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Hyeonsoo Park,Kwang-Youn Kim,Byung Wook Lee,Young Woo Kim,Gon Sup Kim,Chang Keun Kang,Kwnag Il Park 한국예방수의학회 2020 예방수의학회지 Vol.44 No.2
Big data analysis methods are useful tools for sorting valuable data and products. Achyranthes Radix root extract (AR) is a well-known herbal medicine in East Asia due to its anti-osteoarthritis, pro-circulatory, and anti-osteoporosis effects. In this stud y, we investigated the liver- and kidney-protective effects of AR by applying big data analysis to traditional medicine. CDDP (cis-diamminedichloridoplatinum) is an effective cancer cell anti-proliferative agent used in the treatment of diverse types of tumors. However, it is clinically limited due to liver and kidney toxicity. The current study was designed to assess the potential protective effects of AR against CDDP-induced hepato-renal toxicity. For this purpose, male Sprague-Dawley (SD) rats were assigned to four groups, each consisting of four animals. Intravenous injection or oral administration of either saline or AR was performed daily for 14 days, whereas CDDP was injected intraperitoneally on day 3 following AR treatment. Serum biochemistry results revealed that CDDP induced clear hepatic and renal damage while the AR treatment groups showed less damage relative to controls. Next, we tested the pharmacokinetics of AR using 20-hydroxyecdysone (20-HE), which is the most abundant component of AR extract. After intravenous administration of AR, the plasma concentration of 20-HE rapidly declined with a terminal half-life (t1/2) of 0.99±0.47 h. The area under the plasma concentration vs. time curve was 24.96±3.5 h*ng/mL. The present study provides valuable tools for further verification studies of the classical herbal literature and its scientific relevance.
김광세,박철희,강흥원,김천일,윤재식 啓明大學校 醫科大學 1998 계명의대학술지 Vol.17 No.3
신결석의 치료에서 결석의 크기에 따른 요판카테타의 유치는 치료의 성공률과는 상관관계가 없었다. 신결석의 크기가 25 mm 미만인 군에서는 요판카테타를 유치한군에서 배뇨증상만 유의하게 증각되었고, 요관폐쇄나 측복통 등은 유의한 차이가 없었다. 신결석의 크기가 25 mm 이상인 군에서는 요관카테타를 유치한 군에서 통계학적으로 유의하게 측복통과 요관폐쇄는 감소하였으나 배뇨증상은 유의하게 증가하였다. 이상에서 요관카테타의 유치는 신결석의 크기가 25mm 이상인 군에서 요관폐쇄, 측복통 등의 감소목적과 동통에 예민한 환자에서 사용하는 것이 바람직하며 또한 단일신이거나 결석의 위치를 용이하게 할 경우에도 고려된다. Purpose : To ascertain whether insertion of a ureteral stent improves the outcome of renal stones and benefits treated with extracorporeal shock wave lithotripsy(ESWL). Materials and Methods : We retrospectively reviewed the results of ureteral stent use with ESWL in renal calculi. From the August 1995 to June 1997, 45 patients with renal calculi underwent ESWL with or without stents. Patients with renal calculi at least one diameter between 11 and 53mm were eligible for the study. of 45 patients . 30 patients were treated without stents, while 15 patients underwent Double-J stenting before ESWL. Results : There was no significant difference in the stone-free rate in both groups(80% stented group versus 73.3% nonstented group). In renal calculi 25 mm ≤ in diameter, the incidence of ureteral obstruction and pain/renal colic were similar for the two treatment group but voiding symptom was more severe than nonstented group compared with stented group. In renal calculi 25 mm> in diameter, the patients with ureteral stents experienced a significantly lower incidence of flank pain and ureteral obstruction(25%, 37.5% stented group versus 60%, 60% nonstented group) and higher incidence of voiding symptoms(37.5% stented group versus 20% nonstented group). Conclusions: These results suggested that use of an indwelling ureteral stent might not contribute to a higher stone-free for the treatment of renal calculi. But in renal calculi>25 mm in diameter, placement of double-J stent for the purpose of alleviating pain, preventing ureteral obstruction, or in selected cases for example, solitary kidney and aid in stone localization, has a useful adjunctive role in ESWL.
식도 궤양, 급성 담낭염 및 허혈성 대장염의 소견이 현저한 알레르기성 육아 종증(Churg-Strauss Syndrome) 1 예
김광호,박성혜,이상헌,김주현,박현철,남상민,정숙향,김호연,황일순,전형식,추현광 대한내과학회 1993 대한내과학회지 Vol.45 No.3
Churg-Strauss syndrome is a kind of rare systemic vasculitis characterized by peripheral eosinophilia, bronchial asthma and relatively specific pathological findings such as necrotizing vasculitis, eosinophilic infiltration of tissue and/or extravascular granuloma. Clinically multiple organs/systems can be involved with various manifestations of disease of lung, heart, skin, musculoskeletal system, nervous system and gastrointesinal/hepatobiliary tract. Gastrointestinal symtoms were frequently accompanied, but usually mild and easily controllable so that special study for evaluation of the symptoms hardly seemed to be needed. We experienced a case of Churg-Strauss syndrome presenting as esophageal ulcers, acute acalculous cholecystitis and treatment-resistant ischemic colitis in a 24-year-old male patient with acute upper abdominal pain and watery, often bloody diarrhea. He also showed peripheral eosinophilia, bronchial asthma, mononeuritis multiplex, skin rash and arthritis. The patient received high dose corticosteroid, cyclophosphamide and exchange plasmapheresis with resolution of almost all symptoms. But symptoms of ischemic colitis such as abdominal pain and diarrhea are not completely improved in spite of intensive therapy.
N-Acetyl ${\alpha}$-aminoacrylic Acid의 자유라디칼 중합 및 혼성중합
박일현,이종광,최재호,진정일,Il Hyun Park,Chong Kwnag Lee,Jae Ho Choi,Jung-Il Jin 대한화학회 1982 대한화학회지 Vol.26 No.4
본 연구에서는 자유라디칼 메카니즘에 의한 N-acetyl ${\alpha}$-aminoacrylic acid의 단독중합 반응속도와 혼성중합 반응성을 연구하였으며, DMF 용매를 사용하여 $60^{\circ}C$에서 단독중합 시켰을 때의 중합속도 ($R_p$)는 단위체 농도 [M]와 개시제 농도 [I]에 대하여 $R_p$ = $k_p[M]^{0.97}[I]^{0.59}$의 관계를 나타내었다. 또한 이 단위체의 단독중합 총괄 활성화 에너지는 25.2 kcal/mole이었다. N-acetyl ${\alpha}$-aminoacrylic acid를 아크릴산 및 스티렌 단위체와 혼성중합 시켰을 때의 단위체 반응성비는 아래와 같았다. $r_1$(N-acetyl ${\alpha}$-aminoacrylic acid) = 0.49, $r_2$(acrylic acid) = 1.41; $r_1$(N-acetyl ${\alpha}$-aminoacrylic acid) = 0.44, $r_2$(styrene) = 0.91. Alfrey-Price 식을 이용하여 계산한 N-acetyl ${\alpha}$-aminoacrylic acid의 Q와 e값은 두 경우 모두 Q=0.51, e=0.16이었다. 단독중합체 및 혼성중합체들의 열적성질을 DTA 및 TGA법으로 분석하여 비교하여 보았다. The free radical polymerization and copolymerization of N-acetyl ${\alpha}$-aminoacrylic acid were investigated. From the result of kinetic investigation of N-acetyl ${\alpha}$-aminoacrylic acid in DMF at $60^{\circ}C$, a rate equation of $R_p$ = $k_p[M]^{0.97}[I]^{0.59}$ was obtained. The overall activation energy for the polymerization was found to be 25.2 kcal/mole. Copolymerization of N-acetyl ${\alpha}$-aminoacrylic acid with acrylic acid and styrene was carried out for the determination of monomer reactivity ratios. The monomer reactivity ratios for the monomer pairs determined at 70.0{\pm}0.1^{\circ}C$ using benzoyl peroxide as an initiator are; $r_1$(N-acetyl ${\alpha}$-aminoacrylic acid) = 0.49, $r_2$(acrylic acid) = 1.41, $r_1$(N-acetyl ${\alpha}$-aminoacrylic acid) = 0.44, $r_2$(styrene) = 0.91. The values of Alfrey-Price's Q and e parameters for N-acetyl ${\alpha}$-aminoacrylic acid were calculated to be 0.51 and 0.16 for the both systems. Differential thermal analysis and thermogravimetry showed that acrylic acid copolymers have poorer thermal stability as compared with the homopolymer of N-acetyl ${\alpha}$-aminoacrylic acid.