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Bilateral Nongranulomatous Uveitis with Infective Endocarditis
Sang Won Ha,Jae Pil Shin,Si Yeol Kim,Dong Ho Park 대한안과학회 2013 Korean Journal of Ophthalmology Vol.27 No.1
A 32-year-old male who had infective endocarditis complained of photophobia and blurred vision in both eyes. Biomicroscopic examination and fundus examination revealed anterior chamber reaction, vitritis, optic disc swelling, and Roth spots. He was diagnosed with bilateral nongranulomatous uveitis and treated with topical steroid eye drops and posterior sub-Tenon injection of triamcinolone. His visual symptoms were resolved within 1 week, and inflammation resolved within 4 weeks after treatment.
The Korea Cohort Consortium: The Future of Pooling Cohort Studies
Sang-Jun Lee,Kwang-Pil Ko,Jung Eun Lee,Inah Kim,Sun Ha Jee,Aesun Shin,Sun-Seog Kweon,Min-Ho Shin,Sangmin Park,Seungho Ryu,Sun Young Yang,Seung Ho Choi,Jeongseon Kim,Sang-Wook Yi,Daehee Kang,Keun-Young 대한예방의학회 2022 예방의학회지 Vol.55 No.5
Objectives: We introduced the cohort studies included in the Korean Cohort Consortium (KCC), focusing on large-scale cohort studies established in Korea with a prolonged follow-up period. Moreover, we also provided projections of the follow-up and estimates of the sample size that would be necessary for big-data analyses based on pooling established cohort studies, including population-based genomic studies. Methods: We mainly focused on the characteristics of individual cohort studies from the KCC. We developed “PROFAN”, a Shiny application for projecting the follow-up period to achieve a certain number of cases when pooling established cohort studies. As examples, we projected the follow-up periods for 5000 cases of gastric cancer, 2500 cases of prostate and breast cancer, and 500 cases of non-Hodgkin lymphoma. The sample sizes for sequencing-based analyses based on a 1:1 case-control study were also calculated. Results: The KCC consisted of 8 individual cohort studies, of which 3 were community-based and 5 were health screening-based cohorts. The population-based cohort studies were mainly organized by Korean government agencies and research institutes. The projected follow-up period was at least 10 years to achieve 5000 cases based on a cohort of 0.5 million participants. The mean of the minimum to maximum sample sizes for performing sequencing analyses was 5917-72 102. Conclusions: We propose an approach to establish a large-scale consortium based on the standardization and harmonization of existing cohort studies to obtain adequate statistical power with a sufficient sample size to analyze high-risk groups or rare cancer subtypes.
Transparent, Low-Electric-Resistance Nanocomposites of Self-Assembled Block Copolymers and SWNTs
Sung, Jinwoo,Jo, Pil Sung,Shin, Hyein,Huh, June,Min, Byung Gil,Kim, Dong Ha,Park, Cheolmin WILEY-VCH Verlag 2008 Advanced Materials Vol.20 No.8
<B>Graphic Abstract</B> <P>A transparent PS-b-P4VP copolymer/SWNTs nanocomposite film is used as both source and drain electrode in a pentacene OTFT with transmittance and electricresistance values of 85% and 6000 Ω/□, respectively. The low electric resistance of the film is achieved by the selective doping of HAuCl<SUB>4</SUB> in P4VP cores of the self-assembled block copolymer micelles, which simultaneously provides sufficientstability for the SWNTs suspension. <img src='wiley_img/09359648-2008-20-8-ADMA200701535-content.gif' alt='wiley_img/09359648-2008-20-8-ADMA200701535-content'> </P>
( Sung Pil Hong ),( Tae Il Kim ),( Hyun Gun Kim ),( Hyun Soo Kim ),( Seong Eun Kim ),( Kyu Chan Huh ),( Jeong Eun Shin ),( Jae Myung Cha ),( Suck Ho Lee ) 대한장연구학회 2013 Intestinal Research Vol.11 No.4
Background/Aims: Recent guidelines strongly recommend that the interval of surveillance colonoscopy be determined according to the risk stratification obtained at index colonoscopy. However, because of the differences in perception of the classification of colorectal intraepithelial neoplasia between Asian and Western countries, there is some confusion about surveillance colonoscopy. The aim of the present study was to evaluate the clinicopathological characteristics and the interval of surveillance colonoscopy between patients with high-grade dysplasia/carcinoma in situ and those with intramucosal carcinoma. Methods: From January 2003 to June 2010, 727 patients were included from 8 tertiary centers. Four hundred fifteen patients (57.1%) had high-grade dysplasia /carcinoma in situ (group A), and 312 (43.9%) had intramucosal carcinoma (group B). Clinicopathological data were reviewed retrospectively. Results: Group A had a significantly more frequent family history of colorectal cancer (3.1% vs. 0.6%, P<0.001), smaller polyp size (12 mm vs. 15 mm, P=0.001), and more proximal location (31.1% vs. 21.8%, P=0.005) than did group B. Among 727 patients, surveillance colonoscopy was performed within 6 months in 55.8% of patients and within 12 months in 77.8%. Group B had a significantly shorter interval of surveillance colonoscopy than did group A (P<0.001). There was no difference in detection of advanced neoplasia at surveillance colonoscopy between the 2 groups (6.6% vs. 5.4%, P=0.638). Conclusions: The recommended interval of surveillance colonoscopy is not followed in Korea. More education about post-polypectomy surveillance guidelines is required. (Intest Res 2013;11:276-282)
The Role of Collagen Membrane as a Scaffold of Etchant for Regional Acceleratory Phenomenon
Shin, Seung-Woo,Pyo, Sung-Woon,Bae, Sun-Sook,Lee, Pil-Woo,Heo, Hyun-A,Lee, Won Korean Academy of Dental Science 2011 Journal of korean dental science Vol.4 No.2
Purpose: The goal of this research is to find the role of collagen membrane, which can reduce physical damage, as a scaffold for possible alternative to the corticotomy which causes Regional Acceleratory Phenomenon (RAP). Materials and Methods: The experiments were carried out on 12 New Zealand white rabbits, approximately 3.5 kg in bodyweight. We made an incision on the skin of the mandibular border and applied 37% phosphoric acid and collagen membrane to the mandibular bone surface of the first group (experimental group), and only phosphoric acid to the second group (control group). After 3 days, 1 week, and 2 weeks, 4 rabbits each were sacrificed and specimens were obtained. Each specimen was stained by H&E and Tartrate-resistant acid phosphatase (TRAP), and histological changes were observed by light microscope. Results: The demineralization of the experimental group was weak compared to the control group. It also showed a gradual increase of demineralization (after 3 days, 1 week, and 2 weeks) and the control group showed more extensive demineralization than the experimental group. Conclusion: This study demonstrates the amount of demineralization as a result of using phosphoric acid, and as time went by, demineralization increased. The absorbable collagen membrane was used as a scaffold to increase bone demineralization effect and prevent dispersion to adjacent tissues, but rather the amount of bone demineralization decreased. Therefore, the role of collagen membrane as a scaffold for RAP was weak.
Shin, Jae Kook,Cheon, Jae Hee,Lim, Joon Seok,Park, Jae Jun,Moon, Chang Mo,Jeon, Soung Min,Lee, Jin Ha,Hong, Sung Pil,Kim, Tae Il,Kim, Won Ho Blackwell Publishing Asia 2011 Journal of gastroenterology and hepatology Vol.26 No.5
<P><B>Abstract</B></P><P><B>Background and Aim: </B> Computed tomography enterography (CTE) is a promising modality for small bowel imaging. However, the role of CTE in the evaluation of obscure gastrointestinal bleeding (OGIB) has not been established. We investigated the efficacy of CTE in diagnosing OGIB and the long‐term outcomes based on CTE findings, with special reference to negative CTE.</P><P><B>Methods: </B> A total of 63 consecutive patients who had undergone CTE for OGIB were enrolled, and their pre‐ and post‐CTE clinical data were collected. “Specific treatments” were defined as treatments directly aimed at resolving presumed bleeding causes, including hemostasis and operation, while “non‐specific treatments” were defined as symptomatic treatments for anemia.</P><P><B>Results: </B> Among 60 patients for whom long‐term follow‐up data were available, positive lesions were found in 16 patients (26.7%). The overall rebleeding rate was 21.7% during a mean follow up of 17.6 ± 4.7 months. There was no significant difference in the cumulative rebleeding rates between patients with positive and negative CTE results (<I>P</I> = 0.241). All patients who received specific treatments after CTE did not rebleed (0/8). In positive CTE patients, specific treatments significantly reduced the rebleeding rate (<I>P</I> = 0.023).</P><P><B>Conclusions: </B> CTE has a high rate of detecting overt OGIB. However, negative CTE results do not predict lower long‐term rebleeding, and such patients with OGIB should be closely observed. In patients with positive CTE, more vigorous management significantly reduces the incidence of rebleeding.</P>
Numerical modeling for cyclic crack bridging behavior of fiber reinforced cementitious composites
Shin, Kyung-Joon,Lee, Kwang-Myong,Chang, Sung-Pil Techno-Press 2008 Structural Engineering and Mechanics, An Int'l Jou Vol.30 No.2
Recently, many researches have been done to examine the behavior of fiber reinforced concrete (FRC) subjected to the static loading. However, a few studies have been devoted to cyclic behaviors of FRC. A main objective of this paper is to investigate the cyclic behavior of FRC through theoretical method. A new cyclic bridging model was proposed for the analysis of fiber reinforced cementitious composites under cyclic loading. In the model, non-uniform degradation of interfacial bonding under cyclic tension was considered. Fatigue test results for FRC were numerically simulated using proposed models and the proposed model is achieving better agreement than the previous model. Consequently, the model can establish a basis for analyzing cyclic behavior of fiber reinforced composites.