Cancer Activation and Polymorphisms of Human Cytochrome P450 1B1

천영진,김동학 한국독성학회 2016 Toxicological Research Vol.32 No.2

Human cytochrome P450 enzymes (P450s, CYPs) are major oxidative catalysts that metabolize various xenobiotic and endogenous compounds. Many carcinogens induce cancer only after metabolic activation and P450 enzymes play an important role in this phenomenon. P450 1B1 mediates bioactivation of many procarcinogenic chemicals and carcinogenic estrogen. It catalyzes the oxidation reaction of polycyclic aromatic carbons, heterocyclic and aromatic amines, and the 4-hydroxylation reaction of 17β-estradiol. Enhanced expression of P450 1B1 promotes cancer cell proliferation and metastasis. There are at least 25 polymorphic variants of P450 1B1 and some of these have been reported to be associated with eye diseases. In addition, P450 1B1 polymorphisms can greatly affect the metabolic activation of many procarcinogenic compounds. It is necessary to understand the relationship between metabolic activation of such substances and P450 1B1 polymorphisms in order to develop rational strategies for the prevention of its toxic effect on human health.

조력발전소 건설사업에 의한 해양 생물상 영향 사례 고찰

천영진,조범준,김태형 한국환경정책평가연구원 2011 한국환경정책평가연구원 기초연구보고서 Vol.2011 No.-

남자 프로 배구 경기 기록이 V-리그 시즌 승률에 미치는 영향

천영진 한국자료분석학회 2019 Journal of the Korean Data Analysis Society Vol.21 No.1

The purpose of this study is to analyze the variables affecting the season winning percentage using multiple regression analysis in the V-league competition organized by the Korean Volleyball Federation. For this purpose, we have analyzed the results of 13 seasons from 2005-2006 season to 2017-2018 season, and the results of open attack success rate, time difference attack success rate, back attack success rate, quick attack success rate, quick open success rate, serving per set, blocking per set, set per set, dig per set, total number of errors per set, 11 items as explanatory variables, and winning percentage as response variables were analyzed using multiple selection method among multiple regression analysis. As a result, open attack success rate, success rate of back attack, and success rate of quick attack were the variables that have the greatest influence on winning percentage. Quick open success rate, set per set and receive per set were excluded. Based on the above results, if the open attack and the back attack have a certain number of strikers in the team, the success rate is high and the win rate can be increased. In order to increase the success rate of quick attack, it should be based on accurate and stable receive. 본 연구는 한국배구연맹이 주최하는 남자 프로 배구 경기 중 V-리그 경기에서 다중회귀분석을 이용하여 각 시즌의 승률에 영향을 미치는 경기 기록 변인을 분석하고자 하였다. 이를 위하여 2005-2006 시즌부터 2017-2018 시즌까지 총 13 시즌의 경기 결과를 대상으로 경기 기록 변인인 오픈공격 성공률, 시간차공격 성공률, 후위공격 성공률, 속공 성공률, 퀵오픈 성공률, 세트당 서브, 세트당 블로킹, 세트당 디그, 세트당 세트, 세트당 리시브, 세트당 범실 등 총 11개를 설명변수로, 승률을 반응변수로 하여 다중회귀분석 중 단계별 선택방법을 이용하여 분석하였다. 그 결과 승률에 가장 큰 영향을 미치는 변인으로 오픈공격 성공률과 후위공격 성공률, 속공 성공률 순으로 나타났으며, 퀵오픈 성공률, 세트당 세트, 세트당 리시브 변수가 제외되었다. 위와 같은 결과에 따라 승률을 높이기 위해서는 공격 유형 중 특히 오픈공격과 후위공격의 성공률이 높아야 하는데 이를 위해서는 공격 능력이 뛰어난 레프트나 라이트 포지션의 주공격수가 있어야 하고 속공공격과 블로킹을 담당하는 센터의 역할이 중요하며, 안정된 서브 리시브와 디그 후 득점으로 바로 이어질 수 있기 때문에 이를 위한 수비력 강화가 필요하다.

대장균에서 발현된 인간 Cytochrome P450 1A1과 Rat NADPH-P450 Reductase와의 Fusion Protein의 효소 특성 연구

천영진,정태천,이현걸,한상섭,노정구 한국독성학회 1996 Toxicological Research Vol.12 No.2

The enzymatic properties for NADPH-P450 reductase domain of a fusion protein between human cytochrome P450 1A1 and rat NADPH-P450 reductase expressed in Escherichia coli were investigated. The fusion plasmid pCW/1A1OR-expressed E. coli membrane showed high NADPH-cytochrome c reductase activity ($830.1\pm 85.8 nmol\cdot min^{-1}\cdot mg protein^{-1}$), while pCW control vector and P 450 1A1 expression vector pCW/1A1 showed relatively quite low activity ($4.35\pm 0.49, 3.27\pm 0.50 nmol\cdot min^{-1}\cdot mg protein^{-1}$, respectively). The kinetic curves for NADPH-cytochrome c reductase followed typical Michaelis-Menten kinetics. The $K_{max}$ and $V_{max}$ for NADPH-dependent reductase activity were $8.24\pm 2.61\mu $and $817.9\pm 60.8 nmol\cdot min^{-1}\cdot mg protein^{-1}$, respectively, whereas those for cytochrome c-dependent reductase activity were $19.97\pm 2.86\mu M$ and $1303.5\pm 67.1 nmol\cdot min^{-1}\cdot mg protein^{-1}$. The reductase activities were also compared with those of rat, porcine and human liver microsomes. The activity of pCW/ 1A1OR-expressed E. coli membrane was 15.2-fold higher than that of rat liver microsome. Treatment with benzo(a)pyrene, 7-ethoxyresorufin and $\alpha$-naphthofiavone which are known as specific substrates or inhibitor for human P450 1A1 increased NADPH-cytochrome c reductase activity of fusion protein in E. coli membrane dose-dependently. These results demonstrate that the membrane topology of fused enzyme may be important for activity of its NADPH-P450 reductase domain.

프로야구에서 초구 스트라이크에 따른 투수 경기력 분석 및 타격 결과 비교

천영진 한국체육과학회 2022 한국체육과학회지 Vol.31 No.4

The purpose of this study is to investigate the importance of the first strike by comparing the effect of the first strike on the performance of the pitcher and the hitting result according to the count in a professional baseball game. For this purpose, 81 cases that filled the regular innings from the 2015 season to the 2018 season were targeted. The relationship between the pitcher's performance according to the first pitch strike ratio was examined, the hitting results according to the ball count were analyzed, and the performance between domestic and foreign pitchers was compared. As a result of analyzing the data of 81 starting pitchers, the following conclusions were obtained. First, the higher the ratio of first pitch strikes, the lower the pitcher's ERA and WHIP, and the number of walks can also be reduced. Second, when the first ball strikes rather than the ball, batting average, OPS, walks, and home runs can be reduced, and strikeouts and out rates can be increased. Finally, as a starting pitcher, there was no difference in skill between domestic and foreign pitchers.

농구림 높이가 청소년 슛동작의 안정성에 미치는 영향

천영진 空軍士官學校 1999 論文集 Vol.44 No.-

The purpose of this study was to examine the basketball shooting motion in a diverse basketball rim height and age, The subjects were 3 elementary school basketball players, 3 middle school basketball players, and 3 high school basketball players. Each of the subjects executed the shooting five times for every three different height of a basketball rim; 2.60m, 2.80m, 3.05m. The experimental instruments ofr this study consisted of a video camera and a control object. The stability of shooting motion could be detected by number of means of experimental standard deviation of a relative phase. Data were analysed through a tow-way ANOVA. The following results of this study are based on the experimental process and observation. The first, the elementary basketball players used prominently elbow joint over wrist joint, the middle school basketball players used prominently hip joint, and the high school basketball players used prominently shoulder joint. The second, wrist-elbow, wrist-shoulder, wrist-knee, and wrist-ankle coordination showed no significant difference in stability with the height of a baskerball rim, but the middle school basketball players showed instability with all coordination at the high of 2.05m. The third, wrist-hip coordination showed a change in stability with age of athletes, and others coordination showed no changes. The fourth, there was no any relation between the height of a basketball rim and the age. The fifth, the overall coordination stability of the all-round shooting motion showed no significant difference between the height and the age. But, based on the means of standard deviation, the high school basketball players showed the best stability among subjects at the height of 3.05m, and there were no declination of means between else two groups.

산림경영기반시설의 주요 환경영향 -선형사업(임도) 중심으로

천영진,사공희,전동준 한국환경정책평가연구원 2012 한국환경정책평가연구원 기초연구보고서 Vol.2012 No.-

남자 프로배구 경기에서 득점 과정을 이용한 경기 분석

천영진(Young Jin Chun) 한국사회체육학회 2009 한국사회체육학회지 Vol.0 No.38

As the men`s professional volleyball matches being the subject, the goal of this research was placed on examining the notational processes and changes during the set progresses of each matches along with the rate of set scores in analyzing what influences they had on the success and failure of the set. For this research, the 105 regular season matches, the 3 play-offs and 3 championship finals of the 6 participating teams in the 2007-2008 season V-league, adding up to 111 matches and 414 sets were set as subjects to gain the rate of set score and calculate to gain the percentage of the winning probability in accordance to point difference. Also, to verify the difference between the first point and final consequence of the team with the first serve, the chi-squared test was executed. Based on these results, the following conclusions can be achieved. First, during a volleyball match, the winning probability of the team that won the first set displayed to be 80.2% and therefore the effort to win the first set is required more than anything. Secondly, since the winning probability of the team that gains 20 points within a set first, showed to be 88.5% and therefore the team should work to attain 20 point faster than their competing team during a match. Also, when there exists a gap larger than 5 points and it is not during the last set as well as when there exists a gap larger than 6 points during a second technical time out, a alternation of athlete is essential for distributing the physical strength of the athletes and for the preparation of the next set. Third, since the winning probability showed to be high for the team with the first serve to gain the first point, with the exception of the 5th set, the team with the serve should order their serve strongly. Fourth, in a set that does not carry a great difference between the scores, the victory and defeat is judged around the point 23 and therefore, greater amount of concentration is required in the end.

15주 야구 수업을 통한 던지기 동작의 운동학적 변인 변화 분석

천영진 ( Young Jin Chun ),신인식 ( In Sik Shin ) 한국운동역학회 2012 한국운동역학회지 Vol.22 No.1

The purpose of this study was to investigate the pattern change of throwing in baseball after 15 weeks of participation in baseball class, by examining ball speed, trunk and upper body angles. The comparison was with 6 university students that haven`t had any experience in baseball. 8 infra red cameras and 2 force platforms were used to collect the data. First, there was an increase in the speed of the ball after the class. Second, there was no significant difference in the allocated phases during the throw before and after class. Third, the release point was lower and more in front. Forth, there was an increase in the knee flexion at the left foot landing and release point. Finally, there was an increase in the maximum shoulder external rotation and pelvis angle. It is recommended that the coordination between the segments should be investigated to improve our understanding of the learning of throwing in future research.

보행 시 지지면 급변에 따른 연령별 운동학적 반응 형태 비교

천영진 ( Young Jin Chun ),신인식 ( In Sik Shin ) 한국운동역학회 2011 한국운동역학회지 Vol.21 No.3

The purpose of this study was to analyze the difference in reaction patterns during the support phase after perturbation in gait according to different age. A total of 12 subjects participated; 5 elderly and 7 adults(control), to investigate the differences between normal and perturbed gait. The step length didn`t change during normal and perturbed gait but was longer in the control group. There was no difference in the step width. When the right foot was perturbed, the control group`s left foot speed was faster than the elderly group`s which was to maintain stability. The elderly flexed both right and left knees more than the control group. After the perturbation, the elderly group had a larger trunk anterior flexion. With the larger flexion of both legs of the elderly group it shows that the lack of knee flexion strength is a factor, that could cause falling and so a prevention program should focus on strengthening the quadriceps. With the excessive trunk flexion after the perturbation by the elderly group observed, it is suggested that while walking everyday a good routine of walking with an upright posture should be developed.