鬱血症을 同伴한 파킨손氏病에 對한 電氣痙攣療法 治驗 1例

朴哲秀,姜東佑,申瑩均,孫鎭旭,韓圭熙 서울醫大 1990 精神醫學 Vol.15 No.1

정상여성에서 월경주기에 따른 갑상선 부피의 변동에 관한 연구

박진우,박형규,유명희 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1

Previous studies demonstrated that the thyroid gland volume was altered during the menstrual cycle in normal women, but the mechanism has not been clarified. To investigate the role of thyroid hormone and ovarian steroid hormones in the cyclic alteration of the thyroid volume in normal women, we performed a compound ultrasonogram and measured thyroid volume with the method based on the electronic planimetry of a sequential transverse ultrasound scans of the thyroid and performed serial measurements of thyroid and ovarian steroid hormones in 8 normal women during the cycles and 8 normal men. Thyroid volume in men was greater than that in women (18.6±1.6 ㎤ vs. 11.7±1.2 ㎤, P<0.05), but the ratio of thyroid volume to body weight showed no significant difference. Serial thyroid volume measurements showed no significant changes in men. However, in women, significant increases on day 22 compared with day 1 and 8. Serum T_(3), T_(4) and TSH levels were not changed significantly during the cycle in women. Serum progesterone levels increased on day 22, compared with on day 1, 8 and serum estradiol levels elevated on day 15 and 22, compared with on day 8 (p<0.05). Positive correlation was found between serum progesterone concentration and thyroid volume (r=0.45, p<0.01), while no significant correlation was found between serum estradiol level and thyroid volume. These data suggest that progesterone might play a role in the cyclic alteration of the thyroid volume during the menstrual cycle in women, probably by changing the vascularity of the thyroid.

Adiponectin과 비만, 제2형 당뇨병 및 관상동맥질환과의 관계

박형규,유명희 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1

Background : Adiponectin is a novel adipose tissue-specific protein that has been shown to modulate insulin sensitivity and energy homeostasis. In addition, adiponectin has been found to inhibit inflammatory process and possibly atherogenesis. In this study, we tried to investigate the relationship of adiponectin to obesity, type 2 diabetes and coronary artery disease (CAD). Material and methods : We measured fasting serum insulin and adiponectin concentrations in 55 diabetic patients and 25 nondiabetic subjects. Subjects who had stenosis at least 1 major coronary artery, or who had developed myocardial infarction, or had previously undergone percutaneous coronary intervention or coronary artery bypass graft were classified as CAD patients. 23 diabetic patients and 8 nondiabetic subjects had CAD. Results : Fasting adiponectin concentrations were significantly lower in men than in women (5.1±0.8 vs. 7.8±1.1 ng/mL, p<0.05). In men, serum adiponectin levels were negatively correlated with body mass index (BMI, r=-0.36, p<0.05) and log-insulin (r=-0.32, p<0.05). With multivariate regression analysis, adiponectin was significantly related to BMI (p<0.05). However, no correlations were found in women. Fasting adiponectin concentrations were significantly lower in CAD patients than in control subjects (2.8±0.4 vs. 7.2±1.5 ng/mL, p<0.05). Serum adiponectin levels between diabetic and nondiabetic control subjects, and between diabetic patients with CAD and those without CAD did not differ. Conclusion : Low adiponectin levels were closely related to obesity and CAD. These findings suggest that hypoadiponectinemia may contribute to accelerated atherogenesis associated with obesity.

잎갈나무와 잣나무식생의 생산력에 관한 연구

朴奉奎,崔炯善 梨花女子大學校 韓國生活科學硏究院 1979 韓國生活科學硏究院 論叢 Vol.23 No.-

1) 각 숲의 토양 조성은 비교적 유사하였으나 주변 식생은 23종이 공동 출현하엿고, 94종이 단독 출현하여 차이를 보였다. 2) 잎갈나무숲은 수령이 대체로 15~40년 정도가 많았으며, 잣나무숲은 수령이 대체로 35~60년 정도가 많았다. 3) 두 종의 생각곡선은 S字形의 logistic 곡선을 이루고, 이는 Robertson(1907)의 생장식에 적용시킬 수 있었다. 4) 두 종의 최대생장기는 11~13년으로 비슷하엿으나 잣나무가 느린 성장을 이루었다. 5) 두 종의 최대치벌시기는 잎갈나무가 17년 정도이고, 이때의 흉고 주위는 57cm정도이며, 잣나무는 19년 정도이고 이때의 흉고 주위는 53cm정도이다. Larix olgensis and Pinus koraiensis forests in kwangnung were investigated from July through August 1978. In order to Analysis Microevironmental factors, the three layers of forest-tress, shrubs and herb layer, and soil were observed and analyzed. Quantitative and dimension analysis was used to estimate product and productivity for two species at certain times during the year. the growth curve is sigmoid, or S-shaped. theS-shaped curve has an asymptote, and we can use Robertson's growth formula. As s result, estimated maximum productivity time of larix olgensis is 11 years, and pinus koraiensis is 12 years. Maximum cutting time of Larix olgensis is 17 years, Pinus koraiensis is 19 years.

光陵의 전나무 生長의 定量的 分析에 관한 硏究

朴奉奎,崔炳善 梨花女子大學校 韓國生活科學硏究院 1980 韓國生活科學硏究院 論叢 Vol.25 No.-

光陵의 전나무 생장의 정량적 분석 결과는 다음과 같다. 즉, 1) Logistic equation은 곡선이 생장 초기와 생산량의 극한치에 가까운 값들에서 오차가 비교적 크게 나타났기 때문에 측정치에 적합한 생장식이라고 볼 수는 없었으나 최대 생산적 시기를 나타내는 변곡점(inflection point)이 거의 일치하였으므로, 최대 생산력 시기를 구하기 위해서는 Logistic equation을 쓰는게 바람직하다고 볼 수 있었다. 2) 측정치와 3개의 생장식의 이론치와의 비교에서 Gompertz equation에 의한 이론치가 가장 근사한 값을 나타내어 본 연구에서 조사된 전나무의 생장식으로 적합하였으나 최대 생산력시기가 측정치보다 일찍 나타났으므로 최대 생산력시기의 조사를 위해서는 적합하지 않았다. 3) Von Bertalanffy equation의 이론치는 측정치보다 생장이 느리게 나타났고, 최대 생산력시기도 Gompertz equation 보다도 일찍 나타나므로 본 연구에서 조사된 전나무의 생장식으로는 적합치 않다고 볼 수 있었으나 W∞의 값 즉, Logistic 이나 Gompertz equation에서는 계산에 의하여 구할 수 없는 생산량의 극한값을 구하기 우해서는 필히 이 식을 유도 해내는 고정을 도입해야 구해 낼 수 있었다. Quentitative analysis was made to estimate the product of Abies holophylla in Kwangnung forest. The width of annual rings was measured to obtain the overall yearly growth. The growth curve was S-shaped, that had an upper asymptote, so to speak, carrying capacity, and that approached this asymptote smoothy, not abruptly. Three types of sigmoid growth curve-Logistic, Gompertz, and Von Bertalanffy growth equation-was analyzed with and without Rivklefs' technique, by which conversion factors were used. As a result, caluculated maximum growing time by the Logistic equation wals 15-17 years which was comparatively fit in comparison with data obtained by survey. Calculated annua products by the Gompertz equation were fittest among three equations. Asymptote was calculated by Von Bertalanffy equation.

Globus Hystericus 患者의 臨床的 特徵

朴哲秀,姜東佑,申瑩均,孫鎭旭,韓圭熙 서울醫大 1990 精神醫學 Vol.15 No.1

서울시에서의 酸性降雨에 關한 硏究

朴奉奎,李仁淑,崔炯善 梨花女子大學校 韓國生活科學硏究院 1983 韓國生活科學硏究院 論叢 Vol.32 No.-

본 연구는 1982년 5월부터 9월까지 서울특별시를 2×2㎞로 mesh analysis하여 pH, 산성도, 전기전도도를 측정하여 강우에 의한 대기오염현황을 조사한 것이다. 조사지 97지역중 63% 61지역이 산성강우현상을 나타내고 있었고 특히 오염이 심한 지역에서 가용성 염류의 량이 많은 것으로 나타나, 가용성 염류의 량과 수소이온농도와의 밀접한 상관관계를 밝힐 수 있었다. Over the last several decade rain in the world has become more acidic presumably as a result of anthropogenic inputs of SOx and NOx to the atmosphere and their conversion to H_2SO_4 and HNO_3. Generally, precipitation in equilibrium with the carbon dioxide normally present in the atmosphere has an caidity on the pH scale 5.7. Therefore, polluted areas were determined by concentric difference of free H^+ ions in each site and those, in which pH is lower than 5.7, were considered polluted areas. The highest concentric site of free H^+ ions was considered the most polluted area, which also showed the highest conductivity. There were close relationships between quantity of soluble salts and concentration of H^+ ions. When the concentration of free H^+ ions were same in the polluted areas, the more polluted areas were determined by comparison of concentric difference of total H^+ ions of the sites. The higher the concentration of total H^+ ions, the more polluted areas. The results suggest that 73% (61 sites) of the 97 sites in Seoul were polluted areas.

갑상선 종양에서 thrombin receptor (PAR-1)의 발현 양상

박지영,목지오,김여주,박형규,김철희,변동원,서교일,유명희,조현득,오미혜,김상진 순천향의학연구소 2006 Journal of Soonchunhyang Medical Science Vol.12 No.2

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새로운 Acetylcholinesterase inhibitors의 합성

최순규,김형민,조승환,최학기,박유미,이용균,정대일,김인식,한정태 동아대학교 부설 기초과학연구소 2004 基礎科學硏究論文集 Vol.21 No.1

노인성 치매의 일종인 alzheimer's disease의 효과적인 억제제를 합성하기 위해 우리는 분자 모델링에 의한 가장 적합한 물질인 m-[(N,N,N-trimethylammonio)phenyl]boronic acid를 합성하였다. 출발물질인 3-aminophenylboronic acid monohydrate의 경우 boronic acid의 작용기인 hydroxyl group을 protecting시킴으로써 반응의 안정성을 기하였다. Quarternary ammonium salt는 과량의 methyliodide와 염기 촉매인 potassium hydrogen carbonate를 사용하여 용매인 methanol에서 반응시켜 상당히 높은 수율을 얻을 수 있었다. 또한 과량의 methyliodide와 염기촉매인 potassium hydrogen carbonate를 사용하여 용매인 methanol에서 반응시킨 결과 boronic acid의 protection없이도 안정하게 반응이 진행되어짐을 확인할 수 있었다. In order to syntheisize a effective inhibotor for alzheimer's disease, we synthesized m-[(N,N,N-trimethylammonio)phenyl]boronic acid 4 which is designed by molecular modeling form. We protected the hydroxyl group of 3-aminophenylboronic acid monohydrate 1 with ethlyne glycol to remove the reactivity if hydroxyl group. To synthesize m-[(N,N,N-trimethylammonio)phenyl]boronic acid 4, we reacted 3-aminophenylboronic acid monohydrate 1 with ezcess methyl iodide and potassium hydrogen carbonate as a base-catalyst in methanol. but On executed reaction without protection on hydroxyl group, we found out the result that the hydroxyl group of boronic acid group at 3-aminophenylboronic acid monohydrate 1 didn't react with excess methyliodide. Synthesized m-[(N,N,N-trimethylammonio)phenyl]boronic acid 4 is in progress about biological tests as a plausible acetylcholinesterase inhibitor.

平安滑石鑛山 周邊의 植物相

文炯泰,朴元圭 공주대학교 사범대학 과학교육연구소 1986 과학교육연구 Vol.18 No.1

This is the report on the Flora of Pyong-an Talcum Mine circumference, surveyed from Mar. 1986 to Oct 1986. The tracheidophyta in investigated site was recorded 80 families, 208 genera, 250 species, I subspecies, 42 variaties and 2 forma (295 kinds). Even though the plants above the Mine were well preserved, those below the Mine were influenced ill except Eauisetum arvense and Plantage asiatica piled-up discarded ores, I guess.