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사람 갑상선자극호르몬 수용체를 발현하는 Chinese Hamster Ovary(hTSHR-CHO)세포를 이용한 자극형 갑상선자극호르몬 수용체 항체 활성 측정의 임상적 유용성
한희정,원진호,채수홍,김현진,송민호,김영건,노흥규 충남대학교 의과대학 지역사회의학연구소 2000 충남의대잡지 Vol.27 No.1
Detection of thyroid stimulating hormone receptor(TSHR) autoantibodies has clinical value in establishing the diagnosis of Graves ' disease, and in predicting its clinical course with high sensitivity and high specificity. Especially, TBII using radioreceptor assay has been widely used. Recently, for detecting thyroid stimulating antibody(TSAb), a sensitive method using human TSH receptor-transfected Chinese Hamster Ovary(CHO) cells has been developed and clinically used. The aims of this study are to determine the change and discrepancy of 2 TSHR autoantibodics in clinical course and to evaluate the correlation between 2 autoantibodies. We measured TSAb and TBII in 30 newly diagnosed and untreated patients and in 73 previously diagnosed as Graves ' disease and treated with antithyroid drug. Also we compared the changes of the antibodies in clinical course and correlation between 2 antibodies. Thes results are summarized follows. 1. In newly diagnosed patients, all of the 30 patients had positive TBII and/or TSAb. None of them had negative TBII and negative TSAb. And in newly diagnosed patients, mean TBII and mean TSAb values are 46.8% and 361%, respectively. In 73 treated patients mean values are 18. 7% and 196% each other. Therefore, newly diagnosed group has significant greater TBII and TSAb than antithyroid drug-treated group. 2. TBII was significantly different between euthyroid group and thyrotoxic group in antithyroid drug-treated patients, but TSAb was not. 3. TBII was sequentially decreased as increased medication duration, but TSAb was not shown sequential decrease as increased medication duration. 4. There was significant negative correlation between cumulative doses of antithyroid drug and TBII, but no significant correlation between cumulative doses and TSAb. 6. There was significant positive correlation between TBII and TSAb in total patients group and in antithyroid drug medication group, but not in newly diagnosed group. In conclusion, in Graves ' disease patients, detection of TSHR antibodies are clinical values in establishing the diagnosis and prediction of clinical course. A method detecting TSAb using hTSHR-CHO cells should be further studied for standardization of measurement, and for detecting the changes of TSAb in clinical course, long-term follow-up of patients are important.
한억수,이상규,구희조 한국정보전략학회 1999 추계공동학술대회 논문집 Vol.- No.01
This study firstly aims to review the discussions among major nations and international organizations on removal of tariff wall in EC. Secondly, it is analyzed how the trend of tariff reduction of removal will affect an individual economy in a partial balance analysis model on an assumed small-size economy. In closing, political implication for removal of tariffs in EC will be presented. The study concluded that tariff removal on Internet EC has both positive and negative effects on the importing economy. It can improve the efficiency in utilization of economic resources by the importing economy in the long term while cut the financial revenue and aggravate the trade balance of importing country. It is inferred from such a conclusion that tariff removal can lead to trade imbalance between the Information haves and the have-nots.
측뇌실내 수막종 : 임상분석 및 수술접근법 Clinical Analysis and Surgical Approach
양희진,김동규,정희원,이현구,김현집,조병규,최길수,한대희 대한신경외과학회 1992 Journal of Korean neurosurgical society Vol.21 No.10
The authors present six cases of lateral ventricle meningiomas treated at Seoul National University Hospital between 1979 and 1991. These six cases of lateral ventricular meningiomas constitute 1.8 percent of all intracranial meningiomas and 16.7 percent of mass lesions of the lateral ventricle. The mean age was 29 years ranging from 11 to 50 years, younger than that or intracranial meningiomas with a statistical significance(p<0.01). Four of the patients were women and two were men. All cases were located in the trigonal area. The most common clinical symptoms and signs were related to increased intracranial pressure such as headache, nausea and vomiting. Based on the clinical presentation and radiological features(CT. MRI and angiography), correct preoperative diagnosis was possible in five cases. Gross total removal of the tumor was achieved in all cases. There was no operative mortality. A temporal gyrus approach was used in five cases with good surgical results. The benefits and drawbacks of each surgical approach for meningiomas of the lateral ventricle is discussed with review of pertinent literatures.
김분한,이희영,정영미,이은영,김흥규 성인간호학회 2001 성인간호학회지 Vol.13 No.2
This sutdy was undertaken to find out the perception of marital relationship and to understand the typology. The Q-population consisted of 153 statements that were collected and 33 Q-samples were selected. The P-samples for this study were made up of 30 who were married. Each responded to a Q-set of marital relationship according to 9-point scale. The results of Q-sorting were coded and analysed using QUANL PC program. Typological observations were as follows. 1) One in body and spirit type : In type 1, couples had different backgrounds respectively but felt one in body and spirit. 2) Companionship type : 2. Couples had not so much a hierarchial as a horizontal relationship. Couples perceived themselves as interdependent and friends. 3) Adaptation type : Couples readily adapted themselves to a marital relationship. They only depended on their spouses at times and stressed the relationship. Marriage was accepted as destiny rather than choice. On the basis of these results, we suggest: When a marriage is in trouble, that we assess the type of marital relationship in advance and intervene with a proper program. In addition, practical intervention programs need to be developed tailored to the type of subjective perception about the marital relation