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So Ra Kim,Mi-Kyung Kwak,Hye Ran Kang,Seug Yun Yoon,Seong Soon Kwon,Bo Young Kim,Hoo Nam Choi,Hye Jeong Kim,Jae Wook Kim,So-Young Jin,Hyeong Kyu Park,Dong Won Byun,Kyoil Suh,Myung-Hi Yoo 순천향대학교 순천향의학연구소 2014 Journal of Soonchunhyang Medical Science Vol.20 No.2
Although the prognosis of papillary thyroid cancer (PTC) is extremely good, locoregional recurrences after initial treatment occur. Thyroglobulin (Tg) is a reliable tumor marker to detect recurrence or persistence of PTC. However, occasionally serum Tg may miss the detection of a recurrence. We report a 54-year-old female presented with hoarseness due to cervical recurrence without concomitant elevation of serum Tg and anti-Tg antibody, in contrast to extremely increased needle-washout Tg, who had undergone a total thyroidectomy and radioiodine ablation as initial therapies for PTC. Several factors causing such discrepancy between needlewashout Tg and serum Tg can be suggested including site of recurrence, volume of tumor, interference by some kind of plasma antibodies other than anti-Tg antibody, and any conformational defect of Tg protein. Among them, the most convincing explanation is that any conformational defect of Tg may lead to impaired secretion of Tg to blood. We suggest that more studies are needed to find the cause for potential mechanisms involved in PTC recurrences without increased serum Tg.
NPR1 is Instrumental in Priming for the Enhanced flg22-induced MPK3 and MPK6 Activation
Yi, So Young,Min, Sung Ran,Kwon, Suk-Yoon The Korean Society of Plant Pathology 2015 Plant Pathology Journal Vol.31 No.2
Pathogen-associated molecular patterns (PAMPs) activate mitogen-activated protein kinases (MAPKs), essential components of plant defense signaling. Salicylic acid (SA) is also central to plant resistance responses, but its specific role in regulation of MAPK activation is not completely defined. We have investigated the role of SA in PAMP-triggered MAPKs pathways in Arabidopsis SA-related mutants, specifically in the flg22-triggered activation of MPK3 and MPK6. cim6, sid2, and npr1 mutants exhibited wild-type-like flg22-triggered MAPKs activation, suggesting that impairment of SA signaling has no effect on the flg22-triggered MAPKs activation. Pretreatment with low concentrations of SA enhanced flg22-induced MPK3 and MPK6 activation in all seedlings except npr1, indicating that NPR1 is involved in SA-mediated priming that enhanced flg22-induced MAPKs activation.
Eom, So Young,Lee, Yu Ran,Kim, Hong Lae,Kwon, Chan Ho Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.3
Adsorption of 4,4'-bis(mercaptomethyl)biphenyl (44BMBP) on silver nanoparticles has been investigated by surface-enhanced Raman scattering (SERS) spectroscopy. In addition, the Raman spectra of 44BMBP in solid state and in basic condition have been obtained for comparative study to elicit the characteristics of adsorption. The observed Raman and SERS spectra were analyzed comparing with the normal modes and vibrational frequencies from density functional theory (DFT) calculations performed for the feasible structures of 44BMBP molecule. On the basis of excellent agreement between the calculated and the experimental results, the molecule is found to have both the cis- and trans-forms for the mercaptomethyl groups in the solid state as well as in the basic condition. In contrast, the molecule is found to be chemisorbed on the silver surface by forming two Ag-S linkages only in the cis-form but not in the trans-form due to the steric interruption, which indicates the parallel orientation of molecules on the surface. Particularly, the spectral features in the SERS spectra such as the absence of the C-H stretching band and enhancement for the out-of-plane skeletal modes are confirmatory for the parallel geometry through ${\pi}$ interaction between the phenyl rings and the metal surface, based on the electromagnetic surface selection rule.
Managing Complexity in Object-Oriented Analysis
Ine, So-Ran,Youn, Cheong,Misbah, Uddin Mirza,Lee, Kwon-Il,Cha, Seung-Hoon,Byoun, Bo-Gyun,Bae, Doo-Hwan Electronics and Telecommunications Research Instit 1998 ETRI Journal Vol.20 No.2
The current approaches in Object-Oriented Analysis have limitations on modeling complex real world systems because they require priori knowledge about objects and their interactions before applying them. This may be practical in small systems and systems with clear domain knowledge, but not in large real world systems with unclear domain knowledge. Our approach uses a stepwise refinement technique in a top-down manner to the Object-Oriented Analysis stage with the application of use cases. This approach is especially good for new areas where we do not know all the information in advance. We present the approach with an example of its application to the B-ISDN service modeling and distributed systems.
권소란,Kwon, So-Ran 대한심미치과학회 1999 Journal of the Korean Academy of Esthetic Dentistr Vol.8 No.1
The use of fluoride and other preventive methods caused a dramatic decline in dental caries and the need for restorative dentistry. In our modern society that places a high value on appearance, emphasis is now shifting towards esthetic dentistry which has experienced a high popularity with the development of bonding techniques and materials including porcelain and composite. To satisfy patients wanting whiter teeth and a better looking smile, there are many treatment options ranging from full crown coverage to conservative procedures such as bleaching. Whether bleaching should be combined with other esthetic procedures or used alone depends on the type of discoloration and the patient's willingness to accept the various treatment options. Therefore, in order to obtain a successful esthetic outcome, careful diagnosis and treatment planning followed by consultation with the patient is of utmost importance.