한의진단명과 진단요건의 표준화 연구 II (표준화 실례) : 2차년도 연구결과 중간 보고

양기상,최선미,최승훈,안규석,박경모,박종현,김성우,신승호,정우열,전병훈,고현,김정범,신상우,김성훈,김동희,권영규,엄현섭,장혜옥 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the second year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows; - differential diagnosis according to condition of body fluid, differentiation of syndromes according to the state of qi and blood, differential diagnosis according to relative excessiveness or deficiency of yin and yang(氣血陰陽津液辨證) - differentiation of diseases according to pathological changes of the viscera and their interrelation - analyzing and differentiating of febrile diseases in accordance with the theory of the six channels(傷寒辨證) The individual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name(異名), notion of diagnosis pattern, index of differentiation of symptoms and signs(辨證指標), the main point of diagnosis, analysis of diagnosis pattern(證候分析), discrimination of diagnosis pattern(證候鑑別), a way of curing a diseases(治法), prescription(處方), herb in common use(常用藥物), diseases appearing the diagnosis pattern(常見疾病), documents(文獻調査). This study was carried out on the basis of the Chinese documents and references.

담도에 생긴 이소성 췌장에 의한 폐쇄성 황달

신동훈 고신대학교 의과대학 2010 고신대학교 의과대학 학술지 Vol.25 No.2

Ectopic pancreas is an uncommon developmental anomaly, Futhermore obstructive jaundice by ectopic pancreas in common bile duct is very rare. We reported a case of ectopic pancreas in common bile duct mimicking distal cholangiocarcinoma. MRCP and percutaneous cholangiogram demonstrated a distal common bile duct obstruction suspicious of cholangiocarcinoma. A 79-year old male patient presented abdominal pain and obstructive jaundice. He underwent a pylorus-preserving pancreaticoduodectomy. Histology showed a nodule of ectopic pancreatic tissue in distal common bile duct. We report this very rare case of ectopic pancreas in common bile duct mimicking distal cholangiocarcinoma.

상아질 지각과민 처치제의 임상적 효과에 대한 연구

신동훈,조경모 大韓齒科保存學會 2000 Restorative Dentistry & Endodontics Vol.25 No.2

대뇌 기저핵 신경세포 일차배양에서 망간에 의해 유도된 Appoptosis : 형태학적인 소견

신동훈,김상표,정용욱,배재훈,송대규,백원기 大韓産業醫學會 2000 대한직업환경의학회지 Vol.12 No.1

목적 : 본 실험은 대뇌기저핵의 신경세포를 배양하여 망간(MnCl₂)을 투여한 후 망간독성에 의한 신경세포의 apoptosis를 형태학적인 소견으로 관찰하였다. 방법 : 배양된 신경세포에 0.01에서 10μM Mnc12를 48시간동안 처리한 후 TUNEL (TdT-mediated dUTP Nick End Labelling)법 및 투과전자현미경학적으로 관찰하였다. 결과 : TUNEL방법을 이용하여 관찰한 결과 TUNEL반응에 갈색으로 양성반응을 나타내는apoptotic 세포의 수가 대조군에 비해 MnCl₂를 투여한 군에서 유의하게 높게 나타났으며(P〈0.05), 투과전자현미경학적 소견상 대조군의 신경세포들은 핵인(nucleolus)이 두드러지게 특징적으로 보이면서 핵막과 세포질내 소기관들이 잘 보존되어 있으며, 세포질내망(ER)과 사립체(mitochondria)를 특히 많이 가지고 있었다. Mnc12를 48시간 동안 처리한 군에서 이질염색질(heterochromatin)이 핵막으로 이동하면서 응집되어 있었으며, 핵내 불규칙한 형태의 염색질이 나타나 분절이 진행되는 소견을 보였고, Apoptosis의 가장 특징적인 초기 소견인 막으로 둘러싸인 반달모양의 핵내염색질의 분절편(fragment-ed chromatin)과 주위의 상대적으로 정상적인 소기관으로 구성된 apoptotic body를 관찰할 수 있었다. 결론 : 신경세포에서 망간에 의해 apoptosis가 유도됨을 형태학적인 방법으로 확인할 수 있었으며 망간에 의한 세포사망양상에 apoptosis가 하나의 기전이 될 수 있을 것이다. Objectives : Manganese is cytotoxic to the central nervous system including basal gan-glia. Its toxic mechanism is related to oxidative stress, mediated by toxic free radicals but is specultives. In the present study , we have investigated to manifest apoptosis in man-ganese-induced cytotoxicity in primary neuronal cell culture of rat basal ganglia. Methods : To detect apoptotic neuronal cells were stained by the terminal deoxynu-cleotide (TdT) -mediated dUTP nick end-labelling (TUNEL) method and apoptotic changesin nuclei of neurons were observed by electron microscopy. Results : We showed that TUNEL immunostain showed brownish signal in the nuclei of apoptotic cells and the proportions of apoptotic cells in Manganese treatment groups were more higher than controls. On transmission electron microscopy, there were chromatine condensation with margination toward nuclear membrane and condensation of cyto-plasm in the treated with luM MnCl²for 48 hours in a basal ganglia neurons. Apoptotic bodies were found and consisted of semilunar-like condensed nuclei with relatively intact cytoplasmic organelles. Conclusions : Apoptosis appears to be one mechanism in the manganese-induced net-ronal cell death. Manganese intoxication is a convenient model for apoptosis study.

FeTaNC 미세결정박막의 연자기 특성에 관한 연구

申東勳,崔雲,金亨駿,高兌赫 弘益大學校 科學技術硏究所 1996 科學技術硏究論文集 Vol.7 No.1

Magnetic properties and microstructures of FeTaNC thin films, which were deposited by magnetron reactive sputtering method, were investigated as a function of CH₄ and N₂ gas partial pressures. Magnetic properties of FeTaNC films were depended on total reactive gas pressures as well as CH₄/N₂ pressure ratios. For reactive gas partial pressures of 5 ∼ 10 %, optimum magnetic properties were observed in the FeTaNC films with proper CH₄/N₂ ratio. On the other hand, at 15% of gas partial pressure, FeTaN and FeTaC films showed superior properties to FeTaNC films. Above 15%, the magnetic properties of films rapidly degraded due to an excess incorporation of C and/or N atoms. Excellent soft magnetic properties of 17kG of Bs, 0.3 Oe of Hc, and 4000 of μ' (at 5 ㎒) were obtained in the FeTaNC films. The process windows of FeTaNC films which are showing good soft magnetic properties are larger than FeTa(N/C) films. High permeabilities of FeTaNC films could be explained by the Fe lattice distortion caused by N atoms, hence reduction of magnetic anisotopy. While precipitated TaN and TaC particles effectively supress the growth of α-Fe grains leading to a good soft magentic properties, FeN and FeC phases such as Fe3N, Fe4N, FexC have detrimental effects.

섬유가공업체 코팅 부서 근로자들의 유기용제 만성폭로에 의한 신경행동학적 수행능력의 변화

신동훈,이무식,양선희 大韓産業醫學會 1998 대한직업환경의학회지 Vol.10 No.2

The study was conducted to predict the risk of chronic exposure by neurobehavioral test and to use it as a basic source of the management for workers exposed to organic solvents. The exposed group was selected from coating department of textile processing industry. The unexposed group was selected from those who visited the clinic to take an annual check-up. The author administered WHO-NCTB (neurobehavioral core test battery). Also, Scandinavian Questionnaire 16 was tested by self-administration to find the correlation between subjective symptoms and NCTB results, and to assess the availability of the Questionnaire in mass screening test concurrently. The final analysed subjects were 78(27 in exposed group and 51 in unexposed group) workers except who had a neurologic disease or systemic disease affecting the central nervous system. In Questionnaire study, there was no significant difference in total neurotoxic symptom scores between the exposed and the unexposed group. In NCTB, the exposed group had lower mean scores than the unexposed group for all tests. When the effect by age and education were considered, there was a statistically significant difference only in pursuit aming test. This study suggests the availability of NCTB and the Questionnaire for the assessment of neurobehavioral change in workers exposed to organic solvents.

용매추출에 의한 2-propanol회수에 관한 연구

신현심,정상훈,박동원 東亞大學校 海洋資源硏究所 1994 硏究論文集 Vol.7 No.2

The experimental binodal curve and tie line data were determined for ternary systems of 2-propanol-water with isoamylacetate and 1-butanol as solvents at 25℃. Consistency of the experimental data for several correlations was investigated, the experimental tie line data were correlated with NRTL model and the parameters in NRTL model were estimated and the calculated values of tie lines were predicted.

미생물 포괄고정화를 위한 고정화재의 비교검토

신동범,윤창훈,강경수 제주대학교 환경연구소 1997 환경연구논문집 : 제주대 Vol.5 No.-

We conducted the experiments to find out the appropriate gelling materials for the treatment of waste water by immobilizing microorganisms inside the gels. The gelling materials known to immobilize microorganisms or cells in them are polyacrylamide, polyvinylalcohol, sodium alginate, κ-carrageenan and chitosan. The gel strengths were determined by the breaking points of the pellet using a rheometer with reaction time. The polyacrylamide gels were retained their solidities and activities excellently compared with the other pellets of polyvinylalcohol, sodium alginate and chitosan with reaction time. It is considered that, in the other hand, the polyacrylamide gels are toxic to the single microorganisms and cells by free radicals during the formation of gels. We used activated sludge for the mmobilization, so it didn't matter the toxicity caused by free radicals. The profiles of waste water treatment by all the immobilized pellets using in this study were showed nearly similar patterns, but gel strength of all the gels except polyacrylamide pellets were getting weak and weak as reaction time goes by. It was concluded that the polyacrylamide gels are excellent for immobilization of activated sludge for waste water treatment, but in the case of immobilization of single microorganisms or cells, natural polysaccharides of sodium alginate, κ -carrageenan or chitosan are thought to be suitable, and it must be developed the techniques for elevating gel strength of nautral polysaccharides.

고혈압 환자에서 Leukoaraiosis 정도와 망막증과의 연관성 : 예비연구 Preliminary Results

신동익,한현정,서대희,이광훈 關東大學校 醫科大學 醫科學硏究所 2002 關東醫大學術誌 Vol.6 No.1

Changes in the cerebral white matter (leukoaraiosis;LA) are detected with increasing frequency by computed tomography (CT) and magnetic resonance imaging (MRI) in elderly patients with diabetes mellitus and hypertension. The purpose of this study is to determine whether the severity of retinopathy is correlated with degree of LA in patients with hypertension. Twenty-three consecutive patients with patients with hypertension admitted in the department of neurology were evaluated for degree of LA and severity of retinopathy. 8patients were 15female. The age distribution was between 52 and 85 years(mean 69.1years). The duration of hypertension was between 1 and 30 years(mean8.2 years). The degree of LA was correlated with severity of hypertensive retinopathy(p<0.05), especially in relatively young patient, short periods of disease, and female paitents(p<0.05). We can make a rough estimation of degree of LA with fundus examination without CT or MRI evaluations in hypertensive patients, especially in relatively young and female patients with short durations of disease. However, more broad study should be made for these value and relationship.

수종 코어용 복합레진 수복재의 물성에 관한 연구

신수일,신동훈 大韓齒科保存學會 2004 Restorative Dentistry & Endodontics Vol.29 No.2

The purposes of this study were to estimate the material properties of the recently developed domestic composite resins for core filling material (Chemical, Dual A, Dual B; Vericom, Korea) and to compare them with other marketed foreign products (CorePaste, Den-Mat, USA; Ti-Core, Essential Dental Systems, USA: Support, SCI-Pharm, USA). Six assessments were made; working time, setting time, depth of polymerization, flexural strength, bonding strength, and marginal leakage. All items were compared to ISO standards. All domestic products satisfied the minimum requirements from ISO standards (working time: above 90 seconds, setting time: within 5 minutes), and showed significantly higher flexural strength than Core Paste. Dual A and B could, especially, reduce the setting time to 60 seconds when cured with 600 mW/㎠ light intensity. All experimental materials showed 6 mm depth of polymerization. Bond strengths of Ti-Core and Dual B materials were significantly higher than the other materials. Furthermore, three domestic products and Ti-Core could reduce the microleakage effectively.