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Hong, Soon-Pyo,Yang, Joon-Seung,Han, Jung-Yeon,Ha, Sung-Il,Chung, Joong-Wha,Koh, Young-Youp,Chang, Kyong-Sig,Choi, Dong-Hyun Pharmaceutical Society of Great Britain 2011 Journal of pharmacy and pharmacology Vol.63 No.1
<P>The purpose of this study was to examine the effects of lovastatin on cytochrome P450 (CYP) 3A4 and P-glycoprotein (P-gp) in vitro and then to determine the effects of lovastatin on the pharmacokinetics of diltiazem and its main metabolite, desacetyldiltiazem, in rats.</P>
결체 조직 질환에서 조직학적으로 확진된 통상성 간질성 폐렴과 비특이성 간질성 폐렴의 임상상과 흉부 HRCT 소견의 비교 및 방사선학적 변화와 임상적 지표와의 연관성
안중경 ( Joong Kyong Ahn ),고은미 ( Eun Mi Koh ),이유선 ( You Sun Lee ),차훈석 ( Hoon Suk Cha ),정만표 ( Man Pyo Chung ),한정호 ( Jung Ho Han ),오대근 ( Dae Kun Oh ),이경수 ( Kyung Soo Lee ) 대한류마티스학회 2007 대한류마티스학회지 Vol.14 No.3
Objective: The purpose of this study is to assess the clinical characteristics and the serial changes of high resolution CT (HRCT) findings and to correlate those with the results of clinical parameters in biopsy proven nonspecific interstitial pneumonia (NSIP) and usual interstitial pneumonia (UIP) with connective tissue diseases (CTD). Methods: Retrospective analysis was made of forty patients with CTD diagnosed of NSIP and UIP from a single tertiary hospital between January 1996 and February 2006. Results: UIP was common in rheumatoid arthritis, systemic sclerosis and Sjogren`s syndrome, while NSIP was frequent in polymyositis/dermatomyositis. No significant difference was found in the clinical characteristics of patients with NSIP and UIP. In initial HRCT findings, extents of honeycombing and reticulation pattern were significantly more in UIP-CTD than in NSIP-CTD. In bronchoalveolar lavage (BAL) results, proportion of alveolar macrophages was significantly higher in NSIP-CTD than in UIP-CTD. In NSIP-CTD, significant increment in the extent of reticulation and honeycombing was noted in the serial HRCT findings despite the aggressive treatment. Significant correlation was found between leukocytosis and honeycombing change in NSIP-CTD. Despite no significant difference of survival between two groups, patients with UIP-CTD seem to have a higher mortality than those with NSIP-CTD. Conclusion: It is suggested that chest HRCT and BAL fluid analysis may be helpful in the differential diagnosis of NSIP- and UIP-CTD and leukocytosis in initial blood test might be predictive of honeycombing progression in NSIP-CTD. Further study will be required to compare with the prognosis of NSIP- and UIP-CTD.
태아 폐성숙 평가에 있어서 Lamellar Body Count의 임상적 효용성과 경제성
홍승표 ( Seung Pyo Hong ),박은경 ( Eun Kyung Park ),정선영 ( Sun Young Jeong ),주하경 ( Ha Kyong Joo ),이지현 ( Jee Hyun Lee ),문희봉 ( Hee Bong Moon ),고영미 ( Young Me Koh ),신종철 ( Jong Chul Shin ),김창이 ( Chang Yi Kim ) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.11
목적: 신생아 폐성숙을 예측하기 위하여 시행하는 Lamellar body count의 유용성과 경제성을 알아보고자 하였다. 연구 방법: 폐성숙도 평가를 위하여 양수천자를 시행한 후 72시간 내에 분만한 32명의 산모를 대상으로 하였다. Lamellar body count는 경복부 양수천자를 통해 얻어진 양수에서 깨끗한 양수는 바로 검사를 시작하고 혈액이나 태변에 오염된 양수는 3분간 원심 분리한 후 3개의 sample로 나누어서 연속적으로 Coulter Objective: To evaluate the availability and efficacy of the Lamellar body count as a predictor of fetal lung maturity Methods: Amniocentesis was performed for evaluation of fetal lung maturity status within 72 hours of delivery in 32 patients. A Lamellar
Hai Bo Liu,Kyong Pyo Koh,이준희,김정선,박성훈 한국생물공학회 2009 Biotechnology and Bioprocess Engineering Vol.14 No.2
The quorum sensing (QS) mechanism of Pseudomonas aeruginosa has been studied extensively due to its involvement in cystic fibrosis, a deadly disease that is responsible for the death of more than a thousand people annually. In order to develop biochemical assay method for screening QS inhibitor, we have studied the production and characterization of recombinant LasR protein, which is a transcriptional activator for the QS mechanism in P.aeruginosa. In recombinant Escherichia coli BL21, LasR was produced as functionally-active proteins when the cells were cultivated in the presence of a proper signaling molecule (acyl homoserine lactone, AHL) only. Some soluble LasR proteins could be obtained from the cells which were grown in AHL-deficient medium, but they did not show binding affinity to the promoter sequence OP1 (lasB elastase promoter). Furthermore, the active LasR, presumably produced as LasR-AHL complex, was not dissociated into its components (LasR and AHLs)in vitro. The current results indicate that the production of pure and active LasR devoid of AHL is very difficult. It can be concluded that the development of biochemical assay method for screening AHL competitive inhibitors which requires pure and active LasR proteins might not be possible unless the structure of LasR and/or its folding processes is modified
재조합 Agrobacterium tumefaciens NTL4 균주를 이용한 quorum Sensing Autoinducer 검색에 용매와 계면활성제가 미치는 영향
고경표,김연희,김정선,박성훈,Koh, Kyong-Pyo,Kim, Yeon-Hee,Kim, Jung Sun,Park, Sunghoon 한국해양바이오학회 2006 한국해양바이오학회지 Vol.1 No.4
재조합 Agrobacterium tumefaciens균주를 사용한 Liquid Culture Assay는 quorum sensing autoinducer를 검색하는 생물학적 분석 방법으로 개발되었다. 그러나 이 시스템에 사용되는 해양천연물 시료들이 일반적으로 낮은 수용액에 대한 용해도를 갖기 때문에 활성검색에 걸림돌이 되고 있다. 시료의 용해도는 유기용매 혹은 계면활성제의 첨가로 증가될 수 있으나, 유기용매나 계면활성제 자체가 검색결과의 정확한 해석을 방해할 수 있으므로 적절한 조건의 확립이 매우 중요하다. Methanol, ethanol, 1-propanol, DMSO와 DMF를 0~10% 농도 범위에서 재조합 A. tumefaciens균주에 대한 세포 성장에 미치는 영향과 ${\beta}$-galactosidase activity에 미치는 영향을 살펴본 결과 methanol 2%이하의 농도가 가장 적합하였으며, 계면활성제의 경우, Tween 20, Tween 80보다는 Triton X-100이 약 0.05% 농도에서 세포내로의 활성물질의 전달효율을 높이는데 효과적이었다. The Liquid Culture Assay using a recombinant Agrobacterium tumefaciens strain has been developed as a means for quorum sensing autoinducer screening. However, the low aqueous solubility of marine natural product extracts used as potential autoinducers has been a hindrance in the screening process. Although the addition of organic solvents and/or surfactants could increase aqueous solubility, errors in data interpretation including false positive results could be a serious problem. Therefore, determining the best possible solvent and surfactant at the optimum concentration is crucial. Evaluating methanol, ethanol, 1-propanol, DMSO and DMF at concentration ranges of 0~10% revealed < 2% methanol to be most favorable when tested for ${\beta}$-gal activity and growth inhibition of the recombinant A. tumefaciens strain. On the other hand, among surfactants tested, Triton X-100 was similarly effective in increasing the delivery of autoinducers for activity at less than 0.05% concentration.
정숙인,천정학,홍종락,고영민,정만표,권오정,이종헌,백경란,송재훈 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2
기관지성 방선균증은 매우 예외적이고 드물며 임상양상이 다양하여 폐암과의 감별이 어렵기도 하지만 기관지내시경 검사를 통해 진단할 수 있고 항생제 투여로 완치될 수 있는 질환이다. 저자들은 기관지석과 함께 발현한 기관지성 방선균증을 장기간의 경구 항생제 요법으로 완치한 1례를 경험하였기에 보고하는 바이다. Endobronchial actmomycosis is considered as an exceptional event. We report a case of a 49-year-old woman who presented with cough and exertional dyspnea for 20 months. Her chest X-ray showed calcified lymph nodes in the right lower paratracheal and subcarinal area and consolidation in the right middle lobe. Bronchoscopic examination demonstrated whitish broncholithiasis with mucosal nodularity in the bronchus intermedius obstructing the lumen near-completely. The biopsy specimen revealed sulfur granules and calcified material which were consistent with actmomycosis. Prolonged oral antibiotic treatment resulted in complete recovery, without need for surgical resection.
( Dong Hun Kim ),( Dong Hyun Choi ),( Hyun Wook Kim ),( Seo Won Choi ),( Bo Bae Kim ),( Joong Wha Chung ),( Young Youp Koh ),( Kyong Sig Chang ),( Soon Pyo Hong ) 대한내과학회 2014 The Korean Journal of Internal Medicine Vol.29 No.4
Background/Aims: The aim of the present study was to evaluate the relationship between thyroid hormone levels and infarct severity in patients with ST-elevation myocardial infarction (STEMI). Methods: We retrospectively reviewed thyroid hormone levels, infarct severity, and the extent of transmurality in 40 STEMI patients evaluated via contrast-enhanced cardiac magnetic resonance imaging. Results: The high triiodothyronine (T3) group (≥ 68.3 ng/dL) exhibited a significantly higher extent of transmural involvement (late transmural enhancement > 75% after administration of gadolinium contrast agent) than did the low T3 group (60% vs. 15%; p = 0.003). However, no significant difference was evident between the high- and low-thyroid-stimulating hormone/free thyroxine (FT4) groups. When the T3 cutoff level was set to 68.3 ng/dL using a receiver operating characteristic curve, the sensitivity was 80% and the specificity 68% in terms of differentiating between those with and without transmural involvement. Upon logistic regression analysis, high T3 level was an independent predictor of transmural involvement after adjustment for the presence of diabetes mellitus (DM) and the use of glycoprotein IIb/IIIa inhibitors (odds ratio, 40.62; 95% confidence interval, 3.29 to 502; p = 0.004). Conclusions: The T3 level predicted transmural involvement that was independent of glycoprotein IIb/IIIa inhibitor use and DM positivity.