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전경갑 釜山水産大學校 1992 論文集 Vol.47 No.-
The purpose of this study is to investigate philosophical backgrounds of postmodernism from the innovative ideas of poststructuralists such as Derrida, Lacan, Foucault, lyotard and Baudrillard, virtually all of whom had been influenced by the work of Nietzsche, Heidegger and, to a lesser extent, Freud. The conclusion of this study can be briefly summarized as follows. Firstly, postmodernism tends to reject the notion of free, conscious and rational subject, whose thinking procsses are not influenced by social and historical circumstances. This view of Cartesian human subject, or seen in Derrida's deconstruction of Husserlian notion of self-presence, antihumanism, poststructuralism dissolves and decenters the concept of rational subject. Contomporary postmodern critiques of the subject and its reason have their roots in Heidegger's ontoloty, Freudian theory of the unconsciousness and Nietzsche's theory of the will to power. Secondly, another signifant feature of postmodernism is its repudiation of such metadiscourses as the dialectic of spirit, the emancipation of the workers, the accumulation of wealth, the classless society, primarily because the postmodern condition is one in which metadiscourses of modernity have all lost credibility. The postmodernist's rejection of metanarratives and totalizing forms of analysis is anticipated in both Foucault's emphasis on local discourses and Derrida's criticque of any systematic philosophy. The nature of knowledge since the Second World War has been altered as societies enter what is known as the postmodern age. The advanced technology of postmodern societies follow the principle of optimal performance, maximizing output and minmizing input. It is, therfore, a game pertaining not to the true, the just or the beautiful, but to efficiency. The traditional belief that the acquisition of knowledge is indissociable from the discipline of minds is therefore obsolete and anachronistic. The third and related feature of postmodernism is its antipathy to the logocentrism of traditional metaphysics. We may consider as metaphysical system which depends on an unassailable foundation upon which a whole hierarchy of binary opposition may be constructed. Western metaphsics has yearned some 'ultimate word' such as God, Idea, Matter, the Absolute Spirit, the self, etc. Poststructuralist's condemnation of the logocentrism of traditional metaphysics echoes in Nietzsche's antipathy to any foundationalism and Heidegger's destruction of metaphysics. Fourthly, both postmodernism and poststructuralism are highly critical of the binary oppositions of metaphysics such as truth and false, speech and writing, presence and absence, high culture and popular culture, man and woman, essence and appearance, center and marginal, depth and surface. Poststructuralists deconstruct binary oppositions mainly because dichotomies are set up not raitonally but arbitrarily. Finally, according to poststructuralists and postmodernists, history does not reveal the progressive triumph of human rationality, not does it fulfil an ultimate telos. Deeply influenced by Nietzchean theory of eternal recurrence, they rejects evclutionist progressivism. The modernist idea that the history of thought is a progressive enlightenment is now radically interrogated by Foucault, Derrida, Heidegger and Nietzsche. The postmodernist charges that modernism is founded on the notion of rational subject, teleological metadisconrses, logocentrism, pursues elitist hierarchies, has an illusion of progressive emlightenment have their philosophical roots in the work of progressive enlightenment have their philosophical roots in the work of poststructuralists such as Derrida, Lacan, Foucault, Lyotard and Baudrillard, all of whom had been greatly influenced by the philosophical thought of Nietzshe and Heidegger. In short, postmodernism can be certainly supportive of enhancing pluralism and cultural democratization, However, it is unable to specify possible mechanisms of social change, and to state why change is better than no change.
이경갑 제주대학교 1993 논문집 Vol.37 No.-
. The liver of 203 slaughtered Holstein cows, were examined for their gross and histopathological observations. The fatty livers were classificated into mild(0 to 20%), moderate(20 to 40%) and severe(more than 40%). The results obtained were as follows; The number of cows with moderate and severs groups were 94(46.3%) and 43(21.2%), respectively. In the severe case with fatty changes, the size of the fatlet in the liver cell was larger than that of the mild ones. In the liver cells of the severe and moderate groups, the liver cell volume was increased, and the hepatic sinusoids were compressed by the liver cells. The nuclei were displaced to the periphery and lipogranulomas were present in the liver cells of the severe group.
李聖甲,成慶男 한경대학교 2004 論文集 Vol.26 No.1
Mixture of expressed & solvent extracted crude corn oil obtained from corn germ was carried out partial andlor total cooling process through heat exchange. Crude oil mixture at 40℃, 60℃ and 80℃ was storaged in storage tank under direct sunlight irradiation. Final deodorized(RBD) oil obtained through refining process used for storaged crude oil, it was determine color change of this RBD oil. RBD oils obtained were storaged in market and dark place as 0.9 ℓPET packaging bottle. Cause investigation of color reversion was attempted from Lovibond color change during storage period. At the result, color reversion wasn't appeared the linear correlation with refining process like to residual phosphorus con-tent, free fatty acids content and removal degree of pigments. As a result, cause of color reversion in corn oil was color fixation according to storage of crude oil at high temperature. Color fixed crude oil was not able to control at refining process. Prevention method of color reversion in corn oil was low temperature storage of crude oil at less than 40℃.
Thioacetamide에 의한 BALB/c 마우스 간의 시간별 약물대사효소 억제 양상 : A Time-Course Study
이정운,고우석,김갑호,배연경,하현정,한상섭,천영진,정태천 영남대학교 약품개발연구소 2001 영남대학교 약품개발연구소 연구업적집 Vol.11 No.-
Thioacetamide is a potent hepatotoxicant which requires metabolic activation by cytochrome P450s (P450s) for toxicity. In the present study, the elevation kinetic of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities by thioacetamide treatment was investigated in male BALB/c mice. Inaddition, the inhibitory effects of thioacetamide on liver microsomal P450 enzymes were further investigated. Thioacetamide at 100 mg/kg/ was treated intraperitoneally for 6, 12, 24, 36, 48 and 72 hr. The blood was collected at the designated time for assaying the serum enzyme activities. To determine the P450 isozyme-specific activities. ethoxyresorufin O-deethylase (EROD), methoxyresorufin O-demethylase (MROD), and benzyloxyresorufin O-debenzylase (BROD) activities were determined for P450 1A1, 1A2 and 2B1, respectively, in liver microsomal fractions. The activities of ALT and AST were started to be elevated 6 hr after thioacetamide treatment andreached the maximun at 36 hr after the treatment. The elevated activities were dramatically recovered at 72 hr. The microscopic exmination of the liver specimen also showed a similar profile of hepatotoxicity. All P450-associated enzyme activities were time-dependently inhibited by the treatiment with thioacetamide. The maximum inhibition of P450 enzymes was observed 36 hr after the treatment. Because the inhibition of P450 enzymes by thioacetamide was time-dependent, our present results suggest that thioacetamide might inhibit P450 enzymes in mechanism-based inactivation.
The Effect of Codium fragile (Chlorophyta) Extract on Hepatic Dysfunction and Hyperlipidemia in Rats
( Kap Joo Park ),( Eun Kyoung Hwang ),( Chan Sun Park ),( Myung Hwan Cho ),( Jae Seok Lee ) 한국환경생물학회 2010 환경생물 : 환경생물학회지 Vol.28 No.2
To examine the effect of Codium fragile on blood cholesterol and lipid metabolism, hyperlipidemia was induced in experimental animal rats through the administration of a hyper-cholesterolemic diet. Codium fragile powder was then administered to the rats for 5 weeks, after which, blood biochemical changes such as blood cholesterol, Aspartate Aminotransferase (AST: serum SGOT) and Alanine Aminotransferase (ALT: serum SGPT) enzyme activity, etc. were determined. And histological changes in liver cells were examined using an electron microscope. Codium fragile treatment resulted in a significant reduction of the levels of total cholesterol, blood triglyceride and low-density cholesterol (LDL. Chol) compared to the control rats. In contrast the expression levels of high-density cholesterol (HDL. chol.) were increased. The AST value of the Codium fragile administration group was significantly reduced and the blood ALT value of the Codium fragile group showed a significant decrease in comparison to the negative control group. In summary, this study demonstrated the beneficial possibilities of Codium fragile in improving the abnormality of lipid metabolism caused by liver cell damage and hyperlipidemia.