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Chang Seok Oh(Chang Seok Oh),Myeung Ju Kim(Myeung Ju Kim),Yi-Suk Kim(Yi-Suk Kim),Sori Min(Sori Min),Kyong Taek Oh(Kyong Taek Oh),Soong Deok Lee(Soong Deok Lee),Dong Hoon Shin(Dong Hoon Shin) 대한해부학회 2023 Anatomy & Cell Biology Vol.56 No.1
Lactase non-persistence (LNP), one of the causes of lactose intolerance, is related to lactase gene associated single nucleotide polymorphisms (SNPs). Since the frequency of LNP varies by ethnic group and country, the research to reveal the presence or absence of LNP for specific people has been conducted worldwide. However, in East Asia, the study of lactase gene associated SNPs have not been sufficiently examined so far using ancient human specimens from archaeological sites. In our study of Joseon period human remains (n=14), we successfully revealed genetic information of lactase gene associated SNPs (rs1679771596, rs41525747, rs4988236, rs4988235, rs41380347, rs869051967, rs145946881 and rs182549), further confirming that as for eight SNPs, the pre-modern Korean people had a lactase non-persistent genotype. Our report contributes to the establishment of LNP associated SNP analysis technique that can be useful in forthcoming studies on human bones and mummy samples from East Asian archaeological sites.
Cheong, Taek-Chin,Shin, Eon Pil,Kwon, Eun-Kyung,Choi, Ji-Hye,Wang, Kang-Kyun,Sharma, Prashant,Choi, Kyong Hoon,Lim, Jin-Muk,Kim, Hong-Gee,Oh, Keunhee,Jeon, Ju-Hong,So, Insuk,Kim, In-Gyu,Choi, Myung-Si American Chemical Society 2015 ACS CHEMICAL BIOLOGY Vol.10 No.3
<P>Reactive oxygen species (ROS) play an important role in cellular signaling as second messengers. However, studying the role of ROS in physiological redox signaling has been hampered by technical difficulties in controlling their generation within cells. Here, we utilize two inert components, a photosensitizer and light, to finely manipulate the generation of intracellular ROS and examine their specific role in activating dendritic cells (DCs). Photoswitchable generation of intracellular ROS rapidly induced cytosolic mobilization of Ca<SUP>2+</SUP>, differential activation of mitogen-activated protein kinases, and nuclear translocation of NF-κB. Moreover, a transient intracellular ROS surge could activate immature DCs to mature and potently enhance migration <I>in vitro</I> and <I>in vivo</I>. Finally, we observed that intracellular ROS-stimulated DCs enhanced antigen specific T-cell responses <I>in vitro</I> and <I>in vivo</I>, which led to delayed tumor growth and prolonged survival of tumor-bearing mice when immunized with a specific tumor antigen. Therefore, a transient intracellular ROS surge alone, if properly manipulated, can cause immature DCs to differentiate into a motile state and mature forms that are sufficient to initiate adaptive T cell responses <I>in vivo</I>.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/acbcct/2015/acbcct.2015.10.issue-3/cb5009124/production/images/medium/cb-2014-009124_0004.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/cb5009124'>ACS Electronic Supporting Info</A></P>
Using Machine Learning Algorithms to Forecast the Optimal Bidding Rate in Apartment Auctions
Jung Taek Rhee,Won Bin Ahn,Kyong Joo Oh 계명대학교 자연과학연구소 2021 Quantitative Bio-Science Vol.40 No.1
In this paper, we use the machine learning model to make predictions about the winning bid rate of apartments nationwide. The winning bid rate for apartments should consider various variables. There is a possibility that the existing hedonic priming models might predict uncertain results because of methodological constraints. In this paper, we aim to improve the predictions of apartment auction winning rates by utilizing algorithms such as Random Forest, XGBoost, LightGBM, and DNN, which are robust to problems such as nonlinearity and multicollinearity. A total of 111,232 nationwide apartment auction data were learned and tested from January 2010 to June 2020 by using the data provided by the GG auction and macroeconomic variables collected from KOSIS. In addition, a moving window methodology and an extending window methodology are applied considering by the characteristics of the social science data whose probability structure changes over time. Empirical study shows that the Gradient Boosting models outperforms other models in terms of MAPE, RMSE, MedAE, and AbsMean. There is no significant difference between a moving window methodology and an extended window methodology.
Kim, Jin Taek,Kim, Yeonjung,Cho, Young Min,Koo, Bo Kyung,Lee, Eun Kyung,Shin, Hyoung Doo,Jang, Hak Chul,Choi, Jung Won,Oh, Bermseok,Park, Kyong Soo Blackwell Publishing Ltd 2009 Clinical endocrinology Vol.70 No.1
<P>Summary</P><P>Objective </P><P>Adiponectin receptors 1 and 2 (<I>ADIPOR1</I> and <I>ADIPOR2</I>) are considered as candidate genes for type 2 diabetes because they mediate the metabolic effects of adiponectin on target tissues. We investigated whether common polymorphisms of <I>ADIPOR1</I> and <I>ADIPOR2</I> are associated with type 2 diabetes or its related phenotypes in Koreans.</P><P>Design and patients </P><P>By sequencing of the DNA samples from 24 unrelated Korean subjects, we selected seven single nucleotide polymorphisms (SNPs) from <I>ADIPOR1 </I>and four SNPs from <I>ADIPOR2 </I>for genotyping in 757 type 2 diabetic patients and 644 nondiabetic subjects.</P><P>Results </P><P>None of the SNPs were associated with the risk of type 2 diabetes. However, g.−7309A>G (rs75172865) in <I>ADIPOR1 </I>was associated with lower insulin resistance, measured by the homeostasis model assessment of insulin resistance (HOMA-IR). Thereafter, we transfected three different human cell lines with plasmids harbouring g.−7309A>G and found that this variant reduced the promoter activity of <I>ADIPOR1</I>. In <I>ADIPOR2</I>, g.−63442G (novel SNP) and g.33447T (rs1044471) were associated with smaller waist circumference.</P><P>Conclusions </P><P>None of the SNPs in either <I>ADIPOR1 </I>or <I>ADIPOR2</I> were associated with the risk of type 2 diabetes in Koreans. However, the altered activity of the <I>ADIPOR1 </I>promoter was associated with insulin resistance and SNPs of <I>ADIPOR2</I> were associated with waist circumference.</P>
허상택 ( Sang Taek Heo ),박미연 ( Mi Yeoun Park ),최영실 ( Young Sill Choi ),오원섭 ( Won Sup Oh ),고관수 ( Kwan Soo Ko ),백경란 ( Kyong Ran Peck ),송재훈 ( Jae Hoon Song ) 대한내과학회 2008 대한내과학회지 Vol.74 No.1
Q열은 국내에서도 드물지 않은 질환으로 생각되며, 조기에 진단하지 못하는 경우에 심내막염이나 혈관염 등의 만성 Q열로 진행하여 사망에 이를 수 있다. 물론 급성 Q열은 비특이적 증상에서 폐렴이나 간염 소견으로 내원하는 환자가 대부분이나 발열의 원인이 확실한 경우 원인균이 밝혀지지 않아도 Q열의 혈청학적 의뢰를 요하는 경우는 흔하지 않다. 하지만 발열을 주소로 내원한 환자들에 대하여 상기 증례들처럼 불명열의 경우 가축이나 이들의 부산물에 접촉력이 있는 경우 뿐만 아니라 특별한 접촉력이나 직업력이 없더라도 불명열로 내원한 환자들의 감별진단에서 Q열의 가능성을 고려하여 혈청학적 검사 및 핵형 분석을 시행해야 하겠다. 향후 국내에서도 사람뿐만 아니라 가축에서의 대규모의 역학적 조사가 추가적으로 필요할 것으로 생각된다. Q fever is an orthozoonotic infection caused by Coxiella burnetii, which was recently reclassified from the order Rickettsials to the order Legionellales. Although Q fever is usually mild and self-limiting, it may be manifested as a serious disease, such as pneumonia, endocarditis, or meningoencephalitis. We describe three separate cases of acute Q fever, which were diagnosed by an indirect micro-immunofluorescence assay (MIFA) test and DNA amplification (PCR). Three adult patients were admitted between December 2004 and August 2006 because of a fever of greater than three weeks duration. Only one patient had contact history with a dog. Of the three patients, two patients had myalgia, headache, skin rash, lymphadenopathy, and hepatosplenomegaly. Although all sets of blood cultures were negative, anti-phase II antibody titers by using an indirect MIFA (IgG 1:512-1,024 and IgM 1:320) were markedly increased in sera from all of three patients. Concomitant PCR assays also demonstrated the presence of OMP com1 for C. burnetii in blood from all of the three patients. Two patients had complete resolution of symptoms and signs with a two-week course of doxycycline, while one patient had spontaneous defervescence. Although the incidence of Q fever is not well known yet in Korea, it should be considered in the differential diagnosis of patients with fever of unknown origin. (Korean J Med 74:100-105, 2008)
Jun Seok Oh,Kyu Jin Sa,Do Yoon Hyun,Gyu‑Taek Cho,Ju Kyong Lee 한국유전학회 2020 Genes & Genomics Vol.42 No.12
Background: Information on the genetic variation of genetic resource collections is very important for both the conservation and utilization of crop germplasms in genebanks. Var. frutescens of Perilla crop is extensively cultivated in South Korea as both an oil crop and a vegetable crop. Objectives: We used SSR markers to evaluate the genetic diversity, genetic relationships, and population structure of 155 accessions of var. frutescens that have been selected as genetic resources for the development of leaf vegetable cultivars and preserved in the RDA-Genebank collection from South Korea. Methods: A total of 155 accessions of var. frutescens of Perilla crop collected in South Korea were obtained from the RDA-Genebank of the Republic of Korea. We selected 20 SSR markers representing the polymorphism of and adequately amplifying all the Perilla accessions. Results: The average GD and PIC values were 0.642 and 0.592, respectively, with ranges of 0.244–0.935 and 0.232– 0.931. The genetic variability in the southern region of South Korea was higher than that in the central region. The clustering patterns were not clearly distinguished between the accessions of var. frutescens from the central and southern regions of South Korea. Conclusion: These results regarding the genetic diversity and population structure of the 155 accessions of var. frutescens of South Korea provide useful information for understanding the genetic variability of this crop and selecting and managing core germplasm sets in the RDA-Genebank of the Republic of Korea.
Min Sang Park,Kyong Taek Lee,Chang Yong Kang,Gil-Bok Choi,Hyun Chul Sagong,Chang Woo Sohn,Byoung-Gi Min,Jungwoo Oh,Majhi, Prashant,Hsing-Huang Tseng,Lee, Jack C,Jeong-Soo Lee,Jammy, Raj,Yoon-Ha Jeong IEEE 2010 IEEE electron device letters Vol.31 No.10
<P>We present a comparative study of the effects of a Si capping layer on SiGe channel pMOSFETs used for radio-frequency (RF) applications. In Si-capped devices, the drive current increases because Si/SiGe heterojunction layers form a SiGe quantum well, which reduces carrier scattering. Conversely, SiGe samples without a Si capping layer suffer severe interface degradation, due to Ge diffusing into the gate dielectric. Devices using a Si capping layer have enhanced RF performance and reduced low-frequency noise, which is a key factor affecting phase noise. There is an increase in the RF figures of merit. These benefits indicate that a Si capping layer should be used in SiGe channel pMOSFETs.</P>
Son, Young-Jin,Park, Kyong-Hee,Lee, Sang-Yong,Oh, Sung-Jin,Kim, Chang-Kyu,Choi, Byoung-Taek,Park, Yong-Cheol,Seo, Jin-Ho Korean Society for Biotechnology and Bioengineerin 2007 Biotechnology and Bioprocess Engineering Vol.12 No.5
Preproinsulin is a well-known precursor of human insulin for the regulation of blood glucose levels. In this study, fed-batch fermentations of recombinant Eschericha coli JM109/pPT-MRpi were carried out for the overexpression of human preproinsulin. The expression of human preproinsulin was controlled by the temperature inducible P2 promoter. The time-course profiles of fed-batch fermentation and SDS-PAGE analysis showed that human insulin expression was triggered by a culture temperature change from 30 to $37^{\circ}C$. Fermentation shift strategies, including the multi-step increase of temperature and the modulation of initiation time, were optimized to obtain high titers of cell mass and preproinsulin. The optimized fed-batch fermentation, consisting of a three-step shift of culture temperature from 30 to $37^{\circ}C$ for 2 h, gave the best results of 43.1 g/L of dry cell weight and 33.3% preproinsulin content, which corresponded to 2.0- and 1.2-fold increases, respectively, as compared to those of fed-batch culture at a constant temperature of $37^{\circ}C$.
강직척추염 환자에서 TNF-α 억제제 사용 후 악화된 건선
오지민 ( Ji Min Oh ),고은미 ( Eun Mi Koh ),김형진 ( Hyung Jin Kim ),이재준 ( Jae Joon Lee ),안중경 ( Joong Kyong Ahn ),차훈석 ( Hoon Suk Cha ),이주흥 ( Joo Heung Lee ),장기택 ( Kee Taek Jang ) 대한류마티스학회 2010 대한류마티스학회지 Vol.17 No.2
TNF-α antagonists have been successfully utilized in the treatment of autoimmune diseases, including psoriasis and psoriatic arthritis. Paradoxically, new onset or exacerbation of psoriatic lesions during treatment with TNF-α antagonists have been reported. It has been postulated that TNF-α blockade may cause disruption in the balance between TNF-α and type 1 interferon (IFN)-α, which are the key players in the pathogenesis of psoriasis. We report a case of psoriasis exacerbation during TNF-α antagonist therapy in a 53-years-old man with ankylosing spondylitis. The patient has been treated with etanercept for 3 years and 7 months when he developed accelerated deterioration of psoriasis. His condition was previously under control solely by local treatment. Physical examination revealed vigorous desquamative lesions with silvery scale in both lower legs. Deterioration of psoriasis was attributed to etanercept therapy and was subsequently discontinued. Clinical improvement of psoriasis has been observed 2 months following cessation of etanercept.