for the stability in the pressure solution is the so-called Babu$\check{s}$ka-Brezzi stability condition, and the four-node elements based on mixed variational principles do not appear to satisfy this condition. In this study, a pressure continuity residual based on the pressure discontinuity at element edges proposed by Hughes and Franca is used to study the stabilization of pressure solutions in bilinear displacement-constant pressure four-node quadrilateral elements. Also, a solid mechanics problem is presented by which the stability of mixed elements can be studied. It is shown that the pressure solutions, although stable, are shown to exhibit sensitivity to the stabilization parameters.
Control of Robot Manipulators Using Time-Delay Estimation and Fuzzy Logic Systems
Hyo-Jeong Bae,Maolin Jin,Jinho Suh,Jun Young Lee,Pyung-Hun Chang,Doo-sung Ahn 대한전기학회 2017 Journal of Electrical Engineering & Technology Vol.12 No.3
A highly accurate model-free controller is proposed for trajectory tracking control of robot manipulators. The proposed controller incorporates time-delay estimation (TDE) to estimate and cancel continuous nonlinearities of robot dynamics, and exploits fuzzy logic systems to suppress the effect of the TDE error, which is due to discontinuous nonlinearities such as friction. To this end, integral sliding mode is defined using desired error dynamics, and a Mamdani-type fuzzy inference system is constructed. As a result, the proposed controller achieves the desired error dynamics well. Implementation of the proposed controller is easy because the design of the controller is intuitive and straightforward, and calculations of the complex robot dynamics are not required. The tracking performance of the proposed controller is verified experimentally using a 3-degree of freedom PUMAtype robot manipulator.